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Gwenolé Quellec

Gwenolé Quellec contributes to research discovery and scholarly infrastructure.

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Published work

4 published item(s)

preprint2026arXiv

Constrained latent state modeling: A unifying perspective on representation learning under competing constraints

Learning latent representations from complex data is central to modern machine learning, spanning temporal, multimodal, and partially observed systems. In such settings, representations are better understood as latent states capturing underlying system dynamics, rather than as mere compressed summaries of observations. Yet current approaches remain fragmented, relying on distinct -- and often implicit -- assumptions about what these states should represent. We argue that this fragmentation reflects a more fundamental limitation: latent representations are typically learned from underconstrained objectives that fail to specify the properties that meaningful latent states should satisfy. As a result, multiple representations can satisfy the same objective, leading to ambiguity in their structure and interpretation. While many of the underlying principles have been explored in isolation, their interactions have not been explicitly formalized. In this work, we propose constrained latent state modeling (CLSM) as a unifying perspective. We identify a set of core properties -- predictive sufficiency, minimality, temporal coherence, observation compatibility, invariance to nuisance factors, and structural constraints -- and show that they are intrinsically coupled through fundamental trade-offs. Revisiting major modeling families through this lens, we show that existing approaches can be interpreted as enforcing different subsets of constraints, thereby occupying distinct regions of a common design space. This perspective reframes persistent challenges such as lack of identifiability as consequences of underconstrained formulations, rather than isolated technical limitations. More broadly, CLSM provides a principled framework to make design choices explicit, to analyze trade-offs, and to guide the development of more interpretable, robust, and task-aligned latent state models.

preprint2024arXiv

Automated Detection of Myopic Maculopathy in MMAC 2023: Achievements in Classification, Segmentation, and Spherical Equivalent Prediction

Myopic macular degeneration is the most common complication of myopia and the primary cause of vision loss in individuals with pathological myopia. Early detection and prompt treatment are crucial in preventing vision impairment due to myopic maculopathy. This was the focus of the Myopic Maculopathy Analysis Challenge (MMAC), in which we participated. In task 1, classification of myopic maculopathy, we employed the contrastive learning framework, specifically SimCLR, to enhance classification accuracy by effectively capturing enriched features from unlabeled data. This approach not only improved the intrinsic understanding of the data but also elevated the performance of our classification model. For Task 2 (segmentation of myopic maculopathy plus lesions), we have developed independent segmentation models tailored for different lesion segmentation tasks and implemented a test-time augmentation strategy to further enhance the model's performance. As for Task 3 (prediction of spherical equivalent), we have designed a deep regression model based on the data distribution of the dataset and employed an integration strategy to enhance the model's prediction accuracy. The results we obtained are promising and have allowed us to position ourselves in the Top 6 of the classification task, the Top 2 of the segmentation task, and the Top 1 of the prediction task. The code is available at \url{https://github.com/liyihao76/MMAC_LaTIM_Solution}.

preprint2022arXiv

White-box Membership Attack Against Machine Learning Based Retinopathy Classification

The advances in machine learning (ML) have greatly improved AI-based diagnosis aid systems in medical imaging. However, being based on collecting medical data specific to individuals induces several security issues, especially in terms of privacy. Even though the owner of the images like a hospital put in place strict privacy protection provisions at the level of its information system, the model trained over his images still holds disclosure potential. The trained model may be accessible to an attacker as: 1) White-box: accessing to the model architecture and parameters; 2) Black box: where he can only query the model with his own inputs through an appropriate interface. Existing attack methods include: feature estimation attacks (FEA), membership inference attack (MIA), model memorization attack (MMA) and identification attacks (IA). In this work we focus on MIA against a model that has been trained to detect diabetic retinopathy from retinal images. Diabetic retinopathy is a condition that can cause vision loss and blindness in the people who have diabetes. MIA is the process of determining whether a data sample comes from the training data set of a trained ML model or not. From a privacy perspective in our use case where a diabetic retinopathy classification model is given to partners that have at their disposal images along with patients' identifiers, inferring the membership status of a data sample can help to state if a patient has contributed or not to the training of the model.

preprint2020arXiv

Automatic detection of rare pathologies in fundus photographs using few-shot learning

In the last decades, large datasets of fundus photographs have been collected in diabetic retinopathy (DR) screening networks. Through deep learning, these datasets were used to train automatic detectors for DR and a few other frequent pathologies, with the goal to automate screening. One challenge limits the adoption of such systems so far: automatic detectors ignore rare conditions that ophthalmologists currently detect, such as papilledema or anterior ischemic optic neuropathy. The reason is that standard deep learning requires too many examples of these conditions. However, this limitation can be addressed with few-shot learning, a machine learning paradigm where a classifier has to generalize to a new category not seen in training, given only a few examples of this category. This paper presents a new few-shot learning framework that extends convolutional neural networks (CNNs), trained for frequent conditions, with an unsupervised probabilistic model for rare condition detection. It is based on the observation that CNNs often perceive photographs containing the same anomalies as similar, even though these CNNs were trained to detect unrelated conditions. This observation was based on the t-SNE visualization tool, which we decided to incorporate in our probabilistic model. Experiments on a dataset of 164,660 screening examinations from the OPHDIAT screening network show that 37 conditions, out of 41, can be detected with an area under the ROC curve (AUC) greater than 0.8 (average AUC: 0.938). In particular, this framework significantly outperforms other frameworks for detecting rare conditions, including multitask learning, transfer learning and Siamese networks, another few-shot learning solution. We expect these richer predictions to trigger the adoption of automated eye pathology screening, which will revolutionize clinical practice in ophthalmology.