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Published work

27 published item(s)

preprint2026arXiv

Asynchronous Fractional Multi-Agent Deep Reinforcement Learning for Age-Minimal Mobile Edge Computing

In the realm of emerging real-time networked applications such as cyber-physical systems (CPS), the Age of Information (AoI) has emerged as a pivotal metric for evaluating timeliness. To meet the high computational demands, such as those in smart manufacturing within CPS, mobile edge computing (MEC) presents a promising solution for optimizing computing and reducing AoI. In this work, we study the timeliness of compute-intensive updates and explore jointly optimizing the task updating (when to generate a task) and offloading (where to process a task) policies to minimize AoI. Specifically, we consider edge load dynamics and formulate a task scheduling problem to minimize the expected time-average AoI. Solving this problem is challenging due to the fractional objective introduced by AoI and the asynchronous decision-making of the semi-Markov game (SMG). To this end, we propose a fractional reinforcement learning (RL) framework. We begin by introducing a fractional single-agent RL framework and establish its linear convergence rate. Building on this, we develop a fractional multi-agent RL framework, extend Dinkelbach's method, and demonstrate its equivalence to the inexact Newton's method. Furthermore, we provide the conditions under which the framework achieves linear convergence to the Nash equilibrium (NE). To tackle the challenge of asynchronous decision-making in the SMG, we further design an asynchronous model-free fractional multi-agent RL algorithm, where each mobile device can determine the task updating and offloading decisions without knowing the real-time system dynamics and decisions of other devices. Experimental results show that when compared with the best existing baseline algorithm, our proposed algorithm reduces the average AoI by up to 50.6%.

preprint2026arXiv

On IDA-PBC with Maximum Energy Shapeability

Interconnection and Damping Assignment Passivity-Based Control (IDA-PBC) is a well-established stabilization technique for affine nonlinear systems. However, its application is generally hindered by the requirement of solving a set of partial differential equations (PDEs), i.e., the so-called matching equation. This paper introduces the notion of \emph{maximum energy shapeability} which describes the scenario that the homogeneous part of the matching equation admits $m$ independent solutions with $m$ the dimension of the control input. We demonstrate that the maximum energy shapeability enables a systematic procedure for the IDA-PBC design by transforming the matching equation into a set of easier-to-solve PDEs. Sufficient conditions for maximum energy shapeability are also provided. It is shown that some existing constructive IDA-PBC designs actually implicitly exploit the maximum energy shapeability. The proposed procedure for the IDA-PBC design is illustrated with the magnetic levitation system.

preprint2026arXiv

Towards LLM-Assisted Architecture Recovery for Real-World ROS~2 Systems: An Agent-Based Multi-Level Approach to Hierarchical Structural Architecture Reconstruction

Explicit software architecture models are essential artifacts for communicating, analyzing, and evolving complex software-intensive systems. In ROS~2-based robotic systems, however, structural (de-)composition and integration semantics are often only implicitly encoded across distributed artifacts such as source code and launch files, making recovery of hierarchical architecture particularly difficult. Existing approaches mainly focus on node-level entities and communication wiring, while providing limited support for recovering hierarchical structural (de-)composition across multiple abstraction levels. In this paper, we extend our previously proposed blueprint-guided LLM-assisted architecture recovery pipeline for ROS~2 systems through two major enhancements: (1) refined prompting to improve the consistency and controllability of architecture synthesis, and (2) a staged recovery strategy based on multi-level intermediate architectural representations that incorporate the atomic ROS node list and launch file dependencies, thereby enabling structurally constrained reconstruction across multiple abstraction levels. The approach is evaluated on a real-world automated product disassembly system based on cooperative robotic arms and heterogeneous ROS~2 artifacts. Compared to our previous work, the considered case study exhibits substantially higher integration complexity and richer functionality. The results demonstrate improved structural consistency, scalability, and robustness of architecture recovery, while also revealing remaining challenges related to dynamic integration semantics in large-scale ROS~2 systems.

