Source author record

Milos Hauskrecht

Milos Hauskrecht appears in the imported research catalog. Authorship, coauthor and topic links are available while profile ownership is still unclaimed.

ResearcherUnclaimed source record

Machine Learning Artificial Intelligence cs.CY Data Structures and Algorithms

Catalog footprint

What is connected

25works

4topics

4close collaborators

Actions

Connect this record

Open graph Browse works

Inspect adjacent papers, topics, institutions and collaborators without losing the researcher page.

Building this map preview

BZPEER is loading the nearby papers, people, topics and institutions for this page.

preprint2026arXiv

Conditional anomaly detection methods for patient-management alert systems

Anomaly detection methods can be very useful in identifying unusual or interesting patterns in data. A recently proposed conditional anomaly detection framework extends anomaly detection to the problem of identifying anomalous patterns on a subset of attributes in the data. The anomaly always depends (is conditioned) on the value of remaining attributes. The work presented in this paper focuses on instance-based methods for detecting conditional anomalies. The methods rely on the distance metric to identify examples in the dataset that are most critical for detecting the anomaly. We investigate various metrics and metric learning methods to optimize the performance of the instance-based anomaly detection methods. We show the benefits of the instance-based methods on two real-world detection problems: detection of unusual admission decisions for patients with the community-acquired pneumonia and detection of unusual orders of an HPF4 test that is used to confirm Heparin induced thrombocytopenia - a life-threatening condition caused by the Heparin therapy.

preprint2026arXiv

Conditional outlier detection for clinical alerting

We develop and evaluate a data-driven approach for detecting unusual (anomalous) patient-management actions using past patient cases stored in an electronic health record (EHR) system. Our hypothesis is that patient-management actions that are unusual with respect to past patients may be due to a potential error and that it is worthwhile to raise an alert if such a condition is encountered. We evaluate this hypothesis using data obtained from the electronic health records of 4,486 post-cardiac surgical patients. We base the evaluation on the opinions of a panel of experts. The results support that anomaly-based alerting can have reasonably low false alert rates and that stronger anomalies are correlated with higher alert rates.

preprint2026arXiv

Distance metric learning for conditional anomaly detection

Anomaly detection methods can be very useful in identifying unusual or interesting patterns in data. A recently proposed conditional anomaly detection framework extends anomaly detection to the problem of identifying anomalous patterns on a subset of attributes in the data. The anomaly always depends (is conditioned) on the value of remaining attributes. The work presented in this paper focuses on instance-based methods for detecting conditional anomalies. The methods depend heavily on the distance metric that lets us identify examples in the dataset that are most critical for detecting the anomaly. To optimize the performance of such methods we study and devise a metric learning method that learns the distance metric to reflect best the conditional anomaly pattern.

preprint2026arXiv

Evidence-based anomaly detection in clinical domains

Anomaly detection methods can be very useful in identifying interesting or concerning events. In this work, we develop and examine new probabilistic anomaly detection methods that let us evaluate management decisions for a specific patient and identify those decisions that are highly unusual with respect to patients with the same or similar condition. The statistics used in this detection are derived from probabilistic models such as Bayesian networks that are learned from a database of past patient cases. We apply our methods to the problem of identifying unusual patient-management decisions in post-surgical cardiac patients.

preprint2026arXiv

Feature importance analysis for patient management decisions

The objective of this paper is to understand what characteristics and features of clinical data influence physician's decision about ordering laboratory tests or prescribing medications the most. We conduct our analysis on data and decisions extracted from electronic health records of 4486 post-surgical cardiac patients. The summary statistics for 335 different lab order decisions and 407 medication decisions are reported. We show that in many cases, physician's lab-order and medication decisions can be well predicted from a small subset of all features.

preprint2026arXiv

Learning predictive models for combinations of heterogeneous proteomic data sources

Multiple technologies that measure expression levels of protein mixtures in the human body offer a potential for detection and understanding the disease. The recent increase of these technologies prompts researchers to evaluate the individual and combined utility of data generated by the technologies. In this work, we study two data sources to measure the expression of protein mixtures in the human body: whole-sample MS profiling and multiplexed protein arrays. We investigate the individual and combined utility of these technologies by learning and testing a variety of classification models on the data from a pancreatic cancer study. We show that for the combination of these two (heterogeneous) datasets, classification models that work well on one of them individually fail on the combination of the two datasets. We study and propose a class of model fusion methods that acknowledge the differences and try to reap most of the benefits from their combination.

