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Trust 21 - EmergingVerification L1Unclaimed author
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Published work

14 published item(s)

preprint2026arXiv

Convex Dataset Valuation for Post-Training

Improving LLM performance on downstream tasks sometimes requires leveraging auxiliary datasets during post-training. In practice, however, developers face constraints on compute, labeling, and licensing costs that preclude using all available data, necessitating principled dataset-level selection. These constraints are increasingly shaped by dataset marketplaces, where data acquisition is governed by budgets and negotiation. We study dataset valuation as a subset selection problem during LLM post-training. Our goal is to identify and weight auxiliary datasets so as to maximize target task performance given constrained budgets. We first show that commonly used gradient alignment scores provide a reasonable yet incomplete valuation signal, as they ignore redundancy among datasets. To address this, we propose a scalable convex dataset-level valuation method based on kernel mean matching (KMM) in gradient space, which jointly accounts for alignment with the target task and redundancy across auxiliary datasets. Through extensive experiments across diverse post-training settings and tasks, we show that our approach consistently outperforms existing valuation baselines, achieving stronger performance with low computational overhead. Our results position dataset valuation as a practical decision tool for post-training data selection in market-constrained large language model settings. The code is available at https://github.com/uiuctml/convex_data_valuation.

preprint2026arXiv

From Bench to Bedside: A Review of Clinical Trials in Drug Discovery and Development

Clinical trials are an indispensable part of the drug development process, bridging the gap between basic research and clinical application. During the development of new drugs, clinical trials are used not only to evaluate the safety and efficacy of the drug but also to explore its dosage, treatment regimens, and potential side effects. This review discusses the various stages of clinical trials, including Phase I (safety assessment), Phase II (preliminary efficacy evaluation), Phase III (large-scale validation), and Phase IV (post-marketing surveillance), highlighting the characteristics of each phase and their interrelationships. Additionally, the paper addresses the major challenges encountered in clinical trials, such as ethical issues, subject recruitment difficulties, diversity and representativeness concerns, and proposes strategies for overcoming these challenges. With the advancement of technology, innovative technologies such as artificial intelligence, big data, and digitalization are gradually transforming clinical trial design and implementation, improving trial efficiency and data quality. The article also looks forward to the future of clinical trials, particularly the impact of emerging therapies such as gene therapy and immunotherapy on trial design, as well as the importance of regulatory reforms and global collaboration. In conclusion, the core role of clinical trials in drug development will continue to drive the progress of innovative drug development and clinical treatment.

preprint2026arXiv

From In Silico to In Vitro: A Comprehensive Guide to Validating Bioinformatics Findings

The integration of bioinformatics predictions and experimental validation plays a pivotal role in advancing biological research, from understanding molecular mechanisms to developing therapeutic strategies. Bioinformatics tools and methods offer powerful means for predicting gene functions, protein interactions, and regulatory networks, but these predictions must be validated through experimental approaches to ensure their biological relevance. This review explores the various methods and technologies used for experimental validation, including gene expression analysis, protein-protein interaction verification, and pathway validation. We also discuss the challenges involved in translating computational predictions to experimental settings and highlight the importance of collaboration between bioinformatics and experimental research. Finally, emerging technologies, such as CRISPR gene editing, next-generation sequencing, and artificial intelligence, are shaping the future of bioinformatics validation and driving more accurate and efficient biological discoveries.

preprint2026arXiv

Identification of Semiparametric Panel Multinomial Choice Models with Infinite-Dimensional Fixed Effects

This paper proposes a robust method for semiparametric identification and estimation in panel multinomial choice models, where we allow for infinite-dimensional fixed effects that enter into consumer utilities in an additively nonseparable way, thus incorporating rich forms of unobserved heterogeneity. Our identification strategy exploits multivariate monotonicity in parametric indexes, and uses the logical contraposition of an intertemporal inequality on choice probabilities to obtain identifying restrictions. We provide a consistent estimation procedure, and demonstrate the practical advantages of our method with Monte Carlo simulations and an empirical illustration on popcorn sales with the Nielsen data.

