Testing over a continuum of null hypotheses with False Discovery Rate control

preprint2014arXivOpen access

Abstract

We consider statistical hypothesis testing simultaneously over a fairly general, possibly uncountably infinite, set of null hypotheses, under the assumption that a suitable single test (and corresponding pp-value) is known for each individual hypothesis. We extend to this setting the notion of false discovery rate (FDR) as a measure of type I error. Our main result studies specific procedures based on the observation of the pp-value process. Control of the FDR at a nominal level is ensured either under arbitrary dependence of pp-values, or under the assumption that the finite dimensional distributions of the pp-value process have positive correlations of a specific type (weak PRDS). Both cases generalize existing results established in the finite setting. Its interest is demonstrated in several non-parametric examples: testing the mean/signal in a Gaussian white noise model, testing the intensity of a Poisson process and testing the c.d.f. of i.i.d. random variables.

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