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Researcher profile

Lin Liu

Lin Liu contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Machine LearningMethodologyComputer VisionArtificial Intelligencecond-mat.mtrl-scieess.IVeess.SYGenomicsInformation Theorymath.ITQuantitative MethodsRoboticsSystems and ControlApplicationsComputational Engineering, Finance, and ScienceDistributed, Parallel, and Cluster Computingeess.SPInformation Retrievalmath.NAmath.STMultiagent SystemsNumerical Analysisphysics.app-phquant-phStatistics Theory

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Published work

31 published item(s)

preprint2026arXiv

DriveFuture: Future-Aware Latent World Models for Autonomous Driving

Existing latent world models for autonomous driving have opened a promising path toward future-aware driving intelligence. However, they typically treat future latent states as prediction targets or auxiliary signals, rather than directly conditioning trajectory planning. This can entangle current and future features in latent space. In this work, we propose DriveFuture, a future-aware latent world modeling framework for autonomous driving that explicitly learns planning-oriented foresight by conditioning the current latent state modeling process on future world states. Specifically, during training, the model first predicts future latent world states from the current latent state and ego action, and then refines the prediction against the ground-truth future latent state via cross-attention. The resulting future-aware latent serves as an explicit condition for a diffusion-based trajectory planner. During inference, DriveFuture conditions on the predicted future latent state instead of the ground-truth future state. DriveFuture achieves SOTA performance on the public NAVSIM benchmarks, reaching \textbf{55.5} EPDMS on NAVSIM-v2 {\textcolor{blue}{\textit{navhard}}}, \textbf{89.9} EPDMS on NAVSIM-v2 {\textcolor{blue}{\textit{navtest}}}, and \textbf{90.7} PDMS on NAVSIM-v1 {\textcolor{blue}{\textit{navtest}}}, respectively. These results suggest that the key to latent world modeling lies not merely in simulating future states, but more importantly in conditioning current decision-making on future states. Notably, as of April 2026, DriveFuture ranks \textbf{1st} on the \href{https://huggingface.co/spaces/AGC2025/e2e-driving-navhard}{NAVSIM-v2 {\textcolor{blue}{\textit{navhard}}}} leaderboard and achieves SOTA performance on \href{https://huggingface.co/spaces/AGC2024-P/e2e-driving-navtest}{NAVSIM-v1 {\textcolor{blue}{\textit{navtest}}}}.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

A Cooperation-Aware Lane Change Method for Autonomous Vehicles

Lane change for autonomous vehicles (AVs) is an important but challenging task in complex dynamic traffic environments. Due to difficulties in guarantee safety as well as a high efficiency, AVs are inclined to choose relatively conservative strategies for lane change. To avoid the conservatism, this paper presents a cooperation-aware lane change method utilizing interactions between vehicles. We first propose an interactive trajectory prediction method to explore possible cooperations between an AV and the others. Further, an evaluation is designed to make a decision on lane change, in which safety, efficiency and comfort are taken into consideration. Thereafter, we propose a motion planning algorithm based on model predictive control (MPC), which incorporates AV's decision and surrounding vehicles' interactive behaviors into constraints so as to avoid collisions during lane change. Quantitative testing results show that compared with the methods without an interactive prediction, our method enhances driving efficiencies of the AV and other vehicles by 14.8$\%$ and 2.6$\%$ respectively, which indicates that a proper utilization of vehicle interactions can effectively reduce the conservatism of the AV and promote the cooperation between the AV and others.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

