Paper detail

Applications of Machine Learning Methods to Quantifying Phenotypic Traits that Distinguish the Wild Type from the Mutant Arabidopsis Thaliana Seedlings during Root Gravitropism

Post-genomic research deals with challenging problems in screening genomes of organisms for particular functions or potential for being the targets of genetic engineering for desirable biological features. 'Phenotyping' of wild type and mutants is a time-consuming and costly effort by many individuals. This article is a preliminary progress report in research on large-scale automation of phenotyping steps (imaging, informatics and data analysis) needed to study plant gene-proteins networks that influence growth and development of plants. Our results undermine the significance of phenotypic traits that are implicit in patterns of dynamics in plant root response to sudden changes of its environmental conditions, such as sudden re-orientation of the root tip against the gravity vector. Including dynamic features besides the common morphological ones has paid off in design of robust and accurate machine learning methods to automate a typical phenotyping scenario, i.e. to distinguish the wild type from the mutants.