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Vincenzo Vitelli

Vincenzo Vitelli contributes to research discovery and scholarly infrastructure.

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Published work

13 published item(s)

preprint2026arXiv

Informational blueprints reveal condition-dependent gene regulatory architectures

While coding regions in the genome have a direct interpretation in terms of protein products, significant fractions are non-coding and yet control essential biological functions. Unlike the genetic code, there is no "lookup table" that identifies where regulatory proteins, known as transcription factors (TFs), bind. Here, we extract these binding sites by distilling sequences of nucleotide letters into collective coordinates (hyperletters) representing the binding sites that are active under specific environmental conditions. Going beyond local information footprints between individual bases and expression levels, our $\textit{information blueprint}$ algorithm compresses the global information by optimising filters that simultaneously scan an entire promoter sequence. Inspired by renormalisation-group techniques, we identify TF binding sites as coarse-grained variables combining groups of correlated mutations with the highest collective impact on gene expression. We validate our approach on experimental data for $\textit{E. coli}$ and discover novel regulatory elements illustrating its deployment at scale across growth conditions.

preprint2022arXiv

Stokes flows in three-dimensional fluids with odd and parity-violating viscosities

The Stokes equation describes the motion of fluids when inertial forces are negligible compared to viscous forces. In this article, we explore the consequence of parity-violating and non-dissipative (i.e. odd) viscosities on Stokes flows in three dimensions. Parity-violating viscosities are coefficients of the viscosity tensor that are not invariant under mirror reflections of space, while odd viscosities are those which do not contribute to dissipation of mechanical energy. These viscosities can occur in systems ranging from synthetic and biological active fluids to magnetised and rotating fluids. We first systematically enumerate all possible parity-violating viscosities compatible with cylindrical symmetry, highlighting their connection to potential microscopic realizations. Then, using a combination of analytical and numerical methods, we analyze the effects of parity-violating viscosities on the Stokeslet solution, on the flow past a sphere or a bubble, and on many-particle sedimentation. In all the cases we analyze, parity-violating viscosities give rise to an azimuthal flow even when the driving force is parallel to the axis of cylindrical symmetry. For a few sedimenting particles, the azimuthal flow bends the trajectories compared to a traditional Stokes flow. For a cloud of particles, the azimuthal flow impedes the transformation of the spherical cloud into a torus and the subsequent breakup into smaller parts that would otherwise occur. The presence of azimuthal flows in cylindrically symmetric systems (sphere, bubble, cloud of particles) can serve as a probe for parity-violating viscosities in experimental systems.

preprint2022arXiv

The odd ideal gas: Hall viscosity and thermal conductivity from non-Hermitian kinetic theory

The flow of momentum and energy in a fluid is typically associated with dissipative transport coefficients: viscosity and thermal conductivity. Fluids that break certain symmetries such as mirror symmetry and time-reversal invariance can display non-dissipative transport coefficients called odd (or Hall) viscosities and thermal conductivities. The goal of this paper is to elucidate the microscopic origin of these dissipationless transport coefficients using kinetic theory. We show that odd viscosity and odd thermal conductivity arise when the linearized collision operator is not Hermitian. This symmetry breaking occurs when collisions are chiral, i.e. not mirror symmetric. To capture this feature in a minimalistic way, we introduce a modified relaxation time approximation in which the distribution function is rotated by an angle characterizing the average chirality of the collisions. In the limit of an infinitesimal rotation, the effect of the parity-violating collisions can be described as an emergent effective magnetic field.

preprint2021arXiv

Topological active matter

Active matter encompasses different nonequilibrium systems in which individual constituents convert energy into non-conservative forces or motion at the microscale. This review provides an elementary introduction to the role of topology in active matter through experimentally relevant examples. Here, the focus lies on topological defects and topologically protected edge modes with an emphasis on the distinctive properties they acquire in active media. These paradigmatic examples represent two physically distinct classes of phenomena whose robustness can be traced to a common mathematical origin: the presence of topological invariants. These invariants are typically integer numbers that cannot be changed by continuous deformations of the relevant order parameters or physical parameters of the underlying medium. We first explain the mechanisms whereby topological defects self propel and proliferate in active nematics, leading to collective states which can be manipulated by geometry and patterning. Possible implications for active microfluidics and biological tissues are presented. We then illustrate how the propagation of waves in active fluids and solids is affected by the presence of topological invariants characterizing their dispersion relations. We discuss the relevance of these ideas for the design of robotic metamaterials and the properties of active granular and colloidal systems. Open theoretical and experimental challenges are presented as future research prospects.