A splitting Hamiltonian Monte Carlo method for efficient sampling

We propose a splitting Hamiltonian Monte Carlo (SHMC) algorithm, which can be computationally efficient when combined with the random mini-batch strategy. By splitting the potential energy into numerically nonstiff and stiff parts, one makes a proposal using the nonstiff part of $U$, followed by a Metropolis rejection step using the stiff part that is often easy to compute. The splitting allows efficient sampling from systems with singular potentials (or distributions with degenerate points) and/or with multiple potential barriers. In our SHMC algorithm, the proposal only based on the nonstiff part in the splitting is generated by the Hamiltonian dynamics, which can be potentially more efficient than the overdamped Langevin dynamics. We also use random batch strategies to reduce the computational cost to $\mathcal{O}(1)$ per time step in generating the proposals for problems arising from many-body systems and Bayesian inference, and prove that the errors of the Hamiltonian induced by the random batch approximation is $\mathcal{O}(\sqrt{Δt})$ in the strong and $\mathcal{O}(Δt)$ in the weak sense, where $Δt$ is the time step. Numerical experiments are conducted to verify the theoretical results and the computational efficiency of the proposed algorithms in practice.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Assessing Classifier Fairness with Collider Bias

The increasing application of machine learning techniques in everyday decision-making processes has brought concerns about the fairness of algorithmic decision-making. This paper concerns the problem of collider bias which produces spurious associations in fairness assessment and develops theorems to guide fairness assessment avoiding the collider bias. We consider a real-world application of auditing a trained classifier by an audit agency. We propose an unbiased assessment algorithm by utilising the developed theorems to reduce collider biases in the assessment. Experiments and simulations show the proposed algorithm reduces collider biases significantly in the assessment and is promising in auditing trained classifiers.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Discovering Ancestral Instrumental Variables for Causal Inference from Observational Data

Instrumental variable (IV) is a powerful approach to inferring the causal effect of a treatment on an outcome of interest from observational data even when there exist latent confounders between the treatment and the outcome. However, existing IV methods require that an IV is selected and justified with domain knowledge. An invalid IV may lead to biased estimates. Hence, discovering a valid IV is critical to the applications of IV methods. In this paper, we study and design a data-driven algorithm to discover valid IVs from data under mild assumptions. We develop the theory based on partial ancestral graphs (PAGs) to support the search for a set of candidate Ancestral IVs (AIVs), and for each possible AIV, the identification of its conditioning set. Based on the theory, we propose a data-driven algorithm to discover a pair of IVs from data. The experiments on synthetic and real-world datasets show that the developed IV discovery algorithm estimates accurate estimates of causal effects in comparison with the state-of-the-art IV based causal effect estimators.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Dynamic Event-Triggered Consensus of Multi-agent Systems on Matrix-weighted Networks

This paper examines the event-triggered consensus of the multi-agent system on matrix-weighted networks, where the interdependencies among higher-dimensional states of neighboring agents are characterized by matrix-weighted edges in the network. Specifically, a novel distributed dynamic event-triggered coordination strategy is proposed for this category of generalized networks, in which an auxiliary system is employed for each agent to dynamically adjust the triggering threshold, which plays an essential role in guaranteeing that the triggering time sequence does not exhibit Zeno behavior. Distributed event-triggered control protocols are proposed to guarantee leaderless and leader-follower consensus for multi-agent systems on matrix-weighted networks, respectively. Remarkably, the spectrum of matrix-valued weights is crucial in event-triggered mechanism design for matrix-weighted networks, generalizing those results only applicable for scalar-weighted networks. The proposed approach allows each agent to broadcast and receive information only at its triggering instants. Finally, simulation examples are provided to demonstrate the theoretical results.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Explanatory causal effects for model agnostic explanations

This paper studies the problem of estimating the contributions of features to the prediction of a specific instance by a machine learning model and the overall contribution of a feature to the model. The causal effect of a feature (variable) on the predicted outcome reflects the contribution of the feature to a prediction very well. A challenge is that most existing causal effects cannot be estimated from data without a known causal graph. In this paper, we define an explanatory causal effect based on a hypothetical ideal experiment. The definition brings several benefits to model agnostic explanations. First, explanations are transparent and have causal meanings. Second, the explanatory causal effect estimation can be data driven. Third, the causal effects provide both a local explanation for a specific prediction and a global explanation showing the overall importance of a feature in a predictive model. We further propose a method using individual and combined variables based on explanatory causal effects for explanations. We show the definition and the method work with experiments on some real-world data sets.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Global Update Guided Federated Learning

