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Yi Liao

Yi Liao contributes to research discovery and scholarly infrastructure.

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Published work

9 published item(s)

preprint2026arXiv

Annotation-free deep learning for detection and segmentation of fetal germinal matrix-intraventricular hemorrhage in brain MRI

Background: Prenatal germinal matrix-intraventricular hemorrhage (GMH-IVH) is a leading cause of infant mortality and neurodevelopmental impairment. Manual diagnosis and lesion segmentation are labor-intensive and error-prone. Deep learning models offer potential for automation but typically require large annotated datasets, which are challenging to obtain. Purpose: To develop and validate an annotation-free deep learning framework for automated detection and segmentation of GMH-IVH on brain MRI. Materials and Methods: This retrospective study analyzed 2D T2-weighted MRI data from pregnant women collected from October 2015 to October 2023 at one hospital (internal validation) and two hospitals (external validation). Eligible participants included healthy fetuses and those with GMH-IVH. FreeHemoSeg was developed and trained using pseudo GMH-IVH images synthesized from normal fetal data guided by medical priors. Primary outcomes included diagnostic accuracy (area under the ROC curve [AUROC], sensitivity, specificity) and segmentation accuracy (Dice similarity coefficient [DSC]). A reader study evaluated clinical utility. Results: A total of 1674 stacks from 558 pregnant women were analyzed. FreeHemoSeg achieved the highest performance in both internal (sensitivity: 0.914, 95% CI 0.869-0.945; specificity: 0.966, 95% CI 0.946-0.978; DSC: 0.559, 95% CI 0.546-0.571) and external validation (sensitivity: 0.824, 95% CI 0.739-0.885; specificity: 0.943, 95% CI 0.913-0.964; DSC: 0.512, 95% CI 0.497-0.526), outperforming supervised and unsupervised methods. FreeHemoSeg assistance improved radiologists' sensitivity (from 0.882 to 0.941-1.000) and diagnostic confidence while reducing interpretation time by 16.0-52.7%. Conclusion: FreeHemoSeg accurately detects and localizes fetal brain hemorrhages without annotated training data, enabling earlier diagnosis and supporting timely clinical management.

preprint2022arXiv

A resource-efficient deep learning framework for low-dose brain PET image reconstruction and analysis

18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography (PET) imaging usually needs a full-dose radioactive tracer to obtain satisfactory diagnostic results, which raises concerns about the potential health risks of radiation exposure, especially for pediatric patients. Reconstructing the low-dose PET (L-PET) images to the high-quality full-dose PET (F-PET) ones is an effective way that both reduces the radiation exposure and remains diagnostic accuracy. In this paper, we propose a resource-efficient deep learning framework for L-PET reconstruction and analysis, referred to as transGAN-SDAM, to generate F-PET from corresponding L-PET, and quantify the standard uptake value ratios (SUVRs) of these generated F-PET at whole brain. The transGAN-SDAM consists of two modules: a transformer-encoded Generative Adversarial Network (transGAN) and a Spatial Deformable Aggregation Module (SDAM). The transGAN generates higher quality F-PET images, and then the SDAM integrates the spatial information of a sequence of generated F-PET slices to synthesize whole-brain F-PET images. Experimental results demonstrate the superiority and rationality of our approach.

preprint2022arXiv

Extending low energy effective field theory with a complete set of dimension-7 operators

We present a complete and independent set of dimension-7 operators in the low energy effective field theory (LEFT) where the dynamical degrees of freedom are the standard model five quarks and all of the neutral and charged leptons. All operators are non-Hermitian and are classified according to their baryon ($ΔB$) and lepton ($ΔL$) numbers violated. Including Hermitian-conjugated operators, there are in total $3168$, $750$, $588$, $712$ operators with $(ΔB,ΔL)=(0,0)$, $(0,\pm 2)$, $(\pm 1,\mp 1)$, $(\pm 1,\pm 1)$ respectively. We perform the tree-level matching with the standard model effective field theory (SMEFT) up to dimension-7 (dim-7) operators in both LEFT and SMEFT. As a phenomenological application we study the effective neutrino-photon interactions due to dim-7 lepton number violating operators that are induced and much enhanced at one loop from dim-6 operators that in turn are matched from dim-7 SMEFT operators. We compare the cross sections of various neutrino-photon scattering with their counterparts in the standard model and highlight the new features. Finally we illustrate how these effective interactions could arise from ultraviolet completion.

preprint2020arXiv

Effective field theory approach to lepton number violating decays $K^\pm\rightarrow π^\mp l^{\pm}_αl^{\pm}_β$: long-distance contribution

This is a sequel to our recent work [1] in which we calculated the lepton number violating (LNV) $K^\pm$ decays due to contact dimension-9 (dim-9) quark-lepton effective interactions that are induced at a high energy scale. In this work we investigate the long-distance contribution to the decays arising from the exchange of a neutrino. These decays can probe LNV interactions involving the second generation of fermions that are not reachable in nuclear neutrinoless double-$β$ decays. Our study is completely formulated in the framework of effective field theories (EFTs), from the standard model effective field theory (SMEFT) through the low energy effective field theory (LEFT) to chiral perturbation theory. We work to the first nontrivial orders in each effective field theory, collect along the way the matching conditions and renormalization group effects, and express the decay branching ratios in terms of the Wilson coefficients associated with the dim-5 and dim-7 operators in SMEFT. Our result is general in that it does not depend on dynamical details of physics at a high scale that induce the effective interactions in SMEFT and in that it does not appeal to any hadronic models. We find that the long-distance contribution overwhelmingly dominates over the contact or short-distance one. Assuming the new physics scale to be around a TeV, the branching ratios are predicted to be below the current experimental upper bounds by several orders of magnitude.