preprint2020arXiv

Hydrodynamic correlation functions of chiral active fluids

The success of spectroscopy to characterise equilibrium fluids, for example the heat capacity ratio, suggests a parallel approach for active fluids. Here, we start from a hydrodynamic description of chiral active fluids composed of spinning constituents and derive their low-frequency, long-wavelength response functions using the Kadanoff-Martin formalism. We find that the presence of odd (equivalently, Hall) viscosity leads to mixed density-vorticity response even at linear order. Such response, prohibited in time-reversal-invariant fluids, is a large-scale manifestation of the microscopic breaking of time-reversal symmetry. Our work suggests possible experimental probes that can measure anomalous transport coefficients in active fluids through dynamic light scattering.

preprint2020arXiv

Liquid-crystal-based topological photonics

Topological photonics harnesses the physics of topological insulators to control the behavior of light. Photonic modes robust against material imperfections are an example of such control. In this work, we propose a soft-matter platform based on nematic liquid crystals that supports photonic topological insulators. The orientation of liquid crystal molecules introduces an extra geometric degree of freedom which in conjunction with suitably designed structural properties, leads to the creation of topologically protected states of light. The use of soft building blocks potentially allows for reconfigurable systems that exploit the interplay between light and the soft responsive medium.

preprint2020arXiv

Non-Hermitian band topology and skin modes in active elastic media

Solids built out of active components can exhibit non-reciprocal elastic coefficients that give rise to non-Hermitian wave phenomena. Here, we investigate non-Hermitian effects present at the boundary of two-dimensional active elastic media obeying two general assumptions: their microscopic forces conserve linear momentum and arise only from static deformations. Using continuum equations, we demonstrate the existence of the non-Hermitian skin effect in which the boundary hosts an extensive number of localized modes. Furthermore, lattice models reveal non-Hermitian topological transitions mediated by exceptional rings driven by the activity level of individual bonds.

preprint2020arXiv

Nuts and bolts of supersymmetry

A topological mechanism is a zero elastic-energy deformation of a mechanical structure that is robust against smooth changes in system parameters. Here, we map the nonlinear elasticity of a paradigmatic class of topological mechanisms onto linear fermionic models using a supersymmetric field theory introduced by Witten and Olive. Heuristically, this approach consists of taking the square root of a non-linear Hamiltonian and generalizes the standard procedure of obtaining two copies of Dirac equation from the square root of the linear Klein Gordon equation. Our real space formalism goes beyond topological band theory by incorporating non-linearities and spatial inhomogeneities, such as domain walls, where topological states are typically localized. By viewing the two components of the real fermionic field as site and bond displacements respectively, we determine the relation between the supersymmetry transformations and the Bogomolny-Prasad-Sommerfield (BPS) bound saturated by the mechanism. We show that the mechanical constraint, which enforces a BPS saturated kink into the system, simultaneously precludes an anti-kink. This mechanism breaks the usual kink-antikink symmetry and can be viewed as a manifestation of the underlying supersymmetry being half-broken.

preprint2020arXiv

Simple views on symmetries and dualities in the theory of elasticity

Microscopic symmetries impose strong constraints on the elasticity of a crystalline solid. In addition to the usual spatial symmetries captured by the tensorial character of the elastic tensor, hidden non-spatial symmetries can occur microscopically in special classes of mechanical structures. Examples of such non-spatial symmetries occur in families of mechanical metamaterials where a duality transformation relates pairs of different configurations. We show on general grounds how the existence of non-spatial symmetries further constrains the elastic tensor, reducing the number of independent moduli. In systems exhibiting a duality transformation, the resulting constraints on the number of moduli are particularly stringent at the self-dual point but persist even away from it, in a way reminiscent of critical phenomena.

