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Xiangyu Li

Xiangyu Li contributes to research discovery and scholarly infrastructure.

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Published work

14 published item(s)

preprint2026arXiv

Benchmarking AI scientists for omics data driven biological discovery

Recent advances in large language models have enabled the emergence of AI scientists that aim to autonomously analyze biological data and assist scientific discovery. Despite rapid progress, it remains unclear to what extent these systems can extract meaningful biological insights from real experimental data. Existing benchmarks either evaluate reasoning in the absence of data or focus on predefined analytical outputs, failing to reflect realistic, data-driven biological research. Here, we introduce BAISBench (Biological AI Scientist Benchmark), a benchmark for evaluating AI scientists on real single-cell transcriptomic datasets. BAISBench comprises two tasks: cell type annotation across 15 expert-labeled datasets, and scientific discovery through 193 multiple-choice questions derived from biological conclusions reported in 41 published single-cell studies. We evaluated several representative AI scientists using BAISBench and, to provide a human performance baseline, invited six graduate-level bioinformaticians to collectively complete the same tasks. The results show that while current AI scientists fall short of fully autonomous biological discovery, they already demonstrate substantial potential in supporting data-driven biological research. These results position BAISBench as a practical benchmark for characterizing the current capabilities and limitations of AI scientists in biological research. We expect BAISBench to serve as a practical evaluation framework for guiding the development of more capable AI scientists and for helping biologists identify AI systems that can effectively support real-world research workflows. The BAISBench can be found at: https://github.com/EperLuo/BAISBench, https://huggingface.co/datasets/EperLuo/BaisBench.

preprint2026arXiv

EmbodiSkill: Skill-Aware Reflection for Self-Evolving Embodied Agents

Embodied agents can benefit from skills that guide object search, action execution, and state changes across diverse environments. Since embodied environments vary across layouts, object states, and other execution factors, these skills must self-evolve from trajectories generated during task execution. However, existing skill self-evolution methods are mainly developed in digital environments and often convert trajectories into coarse skill updates. Directly applying this paradigm to embodied settings is problematic, because a failed task execution may reflect not only incorrect skill content, but also an execution lapse in which the agent fails to follow valid guidance. We propose EmbodiSkill, a training-free framework for embodied skill self-evolution through skill-aware reflection and targeted revision. EmbodiSkill interprets each trajectory with respect to the current skill, uses skill-changing evidence to update the skill body, and uses execution-lapse evidence to preserve and emphasize valid guidance. Experiments on ALFWorld and EmbodiedBench show that EmbodiSkill consistently improves embodied task success. On ALFWorld, EmbodiSkill enables a frozen Qwen3.5-27B executor to reach 93.28% task success, outperforming GPT-5.2 used as a direct agent without skills by 31.58%. These results show that skill-aware self-evolution helps embodied agents accumulate reusable procedural knowledge from their own trajectories.

preprint2026arXiv

FinDeepForecast: A Live Multi-Agent System for Benchmarking Deep Research Agents in Financial Forecasting

Deep Research (DR) Agents powered by advanced Large Language Models (LLMs) have fundamentally shifted the paradigm for completing complex research tasks. Yet, a comprehensive and live evaluation of their forecasting performance on real-world, research-oriented tasks in high-stakes domains (e.g., finance) remains underexplored. We introduce FinDeepForecast, the first live, end-to-end multi-agent system for automatically evaluating DR agents by continuously generating research-oriented financial forecasting tasks. This system is equipped with a dual-track taxonomy, enabling the dynamic generation of recurrent and non-recurrent forecasting tasks at both corporate and macro levels. With this system, we generate FinDeepForecastBench, a weekly evaluation benchmark over a ten-week horizon, encompassing 8 global economies and 1,314 listed companies, and evaluate 13 representative methods. Extensive experiments show that, while DR agents consistently outperform strong baselines, their performance still falls short of genuine forward-looking financial reasoning. We expect the proposed FinDeepForecast system to consistently facilitate future advancements of DR agents in research-oriented financial forecasting tasks. The benchmark and leaderboard are publicly available on the OpenFinArena Platform.

preprint2026arXiv

GCE-MIL: Faithful and Recoverable Evidence for Multiple Instance Learning in Whole-Slide Imaging

