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Estimating heterogeneous treatment effects in nonstationary time series with state-space models

Randomized trials and observational studies, more often than not, run over a certain period of time. The treatment effect evolves during this period which provides crucial insights into the treatment response and the long-term effects. Many conventional methods for estimating treatment effects are limited to the i.i.d. setting and are not suited for inferring the time dynamics of the treatment effect. The time series encountered in these settings are highly informative but often nonstationary due to the changing effects of treatment. This increases the difficulty, since stationarity, a common assumption in time series analysis, cannot be reasonably assumed. Another challenge is the heterogeneity of the treatment effect when the treatment affects units differently. The task of estimating heterogeneous treatment effects from nonstationary and, in particular, interventional time series is highly relevant but has remained unexplored yet. We propose Causal Transfer, a method which combines regression to adjust for confounding with time series modelling to learn the effect of the treatment and how it evolves over time. Causal Transfer does not assume the data to be stationary and can be applied to randomized trials and observational studies in which treatment is confounded. Causal Transfer adjusts the effect for possible confounders and transfers the learned effect to other time series and, thereby, estimates various forms of treatment effects, such as the average treatment effect (ATE) or the conditional average treatment effect (CATE). By learning the time dynamics of the effect, Causal Transfer can also predict the treatment effect for unobserved future time points and determine the long-term consequences of treatment.