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Zhou Yu

Zhou Yu contributes to research discovery and scholarly infrastructure.

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Published work

2 published item(s)

preprint2026arXiv

HYVINT: Intensity-Driven Hypergraph Generation with Variational Representations

Hypergraphs provide a principled framework for modeling polyadic interactions, with applications in recommendation systems, social networks, and molecular modeling. Hypergraph generation remains challenging because incidence structures are discrete, sparse, and governed by heterogeneous higher-order interactions. Existing generators often rely on implicit latent spaces or continuous incidence decoders, which provide limited mechanistic interpretation of how node-hyperedge incidences arise. To address these limitations, we propose HYVINT, an intensity-driven hypergraph generative framework. Our key innovations are twofold: (i) we develop an intensity-driven incidence formation mechanism for hypergraphs that links latent interaction strength to binary incidence, and (ii) we derive a tractable lower-bound variational estimator for learning latent representations. We provide generation error bounds with asymptotic convergence rates and empirically show that HYVINT achieves strong fidelity while maintaining substantial novelty and diversity on synthetic and real-world hypergraphs.

preprint2026arXiv

Pan-FM: A Pan-Organ Foundation Model with Saliency-Guided Masking for Missing Robustness

Foundation models (FMs) have shown great promise in medical imaging, but most FMs are trained on unimodal data within isolated domains, such as brain MRI alone. Human aging and disease arise through coordinated biological processes across organs, therefore motivating multimodal FMs that learn whole-body representations. A key challenge, however, is that real-world multimodal biomedical data are often missing not at random, which can reduce power, limit generalizability, and introduce bias. We propose Pan-FM, a pan-organ foundation model pre-trained on imaging from seven organs (Brain, Heart, Adipose, Liver, Kidney, Spleen, and Pancreas) under realistic missing-organ scenarios. Pan-FM uses a unified backbone that handles organ missingness during both training and inference, and is pre-trained with masking-based self-distillation. We find that naive multimodal pre-training leads to dominant-organ shortcut learning bias, with the model over-relying on dominant organs such as adipose and heart. To address this, we introduce Saliency-Guided Masking (SGM), which uses the model attention distribution to adaptively mask dominant organs during pre-training, thus encouraging more balanced cross-organ, whole-body learning. Notably, SGM introduces negligible computational overhead and can be seamlessly integrated into existing self-supervised learning frameworks to improve multi-organ representation learning. On the UK Biobank, Pan-FM achieves stronger prediction across 13 disease categories and 14 single disease entities than single-organ and multi-organ baselines, with improved robustness under missing-organ settings. Pan-FM serves as a scalable solution to realistic modality-missingness in multimodal learning in system neuroscience and as a step toward more generalizable whole-body FMs.