preprint2019arXiv

Anisotropic odd viscosity via time-modulated drive

At equilibrium, the structure and response of ordered phases are typically determined by the spontaneous breaking of spatial symmetries. Out of equilibrium, spatial order itself can become a dynamically emergent concept. In this article, we show that spatially anisotropic viscous coefficients and stresses can be designed in a far-from-equilibrium fluid by applying to its constituents a time-modulated drive. If the drive induces a rotation whose rate is slowed down when the constituents point along specific directions, anisotropic structures and mechanical responses arise at long timescales. We demonstrate that the viscous response of such anisotropic driven fluids can acquire a tensorial, dissipationless component called anisotropic odd (or Hall) viscosity. Classical fluids with internal torques can display additional components of the odd viscosity neglected in previous studies of quantum Hall fluids that assumed angular momentum conservation. We show that these anisotropic and angular momentum-violating odd-viscosity coefficients can change even the bulk flow of an incompressible fluid by acting as a source of vorticity. In addition, shear distortions in the shape of an inclusion result in torques.

preprint2019arXiv

Dualities and non-Abelian mechanics

Dualities are mathematical mappings that reveal unexpected links between apparently unrelated systems or quantities in virtually every branch of physics. Systems that are mapped onto themselves by a duality transformation are called self-dual and they often exhibit remarkable properties, as exemplified by an Ising magnet at the critical point. In this Letter, we unveil the role of dualities in mechanics by considering a family of so-called twisted Kagome lattices. These are reconfigurable structures that can change shape thanks to a collapse mechanism easily illustrated using LEGO. Surprisingly, pairs of distinct configurations along the mechanism exhibit the same spectrum of vibrational modes. We show that this puzzling property arises from the existence of a duality transformation between pairs of configurations on either side of a mechanical critical point. This critical point corresponds to a self-dual structure whose vibrational spectrum is two-fold degenerate over the entire Brillouin zone. The two-fold degeneracy originates from a general version of Kramers theorem that applies to classical waves in addition to quantum systems with fermionic time-reversal invariance. We show that the vibrational modes of the self-dual mechanical systems exhibit non-Abelian geometric phases that affect the semi-classical propagation of wave packets. Our results apply to linear systems beyond mechanics and illustrate how dualities can be harnessed to design metamaterials with anomalous symmetries and non-commuting responses.

preprint2019arXiv

Odd elasticity

Hooke's law states that the forces or stresses experienced by an elastic object are proportional to the applied deformations or strains. The number of coefficients of proportionality between stress and strain, i.e., the elastic moduli, is constrained by energy conservation. In this Letter, we lift this restriction and generalize linear elasticity to active media with non-conservative microscopic interactions that violate mechanical reciprocity. This generalized framework, which we dub odd elasticity, reveals that two additional moduli can exist in a two-dimensional isotropic solid with active bonds. Such an odd-elastic solid can be regarded as a distributed engine: work is locally extracted, or injected, during quasi-static cycles of deformation. Using continuum equations, coarse-grained microscopic models, and numerical simulations, we uncover phenomena ranging from activity-induced auxetic behavior to wave propagation powered by self-sustained active elastic cycles. Besides providing insights beyond existing hydrodynamic theories of active solids, odd elasticity suggests design principles for emergent autonomous materials.

preprint2019arXiv

Topological structure and dynamics of three dimensional active nematics

Point-like motile topological defects control the universal dynamics of diverse two-dimensional active nematics ranging from shaken granular rods to cellular monolayers. A comparable understanding in higher dimensions has yet to emerge. We report the creation of three-dimensional active nematics by dispersing extensile microtubule bundles in a passive colloidal liquid crystal. Light-sheet microscopy reveals the millimeter-scale structure of active nematics with a single bundle resolution and the temporal evolution of the associated nematic director field. The dominant excitations of three-dimensional active nematics are extended charge-neutral disclination loops that undergo complex dynamics and recombination events. These studies introduce a new class of non-equilibrium systems whose turbulent-like dynamics arises from the interplay between internally generated active stresses, the chaotic flows and the topological structure of the constituent defects.