preprint2025arXiv

Toward Large-Scale Photonics-Empowered AI Systems: From Physical Design Automation to System-Algorithm Co-Exploration

In this work, we identify three considerations that are essential for realizing practical photonic AI systems at scale: (1) dynamic tensor operation support for modern models rather than only weight-static kernels, especially for attention/Transformer-style workloads; (2) systematic management of conversion, control, and data-movement overheads, where multiplexing and dataflow must amortize electronic costs instead of letting ADC/DAC and I/O dominate; and (3) robustness under hardware non-idealities that become more severe as integration density grows. To study these coupled tradeoffs quantitatively, and to ensure they remain meaningful under real implementation constraints, we build a cross-layer toolchain that supports photonic AI design from early exploration to physical realization. SimPhony provides implementation-aware modeling and rapid cross-layer evaluation, translating physical costs into system-level metrics so architectural decisions are grounded in realistic assumptions. ADEPT and ADEPT-Z enable end-to-end circuit and topology exploration, connecting system objectives to feasible photonic fabrics under practical device and circuit constraints. Finally, Apollo and LiDAR provide scalable photonic physical design automation, turning candidate circuits into manufacturable layouts while accounting for routing, thermal, and crosstalk constraints.

preprint2022arXiv

Dynamic Multi-Branch Layers for On-Device Neural Machine Translation

With the rapid development of artificial intelligence (AI), there is a trend in moving AI applications, such as neural machine translation (NMT), from cloud to mobile devices. Constrained by limited hardware resources and battery, the performance of on-device NMT systems is far from satisfactory. Inspired by conditional computation, we propose to improve the performance of on-device NMT systems with dynamic multi-branch layers. Specifically, we design a layer-wise dynamic multi-branch network with only one branch activated during training and inference. As not all branches are activated during training, we propose shared-private reparameterization to ensure sufficient training for each branch. At almost the same computational cost, our method achieves improvements of up to 1.7 BLEU points on the WMT14 English-German translation task and 1.8 BLEU points on the WMT20 Chinese-English translation task over the Transformer model, respectively. Compared with a strong baseline that also uses multiple branches, the proposed method is up to 1.5 times faster with the same number of parameters.

preprint2022arXiv

Experiments on Anomaly Detection in Autonomous Driving by Forward-Backward Style Transfers

Great progress has been achieved in the community of autonomous driving in the past few years. As a safety-critical problem, however, anomaly detection is a huge hurdle towards a large-scale deployment of autonomous vehicles in the real world. While many approaches, such as uncertainty estimation or segmentation-based image resynthesis, are extremely promising, there is more to be explored. Especially inspired by works on anomaly detection based on image resynthesis, we propose a novel approach for anomaly detection through style transfer. We leverage generative models to map an image from its original style domain of road traffic to an arbitrary one and back to generate pixelwise anomaly scores. However, our experiments have proven our hypothesis wrong, and we were unable to produce significant results. Nevertheless, we want to share our findings, so that others can learn from our experiments.

preprint2022arXiv

Triangular Transfer: Freezing the Pivot for Triangular Machine Translation

Triangular machine translation is a special case of low-resource machine translation where the language pair of interest has limited parallel data, but both languages have abundant parallel data with a pivot language. Naturally, the key to triangular machine translation is the successful exploitation of such auxiliary data. In this work, we propose a transfer-learning-based approach that utilizes all types of auxiliary data. As we train auxiliary source-pivot and pivot-target translation models, we initialize some parameters of the pivot side with a pre-trained language model and freeze them to encourage both translation models to work in the same pivot language space, so that they can be smoothly transferred to the source-target translation model. Experiments show that our approach can outperform previous ones.

preprint2022arXiv

Universal Conditional Masked Language Pre-training for Neural Machine Translation

