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Published work

18 published item(s)

preprint2026arXiv

Evaluating the Utility of Personal Health Records in Personalized Health AI

Patient-managed Personal Health Records (PHRs) promises to empower patients to better understand their health; but information in the record is complex, potentially hindering insights. In this study, we assess the potential of large language models (LLMs, Gemini 3.0 Flash) to provide helpful answers to user health queries, when provided clinical data from PHRs as context. A total of 2,257 user queries were drawn from 3 different distributions to represent patient questions: shorter web search queries, longer questions derived from templates of chatbot conversations, and questions patients asked to their healthcare team (patient calls). Queries were matched with de-identified PHRs (from a pool of 1,945). Gemini responses were generated (1) without PHR context; (2) with a basic summary of demographics, conditions, and medications; (3) with full, extensive clinical notes. For evaluation, we leveraged an existing rating framework (SHARP), and developed a new framework for specific error modes when interpreting PHRs. Evaluation was performed using autoraters for the full set, and with clinician ratings for a subset (n=95), with both sets of raters knowing the full PHR context. We see significant improvements in the helpfulness of answers to all question types with PHR data (p < 0.001, paired t-test). We also observe potential gains in safety, accuracy, relevance and personalization of answers. Our PHR evaluation framework further identifies gaps in LLM understanding of particular aspects of complex PHRs, such as temporal disorientation, and rare but meaningful confabulations. These results suggest potential for PHR data to help people with a wide range of user needs; and provide a framework for monitoring for gaps in LLM answers based on PHR context. This study motivates further work to assess and realize potential benefits to users from understanding their health records.

preprint2022arXiv

A decision support framework for optimal vaccine distribution across a multi-tier cold chain network

In this paper, we present a decision support framework for optimizing multiple aspects of vaccine distribution across a multitier cold chain network. We propose two multi-period optimization formulations within this framework: first to minimize inventory, ordering, transportation, personnel and shortage costs associated with a single vaccine; the second being an extension of the first for the case when multiple vaccines with differing efficacies and costs are available for the same disease. Vaccine transportation and administration lead times are also incorporated within the models. We also develop robust optimization versions of the single vaccine model to account for the impact of uncertainty in model parameters on the optimal vaccine distribution solution. We use the case of the Indian state of Bihar and COVID-19 vaccines to illustrate the implementation of the framework. We present computational experiments to demonstrate: (a) the organization of the model outputs; (b) how the models can be used to assess the impact of cold chain point storage capacities, transportation vehicle capacities, and manufacturer capacities on the optimal vaccine distribution pattern; and (c) the impact of vaccine efficacies and associated costs such as ordering and transportation costs on the vaccine selection decision informed by the model. We then consider the computational expense of the framework for realistic problem instances, and suggest multiple preprocessing techniques to reduce their computational burden. Finally, we also demonstrate how the robust versions of the single vaccine model outperform the deterministic version under multiple levels of uncertainty in key model parameters. Our study presents public health authorities and other stakeholders with a vaccine distribution and capacity planning tool for multi-tier cold chain networks.

preprint2022arXiv

Bottom Up Top Down Detection Transformers for Language Grounding in Images and Point Clouds

Most models tasked to ground referential utterances in 2D and 3D scenes learn to select the referred object from a pool of object proposals provided by a pre-trained detector. This is limiting because an utterance may refer to visual entities at various levels of granularity, such as the chair, the leg of the chair, or the tip of the front leg of the chair, which may be missed by the detector. We propose a language grounding model that attends on the referential utterance and on the object proposal pool computed from a pre-trained detector to decode referenced objects with a detection head, without selecting them from the pool. In this way, it is helped by powerful pre-trained object detectors without being restricted by their misses. We call our model Bottom Up Top Down DEtection TRansformers (BUTD-DETR) because it uses both language guidance (top down) and objectness guidance (bottom-up) to ground referential utterances in images and point clouds. Moreover, BUTD-DETR casts object detection as referential grounding and uses object labels as language prompts to be grounded in the visual scene, augmenting supervision for the referential grounding task in this way. The proposed model sets a new state-of-the-art across popular 3D language grounding benchmarks with significant performance gains over previous 3D approaches (12.6% on SR3D, 11.6% on NR3D and 6.3% on ScanRefer). When applied in 2D images, it performs on par with the previous state of the art. We ablate the design choices of our model and quantify their contribution to performance. Our code and checkpoints can be found at the project website https://butd-detr.github.io.

