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Researcher profile

Zhen Yu

Zhen Yu contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Computer VisionMachine LearningDistributed, Parallel, and Cluster Computingeess.IVMethodology

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Published work

6 published item(s)

preprint2026arXiv

Interpretable Machine Learning for Antepartum Prediction of Pregnancy-Associated Thrombotic Microangiopathy Using Routine Longitudinal Laboratory Data

Background: Pregnancy-associated thrombotic microangiopathy (P-TMA) is rare but life-threatening. Early risk prediction before overt clinical presentation remains challenging, as the associated laboratory abnormalities are subtle, multidimensional, and frequently masked by common physiological changes such as gestational thrombocytopenia and pregnancy-related proteinuria, thus overlapping heavily with benign obstetric and renal conditions. This complexity is poorly captured by univariate or rule-based approaches; however, it is addressable by machine learning, which can extract latent, time-dependent risk signatures from longitudinal clinical tests. Methods: This retrospective study included 300 pregnancies comprising 142 P-TMA cases and 158 controls. After exclusion of identifiers and non-informative variables, 146 longitudinal laboratory predictors were retained. Participants were divided into a training cohort (80%) and a held-out test cohort (20%) using stratified sampling. Five algorithms were evaluated: logistic regression, support vector machine with radial basis function kernel, random forest, extra trees, and gradient boosting. The final model was selected by mean cross-validated AUROC, refitted on the full training cohort, and evaluated once in the held-out test cohort. Interpretability analyses examined global feature importance and distributional patterns of leading predictors. Results: Gradient boosting was prespecified by cross-validation in the training cohort. The model achieved an AUROC of 0.872 (95% CI: 0.769-0.952) and an AUPRC of 0.883 (95% CI: 0.780-0.959) in a held-out test cohort, with sensitivity of 0.750 and specificity of 0.812. Conclusions: Longitudinal clinical laboratory tests obtained during routine care contained informative and clinically plausible signals for P-TMA risk. Notably, cystatin C at week 6 showed promise as an early monitoring indicator.

0 citations0 reviewsNo code linkedOpen access
preprint2024arXiv

Prompt-driven Latent Domain Generalization for Medical Image Classification

Deep learning models for medical image analysis easily suffer from distribution shifts caused by dataset artifacts bias, camera variations, differences in the imaging station, etc., leading to unreliable diagnoses in real-world clinical settings. Domain generalization (DG) methods, which aim to train models on multiple domains to perform well on unseen domains, offer a promising direction to solve the problem. However, existing DG methods assume domain labels of each image are available and accurate, which is typically feasible for only a limited number of medical datasets. To address these challenges, we propose a novel DG framework for medical image classification without relying on domain labels, called Prompt-driven Latent Domain Generalization (PLDG). PLDG consists of unsupervised domain discovery and prompt learning. This framework first discovers pseudo domain labels by clustering the bias-associated style features, then leverages collaborative domain prompts to guide a Vision Transformer to learn knowledge from discovered diverse domains. To facilitate cross-domain knowledge learning between different prompts, we introduce a domain prompt generator that enables knowledge sharing between domain prompts and a shared prompt. A domain mixup strategy is additionally employed for more flexible decision margins and mitigates the risk of incorrect domain assignments. Extensive experiments on three medical image classification tasks and one debiasing task demonstrate that our method can achieve comparable or even superior performance than conventional DG algorithms without relying on domain labels. Our code will be publicly available upon the paper is accepted.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Skin Lesion Recognition with Class-Hierarchy Regularized Hyperbolic Embeddings

In practice, many medical datasets have an underlying taxonomy defined over the disease label space. However, existing classification algorithms for medical diagnoses often assume semantically independent labels. In this study, we aim to leverage class hierarchy with deep learning algorithms for more accurate and reliable skin lesion recognition. We propose a hyperbolic network to learn image embeddings and class prototypes jointly. The hyperbola provably provides a space for modeling hierarchical relations better than Euclidean geometry. Meanwhile, we restrict the distribution of hyperbolic prototypes with a distance matrix that is encoded from the class hierarchy. Accordingly, the learned prototypes preserve the semantic class relations in the embedding space and we can predict the label of an image by assigning its feature to the nearest hyperbolic class prototype. We use an in-house skin lesion dataset which consists of around 230k dermoscopic images on 65 skin diseases to verify our method. Extensive experiments provide evidence that our model can achieve higher accuracy with less severe classification errors than models without considering class relations.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

CNN in CT Image Segmentation: Beyound Loss Function for Expoliting Ground Truth Images

Exploiting more information from ground truth (GT) images now is a new research direction for further improving CNN's performance in CT image segmentation. Previous methods focus on devising the loss function for fulfilling such a purpose. However, it is rather difficult to devise a general and optimization-friendly loss function. We here present a novel and practical method that exploits GT images beyond the loss function. Our insight is that feature maps of two CNNs trained respectively on GT and CT images should be similar on some metric space, because they both are used to describe the same objects for the same purpose. We hence exploit GT images by enforcing such two CNNs' feature maps to be consistent. We assess the proposed method on two data sets, and compare its performance to several competitive methods. Extensive experimental results show that the proposed method is effective, outperforming all the compared methods.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Communication-Efficient Distributed Estimator for Generalized Linear Models with a Diverging Number of Covariates

Distributed statistical inference has recently attracted immense attention. The asymptotic efficiency of the maximum likelihood estimator (MLE), the one-step MLE, and the aggregated estimating equation estimator are established for generalized linear models under the &#34;large $n$, diverging $p_n$&#34; framework, where the dimension of the covariates $p_n$ grows to infinity at a polynomial rate $o(n^α)$ for some $0<α<1$. Then a novel method is proposed to obtain an asymptotically efficient estimator for large-scale distributed data by two rounds of communication. In this novel method, the assumption on the number of servers is more relaxed and thus practical for real-world applications. Simulations and a case study demonstrate the satisfactory finite-sample performance of the proposed estimators.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Melanoma Diagnosis with Spatio-Temporal Feature Learning on Sequential Dermoscopic Images

Existing studies for automated melanoma diagnosis are based on single-time point images of lesions. However, melanocytic lesions de facto are progressively evolving and, moreover, benign lesions can progress into malignant melanoma. Ignoring cross-time morphological changes of lesions thus may lead to misdiagnosis in borderline cases. Based on the fact that dermatologists diagnose ambiguous skin lesions by evaluating the dermoscopic changes over time via follow-up examination, in this study, we propose an automated framework for melanoma diagnosis using sequential dermoscopic images. To capture the spatio-temporal characterization of dermoscopic evolution, we construct our model in a two-stream network architecture which capable of simultaneously learning appearance representations of individual lesions while performing temporal reasoning on both raw pixels difference and abstract features difference. We collect 184 cases of serial dermoscopic image data, which consists of histologically confirmed 92 benign lesions and 92 melanoma lesions, to evaluate the effectiveness of the proposed method. Our model achieved AUC of 74.34%, which is ~8% higher than that of only using single images and ~6% higher than the widely used sequence learning model based on LSTM.

0 citations0 reviewsNo code linkedOpen access