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Igor Balaz

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Published work

6 published item(s)

preprint2026arXiv

Measuring Understanding Through Discrete Compositional Knowledge Structures in Hierarchical Automata

How do we measure genuine understanding in artificial cognitive systems? Current approaches face a measurement gap: probabilistic systems refine confidence gradually, practice-based systems compile knowledge through repeated execution, and neural systems distribute understanding across opaque embedding spaces. We propose that making understanding measurable requires architectures where understanding formation produces discrete, inspectable structural signatures. This paper presents hierarchical automata built from finite state machines representing patterns and higher-order automata representing compositions. Constrained inference constructs automata from single observations. Similarity detection clusters related automata, making concept robustness quantifiable. Graph memory makes compositional knowledge directly inspectable. Metacognitive mechanisms enable observable reconfiguration. We demonstrate understanding measurement in a simple geometric domain. Graph evolution tracking reveals five measurable signatures: immediate representation formation, structural knowledge, generalization capacity, compositional awareness, and metacognitive access. These measurements distinguish structural understanding from statistical correlation. Our contribution is a framework for making understanding measurable through discrete compositional knowledge structures. This measurement capability complements perceptual learning in neural systems and task execution in neurosymbolic architectures.

preprint2021arXiv

Evolutionary computational platform for the automatic discovery of nanocarriers for cancer treatment

We present the EVONANO platform for the evolution of nanomedicines with application to anti-cancer treatments. EVONANO includes a simulator to grow tumours, extract representative scenarios, and then simulate nanoparticle transport through these scenarios to predict nanoparticle distribution. The nanoparticle designs are optimised using machine learning to efficiently find the most effective anti-cancer treatments. We demonstrate our platform with two examples optimising the properties of nanoparticles and treatment to selectively kill cancer cells over a range of tumour environments.

preprint2020arXiv

Novelty search employed into the development of cancer treatment simulations

Conventional optimization methodologies may be hindered when the automated search is stuck into local optima because of a deceptive objective function landscape. Consequently, open ended search methodologies, such as novelty search, have been proposed to tackle this issue. Overlooking the objective, while putting pressure into discovering novel solutions may lead to better solutions in practical problems. Novelty search was employed here to optimize the simulated design of a targeted drug delivery system for tumor treatment under the PhysiCell simulator. A hybrid objective equation was used containing both the actual objective of an effective tumour treatment and the novelty measure of the possible solutions. Different weights of the two components of the hybrid equation were investigated to unveil the significance of each one.

preprint2020arXiv

Utilizing Differential Evolution into optimizing targeted cancer treatments

Working towards the development of an evolvable cancer treatment simulator, the investigation of Differential Evolution was considered, motivated by the high efficiency of variations of this technique in real-valued problems. A basic DE algorithm, namely "DE/rand/1" was used to optimize the simulated design of a targeted drug delivery system for tumor treatment on PhysiCell simulator. The suggested approach proved to be more efficient than a standard genetic algorithm, which was not able to escape local minima after a predefined number of generations. The key attribute of DE that enables it to outperform standard EAs, is the fact that it keeps the diversity of the population high, throughout all the generations. This work will be incorporated with ongoing research in a more wide applicability platform that will design, develop and evaluate targeted drug delivery systems aiming cancer tumours.

preprint2010arXiv

Modeling the Intercelular Exchange of Signalling Molecules depending on Intra- and Inter-Cellular Environmental Parameters

Exchange of biochemical substances is essential way in establishing communication between bacterial cells. It is noticeable that all phases of the process are heavily influenced by perturbations of either internal or external parameters. Therefore, instead to develop an accurate quantitative model of substances exchange between bacterial cells, we are interested in formalization of the basic shape of the process, and creating the appropriate strategy that allows further investigation of synchronization. Using a form of coupled difference logistic equations we investigated synchronization of substances exchange between abstract cells and its sensitivity to fluctuations of environmental parameters using methods of nonlinear dynamics.

preprint2010arXiv

Stability of Intercelular Exchange of Biochemical Substances Affected by Variability of Environmental Parameters

Communication between cells is realized by exchange of biochemical substances. Due to internal organization of living systems and variability of external parameters, the exchange is heavily influenced by perturbations of various parameters at almost all stages of the process. Since communication is one of essential processes for functioning of living systems it is of interest to investigate conditions for its stability. Using previously developed simplified model of bacterial communication in a form of coupled difference logistic equations we investigate stability of exchange of signaling molecules under variability of internal and external parameters.