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Ling Liang

Ling Liang contributes to research discovery and scholarly infrastructure.

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Published work

11 published item(s)

preprint2026arXiv

A Breast Vision Pathology Foundation Model for Real-world Clinical Utility

Pathology foundation models have shown strong retrospective performance, but whether such systems can support clinically relevant use remains unclear. This challenge is particularly important in breast cancer, where pathological assessment serves as the gold standard for diagnosis and guides treatment planning, surgical decision-making and risk stratification across pre-, intra- and post-operative stages. Here we present \textbf{BRAVE}, a breast-adaptive pathology foundation model developed and evaluated using a total resource of 101,638 breast whole-slide images from 32 sources across Asia, Europe and North America. We assessed BRAVE across 34 tasks in 82 cohorts spanning pre-operative biopsy, intra-operative frozen section and post-operative resection, using an evidence chain comprising retrospective benchmarking, clinically challenging scenarios, workflow-oriented clinical impact simulations, prospective observational validation with the thresholds locked in the retrospective cohorts and crossover pathologist-AI interaction studies. Across these settings, BRAVE supported practical roles in the clinical workflow, including safe exclusion of low-risk cases from routine review, AI-assisted second-review rescue of initially missed positives and prioritization of cases for further assessment. In prospective validation across three centres, BRAVE excluded 76.9% of negative biopsy cases (NPV 0.953) and 70.1% of negative frozen-section cases (NPV 0.973), and triaged 78.8% of post-operative subtyping cases as high-confidence clear-cut cases (NPV 1.000). In reader studies, AI assistance improved balanced accuracy from 88.5% to 95.1% (OR 3.14, P<0.001), with better efficiency, confidence and inter-rater agreement. BRAVE-derived scores also independently predicted disease-free survival (adjusted HR 4.79, P<0.001) and overall survival (adjusted HR 8.14, P<0.001).

preprint2026arXiv

A Provably Convergent and Practical Algorithm for Gromov--Wasserstein Optimal Transport

Gromov--Wasserstein optimal transport (GWOT) aligns metric measure spaces by matching their within-domain relational structures, but large-scale GWOT remains challenging because its objective is nonconvex and projection onto the transport polytope is often solved only approximately in practice. This leads to a gap between practical projected-gradient implementations and convergence theory, which typically assumes exact projections. For squared-loss GWOT, we propose an inexact projected-gradient framework with a verifiable feasibility-residual-based inexact condition for the projection subproblem. This condition is directly computable and avoids unknown quantities such as the exact projection point. Under this implementable condition, we prove subsequential convergence to stationary points and, with a mild tolerance-decay condition, convergence of the whole sequence. The resulting method retains the simplicity and sparsity of projected-gradient schemes while providing rigorous convergence guarantees, turning projected-gradient methods into a principled and scalable approach for GWOT with provable reliability.

preprint2026arXiv

Do Less, Achieve More: Do We Need Every-Step Optimization for RL Fine-tuning of Diffusion Models?

Despite strong image-generation performance, diffusion models' reconstruction objectives limit alignment with human preferences. RL enables such alignment through explicit rewards. However, most studies apply RL to the full denoising trajectory, making it computationally costly and weakening preference alignment, i.e., doing more but achieving less. We observe that the impact of RL fine-tuning varies significantly across denoising stages. In the early stage, image structures are unstable and distant from the final reward signal. Applying RL at this stage leads to delayed rewards and action-reward mismatching, resulting in high variance and inefficient updates. Conversely, in the later stage, reward gains saturate, and continued training tends to overfit local details, intensifying reward hacking. To tackle these challenges, we propose AdaScope, an RL-enhanced plug-in that improves generation quality while reducing computational cost. Specifically, AdaScope adaptively identifies the optimal intervention timing for RL by perceiving the structural evolution and semantic consistency during denoising, and dynamically terminates training once the denoising converges and reward gains saturate. As a result, it achieves a rare 'dual benefit': a reduction in computational costs alongside a significant performance improvement. We offer theoretical grounds for the design of AdaScope. Compared with state-of-the-art methods, AdaScope improves performance by 66% while cutting computational cost by 59%.

