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Published work

31 published item(s)

preprint2026arXiv

CD4LM: Consistency Distillation and aDaptive Decoding for Diffusion Language Models

Autoregressive large language models achieve strong results on many benchmarks, but decoding remains fundamentally latency-limited by sequential dependence on previously generated tokens. Diffusion language models (DLMs) promise parallel generation but suffer from a fundamental static-to-dynamic misalignment: Training optimizes local transitions under fixed schedules, whereas efficient inference requires adaptive "long-jump" refinements through unseen states. Our goal is to enable highly parallel decoding for DLMs with low number of function evaluations while preserving generation quality. To achieve this, we propose CD4LM, a framework that decouples training from inference via Discrete-Space Consistency Distillation (DSCD) and Confidence-Adaptive Decoding (CAD). Unlike standard objectives, DSCD trains a student to be trajectory-invariant, mapping diverse noisy states directly to the clean distribution. This intrinsic robustness enables CAD to dynamically allocate compute resources based on token confidence, aggressively skipping steps without the quality collapse typical of heuristic acceleration. On GSM8K, CD4LM matches the LLaDA baseline with a 5.18x wall-clock speedup; across code and math benchmarks, it strictly dominates the accuracy-efficiency Pareto frontier, achieving a 3.62x mean speedup while improving average accuracy. Code is available at https://github.com/yihao-liang/CDLM

preprint2026arXiv

MemEye: A Visual-Centric Evaluation Framework for Multimodal Agent Memory

Long-term agent memory is increasingly multimodal, yet existing evaluations rarely test whether agents preserve the visual evidence needed for later reasoning. In prior work, many visually grounded questions can be answered using only captions or textual traces, allowing answers to be inferred without preserving the fine-grained visual evidence. Meanwhile, harder cases that require reasoning over changing visual states are largely absent. Therefore, we introduce MemEye, a framework that evaluates memory capabilities from two dimensions: one measures the granularity of decisive visual evidence (from scene-level to pixel-level evidence), and the other measures how retrieved evidence must be used (from single evidence to evolutionary synthesis). Under this framework, we construct a new benchmark across 8 life-scenario tasks, with ablation-driven validation gates for assessing answerability, shortcut resistance, visual necessity, and reasoning structure. By evaluating 13 memory methods across 4 VLM backbones, we show that current architectures still struggle to preserve fine-grained visual details and reason about state changes over time. Our findings show that long-term multimodal memory depends on evidence routing, temporal tracking, and detail extraction.

preprint2026arXiv

Micro-Defects Expose Macro-Fakes: Detecting AI-Generated Images via Local Distributional Shifts

Recent generative models can produce images that appear highly realistic, raising challenges in distinguishing real and AI-generated images. Yet existing detectors based on pre-trained feature extractors tend to over-rely on global semantics, limiting sensitivity to the critical micro-defects. In this work, we propose Micro-Defects expose Macro-Fakes (MDMF), a local distribution-aware detection framework that amplifies micro-scale statistical irregularities into macro-level distributional discrepancies. To avoid localized forensic cues being diluted by plain aggregation, we introduce a learnable Patch Forensic Signature that projects semantic patch embeddings into a compact forensic latent space. We then use Maximum Mean Discrepancy (MMD) to quantify distributional discrepancies between generated and real images. Our theory-grounded analysis shows that patch-wise modeling yields provably larger discrepancies when localized forensic signals are present in generated images, enabling more reliable separation from real images. Extensive experiments demonstrate that MDMF consistently outperforms baseline detectors across multiple benchmarks, validating its general effectiveness. Project page: https://zbox1005.github.io/MDMF-project/

preprint2026arXiv

Plasticine: A Traceable Diffusion Model for Medical Image Translation

Domain gaps arising from variations in imaging devices and population distributions pose significant challenges for machine learning in medical image analysis. Existing image-to-image translation methods primarily aim to learn mappings between domains, often generating diverse synthetic data with variations in anatomical scale and shape, but they usually overlook spatial correspondence during the translation process. For clinical applications, traceability, defined as the ability to provide pixel-level correspondences between original and translated images, is equally important. This property enhances clinical interpretability but has been largely overlooked in previous approaches. To address this gap, we propose Plasticine, which is, to the best of our knowledge, the first end-to-end image-to-image translation framework explicitly designed with traceability as a core objective. Our method combines intensity translation and spatial transformation within a denoising diffusion framework. This design enables the generation of synthetic images with interpretable intensity transitions and spatially coherent deformations, supporting pixel-wise traceability throughout the translation process.

