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Nucleation and growth in one dimension, part II: Application to DNA replication kinetics

Inspired by recent experiments on DNA replication, we apply a one-dimensional nucleation-and-growth model to DNA-replication kinetics, focusing on how to extract the time-dependent nucleation rate I(t) and growth speed v from data. We discuss generic experimental problems, namely spatial inhomogeneity, measurement noise, and finite-size effects. After evaluating how each of these affects the measurements of I(t) and v, we give guidelines for the design of experiments. These ideas are then discussed in the context of the DNA-replication experiments.

preprint2004arXivOpen access
Suckjoon JunJohn Bechhoefer
cond-mat.stat-mechcond-mat.soft
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Open access2 authors2 topics
Imported metadata coverageMissing code, dataset, citation and institution fields are tracked without dominating the paper.Details
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Suckjoon JunJohn Bechhoefer

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