Pre-trained sequence-to-sequence models have significantly improved Neural Machine Translation (NMT). Different from prior works where pre-trained models usually adopt an unidirectional decoder, this paper demonstrates that pre-training a sequence-to-sequence model but with a bidirectional decoder can produce notable performance gains for both Autoregressive and Non-autoregressive NMT. Specifically, we propose CeMAT, a conditional masked language model pre-trained on large-scale bilingual and monolingual corpora in many languages. We also introduce two simple but effective methods to enhance the CeMAT, aligned code-switching & masking and dynamic dual-masking. We conduct extensive experiments and show that our CeMAT can achieve significant performance improvement for all scenarios from low- to extremely high-resource languages, i.e., up to +14.4 BLEU on low resource and +7.9 BLEU improvements on average for Autoregressive NMT. For Non-autoregressive NMT, we demonstrate it can also produce consistent performance gains, i.e., up to +5.3 BLEU. To the best of our knowledge, this is the first work to pre-train a unified model for fine-tuning on both NMT tasks. Code, data, and pre-trained models are available at https://github.com/huawei-noah/Pretrained-Language-Model/tree/master/CeMAT.

preprint2021arXiv

A review of data-driven short-term voltage stability assessment of power systems: Concept, principle, and challenges

With the rapid growth of power market reform and power demand, the power transmission capacity of a power grid is approaching its limit, and the secure and stable operation of power systems becomes increasingly important. In particular, in modern power grids, the proportion of dynamic loads with fast recovery characteristics such as air conditioners, refrigerators, and industrial motors is increasing. As well as the increasing proportion of different forms of renewable energy in power systems. Therefore, short-term voltage stability (STVS) of power systems cannot be ignored. This article comprehensively sorts out the STVS problems of power systems from the perspective of data-driven methods and discusses existing challenges.

preprint2021arXiv

Deep Learning for Short-Term Voltage Stability Assessment of Power Systems

To fully learn the latent temporal dependencies from post-disturbance system dynamic trajectories, deep learning is utilized for short-term voltage stability (STVS) assessment of power systems in this paper. First of all, a semi-supervised cluster algorithm is performed to obtain class labels of STVS instances due to the unavailability of reliable quantitative criteria. Secondly, a long short-term memory (LSTM) based assessment model is built through learning the time dependencies from the post-disturbance system dynamics. Finally, the trained assessment model is employed to determine the systems stability status in real time. The test results on the IEEE 39-bus system suggest that the proposed approach manages to assess the stability status of the system accurately and timely. Furthermore, the superiority of the proposed method over traditional shallow learning-based assessment methods has also been proved.

preprint2021arXiv

Dynamic Neural Garments

A vital task of the wider digital human effort is the creation of realistic garments on digital avatars, both in the form of characteristic fold patterns and wrinkles in static frames as well as richness of garment dynamics under avatars' motion. Existing workflow of modeling, simulation, and rendering closely replicates the physics behind real garments, but is tedious and requires repeating most of the workflow under changes to characters' motion, camera angle, or garment resizing. Although data-driven solutions exist, they either focus on static scenarios or only handle dynamics of tight garments. We present a solution that, at test time, takes in body joint motion to directly produce realistic dynamic garment image sequences. Specifically, given the target joint motion sequence of an avatar, we propose dynamic neural garments to jointly simulate and render plausible dynamic garment appearance from an unseen viewpoint. Technically, our solution generates a coarse garment proxy sequence, learns deep dynamic features attached to this template, and neurally renders the features to produce appearance changes such as folds, wrinkles, and silhouettes. We demonstrate generalization behavior to both unseen motion and unseen camera views. Further, our network can be fine-tuned to adopt to new body shape and/or background images. We also provide comparisons against existing neural rendering and image sequence translation approaches, and report clear quantitative improvements.

preprint2021arXiv

Inhibition of Current-spike Formation Based on Longitudinal Phase Space Manipulation for High-Repetition-Rate X-ray FEL