preprint2026arXiv

Outlier detection for patient monitoring and alerting

We develop and evaluate a data-driven approach for detecting unusual (anomalous) patient-management decisions using past patient cases stored in electronic health records (EHRs). Our hypothesis is that a patient-management decision that is unusual with respect to past patient care may be due to an error and that it is worthwhile to generate an alert if such a decision is encountered. We evaluate this hypothesis using data obtained from EHRs of 4486 post-cardiac surgical patients and a subset of 222 alerts generated from the data. We base the evaluation on the opinions of a panel of experts. The results of the study support our hypothesis that the outlier-based alerting can lead to promising true alert rates. We observed true alert rates that ranged from 25\% to 66\% for a variety of patient-management actions, with 66\% corresponding to the strongest outliers.

preprint2022arXiv

Learning to Adapt Clinical Sequences with Residual Mixture of Experts

Clinical event sequences in Electronic Health Records (EHRs) record detailed information about the patient condition and patient care as they occur in time. Recent years have witnessed increased interest of machine learning community in developing machine learning models solving different types of problems defined upon information in EHRs. More recently, neural sequential models, such as RNN and LSTM, became popular and widely applied models for representing patient sequence data and for predicting future events or outcomes based on such data. However, a single neural sequential model may not properly represent complex dynamics of all patients and the differences in their behaviors. In this work, we aim to alleviate this limitation by refining a one-fits-all model using a Mixture-of-Experts (MoE) architecture. The architecture consists of multiple (expert) RNN models covering patient sub-populations and refining the predictions of the base model. That is, instead of training expert RNN models from scratch we define them on the residual signal that attempts to model the differences from the population-wide model. The heterogeneity of various patient sequences is modeled through multiple experts that consist of RNN. Particularly, instead of directly training MoE from scratch, we augment MoE based on the prediction signal from pretrained base GRU model. With this way, the mixture of experts can provide flexible adaptation to the (limited) predictive power of the single base RNN model. We experiment with the newly proposed model on real-world EHRs data and the multivariate clinical event prediction task. We implement RNN using Gated Recurrent Units (GRU). We show 4.1% gain on AUPRC statistics compared to a single RNN prediction.

preprint2016arXiv

Detecting Unusual Input-Output Associations in Multivariate Conditional Data

Despite tremendous progress in outlier detection research in recent years, the majority of existing methods are designed only to detect unconditional outliers that correspond to unusual data patterns expressed in the joint space of all data attributes. Such methods are not applicable when we seek to detect conditional outliers that reflect unusual responses associated with a given context or condition. This work focuses on multivariate conditional outlier detection, a special type of the conditional outlier detection problem, where data instances consist of multi-dimensional input (context) and output (responses) pairs. We present a novel outlier detection framework that identifies abnormal input-output associations in data with the help of a decomposable conditional probabilistic model that is learned from all data instances. Since components of this model can vary in their quality, we combine them with the help of weights reflecting their reliability in assessment of outliers. We study two ways of calculating the component weights: global that relies on all data, and local that relies only on instances similar to the target instance. Experimental results on data from various domains demonstrate the ability of our framework to successfully identify multivariate conditional outliers.

preprint2015arXiv

Active Perceptual Similarity Modeling with Auxiliary Information

Learning a model of perceptual similarity from a collection of objects is a fundamental task in machine learning underlying numerous applications. A common way to learn such a model is from relative comparisons in the form of triplets: responses to queries of the form "Is object a more similar to b than it is to c?". If no consideration is made in the determination of which queries to ask, existing similarity learning methods can require a prohibitively large number of responses. In this work, we consider the problem of actively learning from triplets -finding which queries are most useful for learning. Different from previous active triplet learning approaches, we incorporate auxiliary information into our similarity model and introduce an active learning scheme to find queries that are informative for quickly learning both the relevant aspects of auxiliary data and the directly-learned similarity components. Compared to prior approaches, we show that we can learn just as effectively with much fewer queries. For evaluation, we introduce a new dataset of exhaustive triplet comparisons obtained from humans and demonstrate improved performance for different types of auxiliary information.

preprint2015arXiv

Efficient Online Relative Comparison Kernel Learning

Learning a kernel matrix from relative comparison human feedback is an important problem with applications in collaborative filtering, object retrieval, and search. For learning a kernel over a large number of objects, existing methods face significant scalability issues inhibiting the application of these methods to settings where a kernel is learned in an online and timely fashion. In this paper we propose a novel framework called Efficient online Relative comparison Kernel LEarning (ERKLE), for efficiently learning the similarity of a large set of objects in an online manner. We learn a kernel from relative comparisons via stochastic gradient descent, one query response at a time, by taking advantage of the sparse and low-rank properties of the gradient to efficiently restrict the kernel to lie in the space of positive semidefinite matrices. In addition, we derive a passive-aggressive online update for minimally satisfying new relative comparisons as to not disrupt the influence of previously obtained comparisons. Experimentally, we demonstrate a considerable improvement in speed while obtaining improved or comparable accuracy compared to current methods in the online learning setting.