preprint2025arXiv

Pathology Context Recalibration Network for Ocular Disease Recognition

Pathology context and expert experience play significant roles in clinical ocular disease diagnosis. Although deep neural networks (DNNs) have good ocular disease recognition results, they often ignore exploring the clinical pathology context and expert experience priors to improve ocular disease recognition performance and decision-making interpretability. To this end, we first develop a novel Pathology Recalibration Module (PRM) to leverage the potential of pathology context prior via the combination of the well-designed pixel-wise context compression operator and pathology distribution concentration operator; then this paper applies a novel expert prior Guidance Adapter (EPGA) to further highlight significant pixel-wise representation regions by fully mining the expert experience prior. By incorporating PRM and EPGA into the modern DNN, the PCRNet is constructed for automated ocular disease recognition. Additionally, we introduce an Integrated Loss (IL) to boost the ocular disease recognition performance of PCRNet by considering the effects of sample-wise loss distributions and training label frequencies. The extensive experiments on three ocular disease datasets demonstrate the superiority of PCRNet with IL over state-of-the-art attention-based networks and advanced loss methods. Further visualization analysis explains the inherent behavior of PRM and EPGA that affects the decision-making process of DNNs.

preprint2022arXiv

Machine Learning for Cataract Classification and Grading on Ophthalmic Imaging Modalities: A Survey

Cataracts are the leading cause of visual impairment and blindness globally. Over the years, researchers have achieved significant progress in developing state-of-the-art machine learning techniques for automatic cataract classification and grading, aiming to prevent cataracts early and improve clinicians' diagnosis efficiency. This survey provides a comprehensive survey of recent advances in machine learning techniques for cataract classification/grading based on ophthalmic images. We summarize existing literature from two research directions: conventional machine learning methods and deep learning methods. This survey also provides insights into existing works of both merits and limitations. In addition, we discuss several challenges of automatic cataract classification/grading based on machine learning techniques and present possible solutions to these challenges for future research.

preprint2022arXiv

Retinal Structure Detection in OCTA Image via Voting-based Multi-task Learning

Automated detection of retinal structures, such as retinal vessels (RV), the foveal avascular zone (FAZ), and retinal vascular junctions (RVJ), are of great importance for understanding diseases of the eye and clinical decision-making. In this paper, we propose a novel Voting-based Adaptive Feature Fusion multi-task network (VAFF-Net) for joint segmentation, detection, and classification of RV, FAZ, and RVJ in optical coherence tomography angiography (OCTA). A task-specific voting gate module is proposed to adaptively extract and fuse different features for specific tasks at two levels: features at different spatial positions from a single encoder, and features from multiple encoders. In particular, since the complexity of the microvasculature in OCTA images makes simultaneous precise localization and classification of retinal vascular junctions into bifurcation/crossing a challenging task, we specifically design a task head by combining the heatmap regression and grid classification. We take advantage of three different \textit{en face} angiograms from various retinal layers, rather than following existing methods that use only a single \textit{en face}. To facilitate further research, part of these datasets with the source code and evaluation benchmark have been released for public access:https://github.com/iMED-Lab/VAFF-Net.

preprint2022arXiv

Segment and Complete: Defending Object Detectors against Adversarial Patch Attacks with Robust Patch Detection

Object detection plays a key role in many security-critical systems. Adversarial patch attacks, which are easy to implement in the physical world, pose a serious threat to state-of-the-art object detectors. Developing reliable defenses for object detectors against patch attacks is critical but severely understudied. In this paper, we propose Segment and Complete defense (SAC), a general framework for defending object detectors against patch attacks through detection and removal of adversarial patches. We first train a patch segmenter that outputs patch masks which provide pixel-level localization of adversarial patches. We then propose a self adversarial training algorithm to robustify the patch segmenter. In addition, we design a robust shape completion algorithm, which is guaranteed to remove the entire patch from the images if the outputs of the patch segmenter are within a certain Hamming distance of the ground-truth patch masks. Our experiments on COCO and xView datasets demonstrate that SAC achieves superior robustness even under strong adaptive attacks with no reduction in performance on clean images, and generalizes well to unseen patch shapes, attack budgets, and unseen attack methods. Furthermore, we present the APRICOT-Mask dataset, which augments the APRICOT dataset with pixel-level annotations of adversarial patches. We show SAC can significantly reduce the targeted attack success rate of physical patch attacks. Our code is available at https://github.com/joellliu/SegmentAndComplete.

preprint2022arXiv

Siamese Encoder-based Spatial-Temporal Mixer for Growth Trend Prediction of Lung Nodules on CT Scans

