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Researcher profile

Kexin Huang

Kexin Huang contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Artificial IntelligenceMachine LearningComputation and Languagecs.CYDatabasesGenomicsQuantitative MethodsSound

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Published work

7 published item(s)

preprint2026arXiv

A Versatile AI Agent for Rare Disease Diagnosis and Risk Gene Prioritization

Accurate and timely diagnosis is essential for effective treatment, particularly in the context of rare diseases. However, current diagnostic workflows often lead to prolonged assessment times and low accuracy. To address these limitations, we introduce Hygieia, a multi-modal AI agent system designed to support precision disease diagnosis by integrating diverse data sources, including phenotypic features, genetic profiles, and clinical records. Hygieia features a router-based and knowledge-enhanced framework that mitigates hallucination and tailors diagnostic strategies to different disease categories. Notably, it prioritizes risk-related genomic factors for rare diseases and provides confidence scores to assist clinical decision-making. We conducted a comprehensive evaluation demonstrating that Hygieia achieves state-of-the-art performance across multiple diagnostic benchmarks. In collaboration with clinical experts from Yale School of Medicine and Duke-NUS Medical School, we further validated its practical utility by showing (1) Hygieia's superior diagnostic performance compared to physicians with an improvement from 12%-60% and (2) its effectiveness in assisting clinicians with medical records for handling real-world cases. Our findings indicate that Hygieia not only enhances diagnostic accuracy and interpretability but also significantly reduces clinician workload, highlighting its potential as a valuable tool in clinical decision support systems.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learning

General reasoning represents a long-standing and formidable challenge in artificial intelligence. Recent breakthroughs, exemplified by large language models (LLMs) and chain-of-thought prompting, have achieved considerable success on foundational reasoning tasks. However, this success is heavily contingent upon extensive human-annotated demonstrations, and models' capabilities are still insufficient for more complex problems. Here we show that the reasoning abilities of LLMs can be incentivized through pure reinforcement learning (RL), obviating the need for human-labeled reasoning trajectories. The proposed RL framework facilitates the emergent development of advanced reasoning patterns, such as self-reflection, verification, and dynamic strategy adaptation. Consequently, the trained model achieves superior performance on verifiable tasks such as mathematics, coding competitions, and STEM fields, surpassing its counterparts trained via conventional supervised learning on human demonstrations. Moreover, the emergent reasoning patterns exhibited by these large-scale models can be systematically harnessed to guide and enhance the reasoning capabilities of smaller models.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

WESR: Scaling and Evaluating Word-level Event-Speech Recognition

Speech conveys not only linguistic information but also rich non-verbal vocal events such as laughing and crying. While semantic transcription is well-studied, the precise localization of non-verbal events remains a critical yet under-explored challenge. Current methods suffer from insufficient task definitions with limited category coverage and ambiguous temporal granularity. They also lack standardized evaluation frameworks, hindering the development of downstream applications. To bridge this gap, we first develop a refined taxonomy of 21 vocal events, with a new categorization into discrete (standalone) versus continuous (mixed with speech) types. Based on the refined taxonomy, we introduce WESR-Bench, an expert-annotated evaluation set (900+ utterances) with a novel position-aware protocol that disentangles ASR errors from event detection, enabling precise localization measurement for both discrete and continuous events. We also build a strong baseline by constructing a 1,700+ hour corpus, and train specialized models, surpassing both open-source audio-language models and commercial APIs while preserving ASR quality. We anticipate that WESR will serve as a foundational resource for future research in modeling rich, real-world auditory scenes.

0 citations0 reviewsNo code linkedOpen access
preprint2023arXiv

Learn to Explore: on Bootstrapping Interactive Data Exploration with Meta-learning

Interactive data exploration (IDE) is an effective way of comprehending big data, whose volume and complexity are beyond human abilities. The main goal of IDE is to discover user interest regions from a database through multi-rounds of user labelling. Existing IDEs adopt active-learning framework, where users iteratively discriminate or label the interestingness of selected tuples. The process of data exploration can be viewed as the process of training a classifier, which determines whether a database tuple is interesting to a user. An efficient exploration thus takes very few iterations of user labelling to reach the data region of interest. In this work, we consider the data exploration as the process of few-shot learning, where the classifier is learned with only a few training examples, or exploration iterations. To this end, we propose a learning-to-explore framework, based on meta-learning, which learns how to learn a classifier with automatically generated meta-tasks, so that the exploration process can be much shortened. Extensive experiments on real datasets show that our proposal outperforms existing explore-by-example solutions in terms of accuracy and efficiency.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

HINT: Hierarchical Interaction Network for Trial Outcome Prediction Leveraging Web Data

Clinical trials are crucial for drug development but are time consuming, expensive, and often burdensome on patients. More importantly, clinical trials face uncertain outcomes due to issues with efficacy, safety, or problems with patient recruitment. If we were better at predicting the results of clinical trials, we could avoid having to run trials that will inevitably fail more resources could be devoted to trials that are likely to succeed. In this paper, we propose Hierarchical INteraction Network (HINT) for more general, clinical trial outcome predictions for all diseases based on a comprehensive and diverse set of web data including molecule information of the drugs, target disease information, trial protocol and biomedical knowledge. HINT first encode these multi-modal data into latent embeddings, where an imputation module is designed to handle missing data. Next, these embeddings will be fed into the knowledge embedding module to generate knowledge embeddings that are pretrained using external knowledge on pharmaco-kinetic properties and trial risk from the web. Then the interaction graph module will connect all the embedding via domain knowledge to fully capture various trial components and their complex relations as well as their influences on trial outcomes. Finally, HINT learns a dynamic attentive graph neural network to predict trial outcome. Comprehensive experimental results show that HINT achieves strong predictive performance, obtaining 0.772, 0.607, 0.623, 0.703 on PR-AUC for Phase I, II, III, and indication outcome prediction, respectively. It also consistently outperforms the best baseline method by up to 12.4\% on PR-AUC.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Graph Meta Learning via Local Subgraphs

Prevailing methods for graphs require abundant label and edge information for learning. When data for a new task are scarce, meta-learning can learn from prior experiences and form much-needed inductive biases for fast adaption to new tasks. Here, we introduce G-Meta, a novel meta-learning algorithm for graphs. G-Meta uses local subgraphs to transfer subgraph-specific information and learn transferable knowledge faster via meta gradients. G-Meta learns how to quickly adapt to a new task using only a handful of nodes or edges in the new task and does so by learning from data points in other graphs or related, albeit disjoint label sets. G-Meta is theoretically justified as we show that the evidence for a prediction can be found in the local subgraph surrounding the target node or edge. Experiments on seven datasets and nine baseline methods show that G-Meta outperforms existing methods by up to 16.3%. Unlike previous methods, G-Meta successfully learns in challenging, few-shot learning settings that require generalization to completely new graphs and never-before-seen labels. Finally, G-Meta scales to large graphs, which we demonstrate on a new Tree-of-Life dataset comprising of 1,840 graphs, a two-orders of magnitude increase in the number of graphs used in prior work.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

scGNN: scRNA-seq Dropout Imputation via Induced Hierarchical Cell Similarity Graph

Single-cell RNA sequencing provides tremendous insights to understand biological systems. However, the noise from dropout can corrupt the downstream biological analysis. Hence, it is desirable to impute the dropouts accurately. In this work, we propose a simple and powerful dropout imputation method (scGNN) by applying a bottlenecked Graph Convolutional Neural Network on an induced hierarchical cell similarity graph. We show scGNN has competitive performance against state-of-the-art baselines across three datasets and can improve downstream analysis.

0 citations0 reviewsNo code linkedOpen access