Multiple instance learning (MIL) is the standard approach for whole-slide image (WSI) classification and survival prediction, where attention-based models ag gregate patch features into slide-level predictions. These models treat attention weights as evidence for their predictions, but attention is optimized for classi fication, not for identifying which patches actually support the diagnosis. This conflation leads to three failures: selected patches are insufficient (keeping them alone drops Macro-F1 by 0.078), unnecessary (removing them barely changes the prediction), and unrecoverable (continuous attention scores disagree with discrete patch subsets used at inference). The central premise is that evidence quality should be optimized directly through explicit criteria- Sufficiency, Necessity, and Recov erability (S/N/R)- rather than inherited as a byproduct of classification. GCE-MIL is a backbone-agnostic wrapper implemented through three injection modes and three evidence components: a grounding mechanism that aligns selection with domain-specific concepts, noisy-OR coverage that acts as a differentiable proxy for interventional evidence search, and threshold-plus-repair recovery that converts continuous selectors into discrete subsets through marginal-guided repair. Across 9 backbones and 9 datasets (81 configurations), GCE-MIL improves average Macro-F1 by 0.024 and C-index by 0.014, reduces the continuous-discrete gap by 4-7, and increases complement degradation by 2-4. With optional tile prefiltering after discrete recovery, inference runs up to 5 faster while retaining 0.989 full-bag utility.

preprint2026arXiv

Higher Satisfaction, Lower Cost: A Technical Report on How LLMs Revolutionize Meituan's Intelligent Interaction Systems

Enhancing customer experience is essential for business success, particularly as service demands grow in scale and complexity. Generative artificial intelligence and Large Language Models (LLMs) have empowered intelligent interaction systems to deliver efficient, personalized, and 24/7 support. In practice, intelligent interaction systems encounter several challenges: (1) Constructing high-quality data for cold-start training is difficult, hindering self-evolution and raising labor costs. (2) Multi-turn dialogue performance remains suboptimal due to inadequate intent understanding, rule compliance, and solution extraction. (3) Frequent evolution of business rules affects system operability and transferability, constraining low-cost expansion and adaptability. (4) Reliance on a single LLM is insufficient in complex scenarios, where the absence of multi-agent frameworks and effective collaboration undermines process completeness and service quality. (5) The open-domain nature of multi-turn dialogues, lacking unified golden answers, hampers quantitative evaluation and continuous optimization. To address these challenges, we introduce WOWService, an intelligent interaction system tailored for industrial applications. With the integration of LLMs and multi-agent architectures, WOWService enables autonomous task management and collaborative problem-solving. Specifically, WOWService focuses on core modules including data construction, general capability enhancement, business scenario adaptation, multi-agent coordination, and automated evaluation. Currently, WOWService is deployed on the Meituan App, achieving significant gains in key metrics, e.g., User Satisfaction Metric 1 (USM 1) -27.53% and User Satisfaction Metric 2 (USM 2) +25.51%, demonstrating its effectiveness in capturing user needs and advancing personalized service.

preprint2026arXiv

Spatial Blindness in Whole-Slide Multiple Instance Learning

Whole-slide MIL models are often called context-aware once graphs, Transform ers, or state-space modules are placed above patch embeddings. We show that this label can be deceptive. On pathology tasks where tissue architecture is part of the diagnostic signal, several strong MIL baselines retain nearly unchanged slide level AUC after patch coordinates are permuted. Their predictions are accurate, but largely compositional. We refer to this failure mode as spatial blindness. Our explanation is optimization-based: dense appearance statistics are learned early under slide-level supervision, leaving weak gradients for sparse spatial relations. ResTopoMIL addresses the issue by first fitting a permutation-invariant prototype histogram and then freezing it while a lightweight graph branch learns the residual under a coordinate-shuffling constraint. The architecture is simple by design; the intervention is in how the spatial branch is trained. Across 9 public WSI bench marks, ResTopoMIL improves classification and survival prediction with 1.15M parameters, restores sensitivity to coordinate perturbation, and gives stronger lo calization evidence on CAMELYON-16.

preprint2026arXiv

Temporal Sampling Frequency Matters: A Capacity-Aware Study of End-to-End Driving Trajectory Prediction