preprint2022arXiv

COGMEN: COntextualized GNN based Multimodal Emotion recognitioN

Emotions are an inherent part of human interactions, and consequently, it is imperative to develop AI systems that understand and recognize human emotions. During a conversation involving various people, a person&#39;s emotions are influenced by the other speaker&#39;s utterances and their own emotional state over the utterances. In this paper, we propose COntextualized Graph Neural Network based Multimodal Emotion recognitioN (COGMEN) system that leverages local information (i.e., inter/intra dependency between speakers) and global information (context). The proposed model uses Graph Neural Network (GNN) based architecture to model the complex dependencies (local and global information) in a conversation. Our model gives state-of-the-art (SOTA) results on IEMOCAP and MOSEI datasets, and detailed ablation experiments show the importance of modeling information at both levels.

preprint2022arXiv

Deep learning via LSTM models for COVID-19 infection forecasting in India

The COVID-19 pandemic continues to have major impact to health and medical infrastructure, economy, and agriculture. Prominent computational and mathematical models have been unreliable due to the complexity of the spread of infections. Moreover, lack of data collection and reporting makes modelling attempts difficult and unreliable. Hence, we need to re-look at the situation with reliable data sources and innovative forecasting models. Deep learning models such as recurrent neural networks are well suited for modelling spatiotemporal sequences. In this paper, we apply recurrent neural networks such as long short term memory (LSTM), bidirectional LSTM, and encoder-decoder LSTM models for multi-step (short-term) COVID-19 infection forecasting. We select Indian states with COVID-19 hotpots and capture the first (2020) and second (2021) wave of infections and provide two months ahead forecast. Our model predicts that the likelihood of another wave of infections in October and November 2021 is low; however, the authorities need to be vigilant given emerging variants of the virus. The accuracy of the predictions motivate the application of the method in other countries and regions. Nevertheless, the challenges in modelling remain due to the reliability of data and difficulties in capturing factors such as population density, logistics, and social aspects such as culture and lifestyle.

preprint2022arXiv

Deep Reinforcement Agent for Efficient Instant Search

Instant Search is a paradigm where a search system retrieves answers on the fly while typing. The naïve implementation of an Instant Search system would hit the search back-end for results each time a user types a key, imposing a very high load on the underlying search system. In this paper, we propose to address the load issue by identifying tokens that are semantically more salient towards retrieving relevant documents and utilize this knowledge to trigger an instant search selectively. We train a reinforcement agent that interacts directly with the search engine and learns to predict the word&#39;s importance. Our proposed method treats the underlying search system as a black box and is more universally applicable to a diverse set of architectures. Furthermore, a novel evaluation framework is presented to study the trade-off between the number of triggered searches and the system&#39;s performance. We utilize the framework to evaluate and compare the proposed reinforcement method with other intuitive baselines. Experimental results demonstrate the efficacy of the proposed method towards achieving a superior trade-off.

preprint2022arXiv

Robust estimation algorithms don&#39;t need to know the corruption level

Real data are rarely pure. Hence the past half-century has seen great interest in robust estimation algorithms that perform well even when part of the data is corrupt. However, their vast majority approach optimal accuracy only when given a tight upper bound on the fraction of corrupt data. Such bounds are not available in practice, resulting in weak guarantees and often poor performance. This brief note abstracts the complex and pervasive robustness problem into a simple geometric puzzle. It then applies the puzzle&#39;s solution to derive a universal meta technique that converts any robust estimation algorithm requiring a tight corruption-level upper bound to achieve its optimal accuracy into one achieving essentially the same accuracy without using any upper bounds.

preprint2022arXiv

Robust Estimation for Random Graphs

We study the problem of robustly estimating the parameter $p$ of an Erdős-Rényi random graph on $n$ nodes, where a $γ$ fraction of nodes may be adversarially corrupted. After showing the deficiencies of canonical estimators, we design a computationally-efficient spectral algorithm which estimates $p$ up to accuracy $\tilde O(\sqrt{p(1-p)}/n + γ\sqrt{p(1-p)} /\sqrt{n}+ γ/n)$ for $γ< 1/60$. Furthermore, we give an inefficient algorithm with similar accuracy for all $γ<1/2$, the information-theoretic limit. Finally, we prove a nearly-matching statistical lower bound, showing that the error of our algorithms is optimal up to logarithmic factors.

preprint2022arXiv

Scalable Deep Reinforcement Learning Algorithms for Mean Field Games

Mean Field Games (MFGs) have been introduced to efficiently approximate games with very large populations of strategic agents. Recently, the question of learning equilibria in MFGs has gained momentum, particularly using model-free reinforcement learning (RL) methods. One limiting factor to further scale up using RL is that existing algorithms to solve MFGs require the mixing of approximated quantities such as strategies or $q$-values. This is far from being trivial in the case of non-linear function approximation that enjoy good generalization properties, e.g. neural networks. We propose two methods to address this shortcoming. The first one learns a mixed strategy from distillation of historical data into a neural network and is applied to the Fictitious Play algorithm. The second one is an online mixing method based on regularization that does not require memorizing historical data or previous estimates. It is used to extend Online Mirror Descent. We demonstrate numerically that these methods efficiently enable the use of Deep RL algorithms to solve various MFGs. In addition, we show that these methods outperform SotA baselines from the literature.

