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Published work

93 published item(s)

preprint2026arXiv

FairMedQA: Benchmarking Bias in Large Language Models for Medical Question Answering

Large language models (LLMs) are approaching expert-level performance in medical question answering (QA), demonstrating strong potential to improve public healthcare. However, underlying biases related to sensitive attributes such as sex and race pose life-critical risks. The extent to which such sensitive attributes affect diagnosis remains an open question and requires comprehensive empirical investigation. Additionally, even the latest Counterfactual Patient Variations (CPV) benchmark can hardly distinguish the bias levels of different LLMs. To further explore these dynamics, we propose a new benchmark, FairMedQA, and benchmark 12 representative LLMs. FairMedQA contains 4,806 counterfactual question pairs constructed from 801 clinical vignettes. Our results reveal substantial accuracy disparity ranging from 3 to 19 percentage points across sensitive demographic groups. Notably, FairMedQA exposes biases that are at least 12 percentage points larger than those identified by the latest CPV benchmark, presenting superior benchmarking sensitivity. Our results underscore an urgent need for targeted debiasing techniques and more rigorous, identity-aware validation protocols before LLMs can be safely integrated into practical clinical decision-support systems.

preprint2026arXiv

GeoMamba: A Geometry-driven MambaVision Framework and Dataset for Fine-grained Optical-SAR Object Retrieval

Multi-source remote sensing enables complementary observation of ground objects, while cross-modal fine-grained object retrieval remains challenging, especially under unaligned optical and SAR conditions. Unlike conventional retrieval settings that rely on paired or spatially aligned samples, practical optical-SAR retrieval is affected by substantial modality discrepancy, speckle noise, and structural inconsistency, which limit robust cross-modal representation learning. To address this problem, we propose GeoMamba, a geometry-driven framework tailored for optical-SAR fine-grained retrieval. Specifically, GeoMamba introduces a Geometric Feature Injection (GFI) module that enhances cross-modal feature interaction and incorporates structural priors, thereby improving the robustness of SAR representations and promoting geometry-consistent feature learning. In addition, a Geometric Consistency Constraint (GCC) module, together with a Deep Supervision (DS) strategy, imposes hierarchical geometric constraints using classical operators, which helps preserve informative object structures during representation learning. We further construct a new dataset, FGOS-as, containing 11 aerospace and maritime categories for evaluating unaligned cross-modal fine-grained object retrieval in realistic remote sensing scenarios. Extensive experiments on FGOS-as demonstrate that GeoMamba outperforms existing methods, achieving 63.3% mAP and 77.0% Rank-1 accuracy in all-to-all retrieval setting.

preprint2023arXiv

A deep local attention network for pre-operative lymph node metastasis prediction in pancreatic cancer via multiphase CT imaging

Lymph node (LN) metastasis status is one of the most critical prognostic and cancer staging factors for patients with resectable pancreatic ductal adenocarcinoma (PDAC), or in general, for any types of solid malignant tumors. Preoperative prediction of LN metastasis from non-invasive CT imaging is highly desired, as it might be straightforwardly used to guide the following neoadjuvant treatment decision and surgical planning. Most studies only capture the tumor characteristics in CT imaging to implicitly infer LN metastasis and very few work exploit direct LN's CT imaging information. To the best of our knowledge, this is the first work to propose a fully-automated LN segmentation and identification network to directly facilitate the LN metastasis status prediction task. Nevertheless LN segmentation/detection is very challenging since LN can be easily confused with other hard negative anatomic structures (e.g., vessels) from radiological images. We explore the anatomical spatial context priors of pancreatic LN locations by generating a guiding attention map from related organs and vessels to assist segmentation and infer LN status. As such, LN segmentation is impelled to focus on regions that are anatomically adjacent or plausible with respect to the specific organs and vessels. The metastasized LN identification network is trained to classify the segmented LN instances into positives or negatives by reusing the segmentation network as a pre-trained backbone and padding a new classification head. More importantly, we develop a LN metastasis status prediction network that combines the patient-wise aggregation results of LN segmentation/identification and deep imaging features extracted from the tumor region. Extensive quantitative nested five-fold cross-validation is conducted on a discovery dataset of 749 patients with PDAC.

preprint2023arXiv

HSTFormer: Hierarchical Spatial-Temporal Transformers for 3D Human Pose Estimation

Transformer-based approaches have been successfully proposed for 3D human pose estimation (HPE) from 2D pose sequence and achieved state-of-the-art (SOTA) performance. However, current SOTAs have difficulties in modeling spatial-temporal correlations of joints at different levels simultaneously. This is due to the poses' spatial-temporal complexity. Poses move at various speeds temporarily with various joints and body-parts movement spatially. Hence, a cookie-cutter transformer is non-adaptable and can hardly meet the "in-the-wild" requirement. To mitigate this issue, we propose Hierarchical Spatial-Temporal transFormers (HSTFormer) to capture multi-level joints' spatial-temporal correlations from local to global gradually for accurate 3D HPE. HSTFormer consists of four transformer encoders (TEs) and a fusion module. To the best of our knowledge, HSTFormer is the first to study hierarchical TEs with multi-level fusion. Extensive experiments on three datasets (i.e., Human3.6M, MPI-INF-3DHP, and HumanEva) demonstrate that HSTFormer achieves competitive and consistent performance on benchmarks with various scales and difficulties. Specifically, it surpasses recent SOTAs on the challenging MPI-INF-3DHP dataset and small-scale HumanEva dataset, with a highly generalized systematic approach. The code is available at: https://github.com/qianxiaoye825/HSTFormer.

preprint2022arXiv

A Fair Federated Learning Framework With Reinforcement Learning

Federated learning (FL) is a paradigm where many clients collaboratively train a model under the coordination of a central server, while keeping the training data locally stored. However, heterogeneous data distributions over different clients remain a challenge to mainstream FL algorithms, which may cause slow convergence, overall performance degradation and unfairness of performance across clients. To address these problems, in this study we propose a reinforcement learning framework, called PG-FFL, which automatically learns a policy to assign aggregation weights to clients. Additionally, we propose to utilize Gini coefficient as the measure of fairness for FL. More importantly, we apply the Gini coefficient and validation accuracy of clients in each communication round to construct a reward function for the reinforcement learning. Our PG-FFL is also compatible to many existing FL algorithms. We conduct extensive experiments over diverse datasets to verify the effectiveness of our framework. The experimental results show that our framework can outperform baseline methods in terms of overall performance, fairness and convergence speed.

preprint2022arXiv

A Privacy-Preserving Subgraph-Level Federated Graph Neural Network via Differential Privacy

Currently, the federated graph neural network (GNN) has attracted a lot of attention due to its wide applications in reality without violating the privacy regulations. Among all the privacy-preserving technologies, the differential privacy (DP) is the most promising one due to its effectiveness and light computational overhead. However, the DP-based federated GNN has not been well investigated, especially in the sub-graph-level setting, such as the scenario of recommendation system. The biggest challenge is how to guarantee the privacy and solve the non independent and identically distributed (non-IID) data in federated GNN simultaneously. In this paper, we propose DP-FedRec, a DP-based federated GNN to fill the gap. Private Set Intersection (PSI) is leveraged to extend the local graph for each client, and thus solve the non-IID problem. Most importantly, DP is applied not only on the weights but also on the edges of the intersection graph from PSI to fully protect the privacy of clients. The evaluation demonstrates DP-FedRec achieves better performance with the graph extension and DP only introduces little computations overhead.

preprint2022arXiv

A Study of Different Ways to Use The Conformer Model For Spoken Language Understanding

SLU combines ASR and NLU capabilities to accomplish speech-to-intent understanding. In this paper, we compare different ways to combine ASR and NLU, in particular using a single Conformer model with different ways to use its components, to better understand the strengths and weaknesses of each approach. We find that it is not necessarily a choice between two-stage decoding and end-to-end systems which determines the best system for research or application. System optimization still entails carefully improving the performance of each component. It is difficult to prove that one direction is conclusively better than the other. In this paper, we also propose a novel connectionist temporal summarization (CTS) method to reduce the length of acoustic encoding sequences while improving the accuracy and processing speed of end-to-end models. This method achieves the same intent accuracy as the best two-stage SLU recognition with complicated and time-consuming decoding but does so at lower computational cost. This stacked end-to-end SLU system yields an intent accuracy of 93.97% for the SmartLights far-field set, 95.18% for the close-field set, and 99.71% for FluentSpeech.

preprint2022arXiv

Accurate and Robust Lesion RECIST Diameter Prediction and Segmentation with Transformers

Automatically measuring lesion/tumor size with RECIST (Response Evaluation Criteria In Solid Tumors) diameters and segmentation is important for computer-aided diagnosis. Although it has been studied in recent years, there is still space to improve its accuracy and robustness, such as (1) enhancing features by incorporating rich contextual information while keeping a high spatial resolution and (2) involving new tasks and losses for joint optimization. To reach this goal, this paper proposes a transformer-based network (MeaFormer, Measurement transFormer) for lesion RECIST diameter prediction and segmentation (LRDPS). It is formulated as three correlative and complementary tasks: lesion segmentation, heatmap prediction, and keypoint regression. To the best of our knowledge, it is the first time to use keypoint regression for RECIST diameter prediction. MeaFormer can enhance high-resolution features by employing transformers to capture their long-range dependencies. Two consistency losses are introduced to explicitly build relationships among these tasks for better optimization. Experiments show that MeaFormer achieves the state-of-the-art performance of LRDPS on the large-scale DeepLesion dataset and produces promising results of two downstream clinic-relevant tasks, i.e., 3D lesion segmentation and RECIST assessment in longitudinal studies.

preprint2022arXiv

Adaptive Activation Network For Low Resource Multilingual Speech Recognition

Low resource automatic speech recognition (ASR) is a useful but thorny task, since deep learning ASR models usually need huge amounts of training data. The existing models mostly established a bottleneck (BN) layer by pre-training on a large source language, and transferring to the low resource target language. In this work, we introduced an adaptive activation network to the upper layers of ASR model, and applied different activation functions to different languages. We also proposed two approaches to train the model: (1) cross-lingual learning, replacing the activation function from source language to target language, (2) multilingual learning, jointly training the Connectionist Temporal Classification (CTC) loss of each language and the relevance of different languages. Our experiments on IARPA Babel datasets demonstrated that our approaches outperform the from-scratch training and traditional bottleneck feature based methods. In addition, combining the cross-lingual learning and multilingual learning together could further improve the performance of multilingual speech recognition.

preprint2022arXiv

Adaptive Few-Shot Learning Algorithm for Rare Sound Event Detection

Sound event detection is to infer the event by understanding the surrounding environmental sounds. Due to the scarcity of rare sound events, it becomes challenging for the well-trained detectors which have learned too much prior knowledge. Meanwhile, few-shot learning methods promise a good generalization ability when facing a new limited-data task. Recent approaches have achieved promising results in this field. However, these approaches treat each support example independently, ignoring the information of other examples from the whole task. Because of this, most of previous methods are constrained to generate a same feature embedding for all test-time tasks, which is not adaptive to each inputted data. In this work, we propose a novel task-adaptive module which is easy to plant into any metric-based few-shot learning frameworks. The module could identify the task-relevant feature dimension. Incorporating our module improves the performance considerably on two datasets over baseline methods, especially for the transductive propagation network. Such as +6.8% for 5-way 1-shot accuracy on ESC-50, and +5.9% on noiseESC-50. We investigate our approach in the domain-mismatch setting and also achieve better results than previous methods.

preprint2022arXiv

Adding Connectionist Temporal Summarization into Conformer to Improve Its Decoder Efficiency For Speech Recognition

The Conformer model is an excellent architecture for speech recognition modeling that effectively utilizes the hybrid losses of connectionist temporal classification (CTC) and attention to train model parameters. To improve the decoding efficiency of Conformer, we propose a novel connectionist temporal summarization (CTS) method that reduces the number of frames required for the attention decoder fed from the acoustic sequences generated by the encoder, thus reducing operations. However, to achieve such decoding improvements, we must fine-tune model parameters, as cross-attention observations are changed and thus require corresponding refinements. Our final experiments show that, with a beamwidth of 4, the LibriSpeech's decoding budget can be reduced by up to 20% and for FluentSpeech data it can be reduced by 11%, without losing ASR accuracy. An improvement in accuracy is even found for the LibriSpeech "test-other" set. The word error rate (WER) is reduced by 6\% relative at the beam width of 1 and by 3% relative at the beam width of 4.