Federated learning protects data privacy and security by exchanging models instead of data. However, unbalanced data distributions among participating clients compromise the accuracy and convergence speed of federated learning algorithms. To alleviate this problem, unlike previous studies that limit the distance of updates for local models, we propose global-update-guided federated learning (FedGG), which introduces a model-cosine loss into local objective functions, so that local models can fit local data distributions under the guidance of update directions of global models. Furthermore, considering that the update direction of a global model is informative in the early stage of training, we propose adaptive loss weights based on the update distances of local models. Numerical simulations show that, compared with other advanced algorithms, FedGG has a significant improvement on model convergence accuracies and speeds. Additionally, compared with traditional fixed loss weights, adaptive loss weights enable our algorithm to be more stable and easier to implement in practice.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Identify treatment effect patterns for personalised decisions

In personalised decision making, evidence is required to determine whether an action (treatment) is suitable for an individual. Such evidence can be obtained by modelling treatment effect heterogeneity in subgroups. The existing interpretable modelling methods take a top-down approach to search for subgroups with heterogeneous treatment effects and they may miss the most specific and relevant context for an individual. In this paper, we design a \emph{Treatment effect pattern (TEP)} to represent treatment effect heterogeneity in data. To achieve an interpretable presentation of TEPs, we use a local causal structure around the outcome to explicitly show how those important variables are used in modelling. We also derive a formula for unbiasedly estimating the \emph{Conditional Average Causal Effect (CATE)} using the local structure in our problem setting. In the discovery process, we aim at minimising heterogeneity within each subgroup represented by a pattern. We propose a bottom-up search algorithm to discover the most specific patterns fitting individual circumstances the best for personalised decision making. Experiments show that the proposed method models treatment effect heterogeneity better than three other existing tree based methods in synthetic and real world data sets.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Local search for efficient causal effect estimation

Causal effect estimation from observational data is a challenging problem, especially with high dimensional data and in the presence of unobserved variables. The available data-driven methods for tackling the problem either provide an estimation of the bounds of a causal effect (i.e. nonunique estimation) or have low efficiency. The major hurdle for achieving high efficiency while trying to obtain unique and unbiased causal effect estimation is how to find a proper adjustment set for confounding control in a fast way, given the huge covariate space and considering unobserved variables. In this paper, we approach the problem as a local search task for finding valid adjustment sets in data. We establish the theorems to support the local search for adjustment sets, and we show that unique and unbiased estimation can be achieved from observational data even when there exist unobserved variables. We then propose a data-driven algorithm that is fast and consistent under mild assumptions. We also make use of a frequent pattern mining method to further speed up the search of minimal adjustment sets for causal effect estimation. Experiments conducted on extensive synthetic and real-world datasets demonstrate that the proposed algorithm outperforms the state-of-the-art criteria/estimators in both accuracy and time-efficiency.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Low-Light Video Enhancement with Synthetic Event Guidance

Low-light video enhancement (LLVE) is an important yet challenging task with many applications such as photographing and autonomous driving. Unlike single image low-light enhancement, most LLVE methods utilize temporal information from adjacent frames to restore the color and remove the noise of the target frame. However, these algorithms, based on the framework of multi-frame alignment and enhancement, may produce multi-frame fusion artifacts when encountering extreme low light or fast motion. In this paper, inspired by the low latency and high dynamic range of events, we use synthetic events from multiple frames to guide the enhancement and restoration of low-light videos. Our method contains three stages: 1) event synthesis and enhancement, 2) event and image fusion, and 3) low-light enhancement. In this framework, we design two novel modules (event-image fusion transform and event-guided dual branch) for the second and third stages, respectively. Extensive experiments show that our method outperforms existing low-light video or single image enhancement approaches on both synthetic and real LLVE datasets.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

