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Researcher profile

Ying Tan

Ying Tan contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
astro-ph.HEastro-ph.IMComputation and LanguageComputer Visioneess.SYMachine LearningRoboticsSystems and Controlmath.PR

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Published work

16 published item(s)

preprint2026arXiv

A Breast Vision Pathology Foundation Model for Real-world Clinical Utility

Pathology foundation models have shown strong retrospective performance, but whether such systems can support clinically relevant use remains unclear. This challenge is particularly important in breast cancer, where pathological assessment serves as the gold standard for diagnosis and guides treatment planning, surgical decision-making and risk stratification across pre-, intra- and post-operative stages. Here we present \textbf{BRAVE}, a breast-adaptive pathology foundation model developed and evaluated using a total resource of 101,638 breast whole-slide images from 32 sources across Asia, Europe and North America. We assessed BRAVE across 34 tasks in 82 cohorts spanning pre-operative biopsy, intra-operative frozen section and post-operative resection, using an evidence chain comprising retrospective benchmarking, clinically challenging scenarios, workflow-oriented clinical impact simulations, prospective observational validation with the thresholds locked in the retrospective cohorts and crossover pathologist-AI interaction studies. Across these settings, BRAVE supported practical roles in the clinical workflow, including safe exclusion of low-risk cases from routine review, AI-assisted second-review rescue of initially missed positives and prioritization of cases for further assessment. In prospective validation across three centres, BRAVE excluded 76.9% of negative biopsy cases (NPV 0.953) and 70.1% of negative frozen-section cases (NPV 0.973), and triaged 78.8% of post-operative subtyping cases as high-confidence clear-cut cases (NPV 1.000). In reader studies, AI assistance improved balanced accuracy from 88.5% to 95.1% (OR 3.14, P<0.001), with better efficiency, confidence and inter-rater agreement. BRAVE-derived scores also independently predicted disease-free survival (adjusted HR 4.79, P<0.001) and overall survival (adjusted HR 8.14, P<0.001).

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

Hi-ZFO: Hierarchical Zeroth- and First-Order LLM Fine-Tuning via Importance-Guided Tensor Selection

Fine-tuning large language models (LLMs) using standard first-order (FO) optimization often drives training toward sharp, poorly generalizing minima. Conversely, zeroth-order (ZO) methods offer stronger exploratory behavior without relying on explicit gradients, yet suffer from slow convergence. More critically, our analysis reveals that in generative tasks, the vast output and search space significantly amplify estimation variance, rendering ZO methods both noisy and inefficient. To address these challenges, we propose \textbf{Hi-ZFO} (\textbf{Hi}erarchical \textbf{Z}eroth- and \textbf{F}irst-\textbf{O}rder optimization), a hybrid framework designed to synergize the precision of FO gradients with the exploratory capability of ZO estimation. Hi-ZFO adaptively partitions the model through layer-wise importance profiling, applying precise FO updates to critical layers while leveraging ZO optimization for less sensitive ones. Notably, ZO in Hi-ZFO is not merely a memory-saving surrogate; it is intentionally introduced as a source of &#34;beneficial stochasticity&#34; to help the model escape the local minima where pure FO optimization tends to stagnate. Validated across diverse generative, mathematical, and code reasoning tasks, Hi-ZFO consistently achieves superior performance while significantly reducing the training time. These results demonstrate the effectiveness of hierarchical hybrid optimization for LLM fine-tuning.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

Prior-Informed Zeroth-Order Optimization with Adaptive Direction Alignment for Memory-Efficient LLM Fine-Tuning

Fine-tuning large language models (LLMs) has achieved remarkable success across various NLP tasks, but the substantial memory overhead during backpropagation remains a critical bottleneck, especially as model scales grow. Zeroth-order (ZO) optimization alleviates this issue by estimating gradients through forward passes and Gaussian sampling, avoiding the need for backpropagation. However, conventional ZO methods suffer from high variance in gradient estimation due to their reliance on random perturbations, leading to slow convergence and suboptimal performance. We propose a simple plug-and-play method that incorporates prior-informed perturbations to refine gradient estimation. Our method dynamically computes a guiding vector from Gaussian samples, which directs perturbations toward more informative directions, significantly accelerating convergence compared to standard ZO approaches. We further investigate a greedy perturbation strategy to explore the impact of prior knowledge on gradient estimation. Theoretically, we prove that our gradient estimator achieves stronger alignment with the true gradient direction, enhancing optimization efficiency. Extensive experiments across LLMs of varying scales and architectures demonstrate that our proposed method could seamlessly integrate into existing optimization methods, delivering faster convergence and superior performance. Notably, on the OPT-13B model, our method outperforms traditional ZO optimization across all 11 benchmark tasks and surpasses gradient-based baselines on 9 out of 11 tasks, establishing a robust balance between efficiency and accuracy.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