preprint2022arXiv

Augmentation-induced Consistency Regularization for Classification

Deep neural networks have become popular in many supervised learning tasks, but they may suffer from overfitting when the training dataset is limited. To mitigate this, many researchers use data augmentation, which is a widely used and effective method for increasing the variety of datasets. However, the randomness introduced by data augmentation causes inevitable inconsistency between training and inference, which leads to poor improvement. In this paper, we propose a consistency regularization framework based on data augmentation, called CR-Aug, which forces the output distributions of different sub models generated by data augmentation to be consistent with each other. Specifically, CR-Aug evaluates the discrepancy between the output distributions of two augmented versions of each sample, and it utilizes a stop-gradient operation to minimize the consistency loss. We implement CR-Aug to image and audio classification tasks and conduct extensive experiments to verify its effectiveness in improving the generalization ability of classifiers. Our CR-Aug framework is ready-to-use, it can be easily adapted to many state-of-the-art network architectures. Our empirical results show that CR-Aug outperforms baseline methods by a significant margin.

preprint2022arXiv

Cali3F: Calibrated Fast Fair Federated Recommendation System

The increasingly stringent regulations on privacy protection have sparked interest in federated learning. As a distributed machine learning framework, it bridges isolated data islands by training a global model over devices while keeping data localized. Specific to recommendation systems, many federated recommendation algorithms have been proposed to realize the privacy-preserving collaborative recommendation. However, several constraints remain largely unexplored. One big concern is how to ensure fairness between participants of federated learning, that is, to maintain the uniformity of recommendation performance across devices. On the other hand, due to data heterogeneity and limited networks, additional challenges occur in the convergence speed. To address these problems, in this paper, we first propose a personalized federated recommendation system training algorithm to improve the recommendation performance fairness. Then we adopt a clustering-based aggregation method to accelerate the training process. Combining the two components, we proposed Cali3F, a calibrated fast and fair federated recommendation framework. Cali3F not only addresses the convergence problem by a within-cluster parameter sharing approach but also significantly boosts fairness by calibrating local models with the global model. We demonstrate the performance of Cali3F across standard benchmark datasets and explore the efficacy in comparison to traditional aggregation approaches.

preprint2022arXiv

Debias the Black-box: A Fair Ranking Framework via Knowledge Distillation

Deep neural networks can capture the intricate interaction history information between queries and documents, because of their many complicated nonlinear units, allowing them to provide correct search recommendations. However, service providers frequently face more complex obstacles in real-world circumstances, such as deployment cost constraints and fairness requirements. Knowledge distillation, which transfers the knowledge of a well-trained complex model (teacher) to a simple model (student), has been proposed to alleviate the former concern, but the best current distillation methods focus only on how to make the student model imitate the predictions of the teacher model. To better facilitate the application of deep models, we propose a fair information retrieval framework based on knowledge distillation. This framework can improve the exposure-based fairness of models while considerably decreasing model size. Our extensive experiments on three huge datasets show that our proposed framework can reduce the model size to a minimum of 1% of its original size while maintaining its black-box state. It also improves fairness performance by 15%~46% while keeping a high level of recommendation effectiveness.

preprint2022arXiv

DRVC: A Framework of Any-to-Any Voice Conversion with Self-Supervised Learning

Any-to-any voice conversion problem aims to convert voices for source and target speakers, which are out of the training data. Previous works wildly utilize the disentangle-based models. The disentangle-based model assumes the speech consists of content and speaker style information and aims to untangle them to change the style information for conversion. Previous works focus on reducing the dimension of speech to get the content information. But the size is hard to determine to lead to the untangle overlapping problem. We propose the Disentangled Representation Voice Conversion (DRVC) model to address the issue. DRVC model is an end-to-end self-supervised model consisting of the content encoder, timbre encoder, and generator. Instead of the previous work for reducing speech size to get content, we propose a cycle for restricting the disentanglement by the Cycle Reconstruct Loss and Same Loss. The experiments show there is an improvement for converted speech on quality and voice similarity.

preprint2022arXiv

DT-SV: A Transformer-based Time-domain Approach for Speaker Verification

Speaker verification (SV) aims to determine whether the speaker's identity of a test utterance is the same as the reference speech. In the past few years, extracting speaker embeddings using deep neural networks for SV systems has gone mainstream. Recently, different attention mechanisms and Transformer networks have been explored widely in SV fields. However, utilizing the original Transformer in SV directly may have frame-level information waste on output features, which could lead to restrictions on capacity and discrimination of speaker embeddings. Therefore, we propose an approach to derive utterance-level speaker embeddings via a Transformer architecture that uses a novel loss function named diffluence loss to integrate the feature information of different Transformer layers. Therein, the diffluence loss aims to aggregate frame-level features into an utterance-level representation, and it could be integrated into the Transformer expediently. Besides, we also introduce a learnable mel-fbank energy feature extractor named time-domain feature extractor that computes the mel-fbank features more precisely and efficiently than the standard mel-fbank extractor. Combining Diffluence loss and Time-domain feature extractor, we propose a novel Transformer-based time-domain SV model (DT-SV) with faster training speed and higher accuracy. Experiments indicate that our proposed model can achieve better performance in comparison with other models.

preprint2022arXiv

Efficient Distributed Framework for Collaborative Multi-Agent Reinforcement Learning

Multi-agent reinforcement learning for incomplete information environments has attracted extensive attention from researchers. However, due to the slow sample collection and poor sample exploration, there are still some problems in multi-agent reinforcement learning, such as unstable model iteration and low training efficiency. Moreover, most of the existing distributed framework are proposed for single-agent reinforcement learning and not suitable for multi-agent. In this paper, we design an distributed MARL framework based on the actor-work-learner architecture. In this framework, multiple asynchronous environment interaction modules can be deployed simultaneously, which greatly improves the sample collection speed and sample diversity. Meanwhile, to make full use of computing resources, we decouple the model iteration from environment interaction, and thus accelerate the policy iteration. Finally, we verified the effectiveness of propose framework in MaCA military simulation environment and the SMAC 3D realtime strategy gaming environment with imcomplete information characteristics.

preprint2022arXiv

Enhancing Dual-Encoders with Question and Answer Cross-Embeddings for Answer Retrieval

Dual-Encoders is a promising mechanism for answer retrieval in question answering (QA) systems. Currently most conventional Dual-Encoders learn the semantic representations of questions and answers merely through matching score. Researchers proposed to introduce the QA interaction features in scoring function but at the cost of low efficiency in inference stage. To keep independent encoding of questions and answers during inference stage, variational auto-encoder is further introduced to reconstruct answers (questions) from question (answer) embeddings as an auxiliary task to enhance QA interaction in representation learning in training stage. However, the needs of text generation and answer retrieval are different, which leads to hardness in training. In this work, we propose a framework to enhance the Dual-Encoders model with question answer cross-embeddings and a novel Geometry Alignment Mechanism (GAM) to align the geometry of embeddings from Dual-Encoders with that from Cross-Encoders. Extensive experimental results show that our framework significantly improves Dual-Encoders model and outperforms the state-of-the-art method on multiple answer retrieval datasets.

preprint2022arXiv

Federated Non-negative Matrix Factorization for Short Texts Topic Modeling with Mutual Information

Non-negative matrix factorization (NMF) based topic modeling is widely used in natural language processing (NLP) to uncover hidden topics of short text documents. Usually, training a high-quality topic model requires large amount of textual data. In many real-world scenarios, customer textual data should be private and sensitive, precluding uploading to data centers. This paper proposes a Federated NMF (FedNMF) framework, which allows multiple clients to collaboratively train a high-quality NMF based topic model with locally stored data. However, standard federated learning will significantly undermine the performance of topic models in downstream tasks (e.g., text classification) when the data distribution over clients is heterogeneous. To alleviate this issue, we further propose FedNMF+MI, which simultaneously maximizes the mutual information (MI) between the count features of local texts and their topic weight vectors to mitigate the performance degradation. Experimental results show that our FedNMF+MI methods outperform Federated Latent Dirichlet Allocation (FedLDA) and the FedNMF without MI methods for short texts by a significant margin on both coherence score and classification F1 score.

preprint2022arXiv

Federated Split BERT for Heterogeneous Text Classification

Pre-trained BERT models have achieved impressive performance in many natural language processing (NLP) tasks. However, in many real-world situations, textual data are usually decentralized over many clients and unable to be uploaded to a central server due to privacy protection and regulations. Federated learning (FL) enables multiple clients collaboratively to train a global model while keeping the local data privacy. A few researches have investigated BERT in federated learning setting, but the problem of performance loss caused by heterogeneous (e.g., non-IID) data over clients remain under-explored. To address this issue, we propose a framework, FedSplitBERT, which handles heterogeneous data and decreases the communication cost by splitting the BERT encoder layers into local part and global part. The local part parameters are trained by the local client only while the global part parameters are trained by aggregating gradients of multiple clients. Due to the sheer size of BERT, we explore a quantization method to further reduce the communication cost with minimal performance loss. Our framework is ready-to-use and compatible to many existing federated learning algorithms, including FedAvg, FedProx and FedAdam. Our experiments verify the effectiveness of the proposed framework, which outperforms baseline methods by a significant margin, while FedSplitBERT with quantization can reduce the communication cost by $11.9\times$.

preprint2022arXiv

ICAF: Iterative Contrastive Alignment Framework for Multimodal Abstractive Summarization

Integrating multimodal knowledge for abstractive summarization task is a work-in-progress research area, with present techniques inheriting fusion-then-generation paradigm. Due to semantic gaps between computer vision and natural language processing, current methods often treat multiple data points as separate objects and rely on attention mechanisms to search for connection in order to fuse together. In addition, missing awareness of cross-modal matching from many frameworks leads to performance reduction. To solve these two drawbacks, we propose an Iterative Contrastive Alignment Framework (ICAF) that uses recurrent alignment and contrast to capture the coherences between images and texts. Specifically, we design a recurrent alignment (RA) layer to gradually investigate fine-grained semantical relationships between image patches and text tokens. At each step during the encoding process, cross-modal contrastive losses are applied to directly optimize the embedding space. According to ROUGE, relevance scores, and human evaluation, our model outperforms the state-of-the-art baselines on MSMO dataset. Experiments on the applicability of our proposed framework and hyperparameters settings have been also conducted.

preprint2022arXiv

Improving Human Image Synthesis with Residual Fast Fourier Transformation and Wasserstein Distance

With the rapid development of the Metaverse, virtual humans have emerged, and human image synthesis and editing techniques, such as pose transfer, have recently become popular. Most of the existing techniques rely on GANs, which can generate good human images even with large variants and occlusions. But from our best knowledge, the existing state-of-the-art method still has the following problems: the first is that the rendering effect of the synthetic image is not realistic, such as poor rendering of some regions. And the second is that the training of GAN is unstable and slow to converge, such as model collapse. Based on the above two problems, we propose several methods to solve them. To improve the rendering effect, we use the Residual Fast Fourier Transform Block to replace the traditional Residual Block. Then, spectral normalization and Wasserstein distance are used to improve the speed and stability of GAN training. Experiments demonstrate that the methods we offer are effective at solving the problems listed above, and we get state-of-the-art scores in LPIPS and PSNR.

preprint2022arXiv

Leveraging Causal Inference for Explainable Automatic Program Repair

Deep learning models have made significant progress in automatic program repair. However, the black-box nature of these methods has restricted their practical applications. To address this challenge, this paper presents an interpretable approach for program repair based on sequence-to-sequence models with causal inference and our method is called CPR, short for causal program repair. Our CPR can generate explanations in the process of decision making, which consists of groups of causally related input-output tokens. Firstly, our method infers these relations by querying the model with inputs disturbed by data augmentation. Secondly, it generates a graph over tokens from the responses and solves a partitioning problem to select the most relevant components. The experiments on four programming languages (Java, C, Python, and JavaScript) show that CPR can generate causal graphs for reasonable interpretations and boost the performance of bug fixing in automatic program repair.

preprint2022arXiv

Localized Adversarial Domain Generalization

Deep learning methods can struggle to handle domain shifts not seen in training data, which can cause them to not generalize well to unseen domains. This has led to research attention on domain generalization (DG), which aims to the model's generalization ability to out-of-distribution. Adversarial domain generalization is a popular approach to DG, but conventional approaches (1) struggle to sufficiently align features so that local neighborhoods are mixed across domains; and (2) can suffer from feature space over collapse which can threaten generalization performance. To address these limitations, we propose localized adversarial domain generalization with space compactness maintenance~(LADG) which constitutes two major contributions. First, we propose an adversarial localized classifier as the domain discriminator, along with a principled primary branch. This constructs a min-max game whereby the aim of the featurizer is to produce locally mixed domains. Second, we propose to use a coding-rate loss to alleviate feature space over collapse. We conduct comprehensive experiments on the Wilds DG benchmark to validate our approach, where LADG outperforms leading competitors on most datasets.

