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D. Gil

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Published work

13 published item(s)

preprint2026arXiv

How Sensitive Are Radiomic AI Models to Acquisition Parameters?

A main barrier for the deployment of AI radiomic systems in clinical routine is their drop in performance under heterogeneous multicentre acquisition protocols. This work presents a performance-oriented framework for quantifying scan parameter sensitivity of radiomic AI models, while identifying clinically significant parameter regions associated with improved cross-dataset robustness. We formulate a mixed-effects framework for quantifying the influence that clinically relevant acquisition parameters have on models performance, while accounting for subject-level random effects. We have applied our framework to lung cancer diagnosis in CT scans using two independent multicentre datasets (a public database and own-collected data) and several SoA architectures. To evaluate across-database reproducibility, CT parameters have been adjusted using the data collected and tested on the public set. The optimal configuration selected is the current of the X-ray tube >= 200 mA, spiral pitch <= 1.5, slice thickness <= 1.25 mm, which balances diagnostic quality with low radiation dose. These configuration push metrics from 0.79+-0.04 sensitivity, 0.47+-0.10 specificity in low quality scans to 0.90+-0.10 sensitivity, 0.79 +- 0.13 specificity in high quality ones.

preprint2020arXiv

A flexible outlier detector based on a topology given by graph communities

Outlier, or anomaly, detection is essential for optimal performance of machine learning methods and statistical predictive models. It is not just a technical step in a data cleaning process but a key topic in many fields such as fraudulent document detection, in medical applications and assisted diagnosis systems or detecting security threats. In contrast to population-based methods, neighborhood based local approaches are simple flexible methods that have the potential to perform well in small sample size unbalanced problems. However, a main concern of local approaches is the impact that the computation of each sample neighborhood has on the method performance. Most approaches use a distance in the feature space to define a single neighborhood that requires careful selection of several parameters. This work presents a local approach based on a local measure of the heterogeneity of sample labels in the feature space considered as a topological manifold. Topology is computed using the communities of a weighted graph codifying mutual nearest neighbors in the feature space. This way, we provide with a set of multiple neighborhoods able to describe the structure of complex spaces without parameter fine tuning. The extensive experiments on real-world data sets show that our approach overall outperforms, both, local and global strategies in multi and single view settings.

preprint2020arXiv

Early Screening of SARS-CoV-2 by Intelligent Analysis of X-Ray Images

Future SARS-CoV-2 virus outbreak COVID-XX might possibly occur during the next years. However the pathology in humans is so recent that many clinical aspects, like early detection of complications, side effects after recovery or early screening, are currently unknown. In spite of the number of cases of COVID-19, its rapid spread putting many sanitary systems in the edge of collapse has hindered proper collection and analysis of the data related to COVID-19 clinical aspects. We describe an interdisciplinary initiative that integrates clinical research, with image diagnostics and the use of new technologies such as artificial intelligence and radiomics with the aim of clarifying some of SARS-CoV-2 open questions. The whole initiative addresses 3 main points: 1) collection of standardize data including images, clinical data and analytics; 2) COVID-19 screening for its early diagnosis at primary care centers; 3) define radiomic signatures of COVID-19 evolution and associated pathologies for the early treatment of complications. In particular, in this paper we present a general overview of the project, the experimental design and first results of X-ray COVID-19 detection using a classic approach based on HoG and feature selection. Our experiments include a comparison to some recent methods for COVID-19 screening in X-Ray and an exploratory analysis of the feasibility of X-Ray COVID-19 screening. Results show that classic approaches can outperform deep-learning methods in this experimental setting, indicate the feasibility of early COVID-19 screening and that non-COVID infiltration is the group of patients most similar to COVID-19 in terms of radiological description of X-ray. Therefore, an efficient COVID-19 screening should be complemented with other clinical data to better discriminate these cases.

preprint2012arXiv

Technical Design Report for the: PANDA Micro Vertex Detector

This document illustrates the technical layout and the expected performance of the Micro Vertex Detector (MVD) of the PANDA experiment. The MVD will detect charged particles as close as possible to the interaction zone. Design criteria and the optimisation process as well as the technical solutions chosen are discussed and the results of this process are subjected to extensive Monte Carlo physics studies. The route towards realisation of the detector is outlined.

preprint2010arXiv

Determination of the total width of the eta' meson

Taking advantage of both the low-emittance proton-beam of the Cooler Synchrotron COSY and the high momentum precision of the COSY-11 detector system, the mass distribution of the eta' meson was measured with a resolution of 0.33 MeV/c^2 (FWHM), improving the experimental mass resolution by almost an order of magnitude with respect to previous results. Based on the sample of more than 2300 reconstructed pp --> pp eta' events the total width of the eta' meson was determined to be 0.226 +- 0.017(stat.) +- 0.014(syst.) MeV/c^2.

