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David Chen

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Published work

8 published item(s)

preprint2026arXiv

Neuromorphic Graph Anomaly Detection via Adaptive STDP and Spiking Graph Neural Networks

Anomaly detection in dynamic networks is critical for applications from cybersecurity to industrial monitoring, yet existing methods face challenges in energy efficiency, temporal precision, and adaptability. This paper introduces ASTDP-GAD, a novel Adaptive Spiking Temporal Dynamics Plasticity framework for Graph Anomaly Detection that integrates spiking graph neural networks with STDP learning for energy-efficient neuromorphic detection in dynamic networks. Our framework unifies spiking neural computation, STDP learning, and graph-based anomaly detection through the following key innovations: temporal spike graph encoding with adaptive Leaky Integrate-and-Fire (LIF) dynamics; LIF-based graph attention with lateral inhibition; event-driven hypergraph memory with STDP-inspired prototype updates; spike rate contrast pooling based on spiking irregularity; adaptive STDP layers capturing causal temporal relationships; and multi-scale temporal convolution with multi-factor anomaly fusion. Theoretical analysis provides rigorous guarantees: spike encoding preserves input information with resolution scaling linearly in simulation steps and hidden dimension; LIFGAT approximates any continuous attention function; hypergraph memory converges to optimal prototypes; contrast pooling achieves provable anomaly selection bounds; STDP learning converges stably; and multi-factor fusion produces calibrated scores with up to $5\times$ variance reduction. Extensive experiments on nine datasets on both dynamic and static graphs demonstrate superior anomaly detection accuracy while maintaining biological plausibility and energy efficiency for neuromorphic deployment.

preprint2022arXiv

Estimation of Clinical Workload and Patient Activity using Deep Learning and Optical Flow

Contactless monitoring using thermal imaging has become increasingly proposed to monitor patient deterioration in hospital, most recently to detect fevers and infections during the COVID-19 pandemic. In this letter, we propose a novel method to estimate patient motion and observe clinical workload using a similar technical setup but combined with open source object detection algorithms (YOLOv4) and optical flow. Patient motion estimation was used to approximate patient agitation and sedation, while worker motion was used as a surrogate for caregiver workload. Performance was illustrated by comparing over 32000 frames from videos of patients recorded in an Intensive Care Unit, to clinical agitation scores recorded by clinical workers.

preprint2022arXiv

Interaction of a priori Anatomic Knowledge with Self-Supervised Contrastive Learning in Cardiac Magnetic Resonance Imaging

Training deep learning models on cardiac magnetic resonance imaging (CMR) can be a challenge due to the small amount of expert generated labels and inherent complexity of data source. Self-supervised contrastive learning (SSCL) has recently been shown to boost performance in several medical imaging tasks. However, it is unclear how much the pre-trained representation reflects the primary organ of interest compared to spurious surrounding tissue. In this work, we evaluate the optimal method of incorporating prior knowledge of anatomy into a SSCL training paradigm. Specifically, we evaluate using a segmentation network to explicitly local the heart in CMR images, followed by SSCL pretraining in multiple diagnostic tasks. We find that using a priori knowledge of anatomy can greatly improve the downstream diagnostic performance. Furthermore, SSCL pre-training with in-domain data generally improved downstream performance and more human-like saliency compared to end-to-end training and ImageNet pre-trained networks. However, introducing anatomic knowledge to pre-training generally does not have significant impact.

preprint2022arXiv

Pre-averaging fractional processes contaminated by noise, with an application to turbulence

In this article, we consider the problem of estimating fractional processes based on noisy high-frequency data. Generalizing the idea of pre-averaging to a fractional setting, we exhibit a sequence of consistent estimators for the unknown parameters of interest by proving a law of large numbers for associated variation functionals. In contrast to the semimartingale setting, the optimal window size for pre-averaging depends on the unknown roughness parameter of the underlying process. We evaluate the performance of our estimators in a simulation study and use them to empirically verify Kolmogorov's 2/3-law in turbulence data contaminated by instrument noise.

preprint2020arXiv

Clinical Concept Extraction: a Methodology Review

Background Concept extraction, a subdomain of natural language processing (NLP) with a focus on extracting concepts of interest, has been adopted to computationally extract clinical information from text for a wide range of applications ranging from clinical decision support to care quality improvement. Objectives In this literature review, we provide a methodology review of clinical concept extraction, aiming to catalog development processes, available methods and tools, and specific considerations when developing clinical concept extraction applications. Methods Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a literature search was conducted for retrieving EHR-based information extraction articles written in English and published from January 2009 through June 2019 from Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Scopus, Web of Science, and the ACM Digital Library. Results A total of 6,686 publications were retrieved. After title and abstract screening, 228 publications were selected. The methods used for developing clinical concept extraction applications were discussed in this review.

preprint2016arXiv

Disappearance of Quasiparticles in a Bose Lattice Gas

We use a momentum-space hole-burning technique implemented via stimulated Raman transitions to measure the momentum relaxation time for a gas of bosonic atoms trapped in an optical lattice. By changing the lattice potential depth, we observe a smooth crossover between relaxation times larger and smaller than the bandwidth. The latter condition violates the Mott-Ioffe-Regal bound and indicates a breakdown of the quasi-particle picture. We produce a simple kinetic model that quantitatively predicts these relaxation times. Finally, we introduce a cooling technique based upon our hole-burning technique.

preprint2013arXiv

Slow Thermalization Between a Lattice and Free Bose Gas

Using a 3D spin-dependent optical lattice, we study thermalization and energy exchange between two ultracold Bose gases, one of which is bound to the lattice and another that is free from the lattice potential. Disruption of inter-species thermalization is revealed through measurements of condensate fraction after the lattice is superimposed on the parabolic confining potential. By selectively heating the lattice-bound species and measuring the rate of heat transfer to the free state, suppression of energy exchange is observed. Comparison with a Fermi's golden rule prediction confirms that this effect is caused by a dispersion mismatch that reduces the phase space available for elastic collisions. This result has critical implications for methods proposed to cool strongly correlated lattice gases.

preprint2010arXiv

Adsorption/desorption and electrically controlled flipping of ammonia molecules on graphene

In this paper, we evaluate of the adsorption/ desorption of ammonia molecules on a graphene surface by studying the Fermi level shift. Based on a physically plausible model, the adsorption and desorption rates of ammonia molecules on graphene have been extracted from the measured Fermi level shift as a function of exposure time. An electric field-induced flipping behavior of ammonia molecules on graphene is suggested, based on field effect transistor (FET) measurements.