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Hairong Zheng

Hairong Zheng contributes to research discovery and scholarly infrastructure.

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Published work

12 published item(s)

preprint2026arXiv

StableMind: Source-Free Cross-Subject fMRI Decoding with Regularized Adaptation

Existing cross-subject fMRI decoding methods typically train a model on multiple scanned subjects and then adapt it to a new subject using substantial paired fMRI-image data. However, in realistic scenarios, new-subject fMRI data are often limited due to costly data acquisition, and raw data from previous subjects may be inaccessible, leading existing methods to suffer performance degradation during new-subject adaptation. In this paper, we identify that this degradation stems from two key issues: brain-side instability caused by large subject differences in fMRI responses, and image-side supervision unreliability caused by fine-grained visual details that are not reliably supported by limited fMRI signals. To address these challenges, we propose StableMind, a regularized adaptation framework designed to improve brain-side representation stability and image-side supervision reliability. (1) To stabilize brain representations, StableMind reuses ridge projections from the pretrained model as adaptation priors to constrain limited-data new-subject adaptation, and applies Fourier-based feature-level brain augmentation to improve robustness to individual variability. (2) To improve image supervision reliability, StableMind introduces difficulty-aware image blur for brain-image alignment, reducing the influence of fine-grained visual details that are weakly supported by limited fMRI signals while preserving stable visual structure. Experiments on the Natural Scenes Dataset under a unified 1-hour adaptation protocol demonstrate that StableMind achieves 84.02% image retrieval accuracy and 81.66% brain retrieval accuracy averaged over four subjects, surpassing the state-of-the-art method by 5.71% brain retrieval accuracy with fewer trainable adaptation parameters. Our code is available at https://github.com/lingeringlight/StableMind.

preprint2022arXiv

Dual-domain Attention-based Deep Network for Sparse-view CT Artifact Reduction

Due to the wide applications of X-ray computed tomography (CT) in medical imaging activities, radiation exposure has become a major concern for public health. Sparse-view CT is a promising approach to reduce the radiation dose by down-sampling the total number of acquired projections. However, the CT images reconstructed by this sparse-view imaging approach suffer from severe streaking artifacts and structural information loss. In this work, an end-to-end dual-domain attention-based deep network (DDANet) is proposed to solve such an ill-posed CT image reconstruction problem. The image-domain CT image and the projection-domain sinogram are put into the two parallel sub-networks of the DDANet to independently extract the distinct high-level feature maps. In addition, a specified attention module is introduced to fuse the aforementioned dual-domain feature maps to allow complementary optimizations of removing the streaking artifacts and mitigating the loss of structure. Numerical simulations, anthropomorphic thorax phantom and in vivo pre-clinical experiments are conducted to verify the sparse-view CT imaging performance of the DDANet. Results demonstrate that this newly developed approach is able to robustly remove the streaking artifacts while maintaining the fine structures. As a result, the DDANet provides a promising solution in achieving high quality sparse-view CT imaging.

preprint2022arXiv

Expert Knowledge-guided Geometric Representation Learning for Magnetic Resonance Imaging-based Glioma Grading

Radiomics and deep learning have shown high popularity in automatic glioma grading. Radiomics can extract hand-crafted features that quantitatively describe the expert knowledge of glioma grades, and deep learning is powerful in extracting a large number of high-throughput features that facilitate the final classification. However, the performance of existing methods can still be improved as their complementary strengths have not been sufficiently investigated and integrated. Furthermore, lesion maps are usually needed for the final prediction at the testing phase, which is very troublesome. In this paper, we propose an expert knowledge-guided geometric representation learning (ENROL) framework . Geometric manifolds of hand-crafted features and learned features are constructed to mine the implicit relationship between deep learning and radiomics, and therefore to dig mutual consent and essential representation for the glioma grades. With a specially designed manifold discrepancy measurement, the grading model can exploit the input image data and expert knowledge more effectively in the training phase and get rid of the requirement of lesion segmentation maps at the testing phase. The proposed framework is flexible regarding deep learning architectures to be utilized. Three different architectures have been evaluated and five models have been compared, which show that our framework can always generate promising results.

preprint2022arXiv

Rethinking the optimization process for self-supervised model-driven MRI reconstruction

