Researcher profile

Yuan Xue

Yuan Xue contributes to research discovery and scholarly infrastructure.

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Published work

15 published item(s)

preprint2026arXiv

Uncertainty-Aware Structured Data Extraction from Full CMR Reports via Distilled LLMs

Converting free-text cardiac magnetic resonance (CMR) reports into auditable structured data remains a bottleneck for cohort assembly, longitudinal curation, and clinical decision support. We present CMR-EXTR, a lightweight framework that converts free-text CMR reports into structured data and assigns per-field confidence for quality control. A teacher-student distillation pipeline enables fully offline inference while limiting manual annotation. Uncertainty integrates three complementary principles -- distribution plausibility, sampling stability, and cross-field consistency -- to triage human review. Experiments show that CMR-EXTR achieves 99.65% variable-level accuracy, demonstrating both reliable extraction and informative confidence scores. To our knowledge, this is the first CMR-specific extraction system with integrated confidence estimation. The code is available at https://github.com/yuyi1005/CMR-EXTR.

preprint2022arXiv

Accurate Virus Identification with Interpretable Raman Signatures by Machine Learning

Rapid identification of newly emerging or circulating viruses is an important first step toward managing the public health response to potential outbreaks. A portable virus capture device coupled with label-free Raman Spectroscopy holds the promise of fast detection by rapidly obtaining the Raman signature of a virus followed by a machine learning approach applied to recognize the virus based on its Raman spectrum, which is used as a fingerprint. We present such a machine learning approach for analyzing Raman spectra of human and avian viruses. A Convolutional Neural Network (CNN) classifier specifically designed for spectral data achieves very high accuracy for a variety of virus type or subtype identification tasks. In particular, it achieves 99% accuracy for classifying influenza virus type A vs. type B, 96% accuracy for classifying four subtypes of influenza A, 95% accuracy for differentiating enveloped and non-enveloped viruses, and 99% accuracy for differentiating avian coronavirus (infectious bronchitis virus, IBV) from other avian viruses. Furthermore, interpretation of neural net responses in the trained CNN model using a full-gradient algorithm highlights Raman spectral ranges that are most important to virus identification. By correlating ML-selected salient Raman ranges with the signature ranges of known biomolecules and chemical functional groups (for example, amide, amino acid, carboxylic acid), we verify that our ML model effectively recognizes the Raman signatures of proteins, lipids and other vital functional groups present in different viruses and uses a weighted combination of these signatures to identify viruses.

preprint2022arXiv

Asymmetry Disentanglement Network for Interpretable Acute Ischemic Stroke Infarct Segmentation in Non-Contrast CT Scans

Accurate infarct segmentation in non-contrast CT (NCCT) images is a crucial step toward computer-aided acute ischemic stroke (AIS) assessment. In clinical practice, bilateral symmetric comparison of brain hemispheres is usually used to locate pathological abnormalities. Recent research has explored asymmetries to assist with AIS segmentation. However, most previous symmetry-based work mixed different types of asymmetries when evaluating their contribution to AIS. In this paper, we propose a novel Asymmetry Disentanglement Network (ADN) to automatically separate pathological asymmetries and intrinsic anatomical asymmetries in NCCTs for more effective and interpretable AIS segmentation. ADN first performs asymmetry disentanglement based on input NCCTs, which produces different types of 3D asymmetry maps. Then a synthetic, intrinsic-asymmetry-compensated and pathology-asymmetry-salient NCCT volume is generated and later used as input to a segmentation network. The training of ADN incorporates domain knowledge and adopts a tissue-type aware regularization loss function to encourage clinically-meaningful pathological asymmetry extraction. Coupled with an unsupervised 3D transformation network, ADN achieves state-of-the-art AIS segmentation performance on a public NCCT dataset. In addition to the superior performance, we believe the learned clinically-interpretable asymmetry maps can also provide insights towards a better understanding of AIS assessment. Our code is available at https://github.com/nihaomiao/MICCAI22_ADN.