A Generalized Kyle-Back Strategic Insider Trading Model with Dynamic Information

In this paper we consider a class of generalized Kyle-Back strategic insider trading models in which the insider is able to use the dynamic information obtained by observing the instantaneous movement of an underlying asset that is allowed to be influenced by its market price. Since such a model will be largely outside the Gaussian paradigm, we shall try to Markovize it by introducing an auxiliary diffusion process, in the spirit of the weighted total order process of, e.g., \cite{CCD11}, as a part of the &#34;pricing rule&#34;. As the main technical tool in solving the Kyle-Back equilibrium, we study a class of Stochastic Two-Point Boundary Value Problem (STPBVP), which resembles the dynamic Markovian bridge in the literature, but without insisting on its local martingale requirement. In the case when the solution of the STPBVP has an affine structure, we show that the pricing rule functions, whence the Kyle-Back equilibrium, can be determined by the decoupling field of a forward-backward SDE obtained via a non-linear filtering approach, along with a set of compatibility conditions.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Optimization of Directional Landmark Deployment for Visual Observer on SE(3)

An optimization method is proposed in this paper for novel deployment of given number of directional landmarks (location and pose) within a given region in the 3-D task space. This new deployment technique is built on the geometric models of both landmarks and the monocular camera. In particular, a new concept of Multiple Coverage Probability (MCP) is defined to characterize the probability of at least n landmarks being covered simultaneously by a camera at a fixed position. The optimization is conducted with respect to the position and pose of the given number of landmarks to maximize MCP through globally exploration of the given 3-D space. By adopting the elimination genetic algorithm, the global optimal solutions can be obtained, which are then applied to improve the convergent performance of the visual observer on SE(3) as a demonstration example. Both simulation and experimental results are presented to validate the effectiveness of the proposed landmark deployment optimization method.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Quasi-periodic oscillations of the X-ray burst from the magnetar SGR J1935+2154 and associated with the fast radio burst FRB 200428

The origin(s) and mechanism(s) of fast radio bursts (FRBs), which are short radio pulses from cosmological distances, have remained a major puzzle since their discovery. We report a strong Quasi-Periodic Oscillation(QPO) of 40 Hz in the X-ray burst from the magnetar SGR J1935+2154 and associated with FRB 200428, significantly detected with the Hard X-ray Modulation Telescope (Insight-HXMT) and also hinted by the Konus-Wind data. QPOs from magnetar bursts have only been rarely detected; our 3.4 sigma (p-value is 2.9e-4) detection of the QPO reported here reveals the strongest QPO signal observed from magnetars (except in some very rare giant flares), making this X-ray burst unique among magnetar bursts. The two X-ray spikes coinciding with the two FRB pulses are also among the peaks of the QPO. Our results suggest that at least some FRBs are related to strong oscillation processes of neutron stars. We also show that we may overestimate the significance of the QPO signal and underestimate the errors of QPO parameters if QPO exists only in a fraction of the time series of a X-ray burst which we use to calculate the Leahy-normalized periodogram.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

In-orbit timing calibration of the Insight-Hard X-ray Modulation Telescope

We describe the timing system and the timing calibration results of the three payloads on-board the Insight-Hard X-ray Modulation Telescope (Insight-HXMT). These three payloads are the High Energy X-ray telescope (HE, 20-250 keV), the Medium Energy X-ray telescope (ME, 5-30 keV) and the low Energy X-ray telescope (LE, 1-10 keV). We present a method to correct the temperature-dependent period response and the long-term variation of the on-board crystal oscillator, especially for ME that does not carry a temperature-compensated crystal oscillator. The time of arrivals (ToAs) of the Crab pulsar are measured to evaluate the accuracy of the timing system. As the ephemeris of the Crab pulsar given by Jodrell Bank observatory has systematic errors around 40 μs (Rots et al. 2014), we use the quasi-simultaneous observations of the X-ray Timing Instrument (XTI) on-board the Neutron star Interior Composition Explorer (NICER) to produce the Crab ephemerides and to verify the timing system of Insight-HXMT. The energy-dependent ToAs&#39; offsets relative to the NICER measurements including physical and instrumental origins are about 24.7μs, 10.1μs and 864.7μs, and the systematic errors of the timing system are determined as 12.1μs, 8.6μs, and 15.8μs, for HE, ME and LE respectively.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Discovery of oscillations above 200 keV in a black hole X-ray binary with Insight-HXMT