In the management of lung nodules, we are desirable to predict nodule evolution in terms of its diameter variation on Computed Tomography (CT) scans and then provide a follow-up recommendation according to the predicted result of the growing trend of the nodule. In order to improve the performance of growth trend prediction for lung nodules, it is vital to compare the changes of the same nodule in consecutive CT scans. Motivated by this, we screened out 4,666 subjects with more than two consecutive CT scans from the National Lung Screening Trial (NLST) dataset to organize a temporal dataset called NLSTt. In specific, we first detect and pair regions of interest (ROIs) covering the same nodule based on registered CT scans. After that, we predict the texture category and diameter size of the nodules through models. Last, we annotate the evolution class of each nodule according to its changes in diameter. Based on the built NLSTt dataset, we propose a siamese encoder to simultaneously exploit the discriminative features of 3D ROIs detected from consecutive CT scans. Then we novelly design a spatial-temporal mixer (STM) to leverage the interval changes of the same nodule in sequential 3D ROIs and capture spatial dependencies of nodule regions and the current 3D ROI. According to the clinical diagnosis routine, we employ hierarchical loss to pay more attention to growing nodules. The extensive experiments on our organized dataset demonstrate the advantage of our proposed method. We also conduct experiments on an in-house dataset to evaluate the clinical utility of our method by comparing it against skilled clinicians.

preprint2022arXiv

Structure-consistent Restoration Network for Cataract Fundus Image Enhancement

Fundus photography is a routine examination in clinics to diagnose and monitor ocular diseases. However, for cataract patients, the fundus image always suffers quality degradation caused by the clouding lens. The degradation prevents reliable diagnosis by ophthalmologists or computer-aided systems. To improve the certainty in clinical diagnosis, restoration algorithms have been proposed to enhance the quality of fundus images. Unfortunately, challenges remain in the deployment of these algorithms, such as collecting sufficient training data and preserving retinal structures. In this paper, to circumvent the strict deployment requirement, a structure-consistent restoration network (SCR-Net) for cataract fundus images is developed from synthesized data that shares an identical structure. A cataract simulation model is firstly designed to collect synthesized cataract sets (SCS) formed by cataract fundus images sharing identical structures. Then high-frequency components (HFCs) are extracted from the SCS to constrain structure consistency such that the structure preservation in SCR-Net is enforced. The experiments demonstrate the effectiveness of SCR-Net in the comparison with state-of-the-art methods and the follow-up clinical applications. The code is available at https://github.com/liamheng/ArcNet-Medical-Image-Enhancement.

preprint2022arXiv

SuperVessel: Segmenting High-resolution Vessel from Low-resolution Retinal Image

Vascular segmentation extracts blood vessels from images and serves as the basis for diagnosing various diseases, like ophthalmic diseases. Ophthalmologists often require high-resolution segmentation results for analysis, which leads to super-computational load by most existing methods. If based on low-resolution input, they easily ignore tiny vessels or cause discontinuity of segmented vessels. To solve these problems, the paper proposes an algorithm named SuperVessel, which gives out high-resolution and accurate vessel segmentation using low-resolution images as input. We first take super-resolution as our auxiliary branch to provide potential high-resolution detail features, which can be deleted in the test phase. Secondly, we propose two modules to enhance the features of the interested segmentation region, including an upsampling with feature decomposition (UFD) module and a feature interaction module (FIM) with a constraining loss to focus on the interested features. Extensive experiments on three publicly available datasets demonstrate that our proposed SuperVessel can segment more tiny vessels with higher segmentation accuracy IoU over 6%, compared with other state-of-the-art algorithms. Besides, the stability of SuperVessel is also stronger than other algorithms. We will release the code after the paper is published.

preprint2022arXiv

Weighted Concordance Index Loss-based Multimodal Survival Modeling for Radiation Encephalopathy Assessment in Nasopharyngeal Carcinoma Radiotherapy

Radiation encephalopathy (REP) is the most common complication for nasopharyngeal carcinoma (NPC) radiotherapy. It is highly desirable to assist clinicians in optimizing the NPC radiotherapy regimen to reduce radiotherapy-induced temporal lobe injury (RTLI) according to the probability of REP onset. To the best of our knowledge, it is the first exploration of predicting radiotherapy-induced REP by jointly exploiting image and non-image data in NPC radiotherapy regimen. We cast REP prediction as a survival analysis task and evaluate the predictive accuracy in terms of the concordance index (CI). We design a deep multimodal survival network (MSN) with two feature extractors to learn discriminative features from multimodal data. One feature extractor imposes feature selection on non-image data, and the other learns visual features from images. Because the priorly balanced CI (BCI) loss function directly maximizing the CI is sensitive to uneven sampling per batch. Hence, we propose a novel weighted CI (WCI) loss function to leverage all REP samples effectively by assigning their different weights with a dual average operation. We further introduce a temperature hyper-parameter for our WCI to sharpen the risk difference of sample pairs to help model convergence. We extensively evaluate our WCI on a private dataset to demonstrate its favourability against its counterparts. The experimental results also show multimodal data of NPC radiotherapy can bring more gains for REP risk prediction.

