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Zhen Li

Zhen Li contributes to research discovery and scholarly infrastructure.

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Artificial Intelligence Computer Vision Cryptography and Security eess.IV Information Retrieval Machine Learning physics.med-ph Tissues and Organs

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preprint2026arXiv

Building Digital Twins of Different Human Organs for Personalized Healthcare

Digital twins are virtual replicas of physical entities and are poised to transform personalized medicine through the real-time simulation and prediction of human physiology. Translating this paradigm from engineering to biomedicine requires overcoming profound challenges, including anatomical variability, multi-scale biological processes, and the integration of multi-physics phenomena. This survey systematically reviews methodologies for building digital twins of human organs, structured around a pipeline decoupled into anatomical twinning (capturing patient-specific geometry and structure) and functional twinning (simulating multi-scale physiology from cellular to organ-level function). We categorize approaches both by organ-specific properties and by technical paradigm, with particular emphasis on multi-scale and multi-physics integration. A key focus is the role of artificial intelligence (AI), especially physics-informed AI, in enhancing model fidelity, scalability, and personalization. Furthermore, we discuss the critical challenges of clinical validation and translational pathways. This study not only charts a roadmap for overcoming current bottlenecks in single-organ twins but also outlines the promising, albeit ambitious, future of interconnected multi-organ digital twins for whole-body precision healthcare.

preprint2026arXiv

Evidential Information Fusion on Possibilistic Structure

Dempster's rule is a fundamental tool for combining belief functions from distinct and reliable sources. However, its intersection-based semantics imposes strong structural restrictions, which limits its flexibility in handling complex source states and diverse information fusion scenarios. To overcome this limitation, we propose a reversible transformation, derived from the isopignistic principle, between belief functions and a possibilistic structure defined on the power set. In this transformation, the relationships among subsets are explicitly characterized by a belief evolution network, which provides a more flexible representation of evidential information beyond the conventional mass function structure. On this basis, we further introduce the triangular norm family to develop a general and adaptive evidential information fusion framework. Unlike fusion methods rooted in Dempster semantics, the proposed framework supports more flexible combination behaviors and exhibits advantages in non-distinct source fusion, conflict management, parametric combination design, and heterogeneous information fusion.

preprint2026arXiv

Noise Reduction for Pufferfish Privacy: A Practical Noise Calibration Method

This paper introduces a relaxed noise calibration method to enhance data utility while attaining pufferfish privacy. This work builds on the existing $1$-Wasserstein (Kantorovich) mechanism by alleviating the existing overly strict condition that leads to excessive noise, and proposes a practical mechanism design algorithm as a general solution. We prove that a strict noise reduction by our approach always exists compared to $1$-Wasserstein mechanism for all privacy budgets $ε$ and prior beliefs, and the noise reduction (also represents improvement on data utility) gains increase significantly for low privacy budget situations--which are commonly seen in real-world deployments. We also analyze the variation and optimality of the noise reduction with different prior distributions. Moreover, all the properties of the noise reduction still exist in the worst-case $1$-Wasserstein mechanism we introduced, when the additive noise is largest. We further show that the worst-case $1$-Wasserstein mechanism is equivalent to the $\ell_1$-sensitivity method. Experimental results on three real-world datasets demonstrate $47\%$ to $87\%$ improvement in data utility.

preprint2026arXiv

PTQTP: Post-Training Quantization to Trit-Planes for Large Language Models

Post-training quantization (PTQ) of large language models (LLMs) to extremely low bit-widths remains challenging due to the fundamental trade-off between computational efficiency and representational capacity. While existing ultra-low-bit methods rely on binary approximations or quantization-aware training(QAT), they often suffer from either limited representational capacity or huge training resource overhead. We introduce PTQ to Trit-Planes (PTQTP), a structured PTQ framework that decomposes weight matrices into dual ternary {-1, 0, 1} trit-planes. This approach achieves multiplication-free additive inference by decoupling weights into discrete topology (trit-planes) and continuous magnitude (scales), effectively enabling high-fidelity sparse approximation. PTQTP provides: (1) a theoretically grounded progressive approximation algorithm ensuring global weight consistency; (2) model-agnostic deployment without architectural modifications; and (3) uniform ternary operations that eliminate mixed-precision overhead. Comprehensive experiments on LLaMA3.x and Qwen3 (0.6B-70B) demonstrate that PTQTP significantly outperforms sub-4bit PTQ methods on both language reasoning tasks and mathematical reasoning as well as coding. PTQTP rivals the 1.58-bit QAT performance while requiring only single-hour quantization compared to 10-14 GPU days for training-based methods, and the end-to-end inference speed achieves 4.63$\times$ faster than the FP16 baseline model, establishing a new and practical solution for efficient LLM deployment in resource-constrained environments. Code will available at https://github.com/HeXiao-55/PTQTP.

preprint2026arXiv

VisualCloze: A Universal Image Generation Framework via Visual In-Context Learning

Recent progress in diffusion models significantly advances various image generation tasks. However, the current mainstream approach remains focused on building task-specific models, which have limited efficiency when supporting a wide range of different needs. While universal models attempt to address this limitation, they face critical challenges, including generalizable task instruction, appropriate task distributions, and unified architectural design. To tackle these challenges, we propose VisualCloze, a universal image generation framework, which supports a wide range of in-domain tasks, generalization to unseen ones, unseen unification of multiple tasks, and reverse generation. Unlike existing methods that rely on language-based task instruction, leading to task ambiguity and weak generalization, we integrate visual in-context learning, allowing models to identify tasks from visual demonstrations. Meanwhile, the inherent sparsity of visual task distributions hampers the learning of transferable knowledge across tasks. To this end, we introduce Graph200K, a graph-structured dataset that establishes various interrelated tasks, enhancing task density and transferable knowledge. Furthermore, we uncover that our unified image generation formulation shared a consistent objective with image infilling, enabling us to leverage the strong generative priors of pre-trained infilling models without modifying the architectures.

preprint2025arXiv

OxygenREC: An Instruction-Following Generative Framework for E-commerce Recommendation

Traditional recommendation systems suffer from inconsistency in multi-stage optimization objectives. Generative Recommendation (GR) mitigates them through an end-to-end framework; however, existing methods still rely on matching mechanisms based on inductive patterns. Although responsive, they lack the ability to uncover complex user intents that require deductive reasoning based on world knowledge. Meanwhile, LLMs show strong deep reasoning capabilities, but their latency and computational costs remain challenging for industrial applications. More critically, there are performance bottlenecks in multi-scenario scalability: as shown in Figure 1, existing solutions require independent training and deployment for each scenario, leading to low resource utilization and high maintenance costs-a challenge unaddressed in GR literature. To address these, we present OxygenREC, an industrial recommendation system that leverages Fast-Slow Thinking to deliver deep reasoning with strict latency and multi-scenario requirements of real-world environments. First, we adopt a Fast-Slow Thinking architecture. Slow thinking uses a near-line LLM pipeline to synthesize Contextual Reasoning Instructions, while fast thinking employs a high-efficiency encoder-decoder backbone for real-time generation. Second, to ensure reasoning instructions effectively enhance recommendation generation, we introduce a semantic alignment mechanism with Instruction-Guided Retrieval (IGR) to filter intent-relevant historical behaviors and use a Query-to-Item (Q2I) loss for instruction-item consistency. Finally, to resolve multi-scenario scalability, we transform scenario information into controllable instructions, using unified reward mapping and Soft Adaptive Group Clip Policy Optimization (SA-GCPO) to align policies with diverse business objectives, realizing a train-once-deploy-everywhere paradigm.

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