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Yoseob Han

Yoseob Han contributes to research discovery and scholarly infrastructure.

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Published work

3 published item(s)

preprint2026arXiv

Adaptive Selection of LoRA Components in Privacy-Preserving Federated Learning

Differentially private federated fine-tuning of large models with LoRA suffers from aggregation error caused by LoRA's multiplicative structure, which is further amplified by DP noise and degrades both stability and accuracy. Existing remedies apply a single update mode uniformly across all layers and all communication rounds (or alternate them on a fixed schedule), ignoring both the structural asymmetry between the two LoRA factors and the round-wise dynamics of training. We propose AS-LoRA, an adaptive framework defined by three axes (i) layer-wise freedom, in which each layer independently selects its active component, (ii) round-wise adaptivity, in which the selection updates over communication rounds, and (iii) a curvature-aware score derived from a second-order approximation of the loss. Theoretically, AS-LoRA eliminates the reconstruction-error floor of layer-tied schedules, accelerates convergence, implicitly biases solutions toward flatter minima, and incurs no additional privacy cost. Across GLUE, SQuAD, CIFAR-100, and Tiny-ImageNet under strict DP budgets and non-IID partitions, AS-LoRA improves over the federated LoRA baselines by up to $+7.5$ pp on GLUE and $+12.5$ pp on MNLI-mm for example, while matching or exceeding SVD-based aggregation methods at $33\text{--}180 \times$ lower aggregation cost and with negligible communication overhead. Code for the proposed method is available at https://anonymous.4open.science/r/as_lora-F75F/.

preprint2026arXiv

Hierarchical Perfusion Graphs for Tumor Heterogeneity Modeling in Glioma Molecular Subtyping

Precise molecular subtyping of gliomas, including isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion, directly guides surgical and therapeutic decisions, yet currently relies on invasive tissue sampling. Deep learning on structural MRI has emerged as a non-invasive alternative, but anatomy-only approaches cannot capture the hemodynamic signatures that distinguish molecular subtypes. Radiogenomics based on dynamic susceptibility contrast (DSC) MRI holds immense potential for non-invasively characterizing glioma molecular subtypes, yet clinical deployment has been hindered by inter-site variability and the limitations of voxel-wise analysis. We introduce HiPerfGNN, a framework that first learns discrete hemodynamic representations from raw time-intensity curves using a vector-quantized variational autoencoder (VQ-VAE). These quantized perfusion codes define coarse-level graph nodes representing functional tumor habitats, each of which is hierarchically subdivided into fine-level subregions guided by structural MRI. A hierarchical graph neural network then propagates information across scales for molecular prediction. On an internal cohort (n=475), the model achieved AUCs of 0.96 (IDH), 0.89 (1p/19q), and 0.84 (WHO grade), and maintained robust IDH performance (AUC 0.89) on an independent external cohort (n=397) without recalibration. Gradient-based saliency analysis confirms biologically grounded attention patterns aligned with known glioma pathophysiology. Our results demonstrate the added value of integrating perfusion dynamics into radiogenomic pipelines for glioma molecular subtyping. Code is available at https://github.com/janghana/HiPerfGNN.

preprint2020arXiv

Differentiated Backprojection Domain Deep Learning for Conebeam Artifact Removal

Conebeam CT using a circular trajectory is quite often used for various applications due to its relative simple geometry. For conebeam geometry, Feldkamp, Davis and Kress algorithm is regarded as the standard reconstruction method, but this algorithm suffers from so-called conebeam artifacts as the cone angle increases. Various model-based iterative reconstruction methods have been developed to reduce the cone-beam artifacts, but these algorithms usually require multiple applications of computational expensive forward and backprojections. In this paper, we develop a novel deep learning approach for accurate conebeam artifact removal. In particular, our deep network, designed on the differentiated backprojection domain, performs a data-driven inversion of an ill-posed deconvolution problem associated with the Hilbert transform. The reconstruction results along the coronal and sagittal directions are then combined using a spectral blending technique to minimize the spectral leakage. Experimental results show that our method outperforms the existing iterative methods despite significantly reduced runtime complexity.