preprint2022arXiv

Coordinate Translator for Learning Deformable Medical Image Registration

The majority of deep learning (DL) based deformable image registration methods use convolutional neural networks (CNNs) to estimate displacement fields from pairs of moving and fixed images. This, however, requires the convolutional kernels in the CNN to not only extract intensity features from the inputs but also understand image coordinate systems. We argue that the latter task is challenging for traditional CNNs, limiting their performance in registration tasks. To tackle this problem, we first introduce Coordinate Translator, a differentiable module that identifies matched features between the fixed and moving image and outputs their coordinate correspondences without the need for training. It unloads the burden of understanding image coordinate systems for CNNs, allowing them to focus on feature extraction. We then propose a novel deformable registration network, im2grid, that uses multiple Coordinate Translator's with the hierarchical features extracted from a CNN encoder and outputs a deformation field in a coarse-to-fine fashion. We compared im2grid with the state-of-the-art DL and non-DL methods for unsupervised 3D magnetic resonance image registration. Our experiments show that im2grid outperforms these methods both qualitatively and quantitatively.

preprint2022arXiv

Cost Effective MLaaS Federation: A Combinatorial Reinforcement Learning Approach

With the advancement of deep learning techniques, major cloud providers and niche machine learning service providers start to offer their cloud-based machine learning tools, also known as machine learning as a service (MLaaS), to the public. According to our measurement, for the same task, these MLaaSes from different providers have varying performance due to the proprietary datasets, models, etc. Federating different MLaaSes together allows us to improve the analytic performance further. However, naively aggregating results from different MLaaSes not only incurs significant momentary cost but also may lead to sub-optimal performance gain due to the introduction of possible false-positive results. In this paper, we propose Armol, a framework to federate the right selection of MLaaS providers to achieve the best possible analytic performance. We first design a word grouping algorithm to unify the output labels across different providers. We then present a deep combinatorial reinforcement learning based-approach to maximize the accuracy while minimizing the cost. The predictions from the selected providers are then aggregated together using carefully chosen ensemble strategies. The real-world trace-driven evaluation further demonstrates that Armol is able to achieve the same accuracy results with $67\%$ less inference cost.

preprint2022arXiv

Disentangling A Single MR Modality

Disentangling anatomical and contrast information from medical images has gained attention recently, demonstrating benefits for various image analysis tasks. Current methods learn disentangled representations using either paired multi-modal images with the same underlying anatomy or auxiliary labels (e.g., manual delineations) to provide inductive bias for disentanglement. However, these requirements could significantly increase the time and cost in data collection and limit the applicability of these methods when such data are not available. Moreover, these methods generally do not guarantee disentanglement. In this paper, we present a novel framework that learns theoretically and practically superior disentanglement from single modality magnetic resonance images. Moreover, we propose a new information-based metric to quantitatively evaluate disentanglement. Comparisons over existing disentangling methods demonstrate that the proposed method achieves superior performance in both disentanglement and cross-domain image-to-image translation tasks.

preprint2022arXiv

End-to-end Graph-constrained Vectorized Floorplan Generation with Panoptic Refinement

The automatic generation of floorplans given user inputs has great potential in architectural design and has recently been explored in the computer vision community. However, the majority of existing methods synthesize floorplans in the format of rasterized images, which are difficult to edit or customize. In this paper, we aim to synthesize floorplans as sequences of 1-D vectors, which eases user interaction and design customization. To generate high fidelity vectorized floorplans, we propose a novel two-stage framework, including a draft stage and a multi-round refining stage. In the first stage, we encode the room connectivity graph input by users with a graph convolutional network (GCN), then apply an autoregressive transformer network to generate an initial floorplan sequence. To polish the initial design and generate more visually appealing floorplans, we further propose a novel panoptic refinement network(PRN) composed of a GCN and a transformer network. The PRN takes the initial generated sequence as input and refines the floorplan design while encouraging the correct room connectivity with our proposed geometric loss. We have conducted extensive experiments on a real-world floorplan dataset, and the results show that our method achieves state-of-the-art performance under different settings and evaluation metrics.

preprint2022arXiv

HVS-Inspired Signal Degradation Network for Just Noticeable Difference Estimation

Significant improvement has been made on just noticeable difference (JND) modelling due to the development of deep neural networks, especially for the recently developed unsupervised-JND generation models. However, they have a major drawback that the generated JND is assessed in the real-world signal domain instead of in the perceptual domain in the human brain. There is an obvious difference when JND is assessed in such two domains since the visual signal in the real world is encoded before it is delivered into the brain with the human visual system (HVS). Hence, we propose an HVS-inspired signal degradation network for JND estimation. To achieve this, we carefully analyze the HVS perceptual process in JND subjective viewing to obtain relevant insights, and then design an HVS-inspired signal degradation (HVS-SD) network to represent the signal degradation in the HVS. On the one hand, the well learnt HVS-SD enables us to assess the JND in the perceptual domain. On the other hand, it provides more accurate prior information for better guiding JND generation. Additionally, considering the requirement that reasonable JND should not lead to visual attention shifting, a visual attention loss is proposed to control JND generation. Experimental results demonstrate that the proposed method achieves the SOTA performance for accurately estimating the redundancy of the HVS. Source code will be available at https://github.com/jianjin008/HVS-SD-JND.

