Abstract
We describe a light-cone wave function formalism for hadroproduction of heavy-flavors via gluon-gluon fusion. The developed approach is well suited to address coherence effects in heavy-quark production on nuclei at small $x_{2} \lsim 0.1\cdot A^{-1/3}$. Nuclear attenuation in hadroproduction of heavy-flavors is found to be similar to shadowing effects for heavy-flavor structure functions in deep-inelastic scattering from nuclei. Nevertheless, remaining differences in the theoretical formulation of both processes imply corrections to factorization theorems.
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