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Mo Yang

Mo Yang contributes to research discovery and scholarly infrastructure.

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Published work

4 published item(s)

preprint2026arXiv

From Trajectories to Phenotypes: Disease Progression as Structural Priors for Multi-organ Imaging Representation Learning

Imaging-derived phenotypes (IDPs) summarize multi-organ physiology but provide only static snapshots of diseases that evolve over time. In contrast, longitudinal electronic health records encode disease trajectories through temporal dependencies among past diagnosis events and comorbidity structure. We hypothesize that IDPs and disease trajectories contain partially shared disease-relevant structure. We propose a trajectory-aware distillation framework that transfers structural knowledge from a generative disease trajectory Transformer into an organ-wise IDP encoder. A population-scale trajectory model trained on longitudinal diagnosis sequences produces subject-level embeddings that supervise IDP representation learning via geometry-preserving alignment. During downstream prediction, trajectory and imaging representations can also be fused via cross-attention. Across 159 diseases in the UK Biobank cohort, trajectory-aware pretraining consistently improves both discrimination (AUC) and time-to-onset prediction (MAE), with the largest gains for low-prevalence diseases. Similarity relationships in IDP embedding space also align with those in trajectory space, providing supportive evidence for partially aligned representation geometry. These results suggest that population-scale generative disease models can serve as structural priors for data-limited imaging modalities, improving robustness under realistic cohort constraints.

preprint2026arXiv

Reasoning in Trees: Improving Retrieval-Augmented Generation for Multi-Hop Question Answering

Retrieval-Augmented Generation (RAG) has demonstrated significant effectiveness in enhancing large language models (LLMs) for complex multi-hop question answering (QA). For multi-hop QA tasks, current iterative approaches predominantly rely on LLMs to self-guide and plan multi-step exploration paths during retrieval, leading to substantial challenges in maintaining reasoning coherence across steps from inaccurate query decomposition and error propagation. To address these issues, we introduce Reasoning Tree Guided RAG (RT-RAG), a novel hierarchical framework for complex multi-hop QA. RT-RAG systematically decomposes multi-hop questions into explicit reasoning trees, minimizing inaccurate decomposition through structured entity analysis and consensus-based tree selection that clearly separates core queries, known entities, and unknown entities. Subsequently, a bottom-up traversal strategy employs iterative query rewriting and refinement to collect high-quality evidence, thereby mitigating error propagation. Comprehensive experiments show that RT-RAG substantially outperforms state-of-the-art methods by 7.0% F1 and 6.0% EM, demonstrating the effectiveness of RT-RAG in complex multi-hop QA.

preprint2022arXiv

Asymmetric phenomenon of flow and heat transfer in charging process of thermal energy storage based on an entire domain model

Phase change energy storage is getting increasing attention as a representative technology to achieve carbon neutrality. The phase change process exists typical phenomenon of asymmetry that affects the energy storage performance. However, the mechanism of asymmetry is currently lack of elaboration because the half domain model is always used to simplify the numerical simulation and avoid the appearance of asymmetry. In this study, the entire domain model and boundary conditions were adopted and numerically simulated for the melting process of paraffin wax, i.e., the charging process of energy storage. The nonlinear dynamics method was applied to explain the asymmetric flow and heat transfer phenomenon. The three-stage characteristic based on charging speed was proposed for charging process and was explained by thermal conduction or natural convection. The asymmetric phenomenon was elaborated on the cause of formation, change mechanism, and effect evaluation. Results show that natural convection accounts for the multiple solutions (including the asymmetric ones) of charging process. It is also pointed out that asymmetric solutions can exist under symmetric geometry structure. To accurately solve the charging process, it is necessary to use the entire domain model. Both the charging speed and energy storage capacity have a positive correlation with asymmetry. Thus, a potential idea for energy storage application was proposed to increase the charging speed; that is, adding thermal disturbance during the melting process to destroy flow stability and to enhance convective heat transfer. The research methods and findings will support the development of energy storage and numerical investigation in other related areas.

preprint2020arXiv

Tropical Cyclone Track Forecasting using Fused Deep Learning from Aligned Reanalysis Data

The forecast of tropical cyclone trajectories is crucial for the protection of people and property. Although forecast dynamical models can provide high-precision short-term forecasts, they are computationally demanding, and current statistical forecasting models have much room for improvement given that the database of past hurricanes is constantly growing. Machine learning methods, that can capture non-linearities and complex relations, have only been scarcely tested for this application. We propose a neural network model fusing past trajectory data and reanalysis atmospheric images (wind and pressure 3D fields). We use a moving frame of reference that follows the storm center for the 24h tracking forecast. The network is trained to estimate the longitude and latitude displacement of tropical cyclones and depressions from a large database from both hemispheres (more than 3000 storms since 1979, sampled at a 6 hour frequency). The advantage of the fused network is demonstrated and a comparison with current forecast models shows that deep learning methods could provide a valuable and complementary prediction. Moreover, our method can give a forecast for a new storm in a few seconds, which is an important asset for real-time forecasts compared to traditional forecasts.