NTIRE 2022 Challenge on High Dynamic Range Imaging: Methods and Results

This paper reviews the challenge on constrained high dynamic range (HDR) imaging that was part of the New Trends in Image Restoration and Enhancement (NTIRE) workshop, held in conjunction with CVPR 2022. This manuscript focuses on the competition set-up, datasets, the proposed methods and their results. The challenge aims at estimating an HDR image from multiple respective low dynamic range (LDR) observations, which might suffer from under- or over-exposed regions and different sources of noise. The challenge is composed of two tracks with an emphasis on fidelity and complexity constraints: In Track 1, participants are asked to optimize objective fidelity scores while imposing a low-complexity constraint (i.e. solutions can not exceed a given number of operations). In Track 2, participants are asked to minimize the complexity of their solutions while imposing a constraint on fidelity scores (i.e. solutions are required to obtain a higher fidelity score than the prescribed baseline). Both tracks use the same data and metrics: Fidelity is measured by means of PSNR with respect to a ground-truth HDR image (computed both directly and with a canonical tonemapping operation), while complexity metrics include the number of Multiply-Accumulate (MAC) operations and runtime (in seconds).

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

On genuine entanglement for tripartite systems

We investigate the genuine entanglement in tripartite systems based on partial transposition and the norm of correlation tensors of the density matrices. We first derive an analytical sufficient criterion to detect genuine entanglement of tripartite qubit quantum states combining with the partial transposition of the density matrices. Then we use the norm of correlation tensors to study genuine entanglement for tripartite qudit quantum states and obtain a genuine entanglement criterion by constructing certain matrices. With detailed examples our results are seen to be able to detect more genuine tripartite entangled states than previous studies.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Secuer: ultrafast, scalable and accurate clustering of single-cell RNA-seq data

Identifying cell clusters is a critical step for single-cell transcriptomics study. Despite the numerous clustering tools developed recently, the rapid growth of scRNA-seq volumes prompts for a more (computationally) efficient clustering method. Here, we introduce Secuer, a Scalable and Efficient speCtral clUstERing algorithm for scRNA-seq data. By employing an anchor-based bipartite graph representation algorithm, Secuer enjoys reduced runtime and memory usage by orders of magnitude, especially for ultra-large datasets profiling over 1 or even 10 million cells. Meanwhile, Secuer also achieves better or comparable accuracy than competing methods in small and moderate benchmark datasets. Furthermore, we showcase that Secuer can also serve as a building block for a new consensus clustering method, Secuer-consensus, which again greatly improves the runtime and scalability of state-of-the-art consensus clustering methods while also maintaining the accuracy. Overall, Secuer is a versatile, accurate, and scalable clustering framework suitable for small to ultra-large single-cell clustering tasks.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Sequential Search with Off-Policy Reinforcement Learning

Recent years have seen a significant amount of interests in Sequential Recommendation (SR), which aims to understand and model the sequential user behaviors and the interactions between users and items over time. Surprisingly, despite the huge success Sequential Recommendation has achieved, there is little study on Sequential Search (SS), a twin learning task that takes into account a user's current and past search queries, in addition to behavior on historical query sessions. The SS learning task is even more important than the counterpart SR task for most of E-commence companies due to its much larger online serving demands as well as traffic volume. To this end, we propose a highly scalable hybrid learning model that consists of an RNN learning framework leveraging all features in short-term user-item interactions, and an attention model utilizing selected item-only features from long-term interactions. As a novel optimization step, we fit multiple short user sequences in a single RNN pass within a training batch, by solving a greedy knapsack problem on the fly. Moreover, we explore the use of off-policy reinforcement learning in multi-session personalized search ranking. Specifically, we design a pairwise Deep Deterministic Policy Gradient model that efficiently captures users' long term reward in terms of pairwise classification error. Extensive ablation experiments demonstrate significant improvement each component brings to its state-of-the-art baseline, on a variety of offline and online metrics.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

