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Clinically Translatable Direct Patlak Reconstruction from Dynamic PET with Motion Correction Using Convolutional Neural Network

Patlak model is widely used in 18F-FDG dynamic positron emission tomography (PET) imaging, where the estimated parametric images reveal important biochemical and physiology information. Because of better noise modeling and more information extracted from raw sinogram, direct Patlak reconstruction gains its popularity over the indirect approach which utilizes reconstructed dynamic PET images alone. As the prerequisite of direct Patlak methods, raw data from dynamic PET are rarely stored in clinics and difficult to obtain. In addition, the direct reconstruction is time-consuming due to the bottleneck of multiple-frame reconstruction. All of these impede the clinical adoption of direct Patlak reconstruction.In this work, we proposed a data-driven framework which maps the dynamic PET images to the high-quality motion-corrected direct Patlak images through a convolutional neural network. For the patient motion during the long period of dynamic PET scan, we combined the correction with the backward/forward projection in direct reconstruction to better fit the statistical model. Results based on fifteen clinical 18F-FDG dynamic brain PET datasets demonstrates the superiority of the proposed framework over Gaussian, nonlocal mean and BM4D denoising, regarding the image bias and contrast-to-noise ratio.