The formation of a double-horn current profile is a challenging issue in the achievement of electron bunch with high peak current, especially for high-repetition-rate X-ray free-electron lasers (XFELs) where more nonlinear and intricate beam dynamics propagation is involved. Here, we propose to correct the nonlinear beam longitudinal phase space distortion in the photoinjector section with a dual-mode buncher. In combination with the evolutionary many-objective beam dynamics optimization, this method is shown to be effective in manipulating the longitudinal phase space at the injector exit. Furthermore, the formation of the current spike is avoided after the multi-stage charge density modulation and electron bunch with a peak current of 1.6 kA is achieved for 100-pC bunch charge.Start-to-end simulations based on the Shanghai high-repetition-rate XFEL and extreme light facility demonstrate that the proposed scheme can increase the FEL pulse energy by more than 3 times in a cascading operation of echo-enabled harmonic generation and high-gain harmonic generation. Moreover, this method can also be used for longitudinal phase space shaping of electron beams operating at a high repetition rate to meet the specific demands of different researches.

preprint2021arXiv

L2E: Learning to Exploit Your Opponent

Opponent modeling is essential to exploit sub-optimal opponents in strategic interactions. Most previous works focus on building explicit models to directly predict the opponents' styles or strategies, which require a large amount of data to train the model and lack adaptability to unknown opponents. In this work, we propose a novel Learning to Exploit (L2E) framework for implicit opponent modeling. L2E acquires the ability to exploit opponents by a few interactions with different opponents during training, thus can adapt to new opponents with unknown styles during testing quickly. We propose a novel opponent strategy generation algorithm that produces effective opponents for training automatically. We evaluate L2E on two poker games and one grid soccer game, which are the commonly used benchmarks for opponent modeling. Comprehensive experimental results indicate that L2E quickly adapts to diverse styles of unknown opponents.

preprint2021arXiv

Mechanism Design for Large Scale Network Utility Maximization

Network utility maximization (NUM) is a general framework for designing distributed optimization algorithms for large-scale networks. An economic challenge arises in the presence of strategic agents' private information. Existing studies proposed (economic) mechanisms but largely neglected the issue of large-scale implementation. Specifically, they require certain modifications to the deployed algorithms, which may bring the significant cost. To tackle this challenge, we present the large-scale Vickery-Clark-Grove (VCG) Mechanism for NUM, with a simpler payment rule characterized by the shadow prices. The Large-Scale VCG Mechanism maximizes the network utility and achieves individual rationality and budget balance. With infinitely many agents, agents' truthful reports of their types are their dominant strategies; for the finite case, each agent's incentive to misreport converges quadratically to zero. For practical implementation, we introduce a modified mechanism that possesses an additional important technical property, superimposability, which makes it able to be built upon any (potentially distributed) algorithm that optimally solves the NUM Problem and ensures all agents to obey the algorithm. We then extend this idea to the dynamic case, when agents' types are dynamically evolving as a controlled Markov process. In this case, the mechanism leads to incentive compatible actions of agent for each time slot.

preprint2021arXiv

Projected entangled pair states study of anisotropic-exchange magnets on triangular lattice

The anisotropic-exchange spin-1/2 model on a triangular lattice has been used to describe the rare-earth chalcogenides, which may have exotic ground states. We investigate the quantum phase diagram of the model by using the projected entangled pair state (PEPS) method, and compare it to the classical phase diagram. Besides two stripe-ordered phase, and the 120$^\circ$ state, there is also a multi-\textbf{Q} phase. We identify the multi-\textbf{Q} phase as a $Z_{2}$ vortex state. No quantum spin liquid state is found in the phase diagram, contrary to the previous DMRG calculations.

preprint2021arXiv

Self-Amplification of Coherent Energy Modulation in Seeded Free-Electron Lasers

The spectroscopic techniques for time-resolved fine analysis of matter require coherent X-ray radiation with femtosecond duration and high average brightness. Seeded free-electron lasers (FELs), which use the frequency up-conversion of an external seed laser to improve temporal coherence, are ideal for providing fully coherent soft X-ray pulses. However, it is difficult to operate seeded FELs at a high repetition rate due to the limitations of present state-of-the-art laser systems. Here, we report the novel self-modulation method for enhancing laser-induced energy modulation, thereby significantly reducing the requirement of an external laser system. Driven by this scheme, we experimentally realize high harmonic generation in a seeded FEL using an unprecedentedly small energy modulation. An electron beam with a laser-induced energy modulation as small as 1.8 times the slice energy spread is used for lasing at the 7th harmonic of a 266-nm seed laser in a single-stage high-gain harmonic generation (HGHG) setup and the 30th harmonic of the seed laser in a two-stage HGHG setup. The results mark a major step towards a high-repetition-rate, fully coherent X-ray FEL.