preprint2022arXiv

TURF: A Two-factor, Universal, Robust, Fast Distribution Learning Algorithm

Approximating distributions from their samples is a canonical statistical-learning problem. One of its most powerful and successful modalities approximates every distribution to an $\ell_1$ distance essentially at most a constant times larger than its closest $t$-piece degree-$d$ polynomial, where $t\ge1$ and $d\ge0$. Letting $c_{t,d}$ denote the smallest such factor, clearly $c_{1,0}=1$, and it can be shown that $c_{t,d}\ge 2$ for all other $t$ and $d$. Yet current computationally efficient algorithms show only $c_{t,1}\le 2.25$ and the bound rises quickly to $c_{t,d}\le 3$ for $d\ge 9$. We derive a near-linear-time and essentially sample-optimal estimator that establishes $c_{t,d}=2$ for all $(t,d)\ne(1,0)$. Additionally, for many practical distributions, the lowest approximation distance is achieved by polynomials with vastly varying number of pieces. We provide a method that estimates this number near-optimally, hence helps approach the best possible approximation. Experiments combining the two techniques confirm improved performance over existing methodologies.

preprint2021arXiv

SURF: A Simple, Universal, Robust, Fast Distribution Learning Algorithm

Sample- and computationally-efficient distribution estimation is a fundamental tenet in statistics and machine learning. We present SURF, an algorithm for approximating distributions by piecewise polynomials. SURF is: simple, replacing prior complex optimization techniques by straight-forward {empirical probability} approximation of each potential polynomial piece {through simple empirical-probability interpolation}, and using plain divide-and-conquer to merge the pieces; universal, as well-known polynomial-approximation results imply that it accurately approximates a large class of common distributions; robust to distribution mis-specification as for any degree $d \le 8$, it estimates any distribution to an $\ell_1$ distance $< 3$ times that of the nearest degree-$d$ piecewise polynomial, improving known factor upper bounds of 3 for single polynomials and 15 for polynomials with arbitrarily many pieces; fast, using optimal sample complexity, running in near sample-linear time, and if given sorted samples it may be parallelized to run in sub-linear time. In experiments, SURF outperforms state-of-the art algorithms.

preprint2021arXiv

Variance Penalized On-Policy and Off-Policy Actor-Critic

Reinforcement learning algorithms are typically geared towards optimizing the expected return of an agent. However, in many practical applications, low variance in the return is desired to ensure the reliability of an algorithm. In this paper, we propose on-policy and off-policy actor-critic algorithms that optimize a performance criterion involving both mean and variance in the return. Previous work uses the second moment of return to estimate the variance indirectly. Instead, we use a much simpler recently proposed direct variance estimator which updates the estimates incrementally using temporal difference methods. Using the variance-penalized criterion, we guarantee the convergence of our algorithm to locally optimal policies for finite state action Markov decision processes. We demonstrate the utility of our algorithm in tabular and continuous MuJoCo domains. Our approach not only performs on par with actor-critic and prior variance-penalization baselines in terms of expected return, but also generates trajectories which have lower variance in the return.

preprint2020arXiv

A Framework for Crop Price Forecasting in Emerging Economies by Analyzing the Quality of Time-series Data

Accuracy of crop price forecasting techniques is important because it enables the supply chain planners and government bodies to take appropriate actions by estimating market factors such as demand and supply. In emerging economies such as India, the crop prices at marketplaces are manually entered every day, which can be prone to human-induced errors like the entry of incorrect data or entry of no data for many days. In addition to such human prone errors, the fluctuations in the prices itself make the creation of stable and robust forecasting solution a challenging task. Considering such complexities in crop price forecasting, in this paper, we present techniques to build robust crop price prediction models considering various features such as (i) historical price and market arrival quantity of crops, (ii) historical weather data that influence crop production and transportation, (iii) data quality-related features obtained by performing statistical analysis. We additionally propose a framework for context-based model selection and retraining considering factors such as model stability, data quality metrics, and trend analysis of crop prices. To show the efficacy of the proposed approach, we show experimental results on two crops - Tomato and Maize for 14 marketplaces in India and demonstrate that the proposed approach not only improves accuracy metrics significantly when compared against the standard forecasting techniques but also provides robust models.

preprint2020arXiv

A General Method for Robust Learning from Batches

In many applications, data is collected in batches, some of which are corrupt or even adversarial. Recent work derived optimal robust algorithms for estimating discrete distributions in this setting. We consider a general framework of robust learning from batches, and determine the limits of both classification and distribution estimation over arbitrary, including continuous, domains. Building on these results, we derive the first robust agnostic computationally-efficient learning algorithms for piecewise-interval classification, and for piecewise-polynomial, monotone, log-concave, and gaussian-mixture distribution estimation.