preprint2026arXiv

IIB-LPO: Latent Policy Optimization via Iterative Information Bottleneck

Recent advances in Reinforcement Learning with Verifiable Rewards (RLVR) for Large Language Model (LLM) reasoning have been hindered by a persistent challenge: exploration collapse. The semantic homogeneity of random rollouts often traps models in narrow, over-optimized behaviors. While existing methods leverage policy entropy to encourage exploration, they face inherent limitations. Global entropy regularization is susceptible to reward hacking, which can induce meaningless verbosity, whereas local token-selective updates struggle with the strong inductive bias of pre-trained models. To address this, we propose Latent Policy Optimization via Iterative Information Bottleneck (IIB-LPO), a novel approach that shifts exploration from statistical perturbation of token distributions to topological branching of reasoning trajectories. IIB-LPO triggers latent branching at high-entropy states to diversify reasoning paths and employs the Information Bottleneck principle both as a trajectory filter and a self-reward mechanism, ensuring concise and informative exploration. Empirical results across four mathematical reasoning benchmarks demonstrate that IIB-LPO achieves state-of-the-art performance, surpassing prior methods by margins of up to 5.3% in accuracy and 7.4% in diversity metrics.

preprint2026arXiv

InfiAgent: An Infinite-Horizon Framework for General-Purpose Autonomous Agents

LLM agents can reason and use tools, but they often break down on long-horizon tasks due to unbounded context growth and accumulated errors. Common remedies such as context compression or retrieval-augmented prompting introduce trade-offs between information fidelity and reasoning stability. We present InfiAgent, a general-purpose framework that keeps the agent's reasoning context strictly bounded regardless of task duration by externalizing persistent state into a file-centric state abstraction. At each step, the agent reconstructs context from a workspace state snapshot plus a fixed window of recent actions. Experiments on DeepResearch and an 80-paper literature review task show that, without task-specific fine-tuning, InfiAgent with a 20B open-source model is competitive with larger proprietary systems and maintains substantially higher long-horizon coverage than context-centric baselines. These results support explicit state externalization as a practical foundation for stable long-horizon agents. Github Repo:https://github.com/ChenglinPoly/infiAgent

preprint2026arXiv

Modeling Item-Level Dynamic Variability with Residual Diffusion for Bundle Recommendation

Existing solutions for bundle recommendation (BR) have achieved remarkable effectiveness for predicting the user's preference for prebuilt bundles. However, bundle-item (B-I) affiliation will vary dynamically in real scenarios. For example, a bundle themed as 'casual outfit' may add 'hat' or remove 'watch' due to factors such as seasonal variations, changes in user preferences or inventory adjustments. Our empirical study demonstrates that the performance of mainstream BR models may fluctuate or decline under item-level variability. This paper makes the first attempt to address the above problem and proposes a novel Residual Diffusion for Bundle Recommendation(RDiffBR)asamodel-agnostic generative framework which can assist a BR model in adapting this scenario. During the initial training of the BR model, RDiffBR employs a residual diffusion model to process the item-level bundle embeddings which are generated by the BR model to represent bundle theme via a forward-reverse process. In the inference stage, RDiffBR reverses item-level bundle embeddings obtained by the well-trained bundle model under B-I variability scenarios to generate the effective item level bundle embeddings. In particular, the residual connection in our residual approximator significantly enhances BR models' ability to generate high-quality item-level bundle embeddings. Experiments on six BR models and four public datasets from different domains show that RDiffBR improves the performance of Recall and NDCG of backbone BR models by up to 23%, while only increases training time about 4%.

preprint2026arXiv

Principles of Optics in the Fock Space: Scalable Manipulation of Giant Quantum States