preprint2020arXiv

A Catalog of RV Variable Star Candidates from LAMOST

RV variable stars are important in astrophysics. The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) spectroscopic survey has provided ~ 6.5 million stellar spectra in its Data Release 4 (DR4). During the survey, ~ 4.7 million unique sources were targeted and ~ 1 million stars observed repeatedly. The probabilities of stars being RV variables are estimated by comparing the observed radial velocity variations with the simulated ones. We build a catalog of 80,702 RV variable candidates with probability greater than 0.60 by analyzing the duplicate-observed multi-epoch sources covered by the LAMOST DR4. Simulations and cross-identifications show that the purity of the catalog is higher than 80%. The catalog consists of 77% binary systems and 7% pulsating stars as well as 16% pollution by single stars. 3,138 RV variables are classified through cross-identifications with published results in literatures. By using the 3,138 sources common to both LAMOST and a collection of published RV variable catalogs we are able to analyze LAMOST's RV variable detection rate. The efficiency of the method adopted in this work relies not only on the sampling frequency of observations but also periods and amplitudes of RV variables. With the progress of LAMOST, Gaia and other surveys, more and more RV variables would will be confirmed and classified. This catalog is valuable for other large-scale surveys, especially for RV variable searches. The catalog will be released according to the LAMOST Data Policy via http://dr4.lamost.org.

preprint2020arXiv

Captioning Images Taken by People Who Are Blind

While an important problem in the vision community is to design algorithms that can automatically caption images, few publicly-available datasets for algorithm development directly address the interests of real users. Observing that people who are blind have relied on (human-based) image captioning services to learn about images they take for nearly a decade, we introduce the first image captioning dataset to represent this real use case. This new dataset, which we call VizWiz-Captions, consists of over 39,000 images originating from people who are blind that are each paired with five captions. We analyze this dataset to (1) characterize the typical captions, (2) characterize the diversity of content found in the images, and (3) compare its content to that found in eight popular vision datasets. We also analyze modern image captioning algorithms to identify what makes this new dataset challenging for the vision community. We publicly-share the dataset with captioning challenge instructions at https://vizwiz.org

preprint2020arXiv

Chemically peculiar A and F stars with enhanced s-process and iron-peak elements: stellar radiative acceleration at work

We present $\gtrsim 15,000$ metal-rich (${\rm [Fe/H]}>-0.2$dex) A and F stars whose surface abundances deviate strongly from Solar abundance ratios and cannot plausibly reflect their birth material composition. These stars are identified by their high [Ba/Fe] abundance ratios (${\rm [Ba/Fe]}>1.0$dex) in the LAMOST DR5 spectra analyzed by Xiang et al. (2019). They are almost exclusively main sequence and subgiant stars with $T_{\rm eff}\gtrsim6300$K. Their distribution in the Kiel diagram ($T_{\rm eff}$--$\log g$) traces a sharp border at low temperatures along a roughly fixed-mass trajectory (around $1.4M_\odot)$ that corresponds to an upper limit in convective envelope mass fraction of around $10^{-4}$. Most of these stars exhibit distinctly enhanced abundances of iron-peak elements (Cr, Mn, Fe, Ni) but depleted abundances of Mg and Ca. Rotational velocity measurements from GALAH DR2 show that the majority of these stars rotate slower than typical stars in an equivalent temperature range. These characteristics suggest that they are related to the so-called Am/Fm stars. Their abundance patterns are qualitatively consistent with the predictions of stellar evolution models that incorporate radiative acceleration, suggesting they are a consequence of stellar internal evolution particularly involving the competition between gravitational settling and radiative acceleration. These peculiar stars constitute 40% of the whole population of stars with mass above 1.5$M_\odot$, affirming that "peculiar" photospheric abundances due to stellar evolution effects are a ubiquitous phenomenon for these intermediate-mass stars. This large sample of Ba-enhanced chemically peculiar A/F stars with individual element abundances provides the statistics to test more stringently the mechanisms that alter the surface abundances in stars with radiative envelopes.