preprint2022arXiv

Lumbar Bone Mineral Density Estimation from Chest X-ray Images: Anatomy-aware Attentive Multi-ROI Modeling

Osteoporosis is a common chronic metabolic bone disease often under-diagnosed and under-treated due to the limited access to bone mineral density (BMD) examinations, e.g. via Dual-energy X-ray Absorptiometry (DXA). This paper proposes a method to predict BMD from Chest X-ray (CXR), one of the most commonly accessible and low-cost medical imaging examinations. Our method first automatically detects Regions of Interest (ROIs) of local CXR bone structures. Then a multi-ROI deep model with transformer encoder is developed to exploit both local and global information in the chest X-ray image for accurate BMD estimation. Our method is evaluated on 13719 CXR patient cases with ground truth BMD measured by the gold standard DXA. The model predicted BMD has a strong correlation with the ground truth (Pearson correlation coefficient 0.894 on lumbar 1). When applied in osteoporosis screening, it achieves a high classification performance (average AUC of 0.968). As the first effort of using CXR scans to predict the BMD, the proposed algorithm holds strong potential for early osteoporosis screening and public health promotion.

preprint2022arXiv

MDCNN-SID: Multi-scale Dilated Convolution Network for Singer Identification

Most singer identification methods are processed in the frequency domain, which potentially leads to information loss during the spectral transformation. In this paper, instead of the frequency domain, we propose an end-to-end architecture that addresses this problem in the waveform domain. An encoder based on Multi-scale Dilated Convolution Neural Networks (MDCNN) was introduced to generate wave embedding from the raw audio signal. Specifically, dilated convolution layers are used in the proposed method to enlarge the receptive field, aiming to extract song-level features. Furthermore, skip connection in the backbone network integrates the multi-resolution acoustic features learned by the stack of convolution layers. Then, the obtained wave embedding is passed into the following networks for singer identification. In experiments, the proposed method achieves comparable performance on the benchmark dataset of Artist20, which significantly improves related works.

preprint2022arXiv

MetaSID: Singer Identification with Domain Adaptation for Metaverse

Metaverse has stretched the real world into unlimited space. There will be more live concerts in Metaverse. The task of singer identification is to identify the song belongs to which singer. However, there has been a tough problem in singer identification, which is the different live effects. The studio version is different from the live version, the data distribution of the training set and the test set are different, and the performance of the classifier decreases. This paper proposes the use of the domain adaptation method to solve the live effect in singer identification. Three methods of domain adaptation combined with Convolutional Recurrent Neural Network (CRNN) are designed, which are Maximum Mean Discrepancy (MMD), gradient reversal (Revgrad), and Contrastive Adaptation Network (CAN). MMD is a distance-based method, which adds domain loss. Revgrad is based on the idea that learned features can represent different domain samples. CAN is based on class adaptation, it takes into account the correspondence between the categories of the source domain and target domain. Experimental results on the public dataset of Artist20 show that CRNN-MMD leads to an improvement over the baseline CRNN by 0.14. The CRNN-RevGrad outperforms the baseline by 0.21. The CRNN-CAN achieved state of the art with the F1 measure value of 0.83 on album split.

preprint2022arXiv

Micro-Expression Recognition Based on Attribute Information Embedding and Cross-modal Contrastive Learning

Facial micro-expressions recognition has attracted much attention recently. Micro-expressions have the characteristics of short duration and low intensity, and it is difficult to train a high-performance classifier with the limited number of existing micro-expressions. Therefore, recognizing micro-expressions is a challenge task. In this paper, we propose a micro-expression recognition method based on attribute information embedding and cross-modal contrastive learning. We use 3D CNN to extract RGB features and FLOW features of micro-expression sequences and fuse them, and use BERT network to extract text information in Facial Action Coding System. Through cross-modal contrastive loss, we embed attribute information in the visual network, thereby improving the representation ability of micro-expression recognition in the case of limited samples. We conduct extensive experiments in CASME II and MMEW databases, and the accuracy is 77.82% and 71.04%, respectively. The comparative experiments show that this method has better recognition effect than other methods for micro-expression recognition.

preprint2022arXiv

ODformer: Spatial-Temporal Transformers for Long Sequence Origin-Destination Matrix Forecasting Against Cross Application Scenario

Origin-Destination (OD) matrices record directional flow data between pairs of OD regions. The intricate spatiotemporal dependency in the matrices makes the OD matrix forecasting (ODMF) problem not only intractable but also non-trivial. However, most of the related methods are designed for very short sequence time series forecasting in specific application scenarios, which cannot meet the requirements of the variation in scenarios and forecasting length of practical applications. To address these issues, we propose a Transformer-like model named ODformer, with two salient characteristics: (i) the novel OD Attention mechanism, which captures special spatial dependencies between OD pairs of the same origin (destination), greatly improves the ability of the model to predict cross-application scenarios after combining with 2D-GCN that captures spatial dependencies between OD regions. (ii) a PeriodSparse Self-attention that effectively forecasts long sequence OD matrix series while adapting to the periodic differences in different scenarios. Generous experiments in three application backgrounds (i.e., transportation traffic, IP backbone network traffic, crowd flow) show our method outperforms the state-of-the-art methods.

preprint2022arXiv

QSpeech: Low-Qubit Quantum Speech Application Toolkit

Quantum devices with low qubits are common in the Noisy Intermediate-Scale Quantum (NISQ) era. However, Quantum Neural Network (QNN) running on low-qubit quantum devices would be difficult since it is based on Variational Quantum Circuit (VQC), which requires many qubits. Therefore, it is critical to make QNN with VQC run on low-qubit quantum devices. In this study, we propose a novel VQC called the low-qubit VQC. VQC requires numerous qubits based on the input dimension; however, the low-qubit VQC with linear transformation can liberate this condition. Thus, it allows the QNN to run on low-qubit quantum devices for speech applications. Furthermore, as compared to the VQC, our proposed low-qubit VQC can stabilize the training process more. Based on the low-qubit VQC, we implement QSpeech, a library for quick prototyping of hybrid quantum-classical neural networks in the speech field. It has numerous quantum neural layers and QNN models for speech applications. Experiments on Speech Command Recognition and Text-to-Speech show that our proposed low-qubit VQC outperforms VQC and is more stable.

preprint2022arXiv

r-G2P: Evaluating and Enhancing Robustness of Grapheme to Phoneme Conversion by Controlled noise introducing and Contextual information incorporation

Grapheme-to-phoneme (G2P) conversion is the process of converting the written form of words to their pronunciations. It has an important role for text-to-speech (TTS) synthesis and automatic speech recognition (ASR) systems. In this paper, we aim to evaluate and enhance the robustness of G2P models. We show that neural G2P models are extremely sensitive to orthographical variations in graphemes like spelling mistakes. To solve this problem, we propose three controlled noise introducing methods to synthesize noisy training data. Moreover, we incorporate the contextual information with the baseline and propose a robust training strategy to stabilize the training process. The experimental results demonstrate that our proposed robust G2P model (r-G2P) outperforms the baseline significantly (-2.73\% WER on Dict-based benchmarks and -9.09\% WER on Real-world sources).

preprint2022arXiv

Self-Attention for Incomplete Utterance Rewriting

Incomplete utterance rewriting (IUR) has recently become an essential task in NLP, aiming to complement the incomplete utterance with sufficient context information for comprehension. In this paper, we propose a novel method by directly extracting the coreference and omission relationship from the self-attention weight matrix of the transformer instead of word embeddings and edit the original text accordingly to generate the complete utterance. Benefiting from the rich information in the self-attention weight matrix, our method achieved competitive results on public IUR datasets.

preprint2022arXiv

Singer Identification for Metaverse with Timbral and Middle-Level Perceptual Features

Metaverse is an interactive world that combines reality and virtuality, where participants can be virtual avatars. Anyone can hold a concert in a virtual concert hall, and users can quickly identify the real singer behind the virtual idol through the singer identification. Most singer identification methods are processed using the frame-level features. However, expect the singer's timbre, the music frame includes music information, such as melodiousness, rhythm, and tonal. It means the music information is noise for using frame-level features to identify the singers. In this paper, instead of only the frame-level features, we propose to use another two features that address this problem. Middle-level feature, which represents the music's melodiousness, rhythmic stability, and tonal stability, and is able to capture the perceptual features of music. The timbre feature, which is used in speaker identification, represents the singers' voice features. Furthermore, we propose a convolutional recurrent neural network (CRNN) to combine three features for singer identification. The model firstly fuses the frame-level feature and timbre feature and then combines middle-level features to the mix features. In experiments, the proposed method achieves comparable performance on an average F1 score of 0.81 on the benchmark dataset of Artist20, which significantly improves related works.

preprint2022arXiv

Spatial-Temporal Space Hand-in-Hand: Spatial-Temporal Video Super-Resolution via Cycle-Projected Mutual Learning

Spatial-Temporal Video Super-Resolution (ST-VSR) aims to generate super-resolved videos with higher resolution(HR) and higher frame rate (HFR). Quite intuitively, pioneering two-stage based methods complete ST-VSR by directly combining two sub-tasks: Spatial Video Super-Resolution (S-VSR) and Temporal Video Super-Resolution(T-VSR) but ignore the reciprocal relations among them. Specifically, 1) T-VSR to S-VSR: temporal correlations help accurate spatial detail representation with more clues; 2) S-VSR to T-VSR: abundant spatial information contributes to the refinement of temporal prediction. To this end, we propose a one-stage based Cycle-projected Mutual learning network (CycMu-Net) for ST-VSR, which makes full use of spatial-temporal correlations via the mutual learning between S-VSR and T-VSR. Specifically, we propose to exploit the mutual information among them via iterative up-and-down projections, where the spatial and temporal features are fully fused and distilled, helping the high-quality video reconstruction. Besides extensive experiments on benchmark datasets, we also compare our proposed CycMu-Net with S-VSR and T-VSR tasks, demonstrating that our method significantly outperforms state-of-the-art methods.

preprint2022arXiv

Speech Augmentation Based Unsupervised Learning for Keyword Spotting

In this paper, we investigated a speech augmentation based unsupervised learning approach for keyword spotting (KWS) task. KWS is a useful speech application, yet also heavily depends on the labeled data. We designed a CNN-Attention architecture to conduct the KWS task. CNN layers focus on the local acoustic features, and attention layers model the long-time dependency. To improve the robustness of KWS model, we also proposed an unsupervised learning method. The unsupervised loss is based on the similarity between the original and augmented speech features, as well as the audio reconstructing information. Two speech augmentation methods are explored in the unsupervised learning: speed and intensity. The experiments on Google Speech Commands V2 Dataset demonstrated that our CNN-Attention model has competitive results. Moreover, the augmentation based unsupervised learning could further improve the classification accuracy of KWS task. In our experiments, with augmentation based unsupervised learning, our KWS model achieves better performance than other unsupervised methods, such as CPC, APC, and MPC.

preprint2022arXiv

SpeechEQ: Speech Emotion Recognition based on Multi-scale Unified Datasets and Multitask Learning

Speech emotion recognition (SER) has many challenges, but one of the main challenges is that each framework does not have a unified standard. In this paper, we propose SpeechEQ, a framework for unifying SER tasks based on a multi-scale unified metric. This metric can be trained by Multitask Learning (MTL), which includes two emotion recognition tasks of Emotion States Category (EIS) and Emotion Intensity Scale (EIS), and two auxiliary tasks of phoneme recognition and gender recognition. For this framework, we build a Mandarin SER dataset - SpeechEQ Dataset (SEQD). We conducted experiments on the public CASIA and ESD datasets in Mandarin, which exhibit that our method outperforms baseline methods by a relatively large margin, yielding 8.0% and 6.5% improvement in accuracy respectively. Additional experiments on IEMOCAP with four emotion categories (i.e., angry, happy, sad, and neutral) also show the proposed method achieves a state-of-the-art of both weighted accuracy (WA) of 78.16% and unweighted accuracy (UA) of 77.47%.

