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Researcher profile

Tianyang Wang

Tianyang Wang contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Computer VisionMachine Learningphysics.ins-detArtificial IntelligenceComputation and LanguageComputational Engineering, Finance, and Sciencecs.CYeess.IVeess.SPGenomicshep-exMultimedia

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Published work

9 published item(s)

preprint2026arXiv

A Single-Parameter Factor-Graph Image Prior

We propose a novel piecewise smooth image model with piecewise constant local parameters that are automatically adapted to each image. Technically, the model is formulated in terms of factor graphs with NUP (normal with unknown parameters) priors, and the pertinent computations amount to iterations of conjugate-gradient steps and Gaussian message passing. The proposed model and algorithms are demonstrated with applications to denoising and contrast enhancement.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

Drift Flow Matching

Iterative generative models such as Flow Matching and Diffusion models have demonstrated strong test-time scaling behavior, where additional inference computation can improve generation quality. In contrast, Drift Models offer efficient one-step generation, but their direct generation paradigm limits such flexibility. In this work, we propose Drift Flow Matching (DFM), a framework that connects drifting generative modeling with flow-based iterative generation. DFM preserves the efficiency of direct transport maps while enabling generation to be refined through multiple inference steps when desired. This bridges the gap between one-step Drift Models and multi-step Flow Matching methods, and provides a novel generative paradigm that can adapt sampling computation to different quality--efficiency requirements. Extensive experiments across different tasks and datasets demonstrate the effectiveness and generality of the proposed framework.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

From Bench to Bedside: A Review of Clinical Trials in Drug Discovery and Development

Clinical trials are an indispensable part of the drug development process, bridging the gap between basic research and clinical application. During the development of new drugs, clinical trials are used not only to evaluate the safety and efficacy of the drug but also to explore its dosage, treatment regimens, and potential side effects. This review discusses the various stages of clinical trials, including Phase I (safety assessment), Phase II (preliminary efficacy evaluation), Phase III (large-scale validation), and Phase IV (post-marketing surveillance), highlighting the characteristics of each phase and their interrelationships. Additionally, the paper addresses the major challenges encountered in clinical trials, such as ethical issues, subject recruitment difficulties, diversity and representativeness concerns, and proposes strategies for overcoming these challenges. With the advancement of technology, innovative technologies such as artificial intelligence, big data, and digitalization are gradually transforming clinical trial design and implementation, improving trial efficiency and data quality. The article also looks forward to the future of clinical trials, particularly the impact of emerging therapies such as gene therapy and immunotherapy on trial design, as well as the importance of regulatory reforms and global collaboration. In conclusion, the core role of clinical trials in drug development will continue to drive the progress of innovative drug development and clinical treatment.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

From In Silico to In Vitro: A Comprehensive Guide to Validating Bioinformatics Findings

The integration of bioinformatics predictions and experimental validation plays a pivotal role in advancing biological research, from understanding molecular mechanisms to developing therapeutic strategies. Bioinformatics tools and methods offer powerful means for predicting gene functions, protein interactions, and regulatory networks, but these predictions must be validated through experimental approaches to ensure their biological relevance. This review explores the various methods and technologies used for experimental validation, including gene expression analysis, protein-protein interaction verification, and pathway validation. We also discuss the challenges involved in translating computational predictions to experimental settings and highlight the importance of collaboration between bioinformatics and experimental research. Finally, emerging technologies, such as CRISPR gene editing, next-generation sequencing, and artificial intelligence, are shaping the future of bioinformatics validation and driving more accurate and efficient biological discoveries.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Boosting Active Learning via Improving Test Performance

Central to active learning (AL) is what data should be selected for annotation. Existing works attempt to select highly uncertain or informative data for annotation. Nevertheless, it remains unclear how selected data impacts the test performance of the task model used in AL. In this work, we explore such an impact by theoretically proving that selecting unlabeled data of higher gradient norm leads to a lower upper-bound of test loss, resulting in better test performance. However, due to the lack of label information, directly computing gradient norm for unlabeled data is infeasible. To address this challenge, we propose two schemes, namely expected-gradnorm and entropy-gradnorm. The former computes the gradient norm by constructing an expected empirical loss while the latter constructs an unsupervised loss with entropy. Furthermore, we integrate the two schemes in a universal AL framework. We evaluate our method on classical image classification and semantic segmentation tasks. To demonstrate its competency in domain applications and its robustness to noise, we also validate our method on a cellular imaging analysis task, namely cryo-Electron Tomography subtomogram classification. Results demonstrate that our method achieves superior performance against the state of the art. Our source code is available at https://github.com/xulabs/aitom/blob/master/doc/projects/al_gradnorm.md.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Characterization of Passive CMOS Strip Sensors

Recent advances in CMOS imaging sensor technology , e.g. in CMOS pixel sensors, have proven that the CMOS process is radiation tolerant enough to cope with certain radiation levels required for tracking layers in hadron collider experiments. With the ever-increasing area covered by silicon tracking detectors cost effective alternatives to the current silicon sensors and more integrated designs are desirable. This article describes results obtained from laboratory measurements of silicon strip sensors produced in a passive p-CMOS process. Electrical characterization and charge collection measurements with a 90Sr source and a laser with infrared wavelength showed no effect of the stitching process on the performance of the sensor.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Imbalanced Malware Images Classification: a CNN based Approach

Deep convolutional neural networks (CNNs) can be applied to malware binary detection via image classification. The performance, however, is degraded due to the imbalance of malware families (classes). To mitigate this issue, we propose a simple yet effective weighted softmax loss which can be employed as the final layer of deep CNNs. The original softmax loss is weighted, and the weight value can be determined according to class size. A scaling parameter is also included in computing the weight. Proper selection of this parameter is studied and an empirical option is suggested. The weighted loss aims at alleviating the impact of data imbalance in an end-to-end learning fashion. To validate the efficacy, we deploy the proposed weighted loss in a pre-trained deep CNN model and fine-tune it to achieve promising results on malware images classification. Extensive experiments also demonstrate that the new loss function can well fit other typical CNNs, yielding an improved classification performance.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Parameter-Free Style Projection for Arbitrary Style Transfer

Arbitrary image style transfer is a challenging task which aims to stylize a content image conditioned on arbitrary style images. In this task the feature-level content-style transformation plays a vital role for proper fusion of features. Existing feature transformation algorithms often suffer from loss of content or style details, non-natural stroke patterns, and unstable training. To mitigate these issues, this paper proposes a new feature-level style transformation technique, named Style Projection, for parameter-free, fast, and effective content-style transformation. This paper further presents a real-time feed-forward model to leverage Style Projection for arbitrary image style transfer, which includes a regularization term for matching the semantics between input contents and stylized outputs. Extensive qualitative analysis, quantitative evaluation, and user study have demonstrated the effectiveness and efficiency of the proposed methods.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

DMAPS Monopix developments in large and small electrode designs

LF-Monopix1 and TJ-Monopix1 are depleted monolithic active pixel sensors (DMAPS) in 150 nm LFoundry and 180 nm TowerJazz CMOS technologies respectively. They are designed for usage in high-rate and high-radiation environments such as the ATLAS Inner Tracker at the High-Luminosity Large Hadron Collider (HL-LHC). Both chips are read out using a column-drain readout architecture. LF-Monopix1 follows a design with large charge collection electrode where readout electronics are placed inside. Generally, this offers a homogeneous electrical field in the sensor and short drift distances. TJ-Monopix1 employs a small charge collection electrode with readout electronics separated from the electrode and an additional n-type implant to achieve full depletion of the sensitive volume. This approach offers a low sensor capacitance and therefore low noise and is typically implemented with small pixel size. Both detectors have been characterized before and after irradiation using lab tests and particle beams.

0 citations0 reviewsNo code linkedOpen access