preprint2021arXiv

3D Vessel Reconstruction in OCT-Angiography via Depth Map Estimation

Optical Coherence Tomography Angiography (OCTA) has been increasingly used in the management of eye and systemic diseases in recent years. Manual or automatic analysis of blood vessel in 2D OCTA images (en face angiograms) is commonly used in clinical practice, however it may lose rich 3D spatial distribution information of blood vessels or capillaries that are useful for clinical decision-making. In this paper, we introduce a novel 3D vessel reconstruction framework based on the estimation of vessel depth maps from OCTA images. First, we design a network with structural constraints to predict the depth of blood vessels in OCTA images. In order to promote the accuracy of the predicted depth map at both the overall structure- and pixel- level, we combine MSE and SSIM loss as the training loss function. Finally, the 3D vessel reconstruction is achieved by utilizing the estimated depth map and 2D vessel segmentation results. Experimental results demonstrate that our method is effective in the depth prediction and 3D vessel reconstruction for OCTA images.% results may be used to guide subsequent vascular analysis

preprint2021arXiv

Deep Triplet Hashing Network for Case-based Medical Image Retrieval

Deep hashing methods have been shown to be the most efficient approximate nearest neighbor search techniques for large-scale image retrieval. However, existing deep hashing methods have a poor small-sample ranking performance for case-based medical image retrieval. The top-ranked images in the returned query results may be as a different class than the query image. This ranking problem is caused by classification, regions of interest (ROI), and small-sample information loss in the hashing space. To address the ranking problem, we propose an end-to-end framework, called Attention-based Triplet Hashing (ATH) network, to learn low-dimensional hash codes that preserve the classification, ROI, and small-sample information. We embed a spatial-attention module into the network structure of our ATH to focus on ROI information. The spatial-attention module aggregates the spatial information of feature maps by utilizing max-pooling, element-wise maximum, and element-wise mean operations jointly along the channel axis. The triplet cross-entropy loss can help to map the classification information of images and similarity between images into the hash codes. Extensive experiments on two case-based medical datasets demonstrate that our proposed ATH can further improve the retrieval performance compared to the state-of-the-art deep hashing methods and boost the ranking performance for small samples. Compared to the other loss methods, the triplet cross-entropy loss can enhance the classification performance and hash code-discriminability

preprint2020arXiv

A Two-Stream Meticulous Processing Network for Retinal Vessel Segmentation

Vessel segmentation in fundus is a key diagnostic capability in ophthalmology, and there are various challenges remained in this essential task. Early approaches indicate that it is often difficult to obtain desirable segmentation performance on thin vessels and boundary areas due to the imbalance of vessel pixels with different thickness levels. In this paper, we propose a novel two-stream Meticulous-Processing Network (MP-Net) for tackling this problem. To pay more attention to the thin vessels and boundary areas, we firstly propose an efficient hierarchical model automatically stratifies the ground-truth masks into different thickness levels. Then a novel two-stream adversarial network is introduced to use the stratification results with a balanced loss function and an integration operation to achieve a better performance, especially in thin vessels and boundary areas detecting. Our model is proved to outperform state-of-the-art methods on DRIVE, STARE, and CHASE_DB1 datasets.

preprint2020arXiv

AGE Challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography

Angle closure glaucoma (ACG) is a more aggressive disease than open-angle glaucoma, where the abnormal anatomical structures of the anterior chamber angle (ACA) may cause an elevated intraocular pressure and gradually lead to glaucomatous optic neuropathy and eventually to visual impairment and blindness. Anterior Segment Optical Coherence Tomography (AS-OCT) imaging provides a fast and contactless way to discriminate angle closure from open angle. Although many medical image analysis algorithms have been developed for glaucoma diagnosis, only a few studies have focused on AS-OCT imaging. In particular, there is no public AS-OCT dataset available for evaluating the existing methods in a uniform way, which limits progress in the development of automated techniques for angle closure detection and assessment. To address this, we organized the Angle closure Glaucoma Evaluation challenge (AGE), held in conjunction with MICCAI 2019. The AGE challenge consisted of two tasks: scleral spur localization and angle closure classification. For this challenge, we released a large dataset of 4800 annotated AS-OCT images from 199 patients, and also proposed an evaluation framework to benchmark and compare different models. During the AGE challenge, over 200 teams registered online, and more than 1100 results were submitted for online evaluation. Finally, eight teams participated in the onsite challenge. In this paper, we summarize these eight onsite challenge methods and analyze their corresponding results for the two tasks. We further discuss limitations and future directions. In the AGE challenge, the top-performing approach had an average Euclidean Distance of 10 pixels (10um) in scleral spur localization, while in the task of angle closure classification, all the algorithms achieved satisfactory performances, with two best obtaining an accuracy rate of 100%.