preprint2022arXiv

SUSing: SU-net for Singing Voice Synthesis

Singing voice synthesis is a generative task that involves multi-dimensional control of the singing model, including lyrics, pitch, and duration, and includes the timbre of the singer and singing skills such as vibrato. In this paper, we proposed SU-net for singing voice synthesis named SUSing. Synthesizing singing voice is treated as a translation task between lyrics and music score and spectrum. The lyrics and music score information is encoded into a two-dimensional feature representation through the convolution layer. The two-dimensional feature and its frequency spectrum are mapped to the target spectrum in an autoregressive manner through a SU-net network. Within the SU-net the stripe pooling method is used to replace the alternate global pooling method to learn the vertical frequency relationship in the spectrum and the changes of frequency in the time domain. The experimental results on the public dataset Kiritan show that the proposed method can synthesize more natural singing voices.

preprint2022arXiv

TDASS: Target Domain Adaptation Speech Synthesis Framework for Multi-speaker Low-Resource TTS

Recently, synthesizing personalized speech by text-to-speech (TTS) application is highly demanded. But the previous TTS models require a mass of target speaker speeches for training. It is a high-cost task, and hard to record lots of utterances from the target speaker. Data augmentation of the speeches is a solution but leads to the low-quality synthesis speech problem. Some multi-speaker TTS models are proposed to address the issue. But the quantity of utterances of each speaker imbalance leads to the voice similarity problem. We propose the Target Domain Adaptation Speech Synthesis Network (TDASS) to address these issues. Based on the backbone of the Tacotron2 model, which is the high-quality TTS model, TDASS introduces a self-interested classifier for reducing the non-target influence. Besides, a special gradient reversal layer with different operations for target and non-target is added to the classifier. We evaluate the model on a Chinese speech corpus, the experiments show the proposed method outperforms the baseline method in terms of voice quality and voice similarity.

preprint2022arXiv

TGAVC: Improving Autoencoder Voice Conversion with Text-Guided and Adversarial Training

Non-parallel many-to-many voice conversion remains an interesting but challenging speech processing task. Recently, AutoVC, a conditional autoencoder based method, achieved excellent conversion results by disentangling the speaker identity and the speech content using information-constraining bottlenecks. However, due to the pure autoencoder training method, it is difficult to evaluate the separation effect of content and speaker identity. In this paper, a novel voice conversion framework, named $\boldsymbol T$ext $\boldsymbol G$uided $\boldsymbol A$utoVC(TGAVC), is proposed to more effectively separate content and timbre from speech, where an expected content embedding produced based on the text transcriptions is designed to guide the extraction of voice content. In addition, the adversarial training is applied to eliminate the speaker identity information in the estimated content embedding extracted from speech. Under the guidance of the expected content embedding and the adversarial training, the content encoder is trained to extract speaker-independent content embedding from speech. Experiments on AIShell-3 dataset show that the proposed model outperforms AutoVC in terms of naturalness and similarity of converted speech.

preprint2022arXiv

Tiny-Sepformer: A Tiny Time-Domain Transformer Network for Speech Separation

Time-domain Transformer neural networks have proven their superiority in speech separation tasks. However, these models usually have a large number of network parameters, thus often encountering the problem of GPU memory explosion. In this paper, we proposed Tiny-Sepformer, a tiny version of Transformer network for speech separation. We present two techniques to reduce the model parameters and memory consumption: (1) Convolution-Attention (CA) block, spliting the vanilla Transformer to two paths, multi-head attention and 1D depthwise separable convolution, (2) parameter sharing, sharing the layer parameters within the CA block. In our experiments, Tiny-Sepformer could greatly reduce the model size, and achieves comparable separation performance with vanilla Sepformer on WSJ0-2/3Mix datasets.

preprint2022arXiv

Towards Speaker Age Estimation with Label Distribution Learning

Existing methods for speaker age estimation usually treat it as a multi-class classification or a regression problem. However, precise age identification remains a challenge due to label ambiguity, \emph{i.e.}, utterances from adjacent age of the same person are often indistinguishable. To address this, we utilize the ambiguous information among the age labels, convert each age label into a discrete label distribution and leverage the label distribution learning (LDL) method to fit the data. For each audio data sample, our method produces a age distribution of its speaker, and on top of the distribution we also perform two other tasks: age prediction and age uncertainty minimization. Therefore, our method naturally combines the age classification and regression approaches, which enhances the robustness of our method. We conduct experiments on the public NIST SRE08-10 dataset and a real-world dataset, which exhibit that our method outperforms baseline methods by a relatively large margin, yielding a 10\% reduction in terms of mean absolute error (MAE) on a real-world dataset.

preprint2022arXiv

Uncertainty Calibration for Deep Audio Classifiers

Although deep Neural Networks (DNNs) have achieved tremendous success in audio classification tasks, their uncertainty calibration are still under-explored. A well-calibrated model should be accurate when it is certain about its prediction and indicate high uncertainty when it is likely to be inaccurate. In this work, we investigate the uncertainty calibration for deep audio classifiers. In particular, we empirically study the performance of popular calibration methods: (i) Monte Carlo Dropout, (ii) ensemble, (iii) focal loss, and (iv) spectral-normalized Gaussian process (SNGP), on audio classification datasets. To this end, we evaluate (i-iv) for the tasks of environment sound and music genre classification. Results indicate that uncalibrated deep audio classifiers may be over-confident, and SNGP performs the best and is very efficient on the two datasets of this paper.

preprint2022arXiv

Unsupervised Foggy Scene Understanding via Self Spatial-Temporal Label Diffusion

Understanding foggy image sequence in the driving scenes is critical for autonomous driving, but it remains a challenging task due to the difficulty in collecting and annotating real-world images of adverse weather. Recently, the self-training strategy has been considered a powerful solution for unsupervised domain adaptation, which iteratively adapts the model from the source domain to the target domain by generating target pseudo labels and re-training the model. However, the selection of confident pseudo labels inevitably suffers from the conflict between sparsity and accuracy, both of which will lead to suboptimal models. To tackle this problem, we exploit the characteristics of the foggy image sequence of driving scenes to densify the confident pseudo labels. Specifically, based on the two discoveries of local spatial similarity and adjacent temporal correspondence of the sequential image data, we propose a novel Target-Domain driven pseudo label Diffusion (TDo-Dif) scheme. It employs superpixels and optical flows to identify the spatial similarity and temporal correspondence, respectively and then diffuses the confident but sparse pseudo labels within a superpixel or a temporal corresponding pair linked by the flow. Moreover, to ensure the feature similarity of the diffused pixels, we introduce local spatial similarity loss and temporal contrastive loss in the model re-training stage. Experimental results show that our TDo-Dif scheme helps the adaptive model achieve 51.92% and 53.84% mean intersection-over-union (mIoU) on two publicly available natural foggy datasets (Foggy Zurich and Foggy Driving), which exceeds the state-of-the-art unsupervised domain adaptive semantic segmentation methods. Models and data can be found at https://github.com/velor2012/TDo-Dif.

preprint2022arXiv

VU-BERT: A Unified framework for Visual Dialog

The visual dialog task attempts to train an agent to answer multi-turn questions given an image, which requires the deep understanding of interactions between the image and dialog history. Existing researches tend to employ the modality-specific modules to model the interactions, which might be troublesome to use. To fill in this gap, we propose a unified framework for image-text joint embedding, named VU-BERT, and apply patch projection to obtain vision embedding firstly in visual dialog tasks to simplify the model. The model is trained over two tasks: masked language modeling and next utterance retrieval. These tasks help in learning visual concepts, utterances dependence, and the relationships between these two modalities. Finally, our VU-BERT achieves competitive performance (0.7287 NDCG scores) on VisDial v1.0 Datasets.

preprint2021arXiv

A New Window Loss Function for Bone Fracture Detection and Localization in X-ray Images with Point-based Annotation

Object detection methods are widely adopted for computer-aided diagnosis using medical images. Anomalous findings are usually treated as objects that are described by bounding boxes. Yet, many pathological findings, e.g., bone fractures, cannot be clearly defined by bounding boxes, owing to considerable instance, shape and boundary ambiguities. This makes bounding box annotations, and their associated losses, highly ill-suited. In this work, we propose a new bone fracture detection method for X-ray images, based on a labor effective and flexible annotation scheme suitable for abnormal findings with no clear object-level spatial extents or boundaries. Our method employs a simple, intuitive, and informative point-based annotation protocol to mark localized pathology information. To address the uncertainty in the fracture scales annotated via point(s), we convert the annotations into pixel-wise supervision that uses lower and upper bounds with positive, negative, and uncertain regions. A novel Window Loss is subsequently proposed to only penalize the predictions outside of the uncertain regions. Our method has been extensively evaluated on 4410 pelvic X-ray images of unique patients. Experiments demonstrate that our method outperforms previous state-of-the-art image classification and object detection baselines by healthy margins, with an AUROC of 0.983 and FROC score of 89.6%.

preprint2021arXiv

A Quantitative Metric for Privacy Leakage in Federated Learning

In the federated learning system, parameter gradients are shared among participants and the central modulator, while the original data never leave their protected source domain. However, the gradient itself might carry enough information for precise inference of the original data. By reporting their parameter gradients to the central server, client datasets are exposed to inference attacks from adversaries. In this paper, we propose a quantitative metric based on mutual information for clients to evaluate the potential risk of information leakage in their gradients. Mutual information has received increasing attention in the machine learning and data mining community over the past few years. However, existing mutual information estimation methods cannot handle high-dimensional variables. In this paper, we propose a novel method to approximate the mutual information between the high-dimensional gradients and batched input data. Experimental results show that the proposed metric reliably reflect the extent of information leakage in federated learning. In addition, using the proposed metric, we investigate the influential factors of risk level. It is proven that, the risk of information leakage is related to the status of the task model, as well as the inherent data distribution.

preprint2021arXiv

CASS-NAT: CTC Alignment-based Single Step Non-autoregressive Transformer for Speech Recognition

We propose a CTC alignment-based single step non-autoregressive transformer (CASS-NAT) for speech recognition. Specifically, the CTC alignment contains the information of (a) the number of tokens for decoder input, and (b) the time span of acoustics for each token. The information are used to extract acoustic representation for each token in parallel, referred to as token-level acoustic embedding which substitutes the word embedding in autoregressive transformer (AT) to achieve parallel generation in decoder. During inference, an error-based alignment sampling method is proposed to be applied to the CTC output space, reducing the WER and retaining the parallelism as well. Experimental results show that the proposed method achieves WERs of 3.8%/9.1% on Librispeech test clean/other dataset without an external LM, and a CER of 5.8% on Aishell1 Mandarin corpus, respectively1. Compared to the AT baseline, the CASS-NAT has a performance reduction on WER, but is 51.2x faster in terms of RTF. When decoding with an oracle CTC alignment, the lower bound of WER without LM reaches 2.3% on the test-clean set, indicating the potential of the proposed method.

preprint2021arXiv

Efficient Client Contribution Evaluation for Horizontal Federated Learning

In federated learning (FL), fair and accurate measurement of the contribution of each federated participant is of great significance. The level of contribution not only provides a rational metric for distributing financial benefits among federated participants, but also helps to discover malicious participants that try to poison the FL framework. Previous methods for contribution measurement were based on enumeration over possible combination of federated participants. Their computation costs increase drastically with the number of participants or feature dimensions, making them inapplicable in practical situations. In this paper an efficient method is proposed to evaluate the contributions of federated participants. This paper focuses on the horizontal FL framework, where client servers calculate parameter gradients over their local data, and upload the gradients to the central server. Before aggregating the client gradients, the central server train a data value estimator of the gradients using reinforcement learning techniques. As shown by experimental results, the proposed method consistently outperforms the conventional leave-one-out method in terms of valuation authenticity as well as time complexity.

preprint2021arXiv

Enhancing Data-Free Adversarial Distillation with Activation Regularization and Virtual Interpolation

Knowledge distillation refers to a technique of transferring the knowledge from a large learned model or an ensemble of learned models to a small model. This method relies on access to the original training set, which might not always be available. A possible solution is a data-free adversarial distillation framework, which deploys a generative network to transfer the teacher model's knowledge to the student model. However, the data generation efficiency is low in the data-free adversarial distillation. We add an activation regularizer and a virtual interpolation method to improve the data generation efficiency. The activation regularizer enables the students to match the teacher's predictions close to activation boundaries and decision boundaries. The virtual interpolation method can generate virtual samples and labels in-between decision boundaries. Our experiments show that our approach surpasses state-of-the-art data-free distillation methods. The student model can achieve 95.42% accuracy on CIFAR-10 and 77.05% accuracy on CIFAR-100 without any original training data. Our model's accuracy is 13.8% higher than the state-of-the-art data-free method on CIFAR-100.