preprint2010arXiv

Measurement of the invariant mass distributions for the pp -> ppeta' reaction at excess energy of Q = 16.4 MeV

The proton-proton and proton-eta' invariant mass distributions have been determined for the pp -> ppeta' reaction at an excess energy of Q = 16.4 MeV. The measurement was carried out using the COSY-11 detector setup and the proton beam of the cooler synchrotron COSY. The shapes of the determined invariant mass distributions are similar to those of the pp -> ppeta reaction and reveal an enhancement for large relative proton-proton momenta. This result, together with the fact that the proton-eta interaction is much stronger that the proton-eta' interaction, excludes the hypothesis that the observed enhancement is caused by the interaction between the proton and the meson.

preprint2010arXiv

Two-proton correlation function for the pp -> pp+eta and pp -> pp+pions reactions

For the very first time, the correlation femtoscopy method is applied to a kinematically complete measurement of meson production in the collisions of hadrons. A two-proton correlation function was derived from the data for the pp -> ppX reaction, measured near the threshold of eta meson production. A technique developed for the purpose of this analysis permitted to establish the correlation function separately for the production of the pp+eta and of the pp+pions systems. The shape of the two-proton correlation function for the ppeta differs from that for the pp(pions) and both do not show a peak structure opposite to results determined for inclusive measurements of heavy ion collisions.

preprint2010arXiv

Upper limit of the total cross section for the pn --> pn eta' reaction

The upper limit of the total cross section for the pn --> pn eta' reaction has been determined near the kinematical threshold in the excess energy range from 0 to 24 MeV. The measurement was performed using the COSY-11 detector setup, a deuteron cluster target, and the proton beam of COSY with a momentum of 3.35 GeV/c. The energy dependence of the upper limit of the cross section was extracted exploiting the Fermi momenta of nucleons inside the deuteron. Comparison of the determined upper limit of the ratio R_eta' = sigma(pn --> pn eta') / sigma(pp --> pp eta') with the corresponding ratio for eta-meson production does not favor the dominance of the N*(1535) resonance in the production process of the eta' meson and suggests nonidentical production mechanisms for eta and eta' mesons.

preprint2009arXiv

Invariant mass distributions for the pp to p p eta reaction at Q=10 MeV

Proton-proton and proton-eta invariant mass distributions and the total cross section for the pp to pp eta reaction have been determined near the threshold at an excess energy of Q=10 MeV. The experiment has been conducted using the COSY-11 detector setup and the cooler synchrotron COSY. The determined invariant mass spectra reveal significant enhancements in the region of low proton-proton relative momenta, similarly as observed previously at higher excess energies of Q=15.5 MeV and Q= 40MeV.

preprint2008arXiv

Dynamics of the near threshold eta meson production in proton-proton interaction

We present the results of measurements of the analysing power for the p(pol)p --> pp eta reaction at the excess energies of Q=10 and 36 MeV, and interpret these results within the framework of the meson exchange models. The determined values of the analysing power at both excess energies are consistent with zero implying that the eta meson is produced predominantly in s-wave.

preprint2008arXiv

Near threshold production of the pseudoscalar mesons at the COSY-11 facility

We summarise measurements of the COSY-11 collaboration concerning the excitation functions of the near threshold pseudoscalar meson production in the proton-proton interaction. The results are discussed in the context of the meson-nucleon and hyperon-nucleon interactions. We conclude that the $η$-proton interaction is significantly stronger than the eta'-proton interaction. Similarly, we found that the hyperon Lambda interacts with the nucleon considerably stronger than the hyperon Sigma, and that the interaction of (K-)-proton is much stronger than this of the (K+)-proton.

preprint2006arXiv

Eta and eta' mesons production at COSY-11

The low emittance and small momentum spread of the proton and deuteron beams of the Cooler Synchrotron COSY combined with the high mass resolution of the COSY-11 detection system permit to study the creation of mesons in the nucleon-nucleon interaction down to the fraction of MeV with respect to the kinematical threshold. At such small excess energies, the ejectiles possess low relative momenta and are predominantly produced with the relative angular momentum equal to zero. Taking advantage of these conditions we have performed investigations aiming to determine the mechanism of the production of eta and eta' mesons in the collision of hadrons as well as the hadronic interaction of these mesons with nucleons and nuclei. In this proceedings we address the ongoing studies of the spin and isospin dependence for the production of the eta and eta' mesons in free and quasi-free nucleon-nucleon collisions. New results on the spin observables for the vec(p)p --> pp eta reaction, combined with the previously determined total cross section isospin dependence, reveal a statistically significant indication that the excitation of the nucleon to the S11(1535) resonance, the process which intermediates the production of the eta meson in the nucleon-nucleon interactions, is predominantly due to the exchange of the pi meson between the colliding nucleons.