TAPE: Task-Agnostic Prior Embedding for Image Restoration

Learning a generalized prior for natural image restoration is an important yet challenging task. Early methods mostly involved handcrafted priors including normalized sparsity, l_0 gradients, dark channel priors, etc. Recently, deep neural networks have been used to learn various image priors but do not guarantee to generalize. In this paper, we propose a novel approach that embeds a task-agnostic prior into a transformer. Our approach, named Task-Agnostic Prior Embedding (TAPE), consists of two stages, namely, task-agnostic pre-training and task-specific fine-tuning, where the first stage embeds prior knowledge about natural images into the transformer and the second stage extracts the knowledge to assist downstream image restoration. Experiments on various types of degradation validate the effectiveness of TAPE. The image restoration performance in terms of PSNR is improved by as much as 1.45dB and even outperforms task-specific algorithms. More importantly, TAPE shows the ability of disentangling generalized image priors from degraded images, which enjoys favorable transfer ability to unknown downstream tasks.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

A Learning-based Stochastic Driving Model for Autonomous Vehicle Testing

In the simulation-based testing and evaluation of autonomous vehicles (AVs), how background vehicles (BVs) drive directly influences the AV's driving behavior and further impacts the testing result. Existing simulation platforms use either pre-determined trajectories or deterministic driving models to model the BVs' behaviors. However, pre-determined BV trajectories can not react to the AV's maneuvers, and deterministic models are different from real human drivers due to the lack of stochastic components and errors. Both methods lead to unrealistic traffic scenarios. This paper presents a learning-based stochastic driving model that meets the unique needs of AV testing, i.e. interactive and human-like. The model is built based on the long-short-term-memory (LSTM) architecture. By incorporating the concept of quantile-regression to the loss function of the model, the stochastic behaviors are reproduced without any prior assumption of human drivers. The model is trained with the large-scale naturalistic driving data (NDD) from the Safety Pilot Model Deployment(SPMD) project and then compared with a stochastic intelligent driving model (IDM). Analysis of individual trajectories shows that the proposed model can reproduce more similar trajectories to human drivers than IDM. To validate the ability of the proposed model in generating a naturalistic driving environment, traffic simulation experiments are implemented. The results show that the traffic flow parameters such as speed, range, and headway distribution match closely with the NDD, which is of significant importance for AV testing and evaluation.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Adversarial Mixture Of Experts with Category Hierarchy Soft Constraint

Product search is the most common way for people to satisfy their shopping needs on e-commerce websites. Products are typically annotated with one of several broad categorical tags, such as "Clothing" or "Electronics", as well as finer-grained categories like "Refrigerator" or "TV", both under "Electronics". These tags are used to construct a hierarchy of query categories. Distributions of features such as price and brand popularity vary wildly across query categories. In addition, feature importance for the purpose of CTR/CVR predictions differs from one category to another. In this work, we leverage the Mixture of Expert (MoE) framework to learn a ranking model that specializes for each query category. In particular, our gate network relies solely on the category ids extracted from the user query. While classical MoE's pick expert towers spontaneously for each input example, we explore two techniques to establish more explicit and transparent connections between the experts and query categories. To help differentiate experts on their domain specialties, we introduce a form of adversarial regularization among the expert outputs, forcing them to disagree with one another. As a result, they tend to approach each prediction problem from different angles, rather than copying one another. This is validated by a much stronger clustering effect of the gate output vectors under different categories. In addition, soft gating constraints based on the categorical hierarchy are imposed to help similar products choose similar gate values. and make them more likely to share similar experts. This allows aggregation of training data among smaller sibling categories to overcome data scarcity.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Current-induced magnetization switching in a chemically disordered A1 CoPt single layer