preprint2021arXiv

Joint Intent Detection And Slot Filling Based on Continual Learning Model

Slot filling and intent detection have become a significant theme in the field of natural language understanding. Even though slot filling is intensively associated with intent detection, the characteristics of the information required for both tasks are different while most of those approaches may not fully aware of this problem. In addition, balancing the accuracy of two tasks effectively is an inevitable problem for the joint learning model. In this paper, a Continual Learning Interrelated Model (CLIM) is proposed to consider semantic information with different characteristics and balance the accuracy between intent detection and slot filling effectively. The experimental results show that CLIM achieves state-of-the-art performace on slot filling and intent detection on ATIS and Snips.

preprint2021arXiv

Knowledge Distillation with Adaptive Asymmetric Label Sharpening for Semi-supervised Fracture Detection in Chest X-rays

Exploiting available medical records to train high performance computer-aided diagnosis (CAD) models via the semi-supervised learning (SSL) setting is emerging to tackle the prohibitively high labor costs involved in large-scale medical image annotations. Despite the extensive attentions received on SSL, previous methods failed to 1) account for the low disease prevalence in medical records and 2) utilize the image-level diagnosis indicated from the medical records. Both issues are unique to SSL for CAD models. In this work, we propose a new knowledge distillation method that effectively exploits large-scale image-level labels extracted from the medical records, augmented with limited expert annotated region-level labels, to train a rib and clavicle fracture CAD model for chest X-ray (CXR). Our method leverages the teacher-student model paradigm and features a novel adaptive asymmetric label sharpening (AALS) algorithm to address the label imbalance problem that specially exists in medical domain. Our approach is extensively evaluated on all CXR (N = 65,845) from the trauma registry of anonymous hospital over a period of 9 years (2008-2016), on the most common rib and clavicle fractures. The experiment results demonstrate that our method achieves the state-of-the-art fracture detection performance, i.e., an area under receiver operating characteristic curve (AUROC) of 0.9318 and a free-response receiver operating characteristic (FROC) score of 0.8914 on the rib fractures, significantly outperforming previous approaches by an AUROC gap of 1.63% and an FROC improvement by 3.74%. Consistent performance gains are also observed for clavicle fracture detection.

preprint2021arXiv

Learning from Multiple Datasets with Heterogeneous and Partial Labels for Universal Lesion Detection in CT

Large-scale datasets with high-quality labels are desired for training accurate deep learning models. However, due to the annotation cost, datasets in medical imaging are often either partially-labeled or small. For example, DeepLesion is such a large-scale CT image dataset with lesions of various types, but it also has many unlabeled lesions (missing annotations). When training a lesion detector on a partially-labeled dataset, the missing annotations will generate incorrect negative signals and degrade the performance. Besides DeepLesion, there are several small single-type datasets, such as LUNA for lung nodules and LiTS for liver tumors. These datasets have heterogeneous label scopes, i.e., different lesion types are labeled in different datasets with other types ignored. In this work, we aim to develop a universal lesion detection algorithm to detect a variety of lesions. The problem of heterogeneous and partial labels is tackled. First, we build a simple yet effective lesion detection framework named Lesion ENSemble (LENS). LENS can efficiently learn from multiple heterogeneous lesion datasets in a multi-task fashion and leverage their synergy by proposal fusion. Next, we propose strategies to mine missing annotations from partially-labeled datasets by exploiting clinical prior knowledge and cross-dataset knowledge transfer. Finally, we train our framework on four public lesion datasets and evaluate it on 800 manually-labeled sub-volumes in DeepLesion. Our method brings a relative improvement of 49% compared to the current state-of-the-art approach in the metric of average sensitivity. We have publicly released our manual 3D annotations of DeepLesion in https://github.com/viggin/DeepLesion_manual_test_set.

preprint2021arXiv

LVCNet: Efficient Condition-Dependent Modeling Network for Waveform Generation

In this paper, we propose a novel conditional convolution network, named location-variable convolution, to model the dependencies of the waveform sequence. Different from the use of unified convolution kernels in WaveNet to capture the dependencies of arbitrary waveform, the location-variable convolution uses convolution kernels with different coefficients to perform convolution operations on different waveform intervals, where the coefficients of kernels is predicted according to conditioning acoustic features, such as Mel-spectrograms. Based on location-variable convolutions, we design LVCNet for waveform generation, and apply it in Parallel WaveGAN to design more efficient vocoder. Experiments on the LJSpeech dataset show that our proposed model achieves a four-fold increase in synthesis speed compared to the original Parallel WaveGAN without any degradation in sound quality, which verifies the effectiveness of location-variable convolutions.

preprint2021arXiv

NVAE-GAN Based Approach for Unsupervised Time Series Anomaly Detection

In recent studies, Lots of work has been done to solve time series anomaly detection by applying Variational Auto-Encoders (VAEs). Time series anomaly detection is a very common but challenging task in many industries, which plays an important role in network monitoring, facility maintenance, information security, and so on. However, it is very difficult to detect anomalies in time series with high accuracy, due to noisy data collected from real world, and complicated abnormal patterns. From recent studies, we are inspired by Nouveau VAE (NVAE) and propose our anomaly detection model: Time series to Image VAE (T2IVAE), an unsupervised model based on NVAE for univariate series, transforming 1D time series to 2D image as input, and adopting the reconstruction error to detect anomalies. Besides, we also apply the Generative Adversarial Networks based techniques to T2IVAE training strategy, aiming to reduce the overfitting. We evaluate our model performance on three datasets, and compare it with other several popular models using F1 score. T2IVAE achieves 0.639 on Numenta Anomaly Benchmark, 0.651 on public dataset from NASA, and 0.504 on our dataset collected from real-world scenario, outperforms other comparison models.

preprint2021arXiv

Sequential Learning on Liver Tumor Boundary Semantics and Prognostic Biomarker Mining

The boundary of tumors (hepatocellular carcinoma, or HCC) contains rich semantics: capsular invasion, visibility, smoothness, folding and protuberance, etc. Capsular invasion on tumor boundary has proven to be clinically correlated with the prognostic indicator, microvascular invasion (MVI). Investigating tumor boundary semantics has tremendous clinical values. In this paper, we propose the first and novel computational framework that disentangles the task into two components: spatial vertex localization and sequential semantic classification. (1) A HCC tumor segmentor is built for tumor mask boundary extraction, followed by polar transform representing the boundary with radius and angle. Vertex generator is used to produce fixed-length boundary vertices where vertex features are sampled on the corresponding spatial locations. (2) The sampled deep vertex features with positional embedding are mapped into a sequential space and decoded by a multilayer perceptron (MLP) for semantic classification. Extensive experiments on tumor capsule semantics demonstrate the effectiveness of our framework. Mining the correlation between the boundary semantics and MVI status proves the feasibility to integrate this boundary semantics as a valid HCC prognostic biomarker.

preprint2021arXiv

Unidirectional Memory-Self-Attention Transducer for Online Speech Recognition

Self-attention models have been successfully applied in end-to-end speech recognition systems, which greatly improve the performance of recognition accuracy. However, such attention-based models cannot be used in online speech recognition, because these models usually have to utilize a whole acoustic sequences as inputs. A common method is restricting the field of attention sights by a fixed left and right window, which makes the computation costs manageable yet also introduces performance degradation. In this paper, we propose Memory-Self-Attention (MSA), which adds history information into the Restricted-Self-Attention unit. MSA only needs localtime features as inputs, and efficiently models long temporal contexts by attending memory states. Meanwhile, recurrent neural network transducer (RNN-T) has proved to be a great approach for online ASR tasks, because the alignments of RNN-T are local and monotonic. We propose a novel network structure, called Memory-Self-Attention (MSA) Transducer. Both encoder and decoder of the MSA Transducer contain the proposed MSA unit. The experiments demonstrate that our proposed models improve WER results than Restricted-Self-Attention models by $13.5 on WSJ and $7.1 on SWBD datasets relatively, and without much computation costs increase.

preprint2020arXiv

A Heterogeneous Information Network based Cross Domain Insurance Recommendation System for Cold Start Users

Internet is changing the world, adapting to the trend of internet sales will bring revenue to traditional insurance companies. Online insurance is still in its early stages of development, where cold start problem (prospective customer) is one of the greatest challenges. In traditional e-commerce field, several cross-domain recommendation (CDR) methods have been studied to infer preferences of cold start users based on their preferences in other domains. However, these CDR methods could not be applied to insurance domain directly due to the domain specific properties. In this paper, we propose a novel framework called a Heterogeneous information network based Cross Domain Insurance Recommendation (HCDIR) system for cold start users. Specifically, we first try to learn more effective user and item latent features in both source and target domains. In source domain, we employ gated recurrent unit (GRU) to module user dynamic interests. In target domain, given the complexity of insurance products and the data sparsity problem, we construct an insurance heterogeneous information network (IHIN) based on data from PingAn Jinguanjia, the IHIN connects users, agents, insurance products and insurance product properties together, giving us richer information. Then we employ three-level (relational, node, and semantic) attention aggregations to get user and insurance product representations. After obtaining latent features of overlapping users, a feature mapping between the two domains is learned by multi-layer perceptron (MLP). We apply HCDIR on Jinguanjia dataset, and show HCDIR significantly outperforms the state-of-the-art solutions.

preprint2020arXiv

A Real-time Robot-based Auxiliary System for Risk Evaluation of COVID-19 Infection

In this paper, we propose a real-time robot-based auxiliary system for risk evaluation of COVID-19 infection. It combines real-time speech recognition, temperature measurement, keyword detection, cough detection and other functions in order to convert live audio into actionable structured data to achieve the COVID-19 infection risk assessment function. In order to better evaluate the COVID-19 infection, we propose an end-to-end method for cough detection and classification for our proposed system. It is based on real conversation data from human-robot, which processes speech signals to detect cough and classifies it if detected. The structure of our model are maintained concise to be implemented for real-time applications. And we further embed this entire auxiliary diagnostic system in the robot and it is placed in the communities, hospitals and supermarkets to support COVID-19 testing. The system can be further leveraged within a business rules engine, thus serving as a foundation for real-time supervision and assistance applications. Our model utilizes a pretrained, robust training environment that allows for efficient creation and customization of customer-specific health states.

preprint2020arXiv

A Robust Speaker Clustering Method Based on Discrete Tied Variational Autoencoder

Recently, the speaker clustering model based on aggregation hierarchy cluster (AHC) is a common method to solve two main problems: no preset category number clustering and fix category number clustering. In general, model takes features like i-vectors as input of probability and linear discriminant analysis model (PLDA) aims to form the distance matric in long voice application scenario, and then clustering results are obtained through the clustering model. However, traditional speaker clustering method based on AHC has the shortcomings of long-time running and remains sensitive to environment noise. In this paper, we propose a novel speaker clustering method based on Mutual Information (MI) and a non-linear model with discrete variable, which under the enlightenment of Tied Variational Autoencoder (TVAE), to enhance the robustness against noise. The proposed method named Discrete Tied Variational Autoencoder (DTVAE) which shortens the elapsed time substantially. With experience results, it outperforms the general model and yields a relative Accuracy (ACC) improvement and significant time reduction.

preprint2020arXiv

AlignTTS: Efficient Feed-Forward Text-to-Speech System without Explicit Alignment

Targeting at both high efficiency and performance, we propose AlignTTS to predict the mel-spectrum in parallel. AlignTTS is based on a Feed-Forward Transformer which generates mel-spectrum from a sequence of characters, and the duration of each character is determined by a duration predictor.Instead of adopting the attention mechanism in Transformer TTS to align text to mel-spectrum, the alignment loss is presented to consider all possible alignments in training by use of dynamic programming. Experiments on the LJSpeech dataset show that our model achieves not only state-of-the-art performance which outperforms Transformer TTS by 0.03 in mean option score (MOS), but also a high efficiency which is more than 50 times faster than real-time.

preprint2020arXiv

Anatomy-Aware Siamese Network: Exploiting Semantic Asymmetry for Accurate Pelvic Fracture Detection in X-ray Images

