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Hao Zhou

Hao Zhou contributes to research discovery and scholarly infrastructure.

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Artificial Intelligence Computation and Language Computer Vision Cryptography and Security Machine Learning Quantitative Methods

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preprint2026arXiv

DCFold: Efficient Protein Structure Generation with Single Forward Pass

AlphaFold3 introduces a diffusion-based architecture that elevates protein structure prediction to all-atom resolution with improved accuracy. This state-of-the-art performance has established AlphaFold3 as a foundation model for diverse generation and design tasks. However, its iterative design substantially increases inference time, limiting practical deployment in downstream settings such as virtual screening and protein design. We propose DCFold, a single-step generative model that attains AlphaFold3-level accuracy. Our Dual Consistency training framework, which incorporates a novel Temporal Geodesic Matching (TGM) scheduler, enables DCFold to achieve a 15x acceleration in inference while maintaining predictive fidelity. We validate its effectiveness across both structure prediction and binder design benchmarks.

preprint2026arXiv

Investigating Cross-Modal Skill Injection: Scenarios, Methods, and Hyperparameters

Vision-Language Models (VLMs) have demonstrated remarkable proficiency in general multi-modal understanding; yet they struggle to efficiently acquire continually evolving domain-specific skills. Conventional approaches to enhancing VLM capabilities, such as Supervised Fine-Tuning (SFT), require extensive dataset curation and substantial computational resources. Model merging has emerged as an efficient alternative that enables the transfer of domain-specific expertise from Large Language Models (LLMs) to VLMs without incurring additional training data requirements or significant computational overhead. Unlike conventional merging of homogeneous LLMs, which mainly aggregates existing capabilities, cross-modal skill injection aims to induce emergent cross-modal capabilities by integrating a domain-expert LLM into a VLM. However, existing research lacks a systematic analysis of the applicability and methodology of cross-modal skill injection. In this study, we investigate cross-modal skill injection across three main aspects: scenarios, methods, and hyperparameters. For scenarios, we find that cross-modal skill injection generally performs well in instruction-following and cross-lingual settings, yet struggles with mathematical reasoning. For methods, we find that classic approaches such as TA and DARE consistently achieve superior performance over alternative merging methods. We also provide a systematic and quantitative analysis of the hyperparameter tuning that these classic methods critically depend on.

preprint2026arXiv

Safety Anchor: Defending Harmful Fine-tuning via Geometric Bottlenecks

The safety alignment of Large Language Models (LLMs) remains vulnerable to Harmful Fine-tuning (HFT). While existing defenses impose constraints on parameters, gradients, or internal representations, we observe that they can be effectively circumvented under persistent HFT. Our analysis traces this failure to the inherent redundancy of the high-dimensional parameter space: attackers exploit optimization trajectories that are orthogonal to defense constraints to restore harmful capabilities while deceptively adhering to safety restrictions. To address this, we propose Safety Bottleneck Regularization (SBR). SBR shifts the defensive focus from the redundant parameter space to the unembedding layer, which serves as a geometric bottleneck. By anchoring the final hidden states of harmful queries to those of the safety-aligned model, SBR enables the model to maintain safe responses even under persistent HFT. Extensive experiments confirm SBR's effectiveness, demonstrating that utilizing just a single safety anchor is sufficient to reduce the Harmful Score to $<$10 while preserving competitive performance on benign downstream tasks.

preprint2026arXiv

Video Understanding Reward Modeling: A Robust Benchmark and Performant Reward Models

Multimodal reward models have advanced substantially in text and image domains, yet progress in video understanding reward modeling remains severely limited by the lack of robust evaluation benchmarks and high-quality preference data. To address this, we propose a unified framework spanning benchmark design, data construction, and reward model training. We introduce Video Understanding Reward Bench (VURB), a benchmark featuring 2,100 preference pairs with long chain-of-thought reasoning traces (averaging 1,143 tokens) and majority voting evaluation across general, long, and reasoning-oriented video tasks. We further construct Video Understanding Preference Dataset (VUP-35K) via a fully automated pipeline, providing large-scale high-quality supervision for video reward training. Building on the data, we train VideoDRM and VideoGRM, a discriminative and a generative reward model, both achieving state-of-the-art performance on VURB and VideoRewardBench. Further analysis confirms that VUP-35K enhances both reward performance and model reasoning capability, while VideoDRM and VideoGRM yield significant gains under best-of-$N$ test-time scaling.

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