preprint2015arXiv

MCODE: Multivariate Conditional Outlier Detection

Outlier detection aims to identify unusual data instances that deviate from expected patterns. The outlier detection is particularly challenging when outliers are context dependent and when they are defined by unusual combinations of multiple outcome variable values. In this paper, we develop and study a new conditional outlier detection approach for multivariate outcome spaces that works by (1) transforming the conditional detection to the outlier detection problem in a new (unconditional) space and (2) defining outlier scores by analyzing the data in the new space. Our approach relies on the classifier chain decomposition of the multi-dimensional classification problem that lets us transform the output space into a probability vector, one probability for each dimension of the output space. Outlier scores applied to these transformed vectors are then used to detect the outliers. Experiments on multiple multi-dimensional classification problems with the different outlier injection rates show that our methodology is robust and able to successfully identify outliers when outliers are either sparse (manifested in one or very few dimensions) or dense (affecting multiple dimensions).

preprint2015arXiv

Sparse Multidimensional Patient Modeling using Auxiliary Confidence Labels

In this work, we focus on the problem of learning a classification model that performs inference on patient Electronic Health Records (EHRs). Often, a large amount of costly expert supervision is required to learn such a model. To reduce this cost, we obtain confidence labels that indicate how sure an expert is in the class labels she provides. If meaningful confidence information can be incorporated into a learning method, fewer patient instances may need to be labeled to learn an accurate model. In addition, while accuracy of predictions is important for any inference model, a model of patients must be interpretable so that clinicians can understand how the model is making decisions. To these ends, we develop a novel metric learning method called Confidence bAsed MEtric Learning (CAMEL) that supports inclusion of confidence labels, but also emphasizes interpretability in three ways. First, our method induces sparsity, thus producing simple models that use only a few features from patient EHRs. Second, CAMEL naturally produces confidence scores that can be taken into consideration when clinicians make treatment decisions. Third, the metrics learned by CAMEL induce multidimensional spaces where each dimension represents a different "factor" that clinicians can use to assess patients. In our experimental evaluation, we show on a real-world clinical data set that our CAMEL methods are able to learn models that are as or more accurate as other methods that use the same supervision. Furthermore, we show that when CAMEL uses confidence scores it is able to learn models as or more accurate as others we tested while using only 10% of the training instances. Finally, we perform qualitative assessments on the metrics learned by CAMEL and show that they identify and clearly articulate important factors in how the model performs inference.

preprint2014arXiv

A Mixtures-of-Experts Framework for Multi-Label Classification

We develop a novel probabilistic approach for multi-label classification that is based on the mixtures-of-experts architecture combined with recently introduced conditional tree-structured Bayesian networks. Our approach captures different input-output relations from multi-label data using the efficient tree-structured classifiers, while the mixtures-of-experts architecture aims to compensate for the tree-structured restrictions and build a more accurate model. We develop and present algorithms for learning the model from data and for performing multi-label predictions on future data instances. Experiments on multiple benchmark datasets demonstrate that our approach achieves highly competitive results and outperforms the existing state-of-the-art multi-label classification methods.

preprint2014arXiv

Binary Classifier Calibration: Bayesian Non-Parametric Approach

A set of probabilistic predictions is well calibrated if the events that are predicted to occur with probability p do in fact occur about p fraction of the time. Well calibrated predictions are particularly important when machine learning models are used in decision analysis. This paper presents two new non-parametric methods for calibrating outputs of binary classification models: a method based on the Bayes optimal selection and a method based on the Bayesian model averaging. The advantage of these methods is that they are independent of the algorithm used to learn a predictive model, and they can be applied in a post-processing step, after the model is learned. This makes them applicable to a wide variety of machine learning models and methods. These calibration methods, as well as other methods, are tested on a variety of datasets in terms of both discrimination and calibration performance. The results show the methods either outperform or are comparable in performance to the state-of-the-art calibration methods.