Low-frequency quasi-periodic oscillations (LFQPOs) are commonly found in black hole X-ray binaries, and their origin is still under debate. The properties of LFQPOs at high energies (above 30 keV) are closely related to the nature of the accretion flow in the innermost regions, and thus play a crucial role in critically testing various theoretical models. The Hard X-ray Modulation Telescope (Insight-HXMT) is capable of detecting emissions above 30 keV, and is therefore an ideal instrument to do so. Here we report the discovery of LFQPOs above 200 keV in the new black hole MAXI J1820+070 in the X-ray hard state, which allows us to understand the behaviours of LFQPOs at hundreds of kiloelectronvolts. The phase lag of the LFQPO is constant around zero below 30 keV, and becomes a soft lag (that is, the high-energy photons arrive first) above 30 keV. The soft lag gradually increases with energy and reaches ~0.9s in the 150-200 keV band. The detection at energies above 200 keV, the large soft lag and the energy-related behaviors of the LFQPO pose a great challenge for most currently existing models, but suggest that the LFQPO probably originates from the precession of a small-scale jet.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

In-flight calibration of the Insight-Hard X-ray Modulation Telescope

We present the calibration of the Insight-Hard X-ray Modulation Telescope (Insight-HXMT) X-ray satellite, which can be used to perform timing and spectral studies of bright X-ray sources. Insight-HXMT carries three main payloads onboard: the High Energy X-ray telescope (HE), the Medium Energy X-ray telescope (ME) and the Low Energy X-ray telescope (LE). In orbit, the radioactive sources, activated lines, the fluorescence lines and celestial sources are used to calibrate the energy scale and energy resolution of the payloads. The Crab nebular is adopted as the primary effective area calibrator and empirical functions are constructed to modify the simulated effective areas of the three payloads respectively. The systematic errors of HE, compared to the model of the Crab nebular, are less than 2% in 28--120 keV and 2%--10% above 120 keV. The systematic errors of ME are less than 1.5% in 10--35 keV. The systematic errors of LE are less than 1% in 1--7 keV except the Si K--edge (1.839 keV, up to 1.5%) and less than 2% in 7--10 keV.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Invariance Principles and Observability in Switched Systems with an Application in Consensus

Using any nonnegative function with a nonpositive derivative along trajectories to define a virtual output, the classic LaSalle invariance principle can be extended to switched nonlinear time-varying (NLTV) systems, by considering the weak observability (WO) associated with this output. WO is what the output informs about the limiting behavior of state trajectories (hidden in the zero locus of the output). In the context of switched NLTV systems, WO can be explored using the recently established framework of limiting zeroing-output solutions. Adding to this, an extension of the integral invariance principle for switched NLTV systems with a new method to guarantee uniform global attractivity of a closed set (without assuming uniform Lyapunov stability or dwell-time conditions) is proposed. By way of illustrating the proposed method, a leaderless consensus problem for nonholonomic mobile robots with a switching communication topology is addressed, yielding a new control strategy and a new convergence result.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Personalized On-line Adaptation of Kinematic Synergies for Human-Prosthesis Interfaces

Synergies have been adopted in prosthetic limb applications to reduce complexity of design, but typically involve a single synergy setting for a population and ignore individual preference or adaptation capacity. However, personalization of the synergy setting is necessary for the effective operation of the prosthetic device. Two major challenges hinder the personalization of synergies in human-prosthesis interfaces. The first is related to the process of human motor adaptation and the second to the variation in motor learning dynamics of individuals. In this paper, a systematic personalization of kinematic synergies for human-prosthesis interfaces using on-line measurements from each individual is proposed. The task of reaching using the upper-limb is described by an objective function and the interface is parameterized by a kinematic synergy. Consequently, personalizing the interface for a given individual can be formulated as finding an optimal personalized parameter. A structure to model the observed motor behavior that allows for the personalized traits of motor preference and motor learning is proposed, and subsequently used in an on-line optimization scheme to identify the synergies for an individual. The knowledge of the common features contained in the model enables on-line adaptation of the human-prosthesis interface to happen concurrently to human motor adaptation without the need to re-tune the personalization algorithm for each individual. Human-in-the-loop experimental results with able-bodied subjects, performed in a virtual reality environment to emulate amputation and prosthesis use, show that the proposed personalization algorithm was effective in obtaining optimal synergies with a fast uniform convergence speed across a group of individuals.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