preprint2020arXiv

A Novel Tampering Attack on AES Cores with Hardware Trojans

The implementation of cryptographic primitives in integrated circuits (ICs) continues to increase over the years due to the recent advancement of semiconductor manufacturing and reduction of cost per transistors. The hardware implementation makes cryptographic operations faster and more energy-efficient. However, various hardware attacks have been proposed aiming to extract the secret key in order to undermine the security of these primitives. In this paper, we focus on the widely used advanced encryption standard (AES) block cipher and demonstrate its vulnerability against tampering attack. Our proposed attack relies on implanting a hardware Trojan in the netlist by an untrusted foundry, which can design and implement such a Trojan as it has access to the design layout and mask information. The hardware Trojan&#39;s activation modifies a particular round&#39;s input data by preventing the effect of all previous rounds&#39; key-dependent computation. We propose to use a sequential hardware Trojan to deliver the payload at the input of an internal round for achieving this modification of data. All the internal subkeys, and finally, the secret key can be computed from the observed ciphertext once the Trojan is activated. We implement our proposed tampering attack with a sequential hardware Trojan inserted into a 128-bit AES design from OpenCores benchmark suite and report the area overhead to demonstrate the feasibility of the proposed tampering attack.

preprint2020arXiv

ATPG-Guided Fault Injection Attacks on Logic Locking

Logic Locking is a well-accepted protection technique to enable trust in the outsourced design and fabrication processes of integrated circuits (ICs) where the original design is modified by incorporating additional key gates in the netlist, resulting in a key-dependent functional circuit. The original functionality of the chip is recovered once it is programmed with the secret key, otherwise, it produces incorrect results for some input patterns. Over the past decade, different attacks have been proposed to break logic locking, simultaneously motivating researchers to develop more secure countermeasures. In this paper, we propose a novel stuck-at fault-based differential fault analysis (DFA) attack, which can be used to break logic locking that relies on a stored secret key. This proposed attack is based on self-referencing, where the secret key is determined by injecting faults in the key lines and comparing the response with its fault-free counterpart. A commercial ATPG tool can be used to generate test patterns that detect these faults, which will be used in DFA to determine the secret key. One test pattern is sufficient to determine one key bit, which results in at most |K| test patterns to determine the entire secret key of size |K|. The proposed attack is generic and can be extended to break any logic locked circuits.

preprint2020arXiv

Optimal Robust Learning of Discrete Distributions from Batches

Many applications, including natural language processing, sensor networks, collaborative filtering, and federated learning, call for estimating discrete distributions from data collected in batches, some of which may be untrustworthy, erroneous, faulty, or even adversarial. Previous estimators for this setting ran in exponential time, and for some regimes required a suboptimal number of batches. We provide the first polynomial-time estimator that is optimal in the number of batches and achieves essentially the best possible estimation accuracy.

preprint2019arXiv

A deep learning system for differential diagnosis of skin diseases

Skin conditions affect an estimated 1.9 billion people worldwide. A shortage of dermatologists causes long wait times and leads patients to seek dermatologic care from general practitioners. However, the diagnostic accuracy of general practitioners has been reported to be only 0.24-0.70 (compared to 0.77-0.96 for dermatologists), resulting in referral errors, delays in care, and errors in diagnosis and treatment. In this paper, we developed a deep learning system (DLS) to provide a differential diagnosis of skin conditions for clinical cases (skin photographs and associated medical histories). The DLS distinguishes between 26 skin conditions that represent roughly 80% of the volume of skin conditions seen in primary care. The DLS was developed and validated using de-identified cases from a teledermatology practice serving 17 clinical sites via a temporal split: the first 14,021 cases for development and the last 3,756 cases for validation. On the validation set, where a panel of three board-certified dermatologists defined the reference standard for every case, the DLS achieved 0.71 and 0.93 top-1 and top-3 accuracies respectively. For a random subset of the validation set (n=963 cases), 18 clinicians reviewed the cases for comparison. On this subset, the DLS achieved a 0.67 top-1 accuracy, non-inferior to board-certified dermatologists (0.63, p<0.001), and higher than primary care physicians (PCPs, 0.45) and nurse practitioners (NPs, 0.41). The top-3 accuracy showed a similar trend: 0.90 DLS, 0.75 dermatologists, 0.60 PCPs, and 0.55 NPs. These results highlight the potential of the DLS to augment general practitioners to accurately diagnose skin conditions by suggesting differential diagnoses that may not have been considered. Future work will be needed to prospectively assess the clinical impact of using this tool in actual clinical workflows.