End to end (E2E) autonomous driving trajectory prediction is often trained with camera frames sampled at the highest available temporal frequency, assuming that denser sampling improves performance. We question this assumption by treating temporal sampling frequency as an explicit training set design variable. Starting from high frequency E2E driving datasets, we construct frequency sweep training sets by temporally subsampling camera frames along each trajectory. For each model dataset pair, we train and evaluate the same model under a fixed protocol, so the frequency response reflects how prediction performance changes with sampling frequency. We analyze this response from a capacity aware perspective. Sparse sampling may miss driving relevant cues, while dense sampling may add redundant visual content and off manifold noise. For finite capacity models, this can create a driving irrelevant capacity burden. We evaluate three smaller E2E models and a larger VLA style AutoVLA model on Waymo, nuScenes, and PAVE. Results show model and dataset dependent frequency responses. Smaller E2E models often show non monotonic or near plateau trends and achieve their best 3 second ADE at lower or intermediate frequencies. In contrast, AutoVLA achieves its best 3 second ADE and FDE at the highest evaluated frequency on all three datasets. Iteration matched controls suggest that the advantage of lower or intermediate frequencies for smaller models is not explained only by unequal training update counts. These findings show that temporal sampling frequency should be reported and tuned, rather than fixed to the highest available value.

preprint2023arXiv

The state-of-the-art 3D anisotropic intracranial hemorrhage segmentation on non-contrast head CT: The INSTANCE challenge

Automatic intracranial hemorrhage segmentation in 3D non-contrast head CT (NCCT) scans is significant in clinical practice. Existing hemorrhage segmentation methods usually ignores the anisotropic nature of the NCCT, and are evaluated on different in-house datasets with distinct metrics, making it highly challenging to improve segmentation performance and perform objective comparisons among different methods. The INSTANCE 2022 was a grand challenge held in conjunction with the 2022 International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI). It is intended to resolve the above-mentioned problems and promote the development of both intracranial hemorrhage segmentation and anisotropic data processing. The INSTANCE released a training set of 100 cases with ground-truth and a validation set with 30 cases without ground-truth labels that were available to the participants. A held-out testing set with 70 cases is utilized for the final evaluation and ranking. The methods from different participants are ranked based on four metrics, including Dice Similarity Coefficient (DSC), Hausdorff Distance (HD), Relative Volume Difference (RVD) and Normalized Surface Dice (NSD). A total of 13 teams submitted distinct solutions to resolve the challenges, making several baseline models, pre-processing strategies and anisotropic data processing techniques available to future researchers. The winner method achieved an average DSC of 0.6925, demonstrating a significant growth over our proposed baseline method. To the best of our knowledge, the proposed INSTANCE challenge releases the first intracranial hemorrhage segmentation benchmark, and is also the first challenge that intended to resolve the anisotropic problem in 3D medical image segmentation, which provides new alternatives in these research fields.

preprint2022arXiv

From Bitcoin to Solana -- Innovating Blockchain towards Enterprise Applications

This survey presents a comprehensive study of recent advances in block-chain technologies, focusing on how issues that affecting the enterprise adoption were progressively addressed from the original Bitcoin system to Ethereum, to Solana etc. Key issues preventing the wide adoption are scala-bility and performance, while recent advances in Solana has clearly demon-strated that it is possible to significantly improve on those issues by innovat-ing on data structure, processes and algorithms by consolidating various time-consuming algorithms and security enforcements, and differentiate and balance users and their responsibilities and rights, while maintaining the re-quired security and integrity that blockchain systems inherently offer.

preprint2022arXiv

Siamese Contrastive Embedding Network for Compositional Zero-Shot Learning

Compositional Zero-Shot Learning (CZSL) aims to recognize unseen compositions formed from seen state and object during training. Since the same state may be various in the visual appearance while entangled with different objects, CZSL is still a challenging task. Some methods recognize state and object with two trained classifiers, ignoring the impact of the interaction between object and state; the other methods try to learn the joint representation of the state-object compositions, leading to the domain gap between seen and unseen composition sets. In this paper, we propose a novel Siamese Contrastive Embedding Network (SCEN) (Code: https://github.com/XDUxyLi/SCEN-master) for unseen composition recognition. Considering the entanglement between state and object, we embed the visual feature into a Siamese Contrastive Space to capture prototypes of them separately, alleviating the interaction between state and object. In addition, we design a State Transition Module (STM) to increase the diversity of training compositions, improving the robustness of the recognition model. Extensive experiments indicate that our method significantly outperforms the state-of-the-art approaches on three challenging benchmark datasets, including the recent proposed C-QGA dataset.