preprint2020arXiv

Learning the Graphical Structure of Electronic Health Records with Graph Convolutional Transformer

Effective modeling of electronic health records (EHR) is rapidly becoming an important topic in both academia and industry. A recent study showed that using the graphical structure underlying EHR data (e.g. relationship between diagnoses and treatments) improves the performance of prediction tasks such as heart failure prediction. However, EHR data do not always contain complete structure information. Moreover, when it comes to claims data, structure information is completely unavailable to begin with. Under such circumstances, can we still do better than just treating EHR data as a flat-structured bag-of-features? In this paper, we study the possibility of jointly learning the hidden structure of EHR while performing supervised prediction tasks on EHR data. Specifically, we discuss that Transformer is a suitable basis model to learn the hidden EHR structure, and propose Graph Convolutional Transformer, which uses data statistics to guide the structure learning process. The proposed model consistently outperformed previous approaches empirically, on both synthetic data and publicly available EHR data, for various prediction tasks such as graph reconstruction and readmission prediction, indicating that it can serve as an effective general-purpose representation learning algorithm for EHR data.

preprint2020arXiv

Learning Unstable Dynamical Systems with Time-Weighted Logarithmic Loss

When training the parameters of a linear dynamical model, the gradient descent algorithm is likely to fail to converge if the squared-error loss is used as the training loss function. Restricting the parameter space to a smaller subset and running the gradient descent algorithm within this subset can allow learning stable dynamical systems, but this strategy does not work for unstable systems. In this work, we look into the dynamics of the gradient descent algorithm and pinpoint what causes the difficulty of learning unstable systems. We show that observations taken at different times from the system to be learned influence the dynamics of the gradient descent algorithm in substantially different degrees. We introduce a time-weighted logarithmic loss function to fix this imbalance and demonstrate its effectiveness in learning unstable systems.

preprint2020arXiv

Neural Wireframe Renderer: Learning Wireframe to Image Translations

In architecture and computer-aided design, wireframes (i.e., line-based models) are widely used as basic 3D models for design evaluation and fast design iterations. However, unlike a full design file, a wireframe model lacks critical information, such as detailed shape, texture, and materials, needed by a conventional renderer to produce 2D renderings of the objects or scenes. In this paper, we bridge the information gap by generating photo-realistic rendering of indoor scenes from wireframe models in an image translation framework. While existing image synthesis methods can generate visually pleasing images for common objects such as faces and birds, these methods do not explicitly model and preserve essential structural constraints in a wireframe model, such as junctions, parallel lines, and planar surfaces. To this end, we propose a novel model based on a structure-appearance joint representation learned from both images and wireframes. In our model, structural constraints are explicitly enforced by learning a joint representation in a shared encoder network that must support the generation of both images and wireframes. Experiments on a wireframe-scene dataset show that our wireframe-to-image translation model significantly outperforms the state-of-the-art methods in both visual quality and structural integrity of generated images.

preprint2020arXiv

Semi-Supervised Cervical Dysplasia Classification With Learnable Graph Convolutional Network

Cervical cancer is the second most prevalent cancer affecting women today. As the early detection of cervical carcinoma relies heavily upon screening and pre-clinical testing, digital cervicography has great potential as a primary or auxiliary screening tool, especially in low-resource regions due to its low cost and easy access. Although an automated cervical dysplasia detection system has been desirable, traditional fully-supervised training of such systems requires large amounts of annotated data which are often labor-intensive to collect. To alleviate the need for much manual annotation, we propose a novel graph convolutional network (GCN) based semi-supervised classification model that can be trained with fewer annotations. In existing GCNs, graphs are constructed with fixed features and can not be updated during the learning process. This limits their ability to exploit new features learned during graph convolution. In this paper, we propose a novel and more flexible GCN model with a feature encoder that adaptively updates the adjacency matrix during learning and demonstrate that this model design leads to improved performance. