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Stefan Kesselheim

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Published work

7 published item(s)

preprint2026arXiv

Exploring and Exploiting Stability in Latent Flow Matching

In this work, we show that Latent Flow-Matching (LFM) models are robust to different types of perturbations, including data reduction and model capacity shrinkage. We characterize this stability by their tendency to generate similar outputs under identical noise seeds. We provide a perspective relating this phenomenon to flow matching theory, which indicates that this stability is inherent to the FM objective. We further exploit this stability to derive practical algorithms for more efficient training and inference. Concretely, first, we show that by training LFM models on significantly reduced datasets, the performance does not degrade perceptually or quantitatively. This yields multiple advantages, such as reducing training time by converging faster under limited compute budget, and alleviating annotation effort when training conditional models. Second, LFM stability under architectural shrinkage gives rise to a two-model coarse-to-fine approach, one using a light-weight architecture for the first phase of the FM trajectory, and one with higher capacity for the second, thereby reducing the inference cost substantially. To determine which samples are informative, we introduce three sample-scoring criteria and evaluate them under standard metrics for generative models. Our results are thoroughly evaluated on multiple datasets, demonstrating the practical advantage of this stability, including data saving and a more than two-fold inference speedup while generating comparable outputs.

preprint2026arXiv

Machine Learning for neutron source distributions

In light of the recent advancements in machine learning, we propose a novel approach to neutron source distribution estimation through the utilisation of probabilistic generative models. The estimation is based on a Monte Carlo particle list, which is only required during the training stage of the machine learning model. Once the source distribution has been learned, the model is independent of the original particle list, allowing for further sampling in an efficient, rapid, and memory-costless manner. The performance of various generative models is evaluated, including a variational autoencoder, a normalizing flow, a generative adversarial network, and a denoising diffusion model. These approaches are then compared to existing source distribution estimations, and the advantages and disadvantages of each approach are discussed. The results demonstrate that source distributions can be modeled through the use of probabilistic generative models, which paves the way for further advancements in this field.

preprint2022arXiv

Hearts Gym: Learning Reinforcement Learning as a Team Event

Amidst the COVID-19 pandemic, the authors of this paper organized a Reinforcement Learning (RL) course for a graduate school in the field of data science. We describe the strategy and materials for creating an exciting learning experience despite the ubiquitous Zoom fatigue and evaluate the course qualitatively. The key organizational features are a focus on a competitive hands-on setting in teams, supported by a minimum of lectures providing the essential background on RL. The practical part of the course revolved around Hearts Gym, an RL environment for the card game Hearts that we developed as an entry-level tutorial to RL. Participants were tasked with training agents to explore reward shaping and other RL hyperparameters. For a final evaluation, the agents of the participants competed against each other.

preprint2013arXiv

Hydrodynamic Correlations slow down Crystallization of Soft Colloids

Crystallization is often assumed to be a quasi-static process that is unaffected by details of particle transport other than the bulk diffusion coefficient. Therefore colloidal suspensions are frequently argued to be an ideal toy model for experimentally more difficult systems such as metal melts. In this letter, we want to challenge this assumption. To this aim, we have considered molecular dynamics simulations of the crystallization in a suspension of Yukawa-type colloids. In order to investigate the role of hydrodynamic interactions (HIs) mediated by the solvent, we modeled the solvent both implicitly and explicitly, using Langevin dynamics and the fluctuating Lattice Boltzmann method, respectively. Our simulations show a dramatic reduction of the crystal growth velocity due to HIs even at moderate hydrodynamic coupling. A detailed analysis shows that this slowdown is due to the wall-like properties of the crystal surface, which reduces the colloidal diffusion towards the crystal surface by hydrodynamic screening. Crystallization in suspensions therefore differs strongly from pure melts, making them less useful as a toy model than previously thought.

preprint2012arXiv

Investigation of tracer diffusion in crowded cylindrical channel

Based on a coarse-grained model, we carry out molecular dynamics simulations to analyze the diffusion of a small tracer particle inside a cylindrical channel whose inner wall is covered with randomly grafted short polymeric chains. We observe an interesting transient subdiffusive behavior along the cylindrical axis at high attraction between the tracer and the chains, however, the long time diffusion is always normal. This process is found to be enhanced for the case that we immobilize the grafted chains, i.e. the sub-diffusive behavior sets in at an earlier time and spans over a longer time period before becoming diffusive. Even if the grafted chains are replaced with a frozen sea of repulsive, non-connected particles in the background, the transient subdiffusion is observed. The intermediate subdiffusive behavior only disappears when the grafted chains are replaced with a mobile background sea of mutually repulsive particles. Overall, the long time diffusion coefficient of the tracer along the cylinder axis decreases with the increase in system volume fraction, strength of attraction between the tracer and the background and also on freezing the background. We believe that the simple model presented here could be useful for a qualitative understanding of the process of macromolecular diffusion inside the nuclear pore complex.

preprint2010arXiv

Influence of pore dielectric boundaries on the translocation barrier of DNA

We investigate the impact of dielectric boundary forces on the translocation process of charged rigid DNA segments through solid neutral nanopores. We assess the electrostatic contribution to the translocation free energy barrier of a model DNA segment by evaluating the potential of mean force in absence and presence of polarization effects by means of coarse-grained molecular dynamics simulations. The effect of induced polarization charges has been taken into account by employing ICC*, a recently developed algorithm that can efficiently compute induced polarization charges induced on suitably discretized dielectric boundaries. Since water has a higher dielectric constant than the pore walls, polarization effects repel charged objects in the vicinity of the interface, with the effect of significantly increasing the free energy barrier. Another investigated side effect is the change of the counterion distribution around the charged polymer in presence of the induced pore charges. Furthermore we investigate the influence of adding salt to the solution.

preprint2010arXiv

The ICC* Algorithm: A fast way to include dielectric boundary effects into molecular dynamics simulations

We employ a fast and accurate algorithm to treat dielectric interfaces within molecular dynamics simulations and demonstrate the importance of dielectric boundary forces (DBFs) in two systems of interests in soft-condensed matter science. We investigate a salt solution confined to a slit pore, and a model of a DNA fragment translocating thorugh a narrow pore.