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Xiaoling Zhou

Xiaoling Zhou contributes to research discovery and scholarly infrastructure.

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Machine Learning Artificial Intelligence Computer Vision eess.IV Robotics

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preprint2026arXiv

Annotation-free deep learning for detection and segmentation of fetal germinal matrix-intraventricular hemorrhage in brain MRI

Background: Prenatal germinal matrix-intraventricular hemorrhage (GMH-IVH) is a leading cause of infant mortality and neurodevelopmental impairment. Manual diagnosis and lesion segmentation are labor-intensive and error-prone. Deep learning models offer potential for automation but typically require large annotated datasets, which are challenging to obtain. Purpose: To develop and validate an annotation-free deep learning framework for automated detection and segmentation of GMH-IVH on brain MRI. Materials and Methods: This retrospective study analyzed 2D T2-weighted MRI data from pregnant women collected from October 2015 to October 2023 at one hospital (internal validation) and two hospitals (external validation). Eligible participants included healthy fetuses and those with GMH-IVH. FreeHemoSeg was developed and trained using pseudo GMH-IVH images synthesized from normal fetal data guided by medical priors. Primary outcomes included diagnostic accuracy (area under the ROC curve [AUROC], sensitivity, specificity) and segmentation accuracy (Dice similarity coefficient [DSC]). A reader study evaluated clinical utility. Results: A total of 1674 stacks from 558 pregnant women were analyzed. FreeHemoSeg achieved the highest performance in both internal (sensitivity: 0.914, 95% CI 0.869-0.945; specificity: 0.966, 95% CI 0.946-0.978; DSC: 0.559, 95% CI 0.546-0.571) and external validation (sensitivity: 0.824, 95% CI 0.739-0.885; specificity: 0.943, 95% CI 0.913-0.964; DSC: 0.512, 95% CI 0.497-0.526), outperforming supervised and unsupervised methods. FreeHemoSeg assistance improved radiologists' sensitivity (from 0.882 to 0.941-1.000) and diagnostic confidence while reducing interpretation time by 16.0-52.7%. Conclusion: FreeHemoSeg accurately detects and localizes fetal brain hemorrhages without annotated training data, enabling earlier diagnosis and supporting timely clinical management.

preprint2026arXiv

Mind Dreamer: Untethering Imagination via Active Latent Intervention on Latent Manifolds

Model-Based Reinforcement Learning (MBRL) leverages latent imagination for sample efficiency, yet remains constrained by Historical Tethering: imagination is typically initialized from observed states. This creates a learning asymmetry, where the world model's manifold discovery outpaces the policy's sparse-reward optimization. We propose Mind Dreamer (MD), a framework that operationalizes Active Latent Intervention (ALI) to transcend Markovian continuity. MD reformulates discovery as the minimization of a global Relay Manifold Expected Free Energy (R-EFE); by sampling initial states from a learned generator $s_0 \sim p_{gen}(\cdot)$ rather than the historical buffer, MD utilizes an adversarial generator to synthesize non-continuous latent jumps to epistemic blind spots that are physically plausible yet cognitively challenging. To resolve the credit assignment paradox across these spatial ruptures, we derive the Relay Value Function (RVF) and Relay Uncertainty Function (RUF). These potentials treat synthesized anchors as counterfactual intermediary states, propagating pragmatic and epistemic value through a principled Bellman-style formulation. Notably, we prove that uncertainty propagation across discontinuities necessitates a quadratic discount $γ^2$, establishing a formal epistemic horizon. Theoretically, MD approximates a variance-minimizing importance sampler that expands the manifold's spectral gap, reducing the hitting time to critical bottleneck states. Empirically, MD achieves a 1.67$\times$ average speedup over DreamerV3 on DeepMind Control Suite, reaching 8.8$\times$ in sparse-reward tasks.

preprint2023arXiv

Understanding Difficulty-based Sample Weighting with a Universal Difficulty Measure

Sample weighting is widely used in deep learning. A large number of weighting methods essentially utilize the learning difficulty of training samples to calculate their weights. In this study, this scheme is called difficulty-based weighting. Two important issues arise when explaining this scheme. First, a unified difficulty measure that can be theoretically guaranteed for training samples does not exist. The learning difficulties of the samples are determined by multiple factors including noise level, imbalance degree, margin, and uncertainty. Nevertheless, existing measures only consider a single factor or in part, but not in their entirety. Second, a comprehensive theoretical explanation is lacking with respect to demonstrating why difficulty-based weighting schemes are effective in deep learning. In this study, we theoretically prove that the generalization error of a sample can be used as a universal difficulty measure. Furthermore, we provide formal theoretical justifications on the role of difficulty-based weighting for deep learning, consequently revealing its positive influences on both the optimization dynamics and generalization performance of deep models, which is instructive to existing weighting schemes.

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