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Zixiang Ji

Zixiang Ji appears in the imported research catalog. Authorship, coauthor and topic links are available while profile ownership is still unclaimed.

ResearcherUnclaimed source record
Biological PhysicsComputation and LanguageComputer Visionphysics.app-phphysics.ins-det

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Published work

2 published item(s)

preprint2026arXiv

Continuous quantification of viral plaque dynamics using ultra-large-area label-free imaging enables rapid antiviral susceptibility testing

The plaque reduction assay (PRA) remains the gold standard for antiviral susceptibility testing, evaluating drug potency by measuring reductions in plaque-forming units (PFUs). However, the traditional PRA is time-consuming, labor-intensive, prone to manual counting errors, and offers limited scalability. Moreover, its reliance on destructive fixation and chemical staining reduces the assay to a static, endpoint observation, obscuring the dynamic, time-resolved kinetics of dose-dependent viral inhibition. Here, we introduce a label-free, time-resolved PRA platform that transforms the conventional assay into a continuous, high-dimensional measurement of viral infection dynamics. Our system integrates a compact lens-free imaging setup with a custom-designed ultra-large-area (100 cm^2) thin-film transistor (TFT) image sensor and deep learning-based algorithms to autonomously quantify PFU dynamics within an incubator. Validated using herpes simplex virus type-1 (HSV-1) treated with acyclovir, the platform matched chemically-stained ground truth measurements with zero false positives while accelerating readout by ~26 hours. Crucially, our system revealed that increasing drug concentrations induce temporally distinct delays and suppress new PFU formation, enabling conclusive drug efficacy evaluations within ~60 hours post-infection. This scalable, label-free framework redefines antiviral susceptibility testing as a rapid, time-resolved and information-rich measurement framework, providing a generalizable platform for virology research, high-throughput drug screening, and clinical diagnostics.

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preprint2026arXiv

LongMemEval-V2: Evaluating Long-Term Agent Memory Toward Experienced Colleagues

Long-term memory is crucial for agents in specialized web environments, where success depends on recalling interface affordances, state dynamics, workflows, and recurring failure modes. However, existing memory benchmarks for agents mostly focus on user histories, short traces, or downstream task success, leaving open how to directly evaluate whether memory systems effectively internalize environment-specific experience. To address this gap, we introduce LongMemEval-V2 (LME-V2), a benchmark for evaluating whether memory systems can help agents acquire the experience needed to become knowledgeable colleagues in customized environments. LME-V2 contains 451 manually curated questions covering five core memory abilities for web agents: static state recall, dynamic state tracking, workflow knowledge, environment gotchas, and premise awareness. Questions are paired with history trajectories containing up to 500 trajectories and 115M tokens. We use a context gathering formulation: memory systems consume history trajectories and return compact evidence for downstream question answering. We propose a suite of two memory methods: AgentRunbook-R, an efficient RAG-based memory with knowledge pools for raw state observations, events, and strategy notes, and AgentRunbook-C, which stores trajectories as files and invokes a coding agent to gather evidence in an augmented sandbox. Experiments show that AgentRunbook-C achieves the best performance with 72.5% average accuracy, outperforming the strongest RAG baseline (48.5%) and the off-the-shelf coding agent baseline (69.3%). Despite the strong performance gains, coding agent based methods have high latency costs. While AgentRunbook-C advances the accuracy-latency Pareto frontier, substantial room for improvement remains. Together, these results establish LME-V2 as a challenging testbed for developing long-term memory systems for environment experience.

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