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Zhen Lei

Zhen Lei contributes to research discovery and scholarly infrastructure.

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Machine Learning Artificial Intelligence Computation and Language Computer Vision

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preprint2026arXiv

Reward-Guided Semantic Evolution for Test-time Adaptive Object Detection

Open-vocabulary object detection with vision-language models (VLMs) such as Grounding DINO suffers from performance degradation under test-time distribution shifts, primarily due to semantic misalignment between text embeddings and shifted visual embeddings of region proposals. While recent test-time adaptive object detection methods for VLM-based either rely on costly backpropagation or bypass semantic misalignment via external memory, none directly and efficiently align text and vision in a training-free manner. To address this, we propose Reward-Guided Semantic Evolution (RGSE), a training-free framework that directly refines the text embeddings at test time. Inspired by evolutionary search, RGSE treats text embedding adaptation as a semantic search process: it perturbs text embeddings as candidate variants, evaluates them via cosine similarity with current and historical high-confidence visual proposals as a reward signal, and fuses them into a refined embedding through reward-weighted averaging. Without any backpropagation, RGSE achieves state-of-the-art performance across multiple detection benchmarks while adding minimal computational overhead. Our code will be open source upon publication.

preprint2026arXiv

scHelix: Asymmetric Dual-Stream Integration via Explicit Gene-Level Disentanglement

A critical challenge in single-cell RNA sequencing (scRNA-seq) integration is resolving the tension between eliminating batch effects and maintaining biological fidelity. While recent evidence indicates that batch effects manifest heterogeneously across genes, most existing methods process the transcriptome uniformly, frequently resulting in over-correction and loss of subtle biological signals. To address this, we present scHelix, a dataset-adaptive framework that fundamentally changes how features are processed by explicitly partitioning genes into domain-invariant Anchors and domain-sensitive Variants at the input level. scHelix utilizes a dual-stream sparse diffusion encoder equipped with stop-gradient graph caching to efficiently learn multi-scale structural representations. The core of our approach is a novel asymmetric Align-Refine-Fuse protocol: the unstable Variant stream is first aligned to the robust topology of the Anchor stream, followed by a conservative refinement phase where the Anchor stream absorbs denoised details via bounded residual gating. This divide-and-conquer architecture prevents shortcut learning and ensures robust batch removal without compromising the integrity of biological clusters. Extensive benchmarking demonstrates that scHelix outperforms state-of-the-art methods.

preprint2025arXiv

The Forgotten Shield: Safety Grafting in Parameter-Space for Medical MLLMs

Medical Multimodal Large Language Models (Medical MLLMs) have achieved remarkable progress in specialized medical tasks; however, research into their safety has lagged, posing potential risks for real-world deployment. In this paper, we first establish a multidimensional evaluation framework to systematically benchmark the safety of current SOTA Medical MLLMs. Our empirical analysis reveals pervasive vulnerabilities across both general and medical-specific safety dimensions in existing models, particularly highlighting their fragility against cross-modality jailbreak attacks. Furthermore, we find that the medical fine-tuning process frequently induces catastrophic forgetting of the model's original safety alignment. To address this challenge, we propose a novel "Parameter-Space Intervention" approach for efficient safety re-alignment. This method extracts intrinsic safety knowledge representations from original base models and concurrently injects them into the target model during the construction of medical capabilities. Additionally, we design a fine-grained parameter search algorithm to achieve an optimal trade-off between safety and medical performance. Experimental results demonstrate that our approach significantly bolsters the safety guardrails of Medical MLLMs without relying on additional domain-specific safety data, while minimizing degradation to core medical performance.

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