Visual cues of enforcing bilaterally symmetric anatomies as normal findings are widely used in clinical practice to disambiguate subtle abnormalities from medical images. So far, inadequate research attention has been received on effectively emulating this practice in CAD methods. In this work, we exploit semantic anatomical symmetry or asymmetry analysis in a complex CAD scenario, i.e., anterior pelvic fracture detection in trauma PXRs, where semantically pathological (refer to as fracture) and non-pathological (e.g., pose) asymmetries both occur. Visually subtle yet pathologically critical fracture sites can be missed even by experienced clinicians, when limited diagnosis time is permitted in emergency care. We propose a novel fracture detection framework that builds upon a Siamese network enhanced with a spatial transformer layer to holistically analyze symmetric image features. Image features are spatially formatted to encode bilaterally symmetric anatomies. A new contrastive feature learning component in our Siamese network is designed to optimize the deep image features being more salient corresponding to the underlying semantic asymmetries (caused by pelvic fracture occurrences). Our proposed method have been extensively evaluated on 2,359 PXRs from unique patients (the largest study to-date), and report an area under ROC curve score of 0.9771. This is the highest among state-of-the-art fracture detection methods, with improved clinical indications.

preprint2020arXiv

Bone Suppression on Chest Radiographs With Adversarial Learning

Dual-energy (DE) chest radiography provides the capability of selectively imaging two clinically relevant materials, namely soft tissues, and osseous structures, to better characterize a wide variety of thoracic pathology and potentially improve diagnosis in posteroanterior (PA) chest radiographs. However, DE imaging requires specialized hardware and a higher radiation dose than conventional radiography, and motion artifacts sometimes happen due to involuntary patient motion. In this work, we learn the mapping between conventional radiographs and bone suppressed radiographs. Specifically, we propose to utilize two variations of generative adversarial networks (GANs) for image-to-image translation between conventional and bone suppressed radiographs obtained by DE imaging technique. We compare the effectiveness of training with patient-wisely paired and unpaired radiographs. Experiments show both training strategies yield "radio-realistic'' radiographs with suppressed bony structures and few motion artifacts on a hold-out test set. While training with paired images yields slightly better performance than that of unpaired images when measuring with two objective image quality metrics, namely Structural Similarity Index (SSIM) and Peak Signal-to-Noise Ratio (PSNR), training with unpaired images demonstrates better generalization ability on unseen anteroposterior (AP) radiographs than paired training.

preprint2020arXiv

BS-NAS: Broadening-and-Shrinking One-Shot NAS with Searchable Numbers of Channels

One-Shot methods have evolved into one of the most popular methods in Neural Architecture Search (NAS) due to weight sharing and single training of a supernet. However, existing methods generally suffer from two issues: predetermined number of channels in each layer which is suboptimal; and model averaging effects and poor ranking correlation caused by weight coupling and continuously expanding search space. To explicitly address these issues, in this paper, a Broadening-and-Shrinking One-Shot NAS (BS-NAS) framework is proposed, in which `broadening' refers to broadening the search space with a spring block enabling search for numbers of channels during training of the supernet; while `shrinking' refers to a novel shrinking strategy gradually turning off those underperforming operations. The above innovations broaden the search space for wider representation and then shrink it by gradually removing underperforming operations, followed by an evolutionary algorithm to efficiently search for the optimal architecture. Extensive experiments on ImageNet illustrate the effectiveness of the proposed BS-NAS as well as the state-of-the-art performance.

preprint2020arXiv

DCDIR: A Deep Cross-Domain Recommendation System for Cold Start Users in Insurance Domain

Internet insurance products are apparently different from traditional e-commerce goods for their complexity, low purchasing frequency, etc.So, cold start problem is even worse. In traditional e-commerce field, several cross-domain recommendation (CDR) methods have been studied to infer preferences of cold start users based on their preferences in other domains. However, these CDR methods could not be applied into insurance domain directly due to product complexity. In this paper, we propose a Deep Cross Domain Insurance Recommendation System (DCDIR) for cold start users. Specifically, we first learn more effective user and item latent features in both domains. In target domain, given the complexity of insurance products, we design meta path based method over insurance product knowledge graph. In source domain, we employ GRU to model user dynamic interests. Then we learn a feature mapping function by multi-layer perceptions. We apply DCDIR on our company datasets, and show DCDIR significantly outperforms the state-of-the-art solutions.

preprint2020arXiv

Deep Volumetric Universal Lesion Detection using Light-Weight Pseudo 3D Convolution and Surface Point Regression

Identifying, measuring and reporting lesions accurately and comprehensively from patient CT scans are important yet time-consuming procedures for physicians. Computer-aided lesion/significant-findings detection techniques are at the core of medical imaging, which remain very challenging due to the tremendously large variability of lesion appearance, location and size distributions in 3D imaging. In this work, we propose a novel deep anchor-free one-stage VULD framework that incorporates (1) P3DC operators to recycle the architectural configurations and pre-trained weights from the off-the-shelf 2D networks, especially ones with large capacities to cope with data variance, and (2) a new SPR method to effectively regress the 3D lesion spatial extents by pinpointing their representative key points on lesion surfaces. Experimental validations are first conducted on the public large-scale NIH DeepLesion dataset where our proposed method delivers new state-of-the-art quantitative performance. We also test VULD on our in-house dataset for liver tumor detection. VULD generalizes well in both large-scale and small-sized tumor datasets in CT imaging.

preprint2020arXiv

DeepPrognosis: Preoperative Prediction of Pancreatic Cancer Survival and Surgical Margin via Contrast-Enhanced CT Imaging

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and carries a dismal prognosis. Surgery remains the best chance of a potential cure for patients who are eligible for initial resection of PDAC. However, outcomes vary significantly even among the resected patients of the same stage and received similar treatments. Accurate preoperative prognosis of resectable PDACs for personalized treatment is thus highly desired. Nevertheless, there are no automated methods yet to fully exploit the contrast-enhanced computed tomography (CE-CT) imaging for PDAC. Tumor attenuation changes across different CT phases can reflect the tumor internal stromal fractions and vascularization of individual tumors that may impact the clinical outcomes. In this work, we propose a novel deep neural network for the survival prediction of resectable PDAC patients, named as 3D Contrast-Enhanced Convolutional Long Short-Term Memory network(CE-ConvLSTM), which can derive the tumor attenuation signatures or patterns from CE-CT imaging studies. We present a multi-task CNN to accomplish both tasks of outcome and margin prediction where the network benefits from learning the tumor resection margin related features to improve survival prediction. The proposed framework can improve the prediction performances compared with existing state-of-the-art survival analysis approaches. The tumor signature built from our model has evidently added values to be combined with the existing clinical staging system.

preprint2020arXiv

Detecting Scatteredly-Distributed, Small, andCritically Important Objects in 3D OncologyImaging via Decision Stratification

Finding and identifying scatteredly-distributed, small, and critically important objects in 3D oncology images is very challenging. We focus on the detection and segmentation of oncology-significant (or suspicious cancer metastasized) lymph nodes (OSLNs), which has not been studied before as a computational task. Determining and delineating the spread of OSLNs is essential in defining the corresponding resection/irradiating regions for the downstream workflows of surgical resection and radiotherapy of various cancers. For patients who are treated with radiotherapy, this task is performed by experienced radiation oncologists that involves high-level reasoning on whether LNs are metastasized, which is subject to high inter-observer variations. In this work, we propose a divide-and-conquer decision stratification approach that divides OSLNs into tumor-proximal and tumor-distal categories. This is motivated by the observation that each category has its own different underlying distributions in appearance, size and other characteristics. Two separate detection-by-segmentation networks are trained per category and fused. To further reduce false positives (FP), we present a novel global-local network (GLNet) that combines high-level lesion characteristics with features learned from localized 3D image patches. Our method is evaluated on a dataset of 141 esophageal cancer patients with PET and CT modalities (the largest to-date). Our results significantly improve the recall from $45\%$ to $67\%$ at $3$ FPs per patient as compared to previous state-of-the-art methods. The highest achieved OSLN recall of $0.828$ is clinically relevant and valuable.

preprint2020arXiv

Domain Fingerprints for No-reference Image Quality Assessment

Human fingerprints are detailed and nearly unique markers of human identity. Such a unique and stable fingerprint is also left on each acquired image. It can reveal how an image was degraded during the image acquisition procedure and thus is closely related to the quality of an image. In this work, we propose a new no-reference image quality assessment (NR-IQA) approach called domain-aware IQA (DA-IQA), which for the first time introduces the concept of domain fingerprint to the NR-IQA field. The domain fingerprint of an image is learned from image collections of different degradations and then used as the unique characteristics to identify the degradation sources and assess the quality of the image. To this end, we design a new domain-aware architecture, which enables simultaneous determination of both the distortion sources and the quality of an image. With the distortion in an image better characterized, the image quality can be more accurately assessed, as verified by extensive experiments, which show that the proposed DA-IQA performs better than almost all the compared state-of-the-art NR-IQA methods.

preprint2020arXiv

DREAM: A Dynamic Relational-Aware Model for Social Recommendation

Social connections play a vital role in improving the performance of recommendation systems (RS). However, incorporating social information into RS is challenging. Most existing models usually consider social influences in a given session, ignoring that both users preferences and their friends influences are evolving. Moreover, in real world, social relations are sparse. Modeling dynamic influences and alleviating data sparsity is of great importance. In this paper, we propose a unified framework named Dynamic RElation Aware Model (DREAM) for social recommendation, which tries to model both users dynamic interests and their friends temporal influences. Specifically, we design temporal information encoding modules, because of which user representations are updated in each session. The updated user representations are transferred to relational-GAT modules, subsequently influence the operations on social networks. In each session, to solve social relation sparsity, we utilize glove-based method to complete social network with virtual friends. Then we employ relational-GAT module over completed social networks to update users representations. In the extensive experiments on the public datasets, DREAM significantly outperforms the state-of-the-art solutions.

preprint2020arXiv

E$^2$Net: An Edge Enhanced Network for Accurate Liver and Tumor Segmentation on CT Scans

Developing an effective liver and liver tumor segmentation model from CT scans is very important for the success of liver cancer diagnosis, surgical planning and cancer treatment. In this work, we propose a two-stage framework for 2D liver and tumor segmentation. The first stage is a coarse liver segmentation network, while the second stage is an edge enhanced network (E$^2$Net) for more accurate liver and tumor segmentation. E$^2$Net explicitly models complementary objects (liver and tumor) and their edge information within the network to preserve the organ and lesion boundaries. We introduce an edge prediction module in E$^2$Net and design an edge distance map between liver and tumor boundaries, which is used as an extra supervision signal to train the edge enhanced network. We also propose a deep cross feature fusion module to refine multi-scale features from both objects and their edges. E$^2$Net is more easily and efficiently trained with a small labeled dataset, and it can be trained/tested on the original 2D CT slices (resolve resampling error issue in 3D models). The proposed framework has shown superior performance on both liver and liver tumor segmentation compared to several state-of-the-art 2D, 3D and 2D/3D hybrid frameworks.

preprint2020arXiv

Evolutionary Algorithm Enhanced Neural Architecture Search for Text-Independent Speaker Verification

State-of-the-art speaker verification models are based on deep learning techniques, which heavily depend on the handdesigned neural architectures from experts or engineers. We borrow the idea of neural architecture search(NAS) for the textindependent speaker verification task. As NAS can learn deep network structures automatically, we introduce the NAS conception into the well-known x-vector network. Furthermore, this paper proposes an evolutionary algorithm enhanced neural architecture search method called Auto-Vector to automatically discover promising networks for the speaker verification task. The experimental results demonstrate our NAS-based model outperforms state-of-the-art speaker verification models.

preprint2020arXiv

FedSmart: An Auto Updating Federated Learning Optimization Mechanism

Federated learning has made an important contribution to data privacy-preserving. Many previous works are based on the assumption that the data are independently identically distributed (IID). As a result, the model performance on non-identically independently distributed (non-IID) data is beyond expectation, which is the concrete situation. Some existing methods of ensuring the model robustness on non-IID data, like the data-sharing strategy or pretraining, may lead to privacy leaking. In addition, there exist some participants who try to poison the model with low-quality data. In this paper, a performance-based parameter return method for optimization is introduced, we term it FederatedSmart (FedSmart). It optimizes different model for each client through sharing global gradients, and it extracts the data from each client as a local validation set, and the accuracy that model achieves in round t determines the weights of the next round. The experiment results show that FedSmart enables the participants to allocate a greater weight to the ones with similar data distribution.