Recovering high-quality images from undersampled measurements is critical for accelerated MRI reconstruction. Recently, various supervised deep learning-based MRI reconstruction methods have been developed. Despite the achieved promising performances, these methods require fully sampled reference data, the acquisition of which is resource-intensive and time-consuming. Self-supervised learning has emerged as a promising solution to alleviate the reliance on fully sampled datasets. However, existing self-supervised methods suffer from reconstruction errors due to the insufficient constraint enforced on the non-sampled data points and the error accumulation happened alongside the iterative image reconstruction process for model-driven deep learning reconstrutions. To address these challenges, we propose K2Calibrate, a K-space adaptation strategy for self-supervised model-driven MR reconstruction optimization. By iteratively calibrating the learned measurements, K2Calibrate can reduce the network's reconstruction deterioration caused by statistically dependent noise. Extensive experiments have been conducted on the open-source dataset FastMRI, and K2Calibrate achieves better results than five state-of-the-art methods. The proposed K2Calibrate is plug-and-play and can be easily integrated with different model-driven deep learning reconstruction methods.

preprint2022arXiv

SelfCoLearn: Self-supervised collaborative learning for accelerating dynamic MR imaging

Lately, deep learning has been extensively investigated for accelerating dynamic magnetic resonance (MR) imaging, with encouraging progresses achieved. However, without fully sampled reference data for training, current approaches may have limited abilities in recovering fine details or structures. To address this challenge, this paper proposes a self-supervised collaborative learning framework (SelfCoLearn) for accurate dynamic MR image reconstruction from undersampled k-space data. The proposed framework is equipped with three important components, namely, dual-network collaborative learning, reunderampling data augmentation and a specially designed co-training loss. The framework is flexible to be integrated with both data-driven networks and model-based iterative un-rolled networks. Our method has been evaluated on in-vivo dataset and compared it to four state-of-the-art methods. Results show that our method possesses strong capabilities in capturing essential and inherent representations for direct reconstructions from the undersampled k-space data and thus enables high-quality and fast dynamic MR imaging.

preprint2021arXiv

A coarse-to-fine framework for unsupervised multi-contrast MR image deformable registration with dual consistency constraint

Multi-contrast magnetic resonance (MR) image registration is useful in the clinic to achieve fast and accurate imaging-based disease diagnosis and treatment planning. Nevertheless, the efficiency and performance of the existing registration algorithms can still be improved. In this paper, we propose a novel unsupervised learning-based framework to achieve accurate and efficient multi-contrast MR image registrations. Specifically, an end-to-end coarse-to-fine network architecture consisting of affine and deformable transformations is designed to improve the robustness and achieve end-to-end registration. Furthermore, a dual consistency constraint and a new prior knowledge-based loss function are developed to enhance the registration performances. The proposed method has been evaluated on a clinical dataset containing 555 cases, and encouraging performances have been achieved. Compared to the commonly utilized registration methods, including VoxelMorph, SyN, and LT-Net, the proposed method achieves better registration performance with a Dice score of 0.8397 in identifying stroke lesions. With regards to the registration speed, our method is about 10 times faster than the most competitive method of SyN (Affine) when testing on a CPU. Moreover, we prove that our method can still perform well on more challenging tasks with lacking scanning information data, showing high robustness for the clinical application.

preprint2020arXiv

Achromatic metasurfaces with inversely customized dispersion for ultra-broadband acoustic beam engineering

Metasurfaces, the ultrathin media with extraordinary wavefront modulation ability, have shown versatile potential in manipulating waves. However, existing acoustic metasurfaces are limited by their narrow-band frequency-dependent capability, which severely hinders their real-world applications that usually require customized dispersion. To address this bottlenecking challenge, we report ultra-broadband achromatic metasurfaces that are capable of delivering arbitrary and frequency-independent wave properties by bottom-up topology optimization. We successively demonstrate three ultra-broadband functionalities, including acoustic beam steering, focusing and levitation, featuring record-breaking relative bandwidths of 93.3%, 120% and 118.9%, respectively. All metasurface elements show novel asymmetric geometries containing multiple scatters, curved air channels and local cavities. Moreover, we reveal that the inversely designed metasurfaces can support integrated internal resonances, bi-anisotropy and multiple scattering, which collectively form the mechanism underpinning the ultra-broadband customized dispersion. Our study opens new horizons for ultra-broadband high-efficiency achromatic functional devices on demand, with promising extension to the optical and elastic achromatic metamaterials.

preprint2020arXiv

Deep Low-rank Prior in Dynamic MR Imaging

The deep learning methods have achieved attractive performance in dynamic MR cine imaging. However, all of these methods are only driven by the sparse prior of MR images, while the important low-rank (LR) prior of dynamic MR cine images is not explored, which limits the further improvements on dynamic MR reconstruction. In this paper, a learned singular value thresholding (Learned-SVT) operation is proposed to explore deep low-rank prior in dynamic MR imaging for obtaining improved reconstruction results. In particular, we come up with two novel and distinct schemes to introduce the learnable low-rank prior into deep network architectures in an unrolling manner and a plug-and-play manner respectively. In the unrolling manner, we put forward a model-based unrolling sparse and low-rank network for dynamic MR imaging, dubbed SLR-Net. The SLR-Net is defined over a deep network flow graph, which is unrolled from the iterative procedures in the Iterative Shrinkage-Thresholding Algorithm (ISTA) for optimizing a sparse and low-rank based dynamic MRI model. In the plug-and-play manner, we present a plug-and-play LR network module that can be easily embedded into any other dynamic MR neural networks without changing the network paradigm. Experimental results show that both schemes can further improve the state-of-the-art CS methods, such as k-t SLR, and sparsity-driven deep learning-based methods, such as DC-CNN and CRNN, both qualitatively and quantitatively.