preprint2020arXiv

Effective field theory approach to lepton number violating decays $K^\pm\rightarrow π^\mp l^{\pm}l^{\pm}$: short-distance contribution

This is the first paper of our systematic efforts on lepton number violating (LNV) hadronic decays in the effective field theory approach. These decays provide information complementary to popular nuclear neutrinoless double-$β$ ($0νββ$) decay in that they can probe LNV interactions involving heavier quarks and charged leptons. We may call them hadronic $0νββ$ decays in short, though $β$ refers to all charged leptons. In this work we investigate the decays $K^\pm\rightarrowπ^\mp l^{\pm}l^{\pm}$ that arise from short-distance or contact interactions involving four quark fields and two charged lepton fields, which have canonical dimension nine (dim-9) at leading order in low energy effective field theory (LEFT). We make a complete analysis on the basis of all dim-9 operators that violate lepton number by two units, and compute their one-loop QCD renormalization effects. We match these effective interactions in LEFT to those in chiral perturbation theory ($χ$PT) for pseudoscalar mesons, and determine the resulting hadronic low energy constants (LECs) by chiral symmetry and lattice results in the literature. The obtained decay rate is general in that all physics at and above the electroweak scale is completely parameterized by the relevant Wilson coefficients in LEFT and hadronic LECs in $χ$PT. Assuming the standard model effective field theory (SMEFT) is the appropriate effective field theory between some new physics scale and the electroweak scale, we match our LEFT results to SMEFT whose leading effective interactions arise from LNV dim-7 operators. This connection to SMEFT simplifies significantly the interaction structures entering in the kaon decays, and we employ the current experimental bounds to set constraints on the relevant Wilson coefficients in SMEFT.

preprint2020arXiv

Geometric phase and topological phase diagram of the one-dimensional $XXZ$ Heisenberg spin chain in a longitudinal field

In this paper, we determine the geometric phase for the one-dimensional $XXZ$ Heisenberg chain with spin-$1/2$, the exchange couple $J$ and the spin anisotropy parameter $Δ$ in a longitudinal field(LF) with the reduced field strength $h$. Using the Jordan-Wigner transformation and the mean-field theory based on the Wick&#39;s theorem, a semi-analytical theory has been developed in terms of order parameters which satisfy the self-consistent equations. The values of the order parameters are numerically computed using the matrix-product-state(MPS) method. The validity of the mean-filed theory could be checked through the comparison between the self-consistent solutions and the numerical results. Finally, we draw the the topological phase diagrams in the case $J<0$ and the case $J>0$.

preprint2020arXiv

Imprint of a new light particle at KOTO?

Recently, the KOTO experiment reported their new preliminary result of searching for the decay $K_L\toπ^0ν\barν$. Three candidate events were observed in the signal region, which exceed significantly the expectation based on the standard model. On the other hand, the new NA62 and previous BNL-E949 experiments yielded a consistent result and confirmed the standard model prediction in the charged meson decay $K^+\toπ^+ν\barν$. Furthermore, the two decays are bound by a well-motivated relation from an analysis of isospin symmetry that is hard to break by the new physics of heavy particles. In this work, we study the issue by a systematic effective field theory approach with three of the simplest scenarios, in which the $K_L$ may decay into a new light neutral particle $X$, i.e., $K_L\toπ^0X$, $K_L\to γγX$, or $K_L\toπ^0XX$. We assess the feasibility of the scenarios by simulations and by incorporating constraints coming from NA62 and other relevant experiments. Our main conclusion is that the scenario $K\toπXX$ for a long lived scalar $X$ seems more credible than the other two when combining distributions and other experimental constraints while the region below the KOTO&#39;s blind box provides a good detection environment to search for all three scenarios for a relatively heavy $X$.

preprint2020arXiv

Probabilistically Masked Language Model Capable of Autoregressive Generation in Arbitrary Word Order

Masked language model and autoregressive language model are two types of language models. While pretrained masked language models such as BERT overwhelm the line of natural language understanding (NLU) tasks, autoregressive language models such as GPT are especially capable in natural language generation (NLG). In this paper, we propose a probabilistic masking scheme for the masked language model, which we call probabilistically masked language model (PMLM). We implement a specific PMLM with a uniform prior distribution on the masking ratio named u-PMLM. We prove that u-PMLM is equivalent to an autoregressive permutated language model. One main advantage of the model is that it supports text generation in arbitrary order with surprisingly good quality, which could potentially enable new applications over traditional unidirectional generation. Besides, the pretrained u-PMLM also outperforms BERT on a set of downstream NLU tasks.

preprint2020arXiv

Thermodynamics and phase transition in rotational Kiselev black hole

In this work, we investigate the thermodynamic properties of rotational Kiselev black holes (KBH). Specifically, we use the first-order approximation of the event horizon (EH) to calculate thermodynamic properties for general equations of state $ω$. These thermodynamic properties include areas, entropies, horizon radii, surface gravities, surface temperatures, Komar energies and irreducible masses at the Cauchy horizon (CH) and EH. We study the products of these thermodynamic quantities, we find that these products are determined by the equation of state $ω$ and strength parameter $α$. In the case of the quintessence matter ($ω=-2/3$), radiation ($ω=1/3$) and dust ($ω=0$), we discuss their properties in detail. We also generalize the Smarr mass formula and Christodoulou-Ruffini mass formula to rotational KBH. Finally we study the phase transition and thermodynamic geometry for rotational KBH with radiation ($ω=1/3$). Through analysis, we find that this phase transition is a second order phase transition. Furthermore, we also obtain the scalar curvature in the thermodynamic geometry framework, indicating that the radiation matter may change the phase transition condition and properties for Kerr black hole.