preprint2020arXiv

Deep Detail Enhancement for Any Garment

Creating fine garment details requires significant efforts and huge computational resources. In contrast, a coarse shape may be easy to acquire in many scenarios (e.g., via low-resolution physically-based simulation, linear blend skinning driven by skeletal motion, portable scanners). In this paper, we show how to enhance, in a data-driven manner, rich yet plausible details starting from a coarse garment geometry. Once the parameterization of the garment is given, we formulate the task as a style transfer problem over the space of associated normal maps. In order to facilitate generalization across garment types and character motions, we introduce a patch-based formulation, that produces high-resolution details by matching a Gram matrix based style loss, to hallucinate geometric details (i.e., wrinkle density and shape). We extensively evaluate our method on a variety of production scenarios and show that our method is simple, light-weight, efficient, and generalizes across underlying garment types, sewing patterns, and body motion.

preprint2020arXiv

Joint Bilateral Learning for Real-time Universal Photorealistic Style Transfer

Photorealistic style transfer is the task of transferring the artistic style of an image onto a content target, producing a result that is plausibly taken with a camera. Recent approaches, based on deep neural networks, produce impressive results but are either too slow to run at practical resolutions, or still contain objectionable artifacts. We propose a new end-to-end model for photorealistic style transfer that is both fast and inherently generates photorealistic results. The core of our approach is a feed-forward neural network that learns local edge-aware affine transforms that automatically obey the photorealism constraint. When trained on a diverse set of images and a variety of styles, our model can robustly apply style transfer to an arbitrary pair of input images. Compared to the state of the art, our method produces visually superior results and is three orders of magnitude faster, enabling real-time performance at 4K on a mobile phone. We validate our method with ablation and user studies.

preprint2020arXiv

Leakage-Based Robust Beamforming for Multi-Antenna Broadcast System with Per-Antenna Power Constraints and Quantized CDI

In this paper, we investigate the robust beamforming schemes for a multi-user multiple-input-single-output (MU-MISO) system with per-antenna power constraints and quantized channel direction information (CDI) feedback. Our design objective is to maximize the expectation of the weighted sum-rate performance by means of controlling the interference leakage and properly allocating the power among user equipments (UEs).First, we prove the optimality of the non-robust zero-forcing (ZF) beamforming scheme in the sense of generating the minimum amount of average inter-UE interference under quantized CDI. Then we derive closed-form expressions of the cumulative density function (CDF) of the interference leakage power for the non-robust ZF beamforming scheme, based on which we adjust the leakage thresholds and propose two robust beamforming schemes under per-antenna power constraints with an iterative process to update the per-UE power allocations using the geometric programming (GP). Simulation results show the superiority of the proposed robust beamforming schemes compared with the existing schemes in terms of the average weighted sum-rate performance.

preprint2020arXiv

Learning to Detect Unacceptable Machine Translations for Downstream Tasks

The field of machine translation has progressed tremendously in recent years. Even though the translation quality has improved significantly, current systems are still unable to produce uniformly acceptable machine translations for the variety of possible use cases. In this work, we put machine translation in a cross-lingual pipeline and introduce downstream tasks to define task-specific acceptability of machine translations. This allows us to leverage parallel data to automatically generate acceptability annotations on a large scale, which in turn help to learn acceptability detectors for the downstream tasks. We conduct experiments to demonstrate the effectiveness of our framework for a range of downstream tasks and translation models.

preprint2020arXiv

Multi-objective Optimal Reactive Power Dispatch of Power Systems by Combining Classification Based Multi-objective Evolutionary Algorithm and Integrated Decision Making