The manipulation of distinct degrees of freedom of photons plays a critical role in both classical and quantum information processing. While the principles of wave optics provide elegant and scalable control over classical light in spatial and temporal domains, engineering quantum states in Fock space has been largely restricted to few-photon regimes, hindered by the computational and experimental challenges of large Hilbert spaces. Here, we introduce ``Fock-space optics", establishing a conceptual framework of wave propagation in the quantum domain by treating photon number as a synthetic dimension. Using a superconducting microwave resonator, we experimentally demonstrate Fock-space analogues of optical propagation, refraction, lensing, dispersion, and interference with up to 180 photons. These results establish a fundamental correspondence between Schrödinger evolution in a single bosonic mode and classical paraxial wave propagation. By mapping intuitive optical concepts onto high-dimensional quantum state engineering, our work opens a path toward scalable control of large-scale quantum systems with thousands of photons and advanced bosonic information processing.

preprint2026arXiv

Quantum information of optical magnetometry: Semiclassical Cramer-Rao bound violation and Heisenberg scaling

Optical magnetometers use the rotation of linearly polarized laser light induced by the Faraday effect for high precision magnetic field measurements. Here, we carry out an in-depth quantum information investigation, deploying two distinct models: The first, semiclassical model can violate the quantum Cramer-Rao bound by several orders of magnitude for weak dissipation and large atom numbers, invalidating the semiclassical approach in this parameter regime. The second model, describing the atoms as a collective spin, respects the Cramer-Rao bound for all parameters. Interestingly, the collective model also predicts Heisenberg scaling for the quantum Fisher information. The comparison of both models shows that Heisenberg scaling is a result of measurement-induced quantum correlation in an otherwise non-interacting quantum system. As the Heisenberg scaling appears in a stationary state of a macroscopic quantum system, it can be thus viewed as a new paradigm in quantum sensing. Intriguingly, the comparison of both models with experimental data can constitute a test for the foundations of quantum mechanics in a macroscopic ensemble of atoms.

preprint2026arXiv

Scalable Generation of Macroscopic Fock States Exceeding 10,000 Photons

The scalable preparation of bosonic quantum states with macroscopic excitations poses a fundamental challenge in quantum technologies, limited by control complexity and photon-loss rates that severely constrain prior theoretical and experimental efforts to merely dozens of excitations per mode. Here, based on the duality of the quantum state evolution in Fock state space and the optical wave-function propagation in a waveguide array, we introduce a Kerr-engineered multi-lens protocol in a single bosonic mode to deterministically generate Fock states exceeding $10,000$ photons. By optimizing phase and displacement operations across lens groups, our approach compensates for non-paraxial aberrations, achieving fidelities above $73\%$ in numerical simulations for photon numbers up to $N=100,000$. Counterintuitively, the protocol's execution time scales as $N^{-1/2}$ with the target photon number $N$, exhibiting robustness against the photon loss. Our framework enables exploration of quantum-to-classical transitions of giant Fock states, paving the way for advanced quantum metrology with significant quantum gains, and error-corrected quantum information processing in high-dimensional Hilbert spaces.

preprint2026arXiv

Terminally constrained flow-based generative models from an optimal control perspective

We address the problem of sampling from terminally constrained distributions with pre-trained flow-based generative models through an optimal control formulation. Theoretically, we characterize the value function by a Hamilton-Jacobi-Bellman equation and derive the optimal feedback control as the minimizer of the associated Hamiltonian. We show that as the control penalty increases, the controlled process recovers the reference distribution, while as the penalty vanishes, the terminal law converges to a generalized Wasserstein projection onto the constraint manifold. Algorithmically, we introduce Terminal Optimal Control with Flow-based models (TOCFlow), a geometry-aware sampling-time guidance method for pre-trained flows. Solving the control problem in a terminal co-moving frame that tracks reference trajectories yields a closed-form scalar damping factor along the Riemannian gradient, capturing second-order curvature effects without matrix inversions. TOCFlow therefore matches the geometric consistency of Gauss-Newton updates at the computational cost of standard gradient guidance. We evaluate TOCFlow on three high-dimensional scientific tasks spanning equality, inequality, and global statistical constraints, namely Darcy flow, constrained trajectory planning, and turbulence snapshot generation with Kolmogorov spectral scaling. Across all settings, TOCFlow improves constraint satisfaction over Euclidean guidance and projection baselines while preserving the reference model's generative quality.