preprint2020arXiv

An Optimization Approach to Jacobian Conjecture

Let $n\geq 2$ and $\mathbb K $ be a number field of characteristic $0$. Jacobian Conjecture asserts for a polynomial map $\mathcal P$ from $\mathbb K ^n$ to itself, if the determinant of its Jacobian matrix is a nonzero constant in $\mathbb K $ then the inverse $\mathcal P^{-1}$ exists and is also a polynomial map. This conjecture was firstly proposed by Keller in 1939 for $\mathbb K ^n=\mathbb C^2$ and put in Smale's 1998 list of Mathematical Problems for the Next Century. This study is going to present a proof for the conjecture. Our proof is based on Dru{ż}kowski Map and Hadamard's Diffeomorphism Theorem, and additionally uses some optimization idea.

preprint2020arXiv

Attention-based Saliency Hashing for Ophthalmic Image Retrieval

Deep hashing methods have been proved to be effective for the large-scale medical image search assisting reference-based diagnosis for clinicians. However, when the salient region plays a maximal discriminative role in ophthalmic image, existing deep hashing methods do not fully exploit the learning ability of the deep network to capture the features of salient regions pointedly. The different grades or classes of ophthalmic images may be share similar overall performance but have subtle differences that can be differentiated by mining salient regions. To address this issue, we propose a novel end-to-end network, named Attention-based Saliency Hashing (ASH), for learning compact hash-code to represent ophthalmic images. ASH embeds a spatial-attention module to focus more on the representation of salient regions and highlights their essential role in differentiating ophthalmic images. Benefiting from the spatial-attention module, the information of salient regions can be mapped into the hash-code for similarity calculation. In the training stage, we input the image pairs to share the weights of the network, and a pairwise loss is designed to maximize the discriminability of the hash-code. In the retrieval stage, ASH obtains the hash-code by inputting an image with an end-to-end manner, then the hash-code is used to similarity calculation to return the most similar images. Extensive experiments on two different modalities of ophthalmic image datasets demonstrate that the proposed ASH can further improve the retrieval performance compared to the state-of-the-art deep hashing methods due to the huge contributions of the spatial-attention module.

preprint2020arXiv

Automatic Segmentation and Visualization of Choroid in OCT with Knowledge Infused Deep Learning

The choroid provides oxygen and nourishment to the outer retina thus is related to the pathology of various ocular diseases. Optical coherence tomography (OCT) is advantageous in visualizing and quantifying the choroid in vivo. (1) The lower boundary of the choroid (choroid-sclera interface) in OCT is fuzzy, which makes the automatic segmentation difficult and inaccurate. (2) The visualization of the choroid is hindered by the vessel shadows from the superficial layers of the inner retina. In this paper, we propose to incorporate medical and imaging prior knowledge with deep learning to address these two problems. We propose a biomarker infused global-to-local network for the choroid segmentation. It leverages the choroidal thickness, a primary biomarker in clinic, as a constraint to improve the segmentation accuracy. We also design a global-to-local strategy in the choroid segmentation: a global module is used to segment all the retinal and choroidal layers simultaneously for suppressing overfitting and providing global structure information, then a local module is used to refine the segmentation with the biomarker infusion. To eliminate the retinal vessel shadows, we propose a pipeline that firstly use anatomical and OCT imaging knowledge to locate the shadows using their projection on the retinal pigment epithelium layer, then the contents of the choroidal vasculature at the shadow locations are predicted with an edge-to-texture generative adversarial inpainting network. The experiments show our method outperforms the existing methods on both the segmentation and shadow elimination tasks. We further apply the proposed method in a clinical prospective study for understanding the pathology of glaucoma by detecting the structure and vascular changes of the choroid related to the elevation of intra-ocular pressure.

preprint2020arXiv

Beamforming Through Reconfigurable Intelligent Surfaces in Single-User MIMO Systems: SNR Distribution and Scaling Laws in the Presence of Channel Fading and Phase Noise