preprint2020arXiv

GraphTTS: graph-to-sequence modelling in neural text-to-speech

This paper leverages the graph-to-sequence method in neural text-to-speech (GraphTTS), which maps the graph embedding of the input sequence to spectrograms. The graphical inputs consist of node and edge representations constructed from input texts. The encoding of these graphical inputs incorporates syntax information by a GNN encoder module. Besides, applying the encoder of GraphTTS as a graph auxiliary encoder (GAE) can analyse prosody information from the semantic structure of texts. This can remove the manual selection of reference audios process and makes prosody modelling an end-to-end procedure. Experimental analysis shows that GraphTTS outperforms the state-of-the-art sequence-to-sequence models by 0.24 in Mean Opinion Score (MOS). GAE can adjust the pause, ventilation and tones of synthesised audios automatically. This experimental conclusion may give some inspiration to researchers working on improving speech synthesis prosody.

preprint2020arXiv

Guidance and Evaluation: Semantic-Aware Image Inpainting for Mixed Scenes

Completing a corrupted image with correct structures and reasonable textures for a mixed scene remains an elusive challenge. Since the missing hole in a mixed scene of a corrupted image often contains various semantic information, conventional two-stage approaches utilizing structural information often lead to the problem of unreliable structural prediction and ambiguous image texture generation. In this paper, we propose a Semantic Guidance and Evaluation Network (SGE-Net) to iteratively update the structural priors and the inpainted image in an interplay framework of semantics extraction and image inpainting. It utilizes semantic segmentation map as guidance in each scale of inpainting, under which location-dependent inferences are re-evaluated, and, accordingly, poorly-inferred regions are refined in subsequent scales. Extensive experiments on real-world images of mixed scenes demonstrated the superiority of our proposed method over state-of-the-art approaches, in terms of clear boundaries and photo-realistic textures.

preprint2020arXiv

Harvesting, Detecting, and Characterizing Liver Lesions from Large-scale Multi-phase CT Data via Deep Dynamic Texture Learning

Non-invasive radiological-based lesion characterization and identification, e.g., to differentiate cancer subtypes, has long been a major aim to enhance oncological diagnosis and treatment procedures. Here we study a specific population of human subjects, with the hope of reducing the need for invasive surgical biopsies of liver cancer patients, which can cause many harmful side-effects. To this end, we propose a fully-automated and multi-stage liver tumor characterization framework designed for dynamic contrast computed tomography (CT). Our system comprises four sequential processes of tumor proposal detection, tumor harvesting, primary tumor site selection, and deep texture-based tumor characterization. Our main contributions are that, (1) we propose a 3D non-isotropic anchor-free detection method for liver lesions; (2) we present and validate spatially adaptivedeep texture (SaDT) learning, which allows for more precise characterization of liver lesions; (3) using a semi-automatic process, we bootstrap off of 200 gold standard annotations to curate another 1001 patients. Experimental evaluations demonstrate that our new data curation strategy, combined with the SaDT deep dynamic texture analysis, can effectively improve the mean F1 scores by >8.6% compared with baselines, in differentiating four major liver lesion types. Our F1 score of (hepatocellular carcinoma versus remaining subclasses) is 0.763, which is higher than reported human observer performance using dynamic CT and comparable to an advanced magnetic resonance imagery protocol. Apart from demonstrating the benefits of our data curation approach and physician-inspired workflow, these results also indicate that analyzing texture features, instead of standard object-based analysis, is a promising strategy for lesion differentiation.

preprint2020arXiv

JSSR: A Joint Synthesis, Segmentation, and Registration System for 3D Multi-Modal Image Alignment of Large-scale Pathological CT Scans

Multi-modal image registration is a challenging problem that is also an important clinical task for many real applications and scenarios. As a first step in analysis, deformable registration among different image modalities is often required in order to provide complementary visual information. During registration, semantic information is key to match homologous points and pixels. Nevertheless, many conventional registration methods are incapable in capturing high-level semantic anatomical dense correspondences. In this work, we propose a novel multi-task learning system, JSSR, based on an end-to-end 3D convolutional neural network that is composed of a generator, a registration and a segmentation component. The system is optimized to satisfy the implicit constraints between different tasks in an unsupervised manner. It first synthesizes the source domain images into the target domain, then an intra-modal registration is applied on the synthesized images and target images. The segmentation module are then applied on the synthesized and target images, providing additional cues based on semantic correspondences. The supervision from another fully-annotated dataset is used to regularize the segmentation. We extensively evaluate JSSR on a large-scale medical image dataset containing 1,485 patient CT imaging studies of four different contrast phases (i.e., 5,940 3D CT scans with pathological livers) on the registration, segmentation and synthesis tasks. The performance is improved after joint training on the registration and segmentation tasks by 0.9% and 1.9% respectively compared to a highly competitive and accurate deep learning baseline. The registration also consistently outperforms conventional state-of-the-art multi-modal registration methods.

preprint2020arXiv

Large-scale Transfer Learning for Low-resource Spoken Language Understanding

End-to-end Spoken Language Understanding (SLU) models are made increasingly large and complex to achieve the state-ofthe-art accuracy. However, the increased complexity of a model can also introduce high risk of over-fitting, which is a major challenge in SLU tasks due to the limitation of available data. In this paper, we propose an attention-based SLU model together with three encoder enhancement strategies to overcome data sparsity challenge. The first strategy focuses on the transferlearning approach to improve feature extraction capability of the encoder. It is implemented by pre-training the encoder component with a quantity of Automatic Speech Recognition annotated data relying on the standard Transformer architecture and then fine-tuning the SLU model with a small amount of target labelled data. The second strategy adopts multitask learning strategy, the SLU model integrates the speech recognition model by sharing the same underlying encoder, such that improving robustness and generalization ability. The third strategy, learning from Component Fusion (CF) idea, involves a Bidirectional Encoder Representation from Transformer (BERT) model and aims to boost the capability of the decoder with an auxiliary network. It hence reduces the risk of over-fitting and augments the ability of the underlying encoder, indirectly. Experiments on the FluentAI dataset show that cross-language transfer learning and multi-task strategies have been improved by up to 4:52% and 3:89% respectively, compared to the baseline.

preprint2020arXiv

Learning to Segment Anatomical Structures Accurately from One Exemplar

Accurate segmentation of critical anatomical structures is at the core of medical image analysis. The main bottleneck lies in gathering the requisite expert-labeled image annotations in a scalable manner. Methods that permit to produce accurate anatomical structure segmentation without using a large amount of fully annotated training images are highly desirable. In this work, we propose a novel contribution of Contour Transformer Network (CTN), a one-shot anatomy segmentor including a naturally built-in human-in-the-loop mechanism. Segmentation is formulated by learning a contour evolution behavior process based on graph convolutional networks (GCNs). Training of our CTN model requires only one labeled image exemplar and leverages additional unlabeled data through newly introduced loss functions that measure the global shape and appearance consistency of contours. We demonstrate that our one-shot learning method significantly outperforms non-learning-based methods and performs competitively to the state-of-the-art fully supervised deep learning approaches. With minimal human-in-the-loop editing feedback, the segmentation performance can be further improved and tailored towards the observer desired outcomes. This can facilitate the clinician designed imaging-based biomarker assessments (to support personalized quantitative clinical diagnosis) and outperforms fully supervised baselines.

preprint2020arXiv

Lymph Node Gross Tumor Volume Detection and Segmentation via Distance-based Gating using 3D CT/PET Imaging in Radiotherapy

Finding, identifying and segmenting suspicious cancer metastasized lymph nodes from 3D multi-modality imaging is a clinical task of paramount importance. In radiotherapy, they are referred to as Lymph Node Gross Tumor Volume (GTVLN). Determining and delineating the spread of GTVLN is essential in defining the corresponding resection and irradiating regions for the downstream workflows of surgical resection and radiotherapy of various cancers. In this work, we propose an effective distance-based gating approach to simulate and simplify the high-level reasoning protocols conducted by radiation oncologists, in a divide-and-conquer manner. GTVLN is divided into two subgroups of tumor-proximal and tumor-distal, respectively, by means of binary or soft distance gating. This is motivated by the observation that each category can have distinct though overlapping distributions of appearance, size and other LN characteristics. A novel multi-branch detection-by-segmentation network is trained with each branch specializing on learning one GTVLN category features, and outputs from multi-branch are fused in inference. The proposed method is evaluated on an in-house dataset of $141$ esophageal cancer patients with both PET and CT imaging modalities. Our results validate significant improvements on the mean recall from $72.5\%$ to $78.2\%$, as compared to previous state-of-the-art work. The highest achieved GTVLN recall of $82.5\%$ at $20\%$ precision is clinically relevant and valuable since human observers tend to have low sensitivity (around $80\%$ for the most experienced radiation oncologists, as reported by literature).

preprint2020arXiv

Lymph Node Gross Tumor Volume Detection in Oncology Imaging via Relationship Learning Using Graph Neural Network

Determining the spread of GTV$_{LN}$ is essential in defining the respective resection or irradiating regions for the downstream workflows of surgical resection and radiotherapy for many cancers. Different from the more common enlarged lymph node (LN), GTV$_{LN}$ also includes smaller ones if associated with high positron emission tomography signals and/or any metastasis signs in CT. This is a daunting task. In this work, we propose a unified LN appearance and inter-LN relationship learning framework to detect the true GTV$_{LN}$. This is motivated by the prior clinical knowledge that LNs form a connected lymphatic system, and the spread of cancer cells among LNs often follows certain pathways. Specifically, we first utilize a 3D convolutional neural network with ROI-pooling to extract the GTV$_{LN}$'s instance-wise appearance features. Next, we introduce a graph neural network to further model the inter-LN relationships where the global LN-tumor spatial priors are included in the learning process. This leads to an end-to-end trainable network to detect by classifying GTV$_{LN}$. We operate our model on a set of GTV$_{LN}$ candidates generated by a preliminary 1st-stage method, which has a sensitivity of $>85\%$ at the cost of high false positive (FP) ($>15$ FPs per patient). We validate our approach on a radiotherapy dataset with 142 paired PET/RTCT scans containing the chest and upper abdominal body parts. The proposed method significantly improves over the state-of-the-art (SOTA) LN classification method by $5.5\%$ and $13.1\%$ in F1 score and the averaged sensitivity value at $2, 3, 4, 6$ FPs per patient, respectively.

preprint2020arXiv

MLNET: An Adaptive Multiple Receptive-field Attention Neural Network for Voice Activity Detection

Voice activity detection (VAD) makes a distinction between speech and non-speech and its performance is of crucial importance for speech based services. Recently, deep neural network (DNN)-based VADs have achieved better performance than conventional signal processing methods. The existed DNNbased models always handcrafted a fixed window to make use of the contextual speech information to improve the performance of VAD. However, the fixed window of contextual speech information can't handle various unpredicatable noise environments and highlight the critical speech information to VAD task. In order to solve this problem, this paper proposed an adaptive multiple receptive-field attention neural network, called MLNET, to finish VAD task. The MLNET leveraged multi-branches to extract multiple contextual speech information and investigated an effective attention block to weight the most crucial parts of the context for final classification. Experiments in real-world scenarios demonstrated that the proposed MLNET-based model outperformed other baselines.

preprint2020arXiv

One Click Lesion RECIST Measurement and Segmentation on CT Scans

In clinical trials, one of the radiologists' routine work is to measure tumor sizes on medical images using the RECIST criteria (Response Evaluation Criteria In Solid Tumors). However, manual measurement is tedious and subject to inter-observer variability. We propose a unified framework named SEENet for semi-automatic lesion \textit{SE}gmentation and RECIST \textit{E}stimation on a variety of lesions over the entire human body. The user is only required to provide simple guidance by clicking once near the lesion. SEENet consists of two main parts. The first one extracts the lesion of interest with the one-click guidance, roughly segments the lesion, and estimates its RECIST measurement. Based on the results of the first network, the second one refines the lesion segmentation and RECIST estimation. SEENet achieves state-of-the-art performance in lesion segmentation and RECIST estimation on the large-scale public DeepLesion dataset. It offers a practical tool for radiologists to generate reliable lesion measurements (i.e. segmentation mask and RECIST) with minimal human effort and greatly reduced time.

preprint2020arXiv

Organ at Risk Segmentation for Head and Neck Cancer using Stratified Learning and Neural Architecture Search

