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Hanxiao Zhang

Hanxiao Zhang contributes to research discovery and scholarly infrastructure.

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Computer Vision eess.IV eess.SY physics.optics Software Engineering Systems and Control

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preprint2026arXiv

TriALS: Triphasic-Aided Liver Lesion Segmentation Benchmark in Non-Contrast CT

Automated segmentation of liver lesions on non-contrast computed tomography (NCCT) is clinically important but fundamentally challenging, particularly in low-resource settings across Africa and Asia where contrast agents are frequently unavailable. Progress has been limited by the absence of annotated NCCT benchmarks. Here we describe the TriALS challenge for automated liver lesion segmentation under contrast-limited conditions, supported by a multi-centre dataset of 150 cases with four-phase CT acquisitions (600 volumes) from Egyptian and Chinese institutions. Algorithms were evaluated on 70 cases from three institutions, including an independent external cohort. The top-performing method achieved a mean venous-phase Dice of 0.754, consistent with human-level performance, yet dropped to 0.57 on NCCT. On external validation, the leading method outperformed off-the-shelf models by up to 28% in Dice on NCCT. Algorithm performance was most strongly predicted by training data scale and pre-training strategy. A cross-year comparison exposed a persistent perceptual barrier on NCCT that scaling pre-training alone cannot overcome. Data, annotations, and code are available at https://github.com/xmed-lab/TriALS.

preprint2025arXiv

Unidirectional reflection lasing based on destructive interference and Bragg scattering modulation in defective atomic lattice

The novel and ingenious scheme we propose for achieving unidirectional reflection lasing (URL) involves integrating a one-dimensional (1D) defective atomic lattice with a coherent gain atomic system. Its physical essence lies in the fact that the right-side reflectivity is drastically reduced due to the destructive interference between primary and secondary reflections, whereas on the left-side primary reflection is effectively suppressed and the secondary reflection is efficiently enhanced, ultimately reaching the lasing threshold. Through numerical results and further analyses, we have elucidated how to precisely tailor the lattice parameters and coupling fields to control destructive interference point (DIP), thereby realizing URL and enabling its active modulation. Our scheme is experimentally feasible and not only effectively circumvents the stringent conditions faced in directly realizing URL, providing a new pathway, but also beneficial for integrating active photonic devices into compact quantum networks and may improve the efficiency of optical information transmission.

preprint2022arXiv

BREAK: Bronchi Reconstruction by gEodesic transformation And sKeleton embedding

Airway segmentation is critical for virtual bronchoscopy and computer-aided pulmonary disease analysis. In recent years, convolutional neural networks (CNNs) have been widely used to delineate the bronchial tree. However, the segmentation results of the CNN-based methods usually include many discontinuous branches, which need manual repair in clinical use. A major reason for the breakages is that the appearance of the airway wall can be affected by the lung disease as well as the adjacency of the vessels, while the network tends to overfit to these special patterns in the training set. To learn robust features for these areas, we design a multi-branch framework that adopts the geodesic distance transform to capture the intensity changes between airway lumen and wall. Another reason for the breakages is the intra-class imbalance. Since the volume of the peripheral bronchi may be much smaller than the large branches in an input patch, the common segmentation loss is not sensitive to the breakages among the distal branches. Therefore, in this paper, a breakage-sensitive regularization term is designed and can be easily combined with other loss functions. Extensive experiments are conducted on publicly available datasets. Compared with state-of-the-art methods, our framework can detect more branches while maintaining competitive segmentation performance.

preprint2022arXiv

Faithful learning with sure data for lung nodule diagnosis

Recent evolution in deep learning has proven its value for CT-based lung nodule classification. Most current techniques are intrinsically black-box systems, suffering from two generalizability issues in clinical practice. First, benign-malignant discrimination is often assessed by human observers without pathologic diagnoses at the nodule level. We termed these data as "unsure data". Second, a classifier does not necessarily acquire reliable nodule features for stable learning and robust prediction with patch-level labels during learning. In this study, we construct a sure dataset with pathologically-confirmed labels and propose a collaborative learning framework to facilitate sure nodule classification by integrating unsure data knowledge through nodule segmentation and malignancy score regression. A loss function is designed to learn reliable features by introducing interpretability constraints regulated with nodule segmentation maps. Furthermore, based on model inference results that reflect the understanding from both machine and experts, we explore a new nodule analysis method for similar historical nodule retrieval and interpretable diagnosis. Detailed experimental results demonstrate that our approach is beneficial for achieving improved performance coupled with faithful model reasoning for lung cancer prediction. Extensive cross-evaluation results further illustrate the effect of unsure data for deep-learning-based methods in lung nodule classification.

preprint2022arXiv

Re-thinking and Re-labeling LIDC-IDRI for Robust Pulmonary Cancer Prediction

The LIDC-IDRI database is the most popular benchmark for lung cancer prediction. However, with subjective assessment from radiologists, nodules in LIDC may have entirely different malignancy annotations from the pathological ground truth, introducing label assignment errors and subsequent supervision bias during training. The LIDC database thus requires more objective labels for learning-based cancer prediction. Based on an extra small dataset containing 180 nodules diagnosed by pathological examination, we propose to re-label LIDC data to mitigate the effect of original annotation bias verified on this robust benchmark. We demonstrate in this paper that providing new labels by similar nodule retrieval based on metric learning would be an effective re-labeling strategy. Training on these re-labeled LIDC nodules leads to improved model performance, which is enhanced when new labels of uncertain nodules are added. We further infer that re-labeling LIDC is current an expedient way for robust lung cancer prediction while building a large pathological-proven nodule database provides the long-term solution.

preprint2020arXiv

DDU-Nets: Distributed Dense Model for 3D MRI Brain Tumor Segmentation

Segmentation of brain tumors and their subregions remains a challenging task due to their weak features and deformable shapes. In this paper, three patterns (cross-skip, skip-1 and skip-2) of distributed dense connections (DDCs) are proposed to enhance feature reuse and propagation of CNNs by constructing tunnels between key layers of the network. For better detecting and segmenting brain tumors from multi-modal 3D MR images, CNN-based models embedded with DDCs (DDU-Nets) are trained efficiently from pixel to pixel with a limited number of parameters. Postprocessing is then applied to refine the segmentation results by reducing the false-positive samples. The proposed method is evaluated on the BraTS 2019 dataset with results demonstrating the effectiveness of the DDU-Nets while requiring less computational cost.

preprint2020arXiv

Optimizing the Efficiency of Accelerated Reliability Testing for the Internet Router Motherboard

With the rapid development of internet Router, the complexity of its mainboard has been growing dramatically. The high reliability requirement renders the number of testing cases increasing exponentially, which becomes the bottleneck that prevents further elevation of the production efficiency. In this work, we develop a novel optimization method of two major steps to largely reduce the testing time and increase the testing efficiency. In the first step, it optimizes the selection of test cases given the required amount of testing time reduction while ensuring the coverage of failures. In the second step, selected test cases are optimally scheduled to maximize the efficiency of mainboard testing. A numerical experiment is investigated to illustrate the effectiveness of the proposed methods. The results show that the optimal subset of the test cases can be selected satisfying the 10% testing time reduction requirement, and the effectiveness index of the scheduled sequence can be improved by more than 75% with test case sequencing. Moreover, our method can self-adjust to the new failure data, which realizes the automatic configuration of board test cases.

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