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Researcher profile

Sarath Sivaprasad

Sarath Sivaprasad contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Artificial IntelligenceComputer VisionMachine Learning

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Published work

2 published item(s)

preprint2026arXiv

Automated Detection of Abnormalities in Zebrafish Development

Zebrafish embryos are a valuable model for drug discovery due to their optical transparency and genetic similarity to humans. However, current evaluations rely on manual inspection, which is costly and labor-intensive. While machine learning offers automation potential, progress is limited by the lack of comprehensive datasets. To address this, we introduce a large-scale dataset of high-resolution microscopic image sequences capturing zebrafish embryonic development under both control conditions and exposure to compounds (3,4-dichloroaniline). This dataset, with expert annotations at fine-grained temporal levels, supports two benchmarking tasks: (1) fertility classification, assessing zebrafish egg viability (130,368 images), and (2) toxicity assessment, detecting malformations induced by toxic exposure over time (55,296 images). Alongside the dataset, we present the first transformer-based baseline model that integrates spatiotemporal features to predict developmental abnormalities at early stages. Experimental results present the model's effectiveness, achieving 98% accuracy in fertility classification and 92% in toxicity assessment. These findings underscore the potential of automated approaches to enhance zebrafish-based toxicity analysis.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Reappraising Domain Generalization in Neural Networks

Given that Neural Networks generalize unreasonably well in the IID setting (with benign overfitting and betterment in performance with more parameters), OOD presents a consistent failure case to better the understanding of how they learn. This paper focuses on Domain Generalization (DG), which is perceived as the front face of OOD generalization. We find that the presence of multiple domains incentivizes domain agnostic learning and is the primary reason for generalization in Tradition DG. We show that the state-of-the-art results can be obtained by borrowing ideas from IID generalization and the DG tailored methods fail to add any performance gains. Furthermore, we perform explorations beyond the Traditional DG (TDG) formulation and propose a novel ClassWise DG (CWDG) benchmark, where for each class, we randomly select one of the domains and keep it aside for testing. Despite being exposed to all domains during training, CWDG is more challenging than TDG evaluation. We propose a novel iterative domain feature masking approach, achieving state-of-the-art results on the CWDG benchmark. Overall, while explaining these observations, our work furthers insights into the learning mechanisms of neural networks.

0 citations0 reviewsNo code linkedOpen access