We consider a fading channel in which a multi-antenna transmitter communicates with a multi-antenna receiver through a reconfigurable intelligent surface (RIS) that is made of $N$ reconfigurable passive scatterers impaired by phase noise. The beamforming vector at the transmitter, the combining vector at the receiver, and the phase shifts of the $N$ scatterers are optimized in order to maximize the signal-to-noise-ratio (SNR) at the receiver. By assuming Rayleigh fading (or line-of-sight propagation) on the transmitter-RIS link and Rayleigh fading on the RIS-receiver link, we prove that the SNR is a random variable that is equivalent in distribution to the product of three (or two) independent random variables whose distributions are approximated by two (or one) gamma random variables and the sum of two scaled non-central chi-square random variables. The proposed analytical framework allows us to quantify the robustness of RIS-aided transmission to fading channels. For example, we prove that the amount of fading experienced on the transmitter-RIS-receiver channel linearly decreases with $N$. This proves that RISs of large size can be effectively employed to make fading less severe and wireless channels more reliable.

preprint2020arXiv

Calibrated Intervention and Containment of the COVID-19 Pandemic

Within a short period of time, COVID-19 grew into a world-wide pandemic. Transmission by pre-symptomatic and asymptomatic viral carriers rendered intervention and containment of the disease extremely challenging. Based on reported infection case studies, we construct an epidemiological model that focuses on transmission around the symptom onset. The model is calibrated against incubation period and pairwise transmission statistics during the initial outbreaks of the pandemic outside Wuhan with minimal non-pharmaceutical interventions. Mathematical treatment of the model yields explicit expressions for the size of latent and pre-symptomatic subpopulations during the exponential growth phase, with the local epidemic growth rate as input. We then explore reduction of the basic reproduction number R_0 through specific disease control measures such as contact tracing, testing, social distancing, wearing masks and sheltering in place. When these measures are implemented in combination, their effects on R_0 multiply. We also compare our model behaviour to the first wave of the COVID-19 spreading in various affected regions and highlight generic and less generic features of the pandemic development.

preprint2020arXiv

Digital resolution enhancement in low transverse sampling optical coherence tomography angiography using deep learning

Optical coherence tomography angiography (OCTA) requires high transverse sampling density for visualizing retinal and choroidal capillaries. Low transverse sampling causes resolution degradation, such as the angiograms in wide-field OCTA. In this paper, we propose to address this problem using deep learning. We conducted extensive experiments on converting the centrally cropped 3 x 3 mm2 field of view (FOV) of the 8 x 8 mm2 foveal OCTA images (a sampling density of 22.9 $μ$m) to the native 3 x 3 mm2 en face OCTA images (a sampling density of 12.2 $μ$m). We employed a cycle-consistent adversarial network architecture in this conversion. The quantitative analysis using the perceptual similarity measures shows the generated OCTA images are closer to the native 3 x 3 mm2 scans. Besides, the results show the proposed method could also enhance signal-to-noise ratio. We further applied our method to enhance diseased cases and calculate vascular biomarkers, which demonstrates its generalization performance and clinical perspective.

preprint2020arXiv

Encoding Structure-Texture Relation with P-Net for Anomaly Detection in Retinal Images

Anomaly detection in retinal image refers to the identification of abnormality caused by various retinal diseases/lesions, by only leveraging normal images in training phase. Normal images from healthy subjects often have regular structures (e.g., the structured blood vessels in the fundus image, or structured anatomy in optical coherence tomography image). On the contrary, the diseases and lesions often destroy these structures. Motivated by this, we propose to leverage the relation between the image texture and structure to design a deep neural network for anomaly detection. Specifically, we first extract the structure of the retinal images, then we combine both the structure features and the last layer features extracted from original health image to reconstruct the original input healthy image. The image feature provides the texture information and guarantees the uniqueness of the image recovered from the structure. In the end, we further utilize the reconstructed image to extract the structure and measure the difference between structure extracted from original and the reconstructed image. On the one hand, minimizing the reconstruction difference behaves like a regularizer to guarantee that the image is corrected reconstructed. On the other hand, such structure difference can also be used as a metric for normality measurement. The whole network is termed as P-Net because it has a ``P'' shape. Extensive experiments on RESC dataset and iSee dataset validate the effectiveness of our approach for anomaly detection in retinal images. Further, our method also generalizes well to novel class discovery in retinal images and anomaly detection in real-world images.

preprint2020arXiv

Evaluation of Retinal Image Quality Assessment Networks in Different Color-spaces

Retinal image quality assessment (RIQA) is essential for controlling the quality of retinal imaging and guaranteeing the reliability of diagnoses by ophthalmologists or automated analysis systems. Existing RIQA methods focus on the RGB color-space and are developed based on small datasets with binary quality labels (i.e., `Accept' and `Reject'). In this paper, we first re-annotate an Eye-Quality (EyeQ) dataset with 28,792 retinal images from the EyePACS dataset, based on a three-level quality grading system (i.e., `Good', `Usable' and `Reject') for evaluating RIQA methods. Our RIQA dataset is characterized by its large-scale size, multi-level grading, and multi-modality. Then, we analyze the influences on RIQA of different color-spaces, and propose a simple yet efficient deep network, named Multiple Color-space Fusion Network (MCF-Net), which integrates the different color-space representations at both a feature-level and prediction-level to predict image quality grades. Experiments on our EyeQ dataset show that our MCF-Net obtains a state-of-the-art performance, outperforming the other deep learning methods. Furthermore, we also evaluate diabetic retinopathy (DR) detection methods on images of different quality, and demonstrate that the performances of automated diagnostic systems are highly dependent on image quality.

