Researcher profile

Angelos Angelopoulos

Angelos Angelopoulos contributes to research discovery and scholarly infrastructure.

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Published work

3 published item(s)

preprint2026arXiv

From Prompts to Protocols: An AI Agent for Laboratory Automation

Automating science laboratories enables faster, safer, more accurate, and more reproducible execution of protocols, accelerating the discovery and testing of new materials, drugs, and more. However, setting up and running autonomous labs requires coordinating numerous instruments and robots, forcing scientists to write code, manage configuration files, and navigate complex software infrastructure. We present an AI agent architecture that integrates large language models with laboratory orchestration, enabling scientists to interactively create and monitor automated lab protocols using natural language. Integrated into the Experiment Orchestration System (EOS), the AI agent operates under an agentic loop with automated validation and error correction, and supports the complete experimental lifecycle: creating protocols, running and monitoring both protocols and closed-loop optimization campaigns, and analyzing results. A visual graph editor renders protocols as interactive node-based diagrams synchronized with the AI agent's protocol representation, enabling seamless alternation between AI-assisted and manual protocol construction. Evaluated on three simulated automated labs spanning chemistry, biology, and materials science, the AI agent achieves a 97% first-attempt protocol generation success rate and an order of magnitude reduction in required interface actions.

preprint2022arXiv

CLAS12 Track Reconstruction with Artificial Intelligence

In this article we describe the implementation of Artificial Intelligence models in track reconstruction software for the CLAS12 detector at Jefferson Lab. The Artificial Intelligence based approach resulted in improved track reconstruction efficiency in high luminosity experimental conditions. The track reconstruction efficiency increased by $10-12\%$ for single particle, and statistics in multi-particle physics reactions increased by $15\%-35\%$ depending on the number of particles in the reaction. The implementation of artificial intelligence in the workflow also resulted in a speedup of the tracking by $35\%$.

preprint2022arXiv

Using Machine Learning for Particle Track Identification in the CLAS12 Detector

Particle track reconstruction is the most computationally intensive process in nuclear physics experiments. Traditional algorithms use a combinatorial approach that exhaustively tests track measurements ("hits") to identify those that form an actual particle trajectory. In this article, we describe the development of four machine learning (ML) models that assist the tracking algorithm by identifying valid track candidates from the measurements in drift chambers. Several types of machine learning models were tested, including: Convolutional Neural Networks (CNN), Multi-Layer Perceptrons (MLP), Extremely Randomized Trees (ERT) and Recurrent Neural Networks (RNN). As a result of this work, an MLP network classifier was implemented as part of the CLAS12 reconstruction software to provide the tracking code with recommended track candidates. The resulting software achieved accuracy of greater than 99\% and resulted in an end-to-end speedup of 35\% compared to existing algorithms.