preprint2026arXiv

Inner-Probe: Discovering Copyright-related Data Generation in LLM Architecture

Large Language Models (LLMs) utilize extensive knowledge databases and show powerful text generation ability. However, their reliance on high-quality copyrighted datasets raises concerns about copyright infringements in generated texts. Current research often employs prompt engineering or semantic classifiers to identify copyrighted content, but these approaches have two significant limitations: (1) Challenging to identify which specific subdataset (e.g., works from particular authors) influences an LLM&#39;s output. (2) Treating the entire training database as copyrighted, hence overlooking the inclusion of non-copyrighted training data. We propose Inner-Probe, a lightweight framework designed to evaluate the influence of copyrighted sub-datasets on LLM-generated texts. Unlike traditional methods relying solely on text, we discover that the results of multi-head attention (MHA) during LLM output generation provide more effective information. Thus, Inner-Probe performs sub-dataset contribution analysis using a lightweight LSTM based network trained on MHA results in a supervised manner. Harnessing such a prior, Inner-Probe enables non-copyrighted text detection through a concatenated global projector trained with unsupervised contrastive learning. Inner-Probe demonstrates 3x improved efficiency compared to semantic model training in sub-dataset contribution analysis on Books3, achieves 15.04% - 58.7% higher accuracy over baselines on the Pile, and delivers a 0.104 increase in AUC for non-copyrighted data filtering.

preprint2022arXiv

An efficient implementable inexact entropic proximal point algorithm for a class of linear programming problems

We introduce a class of specially structured linear programming (LP) problems, which has favorable modeling capability for important application problems in different areas such as optimal transport, discrete tomography and economics. To solve these generally large-scale LP problems efficiently, we design an implementable inexact entropic proximal point algorithm (iEPPA) combined with an easy-to-implement dual block coordinate descent method as a subsolver. Unlike existing entropy-type proximal point algorithms, our iEPPA employs a more practically checkable stopping condition for solving the associated subproblems while achieving provable convergence. Moreover, when solving the capacity constrained multi-marginal optimal transport (CMOT) problem (a special case of our LP problem), our iEPPA is able to bypass the underlying numerical instability issues that often appear in the popular entropic regularization approach, since our algorithm does not require the proximal parameter to be very small in order to obtain an accurate approximate solution. Numerous numerical experiments show that our iEPPA is efficient and robust for solving large-scale CMOT problems. The experiments on the discrete tomography problem also highlight the potential modeling power of our model.

preprint2022arXiv

QPPAL: A two-phase proximal augmented Lagrangian method for high dimensional convex quadratic programming problems

In this paper, we aim to solve high dimensional convex quadratic programming (QP) problems with a large number of quadratic terms, linear equality and inequality constraints. In order to solve the targeted {\bf QP} problems to a desired accuracy efficiently, we develop a two-phase {\bf P}roximal {\bf A}ugmented {\bf L}agrangian method {(QPPAL)}, with Phase I to generate a reasonably good initial point to warm start Phase II to obtain an accurate solution efficiently. More specifically, in Phase I, based on the recently developed symmetric Gauss-Seidel (sGS) decomposition technique, we design a novel sGS based semi-proximal augmented Lagrangian method for the purpose of finding a solution of low to medium accuracy. Then, in Phase II, a proximal augmented Lagrangian algorithm is proposed to obtain a more accurate solution efficiently. Extensive numerical results evaluating the performance of {QPPAL} against {existing state-of-the-art solvers Gurobi, OSQP and QPALM} are presented to demonstrate the high efficiency and robustness of our proposed algorithm for solving various classes of large-scale convex QP problems. {The MATLAB implementation of the software package QPPAL is available at: \url{https://blog.nus.edu.sg/mattohkc/softwares/qppal/}.

preprint2022arXiv

Toward Robust Spiking Neural Network Against Adversarial Perturbation

As spiking neural networks (SNNs) are deployed increasingly in real-world efficiency critical applications, the security concerns in SNNs attract more attention. Currently, researchers have already demonstrated an SNN can be attacked with adversarial examples. How to build a robust SNN becomes an urgent issue. Recently, many studies apply certified training in artificial neural networks (ANNs), which can improve the robustness of an NN model promisely. However, existing certifications cannot transfer to SNNs directly because of the distinct neuron behavior and input formats for SNNs. In this work, we first design S-IBP and S-CROWN that tackle the non-linear functions in SNNs&#39; neuron modeling. Then, we formalize the boundaries for both digital and spike inputs. Finally, we demonstrate the efficiency of our proposed robust training method in different datasets and model architectures. Based on our experiment, we can achieve a maximum $37.7\%$ attack error reduction with $3.7\%$ original accuracy loss. To the best of our knowledge, this is the first analysis on robust training of SNNs.

preprint2020arXiv

Comprehensive SNN Compression Using ADMM Optimization and Activity Regularization