For the purpose of addressing the multi-objective optimal reactive power dispatch (MORPD) problem, a two-step approach is proposed in this paper. First of all, to ensure the economy and security of the power system, the MORPD model aiming to minimize active power loss and voltage deviation is formulated. And then the two-step approach integrating decision-making into optimization is proposed to solve the model. Specifically speaking, the first step aims to seek the Pareto optimal solutions (POSs) with good distribution by using a multi-objective optimization (MOO) algorithm named classification and Pareto domination based multi-objective evolutionary algorithm (CPSMOEA). Furthermore, the reference Pareto-optimal front is generated to validate the Pareto front obtained using CPSMOEA; in the second step, integrated decision-making by combining fuzzy c-means algorithm (FCM) with grey relation projection method (GRP) aims to extract the best compromise solutions which reflect the preferences of decision-makers from the POSs. Based on the test results on the IEEE 30-bus and IEEE 118-bus test systems, it is demonstrated that the proposed approach not only manages to address the MORPD issue but also outperforms other commonly-used MOO algorithms including multi-objective particle swarm optimization (MOPSO), preference-inspired coevolutionary algorithm (PICEAg) and the third evolution step of generalized differential evolution (GDE3).

preprint2020arXiv

QoS-Based Source and Relay Secure Optimization Design with Presence of Channel Uncertainty

In this letter, we study relay-aided networks with presence of single eavesdropper. We provide joint beamforming design of the source and relay that can minimize the overall power consumption while satisfying our predefined quality-of-service (QoS) requirements. Additionally, we investigate the case that the channel between relay and eavesdropper suffers from channel uncertainty. Finally, simulation results are provided to verify the effectiveness of our algorithm.

preprint2020arXiv

Rapid Determination of Antimicrobial Susceptibility by Stimulated Raman Scattering Imaging of D2O Metabolic Incorporation in a Single Bacterium

Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with correct antibiotics and slowing down the emergence of antibiotic-resistant bacteria. Here, we report a phenotypic platform that rapidly produces AST results by femtosecond stimulated Raman scattering imaging of deuterium oxide (D2O) metabolism. Metabolic incorporation of D2O into biomass in a single bacterium is probed in as short as 10 minutes after culture in 70% D2O medium, the fastest among current technologies. Single-cell metabolism inactivation concentration (SC-MIC) is obtained in less than 2.5 hours from colony to results. The SC-MIC results of 37 sets of samples, which include 8 major bacterial species and 14 different antibiotics often encountered in clinic, are validated by standard minimal inhibitory concentration blindly measured via broth microdilution. Towards clinical translation, SRS imaging of D2O metabolic incorporation and SC-MIC determination after 1-h antibiotics treatment and 30-minutes mixture of D2O and antibiotics incubation of bacteria in urine or whole blood is demonstrated.

preprint2020arXiv

Robust Beamforming Design for Sum Secrecy Rate Optimization in MU-MISO Networks

This paper studies the beamforming design problem of a multi-user downlink network, assuming imperfect channel state information known to the base station. In this scenario, the base station is equipped with multiple antennas, and each user is wiretapped by a specific eavesdropper where each user or eavesdropper is equipped with one antenna. It is supposed that the base station employs transmit beamforming with a given requirement on sum transmitting power. The objective is to maximize the sum secrecy rate of the network. Due to the uncertainty of the channel, it is difficult to calculate the exact sum secrecy rate of the system. Thus, the maximum of lower bound of sum secrecy rate is considered. The optimization of the lower bound of sum secrecy rate still makes the considered beamforming design problem difficult to handle. To solve this problem, a beamforming design scheme is proposed to transform the original problem into a convex approximation problem, by employing semidefinite relaxation and first-order approximation technique based on Taylor expansion. Besides, with the advantage of low complexity, a zero-forcing based beamforming method is presented in the case that base station is able to nullify the eavesdroppers' rate. When the base station doesn't have the ability, user selection algorithm would be in use. Numerical results show that the former strategy achieves better performance than the latter one, which is mainly due to the ability of optimizing beamforming direction, and both outperform the signal-to-leakage-and-noise ratio based algorithm.