preprint2020arXiv

High signal-to-noise ratio reconstruction of low bit-depth optical coherence tomography using deep learning

Reducing the bit-depth is an effective approach to lower the cost of optical coherence tomography (OCT) systems and increase the transmission efficiency in data acquisition and telemedicine. However, a low bit-depth will lead to the degeneration of the detection sensitivity thus reduce the signal-to-noise ratio (SNR) of OCT images. In this paper, we propose to use deep learning for the reconstruction of the high SNR OCT images from the low bit-depth acquisition. Its feasibility was preliminarily evaluated by applying the proposed method to the quantized $3\sim8$-bit data from native 12-bit interference fringes. We employed a pixel-to-pixel generative adversarial network architecture in the low to high bit-depth OCT image transition. Retinal OCT data of a healthy subject from a homemade spectral-domain OCT system was used in the study. Extensively qualitative and quantitative results show this deep-learning-based approach could significantly improve the SNR of the low bit-depth OCT images especially at the choroidal region. Superior similarity and SNR between the reconstructed images and the original 12-bit OCT images could be derived when the bit-depth $\geq 5$. This work demonstrates the proper integration of OCT and deep learning could benefit the development of healthcare in low-resource settings.

preprint2020arXiv

Lossless Attention in Convolutional Networks for Facial Expression Recognition in the Wild

Unlike the constraint frontal face condition, faces in the wild have various unconstrained interference factors, such as complex illumination, changing perspective and various occlusions. Facial expressions recognition (FER) in the wild is a challenging task and existing methods can't perform well. However, for occluded faces (containing occlusion caused by other objects and self-occlusion caused by head posture changes), the attention mechanism has the ability to focus on the non-occluded regions automatically. In this paper, we propose a Lossless Attention Model (LLAM) for convolutional neural networks (CNN) to extract attention-aware features from faces. Our module avoids decay information in the process of generating attention maps by using the information of the previous layer and not reducing the dimensionality. Sequentially, we adaptively refine the feature responses by fusing the attention map with the feature map. We participate in the seven basic expression classification sub-challenges of FG-2020 Affective Behavior Analysis in-the-wild Challenge. And we validate our method on the Aff-Wild2 datasets released by the Challenge. The total accuracy (Accuracy) and the unweighted mean (F1) of our method on the validation set are 0.49 and 0.38 respectively, and the final result is 0.42 (0.67 F1-Score + 0.33 Accuracy).

preprint2020arXiv

Open-Narrow-Synechiae Anterior Chamber Angle Classification in AS-OCT Sequences

Anterior chamber angle (ACA) classification is a key step in the diagnosis of angle-closure glaucoma in Anterior Segment Optical Coherence Tomography (AS-OCT). Existing automated analysis methods focus on a binary classification system (i.e., open angle or angle-closure) in a 2D AS-OCT slice. However, clinical diagnosis requires a more discriminating ACA three-class system (i.e., open, narrow, or synechiae angles) for the benefit of clinicians who seek better to understand the progression of the spectrum of angle-closure glaucoma types. To address this, we propose a novel sequence multi-scale aggregation deep network (SMA-Net) for open-narrow-synechiae ACA classification based on an AS-OCT sequence. In our method, a Multi-Scale Discriminative Aggregation (MSDA) block is utilized to learn the multi-scale representations at slice level, while a ConvLSTM is introduced to study the temporal dynamics of these representations at sequence level. Finally, a multi-level loss function is used to combine the slice-based and sequence-based losses. The proposed method is evaluated across two AS-OCT datasets. The experimental results show that the proposed method outperforms existing state-of-the-art methods in applicability, effectiveness, and accuracy. We believe this work to be the first attempt to classify ACAs into open, narrow, or synechia types grading using AS-OCT sequences.

preprint2020arXiv

Reconstruction and Quantification of 3D Iris Surface for Angle-Closure Glaucoma Detection in Anterior Segment OCT