We report the first demonstration of the current-induced magnetization switching in a perpendicularly magnetized A1 CoPt single layer. We show that good perpendicular magnetic anisotropy can be obtained in a wide composition range of the A1 Co1-xPtx single layers, which allows to fabricate perpendicularly magnetized CoPt single layer with composition gradient to break the inversion symmetry of the structure. By fabricating the gradient CoPt single layer, we have evaluated the SOT efficiency and successfully realized the SOT-induced magnetization switching. Our study provides an approach to realize the current-induced magnetization in the ferromagnetic single layers without attaching SOT source materials.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Efficient estimation of optimal regimes under a no direct effect assumption

We derive new estimators of an optimal joint testing and treatment regime under the no direct effect (NDE) assumption that a given laboratory, diagnostic, or screening test has no effect on a patient's clinical outcomes except through the effect of the test results on the choice of treatment. We model the optimal joint strategy using an optimal regime structural nested mean model (opt-SNMM). The proposed estimators are more efficient than previous estimators of the parameters of an opt-SNMM because they efficiently leverage the `no direct effect (NDE) of testing' assumption. Our methods will be of importance to decision scientists who either perform cost-benefit analyses or are tasked with the estimation of the `value of information' supplied by an expensive diagnostic test (such as an MRI to screen for lung cancer).

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Spatial Modulation: an Attractive Secure Solution to Future Wireless Network

As a green and secure wireless transmission method, secure spatial modulation (SM) is becoming a hot research area. Its basic idea is to exploit both the index of activated transmit antenna and amplitude phase modulation signal to carry messages, improve security, and save energy. In this paper, we review its crucial challenges: transmit antenna selection (TAS), artificial noise (AN) projection, power allocation (PA) and joint detection at the desired receiver. As the size of signal constellation tends to medium-scale or large-scale, the complexity of traditional maximum likelihood detector becomes prohibitive. To reduce this complexity, a low-complexity maximum likelihood (ML) detector is proposed. To further enhance the secrecy rate (SR) performance, a deep-neural-network (DNN) PA strategy is proposed. Simulation results show that the proposed low-complexity ML detector, with a lower-complexity, has the same bit error rate performance as the joint ML method while the proposed DNN method strikes a good balance between complexity and SR performance.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Switching magnon chirality in artificial antiferromagnet

Magnons in antiferromagnets can support both right-handed and left-handed chiralities, which shed a light on the chirality-based spintronics. Here we demonstrate the switching and reading of magnon chirality in an artificial antiferromagnet. The coexisting antiferromagnetic and ferromagnetic characteristic resonance modes are discovered, which permits a high tunability in the modulation of magnon chirality. The reading of the chirality is accomplished via the chirality-dependent spin pumping as well as spin rectification effect. Our result illustrates an ideal antiferromagnetic platform for handling magnon chirality and paves the way for chirality-based spintronics.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

A Comprehensive Study of Data Augmentation Strategies for Prostate Cancer Detection in Diffusion-weighted MRI using Convolutional Neural Networks

Data augmentation refers to a group of techniques whose goal is to battle limited amount of available data to improve model generalization and push sample distribution toward the true distribution. While different augmentation strategies and their combinations have been investigated for various computer vision tasks in the context of deep learning, a specific work in the domain of medical imaging is rare and to the best of our knowledge, there has been no dedicated work on exploring the effects of various augmentation methods on the performance of deep learning models in prostate cancer detection. In this work, we have statically applied five most frequently used augmentation techniques (random rotation, horizontal flip, vertical flip, random crop, and translation) to prostate Diffusion-weighted Magnetic Resonance Imaging training dataset of 217 patients separately and evaluated the effect of each method on the accuracy of prostate cancer detection. The augmentation algorithms were applied independently to each data channel and a shallow as well as a deep Convolutional Neural Network (CNN) were trained on the five augmented sets separately. We used Area Under Receiver Operating Characteristic (ROC) curve (AUC) to evaluate the performance of the trained CNNs on a separate test set of 95 patients, using a validation set of 102 patients for finetuning. The shallow network outperformed the deep network with the best 2D slice-based AUC of 0.85 obtained by the rotation method.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Clinically Relevant Mediation Analysis using Controlled Indirect Effect

