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Durba Bhattacharya

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3 published item(s)

preprint2026arXiv

The Bayesian Reflex: Online Learning as the Autonomic Nervous System of Modern and Future AI

This chapter introduces the Bayesian reflex -- an analogy with the autonomic nervous system -- as a unifying framework for online learning in AI. Bayesian online algorithms automatically maintain equilibrium in dynamic environments via three mechanisms: belief maintenance through probabilistic representations, sequential updating via Bayes' theorem, and uncertainty-driven action balancing exploration and exploitation. We survey online Bayesian methods, highlighting two computational principles: the look-up table principle for sequential inference in function space, and the ellipsoidal decomposition framework for nearly exact i.i.d. sampling from arbitrary posteriors. These principles are generalized across dynamic emulation, nonparametric state-space models, circular time series, inverse regression for climate model evaluation, and deep architectures via Recursive Gaussian Processes. Decision-making is explored via Thompson sampling and restless bandits. We extend the framework to assess infinite series convergence (applied to climate dynamics and the Riemann Hypothesis), model prime number distributions leading to the discovery of 184 strong Mersenne prime candidates, detect stationarity, and characterize point processes. The Bayesian reflex provides a foundational infrastructure for adaptive AI that continuously learns in a complex world.

preprint2020arXiv

A Non-Gaussian, Nonparametric Structure for Gene-Gene and Gene-Environment Interactions in Case-Control Studies Based on Hierarchies of Dirichlet Processes

It is becoming increasingly clear that complex interactions among genes and environmental factors play crucial roles in triggering complex diseases. Thus, understanding such interactions is vital, which is possible only through statistical models that adequately account for such intricate, albeit unknown, dependence structures. Bhattacharya & Bhattacharya (2016b) attempt such modeling, relating finite mixtures composed of Dirichlet processes that represent unknown number of genetic sub-populations through a hierarchical matrix-normal structure that incorporates gene-gene interactions, and possible mutations, induced by environmental variables. However, the product dependence structure implied by their matrix-normal model seems to be too simple to be appropriate for general complex, realistic situations. In this article, we propose and develop a novel nonparametric Bayesian model for case-control genotype data using hierarchies of Dirichlet processes that offers a more realistic and nonparametric dependence structure between the genes, induced by the environmental variables. In this regard, we propose a novel and highly parallelisable MCMC algorithm that is rendered quite efficient by the combination of modern parallel computing technology, effective Gibbs sampling steps, retrospective sampling and Transformation based Markov Chain Monte Carlo (TMCMC). We use appropriate Bayesian hypothesis testing procedures to detect the roles of genes and environment in case-control studies. We apply our ideas to 5 biologically realistic case-control genotype datasets simulated under distinct set-ups, and obtain encouraging results in each case. We finally apply our ideas to a real, myocardial infarction dataset, and obtain interesting results on gene-gene and gene-environment interaction, while broadly agreeing with the results reported in the literature.

preprint2020arXiv

Hierarchical Bayesian Approach for Improving Weights for Solving Multi-Objective Route Optimization Problem

The weighted sum method is a simple and widely used technique that scalarizes multiple conflicting objectives into a single objective function. It suffers from the problem of determining the appropriate weights corresponding to the objectives. This paper proposes a novel Hierarchical Bayesian model based on Multinomial distribution and Dirichlet prior to refine the weights for solving such multi-objective route optimization problems. The model and methodologies revolve around data obtained from a small scale pilot survey. The method aims at improving the existing methods of weight determination in the field of Intelligent Transport Systems as data driven choice of weights through appropriate probabilistic modelling ensures, on an average, much reliable results than non-probabilistic techniques. Application of this model and methodologies to simulated as well as real data sets revealed quite encouraging performances with respect to stabilizing the estimates of weights.