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Gold/Silica biochips: applications to Surface Plasmon Resonance and fluorescence quenching

We report Gold/Silica biochips for low cost biosensor devices. Firstly, the study of biochemical interactions on silica by means of Surface Plasmon Resonance (SPR) is presented. Secondly, Gold/Silica biochips are employed to reduce the strong quenching that occurs when a fluorophore is close to the gold surface. Furthermore, the control of the Silica-like thickness allows optimizing the distance between the metallic surface and the fluorophore in order to enhance the fluorescent signal. These results represent the first steps towards highly sensitive, specific and low cost biosensors based, for example, on Surface Plasmon Coupled Emission (SPCE) techniques.

preprint2010arXivOpen access
Thomas MangeatAlexandre BerthierCéline Elie-CailleMaud PerrinWilfrid BoireauChristian PieralliBruno Wacogne
physics.ins-detcond-mat.mtrl-sciphysics.optics
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Open access7 authors3 topics
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Thomas MangeatAlexandre BerthierCéline Elie-CailleMaud PerrinWilfrid BoireauChristian PieralliBruno Wacogne

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