Mediation analysis allows one to use observational data to estimate the importance of each potential mediating pathway involved in the causal effect of an exposure on an outcome. However, current approaches to mediation analysis with multiple mediators either involve assumptions not verifiable by experiments, or estimate the effect when mediators are manipulated jointly which precludes the practical design of experiments due to curse of dimensionality, or are difficult to interpret when arbitrary causal dependencies are present. We propose a method for mediation analysis for multiple manipulable mediators with arbitrary causal dependencies. The proposed method is clinically relevant because the decomposition of the total effect does not involve effects under cross-world assumptions and focuses on the effects after manipulating (i.e. treating) one single mediator, which is more relevant in a clinical scenario. We illustrate the approach using simulated data, the "framing" dataset from political science, and the HIV-Brain Age dataset from a clinical retrospective cohort study. Our results provide potential guidance for clinical practitioners to make justified choices to manipulate one of the mediators to optimize the outcome.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Computational methods for cancer driver discovery: A survey

Motivation: Uncovering the genomic causes of cancer, known as cancer driver genes, is a fundamental task in biomedical research. Cancer driver genes drive the development and progression of cancer, thus identifying cancer driver genes and their regulatory mechanism is crucial to the design of cancer treatment and intervention. Many computational methods, which take the advantages of computer science and data science, have been developed to utilise multiple types of genomic data to reveal cancer drivers and their regulatory mechanism behind cancer development and progression. Due to the complexity of the mechanistic insight of cancer genes in driving cancer and the fast development of the field, it is necessary to have a comprehensive review about the current computational methods for discovering different types of cancer drivers. Results: We survey computational methods for identifying cancer drivers from genomic data. We categorise the methods into three groups, methods for single driver identification, methods for driver module identification, and methods for identifying personalised cancer drivers. We also conduct a case study to compare the performance of the current methods. We further analyse the advantages and limitations of the current methods, and discuss the challenges and future directions of the topic. In addition, we investigate the resources for discovering and validating cancer drivers in order to provide a one-stop reference of the tools to facilitate cancer driver discovery. The ultimate goal of the paper is to help those interested in the topic to establish a solid background to carry out further research in the field.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Hierarchical Feature Embedding for Attribute Recognition

Attribute recognition is a crucial but challenging task due to viewpoint changes, illumination variations and appearance diversities, etc. Most of previous work only consider the attribute-level feature embedding, which might perform poorly in complicated heterogeneous conditions. To address this problem, we propose a hierarchical feature embedding (HFE) framework, which learns a fine-grained feature embedding by combining attribute and ID information. In HFE, we maintain the inter-class and intra-class feature embedding simultaneously. Not only samples with the same attribute but also samples with the same ID are gathered more closely, which could restrict the feature embedding of visually hard samples with regard to attributes and improve the robustness to variant conditions. We establish this hierarchical structure by utilizing HFE loss consisted of attribute-level and ID-level constraints. We also introduce an absolute boundary regularization and a dynamic loss weight as supplementary components to help build up the feature embedding. Experiments show that our method achieves the state-of-the-art results on two pedestrian attribute datasets and a facial attribute dataset.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

On nearly assumption-free tests of nominal confidence interval coverage for causal parameters estimated by machine learning