OAR segmentation is a critical step in radiotherapy of head and neck (H&N) cancer, where inconsistencies across radiation oncologists and prohibitive labor costs motivate automated approaches. However, leading methods using standard fully convolutional network workflows that are challenged when the number of OARs becomes large, e.g. > 40. For such scenarios, insights can be gained from the stratification approaches seen in manual clinical OAR delineation. This is the goal of our work, where we introduce stratified organ at risk segmentation (SOARS), an approach that stratifies OARs into anchor, mid-level, and small & hard (S&H) categories. SOARS stratifies across two dimensions. The first dimension is that distinct processing pipelines are used for each OAR category. In particular, inspired by clinical practices, anchor OARs are used to guide the mid-level and S&H categories. The second dimension is that distinct network architectures are used to manage the significant contrast, size, and anatomy variations between different OARs. We use differentiable neural architecture search (NAS), allowing the network to choose among 2D, 3D or Pseudo-3D convolutions. Extensive 4-fold cross-validation on 142 H&N cancer patients with 42 manually labeled OARs, the most comprehensive OAR dataset to date, demonstrates that both pipeline- and NAS-stratification significantly improves quantitative performance over the state-of-the-art (from 69.52% to 73.68% in absolute Dice scores). Thus, SOARS provides a powerful and principled means to manage the highly complex segmentation space of OARs.

preprint2020arXiv

Prosody Learning Mechanism for Speech Synthesis System Without Text Length Limit

Recent neural speech synthesis systems have gradually focused on the control of prosody to improve the quality of synthesized speech, but they rarely consider the variability of prosody and the correlation between prosody and semantics together. In this paper, a prosody learning mechanism is proposed to model the prosody of speech based on TTS system, where the prosody information of speech is extracted from the melspectrum by a prosody learner and combined with the phoneme sequence to reconstruct the mel-spectrum. Meanwhile, the sematic features of text from the pre-trained language model is introduced to improve the prosody prediction results. In addition, a novel self-attention structure, named as local attention, is proposed to lift this restriction of input text length, where the relative position information of the sequence is modeled by the relative position matrices so that the position encodings is no longer needed. Experiments on English and Mandarin show that speech with more satisfactory prosody has obtained in our model. Especially in Mandarin synthesis, our proposed model outperforms baseline model with a MOS gap of 0.08, and the overall naturalness of the synthesized speech has been significantly improved.

preprint2020arXiv

Reliable Liver Fibrosis Assessment from Ultrasound using Global Hetero-Image Fusion and View-Specific Parameterization

Ultrasound (US) is a critical modality for diagnosing liver fibrosis. Unfortunately, assessment is very subjective, motivating automated approaches. We introduce a principled deep convolutional neural network (CNN) workflow that incorporates several innovations. First, to avoid overfitting on non-relevant image features, we force the network to focus on a clinical region of interest (ROI), encompassing the liver parenchyma and upper border. Second, we introduce global heteroimage fusion (GHIF), which allows the CNN to fuse features from any arbitrary number of images in a study, increasing its versatility and flexibility. Finally, we use 'style'-based view-specific parameterization (VSP) to tailor the CNN processing for different viewpoints of the liver, while keeping the majority of parameters the same across views. Experiments on a dataset of 610 patient studies (6979 images) demonstrate that our pipeline can contribute roughly 7% and 22% improvements in partial area under the curve and recall at 90% precision, respectively, over conventional classifiers, validating our approach to this crucial problem.

preprint2020arXiv

Robust Pancreatic Ductal Adenocarcinoma Segmentation with Multi-Institutional Multi-Phase Partially-Annotated CT Scans

Accurate and automated tumor segmentation is highly desired since it has the great potential to increase the efficiency and reproducibility of computing more complete tumor measurements and imaging biomarkers, comparing to (often partial) human measurements. This is probably the only viable means to enable the large-scale clinical oncology patient studies that utilize medical imaging. Deep learning approaches have shown robust segmentation performances for certain types of tumors, e.g., brain tumors in MRI imaging, when a training dataset with plenty of pixel-level fully-annotated tumor images is available. However, more than often, we are facing the challenge that only (very) limited annotations are feasible to acquire, especially for hard tumors. Pancreatic ductal adenocarcinoma (PDAC) segmentation is one of the most challenging tumor segmentation tasks, yet critically important for clinical needs. Previous work on PDAC segmentation is limited to the moderate amounts of annotated patient images (n<300) from venous or venous+arterial phase CT scans. Based on a new self-learning framework, we propose to train the PDAC segmentation model using a much larger quantity of patients (n~=1,000), with a mix of annotated and un-annotated venous or multi-phase CT images. Pseudo annotations are generated by combining two teacher models with different PDAC segmentation specialties on unannotated images, and can be further refined by a teaching assistant model that identifies associated vessels around the pancreas. A student model is trained on both manual and pseudo annotated multi-phase images. Experiment results show that our proposed method provides an absolute improvement of 6.3% Dice score over the strong baseline of nnUNet trained on annotated images, achieving the performance (Dice = 0.71) similar to the inter-observer variability between radiologists.

preprint2020arXiv

UBER-GNN: A User-Based Embeddings Recommendation based on Graph Neural Networks

The problem of session-based recommendation aims to predict user next actions based on session histories. Previous methods models session histories into sequences and estimate user latent features by RNN and GNN methods to make recommendations. However under massive-scale and complicated financial recommendation scenarios with both virtual and real commodities , such methods are not sufficient to represent accurate user latent features and neglect the long-term characteristics of users. To take long-term preference and dynamic interests into account, we propose a novel method, i.e. User-Based Embeddings Recommendation with Graph Neural Network, UBER-GNN for brevity. UBER-GNN takes advantage of structured data to generate longterm user preferences, and transfers session sequences into graphs to generate graph-based dynamic interests. The final user latent feature is then represented as the composition of the long-term preferences and the dynamic interests using attention mechanism. Extensive experiments conducted on real Ping An scenario show that UBER-GNN outperforms the state-of-the-art session-based recommendation methods.

preprint2020arXiv

Universal Lesion Detection by Learning from Multiple Heterogeneously Labeled Datasets

Lesion detection is an important problem within medical imaging analysis. Most previous work focuses on detecting and segmenting a specialized category of lesions (e.g., lung nodules). However, in clinical practice, radiologists are responsible for finding all possible types of anomalies. The task of universal lesion detection (ULD) was proposed to address this challenge by detecting a large variety of lesions from the whole body. There are multiple heterogeneously labeled datasets with varying label completeness: DeepLesion, the largest dataset of 32,735 annotated lesions of various types, but with even more missing annotation instances; and several fully-labeled single-type lesion datasets, such as LUNA for lung nodules and LiTS for liver tumors. In this work, we propose a novel framework to leverage all these datasets together to improve the performance of ULD. First, we learn a multi-head multi-task lesion detector using all datasets and generate lesion proposals on DeepLesion. Second, missing annotations in DeepLesion are retrieved by a new method of embedding matching that exploits clinical prior knowledge. Last, we discover suspicious but unannotated lesions using knowledge transfer from single-type lesion detectors. In this way, reliable positive and negative regions are obtained from partially-labeled and unlabeled images, which are effectively utilized to train ULD. To assess the clinically realistic protocol of 3D volumetric ULD, we fully annotated 1071 CT sub-volumes in DeepLesion. Our method outperforms the current state-of-the-art approach by 29% in the metric of average sensitivity.

preprint2020arXiv

User-Guided Domain Adaptation for Rapid Annotation from User Interactions: A Study on Pathological Liver Segmentation

Mask-based annotation of medical images, especially for 3D data, is a bottleneck in developing reliable machine learning models. Using minimal-labor user interactions (UIs) to guide the annotation is promising, but challenges remain on best harmonizing the mask prediction with the UIs. To address this, we propose the user-guided domain adaptation (UGDA) framework, which uses prediction-based adversarial domain adaptation (PADA) to model the combined distribution of UIs and mask predictions. The UIs are then used as anchors to guide and align the mask prediction. Importantly, UGDA can both learn from unlabelled data and also model the high-level semantic meaning behind different UIs. We test UGDA on annotating pathological livers using a clinically comprehensive dataset of 927 patient studies. Using only extreme-point UIs, we achieve a mean (worst-case) performance of 96.1%(94.9%), compared to 93.0% (87.0%) for deep extreme points (DEXTR). Furthermore, we also show UGDA can retain this state-of-the-art performance even when only seeing a fraction of available UIs, demonstrating an ability for robust and reliable UI-guided segmentation with extremely minimal labor demands.

preprint2020arXiv

Weakly Supervised Lesion Co-segmentation on CT Scans

Lesion segmentation in medical imaging serves as an effective tool for assessing tumor sizes and monitoring changes in growth. However, not only is manual lesion segmentation time-consuming, but it is also expensive and requires expert radiologist knowledge. Therefore many hospitals rely on a loose substitute called response evaluation criteria in solid tumors (RECIST). Although these annotations are far from precise, they are widely used throughout hospitals and are found in their picture archiving and communication systems (PACS). Therefore, these annotations have the potential to serve as a robust yet challenging means of weak supervision for training full lesion segmentation models. In this work, we propose a weakly-supervised co-segmentation model that first generates pseudo-masks from the RECIST slices and uses these as training labels for an attention-based convolutional neural network capable of segmenting common lesions from a pair of CT scans. To validate and test the model, we utilize the DeepLesion dataset, an extensive CT-scan lesion dataset that contains 32,735 PACS bookmarked images. Extensive experimental results demonstrate the efficacy of our co-segmentation approach for lesion segmentation with a mean Dice coefficient of 90.3%.

preprint2020arXiv

Weakly-Supervised Lesion Segmentation on CT Scans using Co-Segmentation

Lesion segmentation on computed tomography (CT) scans is an important step for precisely monitoring changes in lesion/tumor growth. This task, however, is very challenging since manual segmentation is prohibitively time-consuming, expensive, and requires professional knowledge. Current practices rely on an imprecise substitute called response evaluation criteria in solid tumors (RECIST). Although these markers lack detailed information about the lesion regions, they are commonly found in hospitals&#39; picture archiving and communication systems (PACS). Thus, these markers have the potential to serve as a powerful source of weak-supervision for 2D lesion segmentation. To approach this problem, this paper proposes a convolutional neural network (CNN) based weakly-supervised lesion segmentation method, which first generates the initial lesion masks from the RECIST measurements and then utilizes co-segmentation to leverage lesion similarities and refine the initial masks. In this work, an attention-based co-segmentation model is adopted due to its ability to learn more discriminative features from a pair of images. Experimental results on the NIH DeepLesion dataset demonstrate that the proposed co-segmentation approach significantly improves lesion segmentation performance, e.g the Dice score increases about 4.0% (from 85.8% to 89.8%).

preprint2019arXiv

Nanoconfined, dynamic electrolyte gating and memory effects in multilayered graphene-based membranes

Multilayered graphene-based nanoporous membranes with electrolyte incorporated between individual sheets is a unique nano-heterostructure system in which nanoconfined electrons in graphene and ions confined in between sheets are intimately coupled throughout the entire membrane. In contrast to the general notion that the electrolyte gating is unlikely to appear in multilayered graphene stacks, it is demonstrated in this work that the electrolyte gating effect in monolayer graphene can be transferred to its corresponding multilayered porous membranes. This gating effect presented on each individual graphene sheets through electrolyte confined in nanopores provides a real-time, electrical approach for probing the complex dynamics of nanoconfined electrical double layer. This has enabled the observation of the ionic memory effect in supercapacitors and produces new insights into the charging dynamics of supercapacitors. Such discoveries may stimulate the design of novel nanoionic devices.

preprint2019arXiv

Weakly Supervised Universal Fracture Detection in Pelvic X-rays

Hip and pelvic fractures are serious injuries with life-threatening complications. However, diagnostic errors of fractures in pelvic X-rays (PXRs) are very common, driving the demand for computer-aided diagnosis (CAD) solutions. A major challenge lies in the fact that fractures are localized patterns that require localized analyses. Unfortunately, the PXRs residing in hospital picture archiving and communication system do not typically specify region of interests. In this paper, we propose a two-stage hip and pelvic fracture detection method that executes localized fracture classification using weakly supervised ROI mining. The first stage uses a large capacity fully-convolutional network, i.e., deep with high levels of abstraction, in a multiple instance learning setting to automatically mine probable true positive and definite hard negative ROIs from the whole PXR in the training data. The second stage trains a smaller capacity model, i.e., shallower and more generalizable, with the mined ROIs to perform localized analyses to classify fractures. During inference, our method detects hip and pelvic fractures in one pass by chaining the probability outputs of the two stages together. We evaluate our method on 4 410 PXRs, reporting an area under the ROC curve value of 0.975, the highest among state-of-the-art fracture detection methods. Moreover, we show that our two-stage approach can perform comparably to human physicians (even outperforming emergency physicians and surgeons), in a preliminary reader study of 23 readers.