preprint2021arXiv

Atomistic metrics of BaSO$_4$ as an ultra-efficient radiative cooling material: a first-principles prediction

Radiative cooling has recently revived due to its significant potential as an environmentally friendly cooling technology. However, the design of particle-matrix cooling nanocomposites was generally carried out via tedious trial-and-error approaches, and the atomistic physics for efficient radiative cooling was not well understood. In this work, we identify the atomistic metrics of Barium Sulfate (BaSO$_4$) nanocomposite, which is an ultra-efficient radiative cooling material, using a predictive first-principles approach coupled with Monte Carlo simulations. Our results show that BaSO$_4$-acrylic nanocomposites not only attain high total solar reflectance of 92.5% (0.28 - 4.0 um), but also simultaneously demonstrate high normal emittance of 96.0% in the sky window region (8 - 13 um), outperforming the commonly used $α$-quartz ($α$-SiO$_2$). We identify two pertinent characters of ultra-efficient radiative cooling paints: i) a balanced band gap and refractive index, which enables strong scattering while negating absorption in the solar spectrum, and ii) a sufficient number of infrared-active optical resonance phonon modes resulting in abundant Reststrahlen bands and high emissivity in the sky window. The first principles approach and the resulted physical insights in this work pave the way for further search of ultra-efficient radiative cooling materials.

preprint2021arXiv

Trear: Transformer-based RGB-D Egocentric Action Recognition

In this paper, we propose a \textbf{Tr}ansformer-based RGB-D \textbf{e}gocentric \textbf{a}ction \textbf{r}ecognition framework, called Trear. It consists of two modules, inter-frame attention encoder and mutual-attentional fusion block. Instead of using optical flow or recurrent units, we adopt self-attention mechanism to model the temporal structure of the data from different modalities. Input frames are cropped randomly to mitigate the effect of the data redundancy. Features from each modality are interacted through the proposed fusion block and combined through a simple yet effective fusion operation to produce a joint RGB-D representation. Empirical experiments on two large egocentric RGB-D datasets, THU-READ and FPHA, and one small dataset, WCVS, have shown that the proposed method outperforms the state-of-the-art results by a large margin.

preprint2021arXiv

Zero-field spin noise spectrum of an alkali vapor with strong spin-exchange coupling

We study the zero-field optical spin noise spectra (OSN) for a thermal state hot 87Rb vapor with strong spin exchange coupling. Our main findings are: (1) The OSN spectrum consists of two components representing a positive and a negative hyperfine spin correlation (HSC), the relative power of which varies dramatically with the detuning frequency of the probe. (2) There exist two polar frequencies at which the OSN spectrum is completely polarized with one type of HSC. (3) At the limit of far detuning, the power ratio of the positive and negative HSC component of the OSN is 4:5. (4) The total power of the OSN is independent of the strength of SE coupling. (5) We give a simple way of deriving the OSN using the eigensolution of the density matrix equation.

preprint2020arXiv

Transformer Guided Geometry Model for Flow-Based Unsupervised Visual Odometry

Existing unsupervised visual odometry (VO) methods either match pairwise images or integrate the temporal information using recurrent neural networks over a long sequence of images. They are either not accurate, time-consuming in training or error accumulative. In this paper, we propose a method consisting of two camera pose estimators that deal with the information from pairwise images and a short sequence of images respectively. For image sequences, a Transformer-like structure is adopted to build a geometry model over a local temporal window, referred to as Transformer-based Auxiliary Pose Estimator (TAPE). Meanwhile, a Flow-to-Flow Pose Estimator (F2FPE) is proposed to exploit the relationship between pairwise images. The two estimators are constrained through a simple yet effective consistency loss in training. Empirical evaluation has shown that the proposed method outperforms the state-of-the-art unsupervised learning-based methods by a large margin and performs comparably to supervised and traditional ones on the KITTI and Malaga dataset.