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Bayesian nonparametric analysis of reversible Markov chains

We introduce a three-parameter random walk with reinforcement, called the $(θ,α,β)$ scheme, which generalizes the linearly edge reinforced random walk to uncountable spaces. The parameter $β$ smoothly tunes the $(θ,α,β)$ scheme between this edge reinforced random walk and the classical exchangeable two-parameter Hoppe urn scheme, while the parameters $α$ and $θ$ modulate how many states are typically visited. Resorting to de Finetti's theorem for Markov chains, we use the $(θ,α,β)$ scheme to define a nonparametric prior for Bayesian analysis of reversible Markov chains. The prior is applied in Bayesian nonparametric inference for species sampling problems with data generated from a reversible Markov chain with an unknown transition kernel. As a real example, we analyze data from molecular dynamics simulations of protein folding.