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Ziqiao Meng

Ziqiao Meng contributes to research discovery and scholarly infrastructure.

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Published work

4 published item(s)

preprint2026arXiv

Learning the Interaction Prior for Protein-Protein Interaction Prediction: A Model-Agnostic Approach

Protein-protein interactions (PPIs) are fundamental to cellular function and disease mechanisms. Current learning-based PPI predictors focus on learning powerful protein representations but neglect designing specialized classification heads. They mainly rely on generic aggregating methods like concatenation or dot products, which lack biological insight. Motivated by the biological "L3 rule", where multiple length-3 paths between a pair of proteins indicate their interaction likelihood, our study addresses this gap by designing a biologically informed PPI classifier. In this paper, we provide empirical evidence that popular PPI datasets strongly support the L3 rule. We propose an L3-path-regularized graph prompt learning method called L3-PPI, which can generate a prompt graph with virtual L3 paths based on protein representations and controls the number of paths. L3-PPI reformulates the classification of protein embedding pairs into a graph-level classification task over the generated prompt graph. This lightweight module seamlessly integrates with PPI predictors as a plug-and-play component, injecting the interaction prior of complementarity to enhance performance. Extensive experiments show that L3-PPI achieves superior performance enhancements over advanced competitors.

preprint2022arXiv

Graph-adaptive Rectified Linear Unit for Graph Neural Networks

Graph Neural Networks (GNNs) have achieved remarkable success by extending traditional convolution to learning on non-Euclidean data. The key to the GNNs is adopting the neural message-passing paradigm with two stages: aggregation and update. The current design of GNNs considers the topology information in the aggregation stage. However, in the updating stage, all nodes share the same updating function. The identical updating function treats each node embedding as i.i.d. random variables and thus ignores the implicit relationships between neighborhoods, which limits the capacity of the GNNs. The updating function is usually implemented with a linear transformation followed by a non-linear activation function. To make the updating function topology-aware, we inject the topological information into the non-linear activation function and propose Graph-adaptive Rectified Linear Unit (GReLU), which is a new parametric activation function incorporating the neighborhood information in a novel and efficient way. The parameters of GReLU are obtained from a hyperfunction based on both node features and the corresponding adjacent matrix. To reduce the risk of overfitting and the computational cost, we decompose the hyperfunction as two independent components for nodes and features respectively. We conduct comprehensive experiments to show that our plug-and-play GReLU method is efficient and effective given different GNN backbones and various downstream tasks.

preprint2022arXiv

Modeling Scale-free Graphs with Hyperbolic Geometry for Knowledge-aware Recommendation

Aiming to alleviate data sparsity and cold-start problems of traditional recommender systems, incorporating knowledge graphs (KGs) to supplement auxiliary information has recently gained considerable attention. Via unifying the KG with user-item interactions into a tripartite graph, recent works explore the graph topologies to learn the low-dimensional representations of users and items with rich semantics. However, these real-world tripartite graphs are usually scale-free, the intrinsic hierarchical graph structures of which are underemphasized in existing works, consequently, leading to suboptimal recommendation performance. To address this issue and provide more accurate recommendation, we propose a knowledge-aware recommendation method with the hyperbolic geometry, namely Lorentzian Knowledge-enhanced Graph convolutional networks for Recommendation (LKGR). LKGR facilitates better modeling of scale-free tripartite graphs after the data unification. Specifically, we employ different information propagation strategies in the hyperbolic space to explicitly encode heterogeneous information from historical interactions and KGs. Our proposed knowledge-aware attention mechanism enables the model to automatically measure the information contribution, producing the coherent information aggregation in the hyperbolic space. Extensive experiments on three real-world benchmarks demonstrate that LKGR outperforms state-of-the-art methods by 3.6-15.3% of Recall@20 on Top-K recommendation.

preprint2020arXiv

MAGNN: Metapath Aggregated Graph Neural Network for Heterogeneous Graph Embedding

A large number of real-world graphs or networks are inherently heterogeneous, involving a diversity of node types and relation types. Heterogeneous graph embedding is to embed rich structural and semantic information of a heterogeneous graph into low-dimensional node representations. Existing models usually define multiple metapaths in a heterogeneous graph to capture the composite relations and guide neighbor selection. However, these models either omit node content features, discard intermediate nodes along the metapath, or only consider one metapath. To address these three limitations, we propose a new model named Metapath Aggregated Graph Neural Network (MAGNN) to boost the final performance. Specifically, MAGNN employs three major components, i.e., the node content transformation to encapsulate input node attributes, the intra-metapath aggregation to incorporate intermediate semantic nodes, and the inter-metapath aggregation to combine messages from multiple metapaths. Extensive experiments on three real-world heterogeneous graph datasets for node classification, node clustering, and link prediction show that MAGNN achieves more accurate prediction results than state-of-the-art baselines.