For many causal effect parameters of interest, doubly robust machine learning (DRML) estimators $\hatψ_{1}$ are the state-of-the-art, incorporating the good prediction performance of machine learning; the decreased bias of doubly robust estimators; and the analytic tractability and bias reduction of sample splitting with cross fitting. Nonetheless, even in the absence of confounding by unmeasured factors, the nominal $(1 - α)$ Wald confidence interval $\hatψ_{1} \pm z_{α/ 2} \widehat{\mathsf{se}} [\hatψ_{1}]$ may still undercover even in large samples, because the bias of $\hatψ_{1}$ may be of the same or even larger order than its standard error of order $n^{-1/2}$. In this paper, we introduce essentially assumption-free tests that (i) can falsify the null hypothesis that the bias of $\hatψ_{1}$ is of smaller order than its standard error, (ii) can provide an upper confidence bound on the true coverage of the Wald interval, and (iii) are valid under the null under no smoothness/sparsity assumptions on the nuisance parameters. The tests, which we refer to as \underline{A}ssumption \underline{F}ree \underline{E}mpirical \underline{C}overage \underline{T}ests (AFECTs), are based on a U-statistic that estimates part of the bias of $\hatψ_{1}$.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Receive Antenna Selection for Secure Pre-coding Aided Spatial Modulation

In this paper, we make an investigation of receive antenna selection (RAS) strategies in the secure pre-coding aided spatial modulation (PSM) system with the aid of artificial noise. Due to a lack of the closed-form expression for secrecy rate (SR) in secure PSM systems, it is hard to optimize the RAS. To address this issue, the cut-off rate is used as an approximation of the SR. Further, two low-complexity RAS schemes for maximizing SR, called Max-SR-L and Max-SR-H, are derived in the low and high signal-to-noise ratio (SNR) regions, respectively. Due to the fact that the former works well in the low SNR region but becomes worse in the medium and high SNR regions while the latter also has the similar problem, a novel RAS strategy Max-SR-A is proposed to cover all SNR regions. Simulation results show that the proposed Max-SR-H and Max-SR-L schemes approach the optimal SR performances of the exhaustive search (ES) in the high and low SNR regions, respectively. In particular, the SR performance of the proposed Max-SR-A is close to that of the optimal ES and better than that of the random method in almost all SNR regions.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Sufficient Dimension Reduction for Average Causal Effect Estimation

Having a large number of covariates can have a negative impact on the quality of causal effect estimation since confounding adjustment becomes unreliable when the number of covariates is large relative to the samples available. Propensity score is a common way to deal with a large covariate set, but the accuracy of propensity score estimation (normally done by logistic regression) is also challenged by large number of covariates. In this paper, we prove that a large covariate set can be reduced to a lower dimensional representation which captures the complete information for adjustment in causal effect estimation. The theoretical result enables effective data-driven algorithms for causal effect estimation. We develop an algorithm which employs a supervised kernel dimension reduction method to search for a lower dimensional representation for the original covariates, and then utilizes nearest neighbor matching in the reduced covariate space to impute the counterfactual outcomes to avoid large-sized covariate set problem. The proposed algorithm is evaluated on two semi-synthetic and three real-world datasets and the results have demonstrated the effectiveness of the algorithm.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Wavelet-Based Dual-Branch Network for Image Demoireing

When smartphone cameras are used to take photos of digital screens, usually moire patterns result, severely degrading photo quality. In this paper, we design a wavelet-based dual-branch network (WDNet) with a spatial attention mechanism for image demoireing. Existing image restoration methods working in the RGB domain have difficulty in distinguishing moire patterns from true scene texture. Unlike these methods, our network removes moire patterns in the wavelet domain to separate the frequencies of moire patterns from the image content. The network combines dense convolution modules and dilated convolution modules supporting large receptive fields. Extensive experiments demonstrate the effectiveness of our method, and we further show that WDNet generalizes to removing moire artifacts on non-screen images. Although designed for image demoireing, WDNet has been applied to two other low-levelvision tasks, outperforming state-of-the-art image deraining and derain-drop methods on the Rain100h and Raindrop800 data sets, respectively.

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