preprint2014arXiv

Binary Classifier Calibration: Non-parametric approach

Accurate calibration of probabilistic predictive models learned is critical for many practical prediction and decision-making tasks. There are two main categories of methods for building calibrated classifiers. One approach is to develop methods for learning probabilistic models that are well-calibrated, ab initio. The other approach is to use some post-processing methods for transforming the output of a classifier to be well calibrated, as for example histogram binning, Platt scaling, and isotonic regression. One advantage of the post-processing approach is that it can be applied to any existing probabilistic classification model that was constructed using any machine-learning method. In this paper, we first introduce two measures for evaluating how well a classifier is calibrated. We prove three theorems showing that using a simple histogram binning post-processing method, it is possible to make a classifier be well calibrated while retaining its discrimination capability. Also, by casting the histogram binning method as a density-based non-parametric binary classifier, we can extend it using two simple non-parametric density estimation methods. We demonstrate the performance of the proposed calibration methods on synthetic and real datasets. Experimental results show that the proposed methods either outperform or are comparable to existing calibration methods.

preprint2014arXiv

Relative Comparison Kernel Learning with Auxiliary Kernels

In this work we consider the problem of learning a positive semidefinite kernel matrix from relative comparisons of the form: "object A is more similar to object B than it is to C", where comparisons are given by humans. Existing solutions to this problem assume many comparisons are provided to learn a high quality kernel. However, this can be considered unrealistic for many real-world tasks since relative assessments require human input, which is often costly or difficult to obtain. Because of this, only a limited number of these comparisons may be provided. In this work, we explore methods for aiding the process of learning a kernel with the help of auxiliary kernels built from more easily extractable information regarding the relationships among objects. We propose a new kernel learning approach in which the target kernel is defined as a conic combination of auxiliary kernels and a kernel whose elements are learned directly. We formulate a convex optimization to solve for this target kernel that adds only minor overhead to methods that use no auxiliary information. Empirical results show that in the presence of few training relative comparisons, our method can learn kernels that generalize to more out-of-sample comparisons than methods that do not utilize auxiliary information, as well as similar methods that learn metrics over objects.

preprint2013arXiv

A Clustering Approach to Solving Large Stochastic Matching Problems

In this work we focus on efficient heuristics for solving a class of stochastic planning problems that arise in a variety of business, investment, and industrial applications. The problem is best described in terms of future buy and sell contracts. By buying less reliable, but less expensive, buy (supply) contracts, a company or a trader can cover a position of more reliable and more expensive sell contracts. The goal is to maximize the expected net gain (profit) by constructing a dose to optimum portfolio out of the available buy and sell contracts. This stochastic planning problem can be formulated as a two-stage stochastic linear programming problem with recourse. However, this formalization leads to solutions that are exponential in the number of possible failure combinations. Thus, this approach is not feasible for large scale problems. In this work we investigate heuristic approximation techniques alleviating the efficiency problem. We primarily focus on the clustering approach and devise heuristics for finding clusterings leading to good approximations. We illustrate the quality and feasibility of the approach through experimental data.

preprint2013arXiv

Hierarchical Solution of Markov Decision Processes using Macro-actions

We investigate the use of temporally abstract actions, or macro-actions, in the solution of Markov decision processes. Unlike current models that combine both primitive actions and macro-actions and leave the state space unchanged, we propose a hierarchical model (using an abstract MDP) that works with macro-actions only, and that significantly reduces the size of the state space. This is achieved by treating macroactions as local policies that act in certain regions of state space, and by restricting states in the abstract MDP to those at the boundaries of regions. The abstract MDP approximates the original and can be solved more efficiently. We discuss several ways in which macro-actions can be generated to ensure good solution quality. Finally, we consider ways in which macro-actions can be reused to solve multiple, related MDPs; and we show that this can justify the computational overhead of macro-action generation.

preprint2013arXiv

Sparse Linear Dynamical System with Its Application in Multivariate Clinical Time Series

Linear Dynamical System (LDS) is an elegant mathematical framework for modeling and learning multivariate time series. However, in general, it is difficult to set the dimension of its hidden state space. A small number of hidden states may not be able to model the complexities of a time series, while a large number of hidden states can lead to overfitting. In this paper, we study methods that impose an $\ell_1$ regularization on the transition matrix of an LDS model to alleviate the problem of choosing the optimal number of hidden states. We incorporate a generalized gradient descent method into the Maximum a Posteriori (MAP) framework and use Expectation Maximization (EM) to iteratively achieve sparsity on the transition matrix of an LDS model. We show that our Sparse Linear Dynamical System (SLDS) improves the predictive performance when compared to ordinary LDS on a multivariate clinical time series dataset.