Precise characterization and analysis of iris shape from Anterior Segment OCT (AS-OCT) are of great importance in facilitating diagnosis of angle-closure-related diseases. Existing methods focus solely on analyzing structural properties identified from the 2D slice, while accurate characterization of morphological changes of iris shape in 3D AS-OCT may be able to reveal in addition the risk of disease progression. In this paper, we propose a novel framework for reconstruction and quantification of 3D iris surface from AS-OCT imagery. We consider it to be the first work to detect angle-closure glaucoma by means of 3D representation. An iris segmentation network with wavelet refinement block (WRB) is first proposed to generate the initial shape of the iris from single AS-OCT slice. The 3D iris surface is then reconstructed using a guided optimization method with Poisson-disk sampling. Finally, a set of surface-based features are extracted, which are used in detecting of angle-closure glaucoma. Experimental results demonstrate that our method is highly effective in iris segmentation and surface reconstruction. Moreover, we show that 3D-based representation achieves better performance in angle-closure glaucoma detection than does 2D-based feature.

preprint2020arXiv

Sparse-GAN: Sparsity-constrained Generative Adversarial Network for Anomaly Detection in Retinal OCT Image

With the development of convolutional neural network, deep learning has shown its success for retinal disease detection from optical coherence tomography (OCT) images. However, deep learning often relies on large scale labelled data for training, which is oftentimes challenging especially for disease with low occurrence. Moreover, a deep learning system trained from data-set with one or a few diseases is unable to detect other unseen diseases, which limits the practical usage of the system in disease screening. To address the limitation, we propose a novel anomaly detection framework termed Sparsity-constrained Generative Adversarial Network (Sparse-GAN) for disease screening where only healthy data are available in the training set. The contributions of Sparse-GAN are two-folds: 1) The proposed Sparse-GAN predicts the anomalies in latent space rather than image-level; 2) Sparse-GAN is constrained by a novel Sparsity Regularization Net. Furthermore, in light of the role of lesions for disease screening, we present to leverage on an anomaly activation map to show the heatmap of lesions. We evaluate our proposed Sparse-GAN on a publicly available dataset, and the results show that the proposed method outperforms the state-of-the-art methods.

preprint2020arXiv

Universal digital filtering for denoising volumetric retinal OCT and OCT angiography in 3D shearlet domain

Retinal optical coherence tomography (OCT) and OCT angiography (OCTA) suffer from the degeneration of image quality due to speckle noise and bulk-motion noise, respectively. Because the cross-sectional retina has distinct features in OCT and OCTA B-scans, existing digital filters that can denoise OCT efficiently are unable to handle the bulk-motion noise in OCTA. In this Letter, we propose a universal digital filtering approach that is capable of minimizing both types of noise. Considering the retinal capillaries in OCTA are hard to differentiate in B-scans while having distinct curvilinear structures in 3D volumes, we decompose the volumetric OCT and OCTA data with 3D shearlets thus efficiently separate the retinal tissue and vessels from the noise in this transform domain. Compared with wavelets and curvelets, the shearlets provide better representation of the layer edges in OCT and the vasculature in OCTA. Qualitative and quantitative results show the proposed method outperforms the state-of-the-art OCT and OCTA denoising methods. Besides, the superiority of 3D denoising is demonstrated by comparing the 3D shearlet filtering with its 2D counterpart.

preprint2019arXiv

Assessment of Generative Adversarial Networks Model for Synthetic Optical Coherence Tomography Images of Retinal Disorders

Purpose: To assess whether a generative adversarial network (GAN) could synthesize realistic optical coherence tomography (OCT) images that satisfactorily serve as the educational images for retinal specialists and the training datasets for the classification of various retinal disorders using deep learning (DL). Methods: The GANs architecture was adopted to synthesis high-resolution OCT images training on a publicly available OCT dataset including urgent referrals (choroidal neovascularization and diabetic macular edema) and non-urgent referrals (normal and drusen). 400 real and synthetic OCT images were evaluated by 2 retinal specialists to assess image quality. We further trained 2 DL models on either real or synthetic datasets and compared the performance of urgent vs nonurgent referrals diagnosis tested on a local (1000 images from the public dataset) and clinical validation dataset (278 images from Shanghai Shibei Hospital). Results: The image quality of real vs synthetic OCT images was similar as assessed by 2 retinal specialists. The accuracy of discrimination as real vs synthetic OCT images was 59.50% for retinal specialist 1 and 53.67% for retinal specialist 2. For the local dataset, the DL model trained on real (DL_Model_R) and synthetic OCT images (DL_Model_S) had an area under the curve (AUC) of 0.99, and 0.98 respectively. For the clinical dataset, the AUC was 0.94 for DL_Model_R, 0.90 for DL_Model_S. Conclusions: The GAN-synthetic OCT images can be used by clinicians for educational purposes and developing DL algorithms. Translational Relevance: The medical image synthesis based on GANs is promising in human and machine to fulfill clinical tasks.