As well known, the huge memory and compute costs of both artificial neural networks (ANNs) and spiking neural networks (SNNs) greatly hinder their deployment on edge devices with high efficiency. Model compression has been proposed as a promising technique to improve the running efficiency via parameter and operation reduction. Whereas, this technique is mainly practiced in ANNs rather than SNNs. It is interesting to answer how much an SNN model can be compressed without compromising its functionality, where two challenges should be addressed: i) the accuracy of SNNs is usually sensitive to model compression, which requires an accurate compression methodology; ii) the computation of SNNs is event-driven rather than static, which produces an extra compression dimension on dynamic spikes. To this end, we realize a comprehensive SNN compression through three steps. First, we formulate the connection pruning and weight quantization as a constrained optimization problem. Second, we combine spatio-temporal backpropagation (STBP) and alternating direction method of multipliers (ADMM) to solve the problem with minimum accuracy loss. Third, we further propose activity regularization to reduce the spike events for fewer active operations. These methods can be applied in either a single way for moderate compression or a joint way for aggressive compression. We define several quantitative metrics to evaluation the compression performance for SNNs. Our methodology is validated in pattern recognition tasks over MNIST, N-MNIST, CIFAR10, and CIFAR100 datasets, where extensive comparisons, analyses, and insights are provided. To our best knowledge, this is the first work that studies SNN compression in a comprehensive manner by exploiting all compressible components and achieves better results.

preprint2020arXiv

HyGCN: A GCN Accelerator with Hybrid Architecture

In this work, we first characterize the hybrid execution patterns of GCNs on Intel Xeon CPU. Guided by the characterization, we design a GCN accelerator, HyGCN, using a hybrid architecture to efficiently perform GCNs. Specifically, first, we build a new programming model to exploit the fine-grained parallelism for our hardware design. Second, we propose a hardware design with two efficient processing engines to alleviate the irregularity of Aggregation phase and leverage the regularity of Combination phase. Besides, these engines can exploit various parallelism and reuse highly reusable data efficiently. Third, we optimize the overall system via inter-engine pipeline for inter-phase fusion and priority-based off-chip memory access coordination to improve off-chip bandwidth utilization. Compared to the state-of-the-art software framework running on Intel Xeon CPU and NVIDIA V100 GPU, our work achieves on average 1509$\times$ speedup with 2500$\times$ energy reduction and average 6.5$\times$ speedup with 10$\times$ energy reduction, respectively.

preprint2020arXiv

SEALing Neural Network Models in Secure Deep Learning Accelerators

Deep learning (DL) accelerators are increasingly deployed on edge devices to support fast local inferences. However, they suffer from a new security problem, i.e., being vulnerable to physical access based attacks. An adversary can easily obtain the entire neural network (NN) model by physically snooping the GDDR memory bus that connects the accelerator chip with DRAM memory. Therefore, memory encryption becomes important for DL accelerators on edge devices to improve the security of NN models. Nevertheless, we observe that traditional memory encryption solutions that have been efficiently used in CPU systems cause significant performance degradation when directly used in DL accelerators. The main reason comes from the big bandwidth gap between the GDDR memory bus and the encryption engine. To address this problem, our paper proposes SEAL, a Secure and Efficient Accelerator scheme for deep Learning. SEAL enhances the performance of the encrypted DL accelerator from two aspects, i.e., improving the data access bandwidth and the efficiency of memory encryption. Specifically, to improve the data access bandwidth, SEAL leverages a criticality-aware smart encryption scheme which identifies partial data that have no impact on the security of NN models and allows them to bypass the encryption engine, thus reducing the amount of data to be encrypted. To improve the efficiency of memory encryption, SEAL leverages a colocation mode encryption scheme to eliminate memory accesses from counters used for encryption by co-locating data and their counters. Our experimental results demonstrate that, compared with traditional memory encryption solutions, SEAL achieves 1.4 ~ 1.6 times IPC improvement and reduces the inference latency by 39% ~ 60%. Compared with a baseline accelerator without memory encryption, SEAL compromises only 5% ~ 7% IPC for significant security improvement.

preprint2019arXiv

Neural Network Model Extraction Attacks in Edge Devices by Hearing Architectural Hints

As neural networks continue their reach into nearly every aspect of software operations, the details of those networks become an increasingly sensitive subject. Even those that deploy neural networks embedded in physical devices may wish to keep the inner working of their designs hidden -- either to protect their intellectual property or as a form of protection from adversarial inputs. The specific problem we address is how, through heavy system stack, given noisy and imperfect memory traces, one might reconstruct the neural network architecture including the set of layers employed, their connectivity, and their respective dimension sizes. Considering both the intra-layer architecture features and the inter-layer temporal association information introduced by the DNN design empirical experience, we draw upon ideas from speech recognition to solve this problem. We show that off-chip memory address traces and PCIe events provide ample information to reconstruct such neural network architectures accurately. We are the first to propose such accurate model extraction techniques and demonstrate an end-to-end attack experimentally in the context of an off-the-shelf Nvidia GPU platform with full system stack. Results show that the proposed techniques achieve a high reverse engineering accuracy and improve the one&#39;s ability to conduct targeted adversarial attack with success rate from 14.6\%$\sim$25.5\% (without network architecture knowledge) to 75.9\% (with extracted network architecture).