The Background Model of the Medium Energy X-ray telescope of Insight-HXMT

The Medium Energy X-ray Telescope (ME) is one of the main payloads of the Hard X-ray Modulation Telescope (dubbed as Insight-HXMT). The background of Insight-HXMT/ME is mainly caused by the environmental charged particles and the background intensity is modulated remarkably by the geomagnetic field, as well as the geographical location. At the same geographical location, the background spectral shape is stable but the intensity varies with the level of the environmental charged particles. In this paper, we develop a model to estimate the ME background based on the ME database that is established with the two-year blank sky observations of the high Galactic latitude. In this model, the entire geographical area covered by Insight-HXMT is divided into grids of $5^{\circ}\times5^{\circ}$ in geographical coordinate system. For each grid, the background spectral shape can be obtained from the background database and the intensity can be corrected by the contemporary count rate of the blind FOV detectors. Thus the background spectrum can be obtained by accumulating the background of all the grids passed by Insight-HXMT during the effective observational time. The model test with the blank sky observations shows that the systematic error of the background estimation in $8.9-44.0$ keV is $\sim1.3\%$ for a pointing observation with an average exposure $\sim5.5$ ks. We also find that the systematic error is anti-correlated with the exposure, which indicates the systematic error is partly contributed by the statistical error of count rate measured by the blind FOV detectors.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

The Use of Implicit Human Motor Behaviour in the Online Personalisation of Prosthetic Interfaces

In previous work, the authors proposed a data-driven optimisation algorithm for the personalisation of human-prosthetic interfaces, demonstrating the possibility of adapting prosthesis behaviour to its user while the user performs tasks with it. This method requires that the human and the prosthesis personalisation algorithm have same pre-defined objective function. This was previously ensured by providing the human with explicit feedback on what the objective function is. However, constantly displaying this information to the prosthesis user is impractical. Moreover, the method utilised task information in the objective function which may not be available from the wearable sensors typically used in prosthetic applications. In this work, the previous approach is extended to use a prosthesis objective function based on implicit human motor behaviour, which represents able-bodied human motor control and is measureable using wearable sensors. The approach is tested in a hardware implementation of the personalisation algorithm on a prosthetic elbow, where the prosthetic objective function is a function of upper-body compensation, and is measured using wearable IMUs. Experimental results on able-bodied subjects using a supernumerary prosthetic elbow mounted on an elbow orthosis suggest that it is possible to use a prosthesis objective function which is implicit in human behaviour to achieve collaboration without providing explicit feedback to the human, motivating further studies.

0 citations0 reviewsNo code linkedOpen access
preprint2019arXiv

In-orbit calibration status of the Insight-HXMT

As China&#39;s first X-ray astronomical satellite, Insight-HXMT (Hard X-ray Modulation Telescope) successfully launched on Jun 15, 2017. It performs timing and spectral studies of bright sources to determine their physical parameters. HXMT carries three main payloads onboard: the High Energy X-ray telescope (HE, 20-250 keV, NaI(Tl)/CsI(Na)), the Medium Energy X-ray Telescope (ME, 5-30 keV, Si-Pin) and the Low Energy X-ray telescope (LE, 1-15 keV, SCD). In orbit, we have used the radioactive sources, activated lines, the fluorescence line, and Cas A to calibrate the gain and energy resolution of the payloads. The Crab pulsar was adopted as the primary effective area calibrator and an empirical function was found to modify the simulated effective areas. The absolute timing accuracy of HXMT is about 100us from the TOA of Crab Pulsar.

0 citations0 reviewsNo code linkedOpen access
preprint2019arXiv

Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite

As China&#39;s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band (1-250 keV) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 MeV. It was designed to perform pointing, scanning and gamma-ray burst (GRB) observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed. Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.

0 citations0 reviewsNo code linkedOpen access
preprint2019arXiv

The Medium Energy (ME) X-ray telescope onboard the Insight-HXMT astronomy satellite

The Medium Energy X-ray telescope (ME) is one of the three main telescopes on board the Insight Hard X-ray Modulation Telescope (Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 keV with a total geometrical area of 952 cm2. Application Specific Integrated Circuit (ASIC) chips, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views (FOVs) for the telescope, 1°{\times}4°, 4°{\times}4°, and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components. The energy resolution of ME is ~3 keV at 17.8 keV (FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME.

0 citations0 reviewsNo code linkedOpen access