preprint2020arXiv

DIRECT-Net: a unified mutual-domain material decomposition network for quantitative dual-energy CT imaging

By acquiring two sets of tomographic measurements at distinct X-ray spectra, the dual-energy CT (DECT) enables quantitative material-specific imaging. However, the conventionally decomposed material basis images may encounter severe image noise amplification and artifacts, resulting in degraded image quality and decreased quantitative accuracy. Iterative DECT image reconstruction algorithms incorporating either the sinogram or the CT image prior information have shown potential advantages in noise and artifact suppression, but with the expense of large computational resource, prolonged reconstruction time, and tedious manual selections of algorithm parameters. To partially overcome these limitations, we develop a domain-transformation enabled end-to-end deep convolutional neural network (DIRECT-Net) to perform high quality DECT material decomposition. Specifically, the proposed DIRECT-Net has immediate accesses to mutual-domain data, and utilizes stacked convolution neural network (CNN) layers for noise reduction and material decomposition. The training data are numerically simulated based on the underlying physics of DECT imaging.The XCAT digital phantom, iodine solutions phantom, and biological specimen are used to validate the performance of DIRECT-Net. The qualitative and quantitative results demonstrate that this newly developed DIRECT-Net is promising in suppressing noise, improving image accuracy, and reducing computation time for future DECT imaging.

preprint2020arXiv

Estimation of angular sensitivity for X-ray interferometers with multiple phase gratings

Recently, X-ray interferometers with more than one phase grating have been developed for differential phase contrast (DPC) imaging. In this study, a novel framework is developed to predict such interferometers' angular sensitivity responses (the minimum detectable refraction angle). Experiments are performed on the dual and triple phase grating interferometers, separately. Measurements show strong consistency with the predicted sensitivity values. Using this new approach, the DPC imaging performance of X-ray interferometers with multiple phase gratings can be further optimized for future biomedical applications.

preprint2019arXiv

Automatic image-domain Moire artifact reduction method in grating-based x-ray interferometry imaging

The aim of this study is to demonstrate the feasibility of removing the image Moire artifacts caused by system inaccuracies in grating-based x-ray interferometry imaging system via convolutional neural network (CNN) technique. Instead of minimizing these inconsistencies between the acquired phase stepping data via certain optimized signal retrieval algorithms, our newly proposed CNN-based method reduces the Moire artifacts in the image-domain via a learned image post-processing procedure. To ease the training data preparations, we propose to synthesize them with numerical natural images and experimentally obtained Moire artifact-only-images. Moreover, a fast signal processing method has also been developed to generate the needed large number of high quality Moire artifact-only images from finite number of acquired experimental phase stepping data. Experimental results show that the CNN method is able to remove Moire artifacts effectively, while maintaining the signal accuracy and image resolution.

preprint2019arXiv

CLCI-Net: Cross-Level fusion and Context Inference Networks for Lesion Segmentation of Chronic Stroke

Segmenting stroke lesions from T1-weighted MR images is of great value for large-scale stroke rehabilitation neuroimaging analyses. Nevertheless, there are great challenges with this task, such as large range of stroke lesion scales and the tissue intensity similarity. The famous encoder-decoder convolutional neural network, which although has made great achievements in medical image segmentation areas, may fail to address these challenges due to the insufficient uses of multi-scale features and context information. To address these challenges, this paper proposes a Cross-Level fusion and Context Inference Network (CLCI-Net) for the chronic stroke lesion segmentation from T1-weighted MR images. Specifically, a Cross-Level feature Fusion (CLF) strategy was developed to make full use of different scale features across different levels; Extending Atrous Spatial Pyramid Pooling (ASPP) with CLF, we have enriched multi-scale features to handle the different lesion sizes; In addition, convolutional long short-term memory (ConvLSTM) is employed to infer context information and thus capture fine structures to address the intensity similarity issue. The proposed approach was evaluated on an open-source dataset, the Anatomical Tracings of Lesions After Stroke (ATLAS) with the results showing that our network outperforms five state-of-the-art methods. We make our code and models available at https://github.com/YH0517/CLCI_Net.