preprint2013arXiv

The Bregman Variational Dual-Tree Framework

Graph-based methods provide a powerful tool set for many non-parametric frameworks in Machine Learning. In general, the memory and computational complexity of these methods is quadratic in the number of examples in the data which makes them quickly infeasible for moderate to large scale datasets. A significant effort to find more efficient solutions to the problem has been made in the literature. One of the state-of-the-art methods that has been recently introduced is the Variational Dual-Tree (VDT) framework. Despite some of its unique features, VDT is currently restricted only to Euclidean spaces where the Euclidean distance quantifies the similarity. In this paper, we extend the VDT framework beyond the Euclidean distance to more general Bregman divergences that include the Euclidean distance as a special case. By exploiting the properties of the general Bregman divergence, we show how the new framework can maintain all the pivotal features of the VDT framework and yet significantly improve its performance in non-Euclidean domains. We apply the proposed framework to different text categorization problems and demonstrate its benefits over the original VDT.

preprint2012arXiv

Monte-Carlo optimizations for resource allocation problems in stochastic network systems

Real-world distributed systems and networks are often unreliable and subject to random failures of its components. Such a stochastic behavior affects adversely the complexity of optimization tasks performed routinely upon such systems, in particular, various resource allocation tasks. In this work we investigate and develop Monte Carlo solutions for a class of two-stage optimization problems in stochastic networks in which the expected value of resource allocations before and after stochastic failures needs to be optimized. The limitation of these problems is that their exact solutions are exponential in the number of unreliable network components: thus, exact methods do not scale-up well to large networks often seen in practice. We first prove that Monte Carlo optimization methods can overcome the exponential bottleneck of exact methods. Next we support our theoretical findings on resource allocation experiments and show a very good scale-up potential of the new methods to large stochastic networks.

preprint2012arXiv

Partitioned Linear Programming Approximations for MDPs

Approximate linear programming (ALP) is an efficient approach to solving large factored Markov decision processes (MDPs). The main idea of the method is to approximate the optimal value function by a set of basis functions and optimize their weights by linear programming (LP). This paper proposes a new ALP approximation. Comparing to the standard ALP formulation, we decompose the constraint space into a set of low-dimensional spaces. This structure allows for solving the new LP efficiently. In particular, the constraints of the LP can be satisfied in a compact form without an exponential dependence on the treewidth of ALP constraints. We study both practical and theoretical aspects of the proposed approach. Moreover, we demonstrate its scale-up potential on an MDP with more than 2^100 states.

preprint2012arXiv

Solving Factored MDPs with Continuous and Discrete Variables

Although many real-world stochastic planning problems are more naturally formulated by hybrid models with both discrete and continuous variables, current state-of-the-art methods cannot adequately address these problems. We present the first framework that can exploit problem structure for modeling and solving hybrid problems efficiently. We formulate these problems as hybrid Markov decision processes (MDPs with continuous and discrete state and action variables), which we assume can be represented in a factored way using a hybrid dynamic Bayesian network (hybrid DBN). This formulation also allows us to apply our methods to collaborative multiagent settings. We present a new linear program approximation method that exploits the structure of the hybrid MDP and lets us compute approximate value functions more efficiently. In particular, we describe a new factored discretization of continuous variables that avoids the exponential blow-up of traditional approaches. We provide theoretical bounds on the quality of such an approximation and on its scale-up potential. We support our theoretical arguments with experiments on a set of control problems with up to 28-dimensional continuous state space and 22-dimensional action space.

preprint2012arXiv

Variational Dual-Tree Framework for Large-Scale Transition Matrix Approximation

In recent years, non-parametric methods utilizing random walks on graphs have been used to solve a wide range of machine learning problems, but in their simplest form they do not scale well due to the quadratic complexity. In this paper, a new dual-tree based variational approach for approximating the transition matrix and efficiently performing the random walk is proposed. The approach exploits a connection between kernel density estimation, mixture modeling, and random walk on graphs in an optimization of the transition matrix for the data graph that ties together edge transitions probabilities that are similar. Compared to the de facto standard approximation method based on k-nearestneighbors, we demonstrate order of magnitudes speedup without sacrificing accuracy for Label Propagation tasks on benchmark data sets in semi-supervised learning.

Institution

Affiliation not imported yet

This author record came from a source that does not expose affiliation metadata. Once the author claims the profile or we enrich the record from another provider, this section will link to the concrete institution.

Topic footprint

Fields this researcher appears in

Machine Learning Artificial Intelligence cs.CY Data Structures and Algorithms

Source provenance