preprint2026arXiv

Towards Valid Student Simulation with Large Language Models

This paper presents a conceptual and methodological framework for large language model (LLM) based student simulation in educational settings. The authors identify a core failure mode, termed the "competence paradox" in which broadly capable LLMs are asked to emulate partially knowledgeable learners, leading to unrealistic error patterns and learning dynamics. To address this, the paper reframes student simulation as a constrained generation problem governed by an explicit Epistemic State Specification (ESS), which defines what a simulated learner can access, how errors are structured, and how learner state evolves over time. The work further introduces a Goal-by-Environment framework to situate simulated student systems according to behavioral objectives and deployment contexts. Rather than proposing a new system or benchmark, the paper synthesizes prior literature, formalizes key design dimensions, and articulates open challenges related to validity, evaluation, and ethical risks. Overall, the paper argues for epistemic fidelity over surface realism as a prerequisite for using LLM-based simulated students as reliable scientific and pedagogical instruments.

preprint2026arXiv

UniF$^2$ace: A Unified Fine-grained Face Understanding and Generation Model

Unified multimodal models (UMMs) have emerged as a powerful paradigm in fundamental cross-modality research, demonstrating significant potential in both image understanding and generation. However, existing research in the face domain primarily faces two challenges: $\textbf{(1)}$ $\textbf{fragmentation development}$, with existing methods failing to unify understanding and generation into a single one, hindering the way to artificial general intelligence. $\textbf{(2) lack of fine-grained facial attributes}$, which are crucial for high-fidelity applications. To handle those issues, we propose $\textbf{UniF$^2$ace}$, $\textit{the first UMM specifically tailored for fine-grained face understanding and generation}$. $\textbf{First}$, we introduce a novel theoretical framework with a Dual Discrete Diffusion (D3Diff) loss, unifying masked generative models with discrete score matching diffusion and leading to a more precise approximation of the negative log-likelihood. Moreover, this D3Diff significantly enhances the model's ability to synthesize high-fidelity facial details aligned with text input. $\textbf{Second}$, we propose a multi-level grouped Mixture-of-Experts architecture, adaptively incorporating the semantic and identity facial embeddings to complement the attribute forgotten phenomenon in representation evolvement. $\textbf{Finally}$, to this end, we construct UniF$^2$aceD-1M, a large-scale dataset comprising 130K fine-grained image-caption pairs and 1M visual question-answering pairs, spanning a much wider range of facial attributes than existing datasets. Extensive experiments demonstrate that UniF$^2$ace outperforms existing models with a similar scale in both understanding and generation tasks, with 7.1\% higher Desc-GPT and 6.6\% higher VQA-score, respectively.

preprint2025arXiv

High-performance quantum interconnect between bosonic modules beyond transmission loss constraints

Distributed quantum computing architectures require high-performance quantum interconnects between quantum information processing units, while previous implementations have been fundamentally limited by transmission line losses. Here, we demonstrate a low-loss interconnect between two superconducting modules using an aluminum coaxial cable, achieving a bus mode quality factor of 1.7e6. By employing SNAIL as couplers, we realize inter-modular state transfer in 0.8 μs via a three-wave mixing process. The state transfer fidelity reaches 98.2% for quantum states encoded in the first two energy levels, achieving a Bell state fidelity of 92.5%. Furthermore, we show the capability to transfer high-dimensional states by successfully transmitting binomially encoded logical states. Systematic characterization reveals that performance constraints have shifted from transmission line losses (contributing merely 0.2% infidelity) to module-channel interface effects and local Kerr nonlinearities. Our work advances the realization of quantum interconnects approaching fundamental capacity limits, paving the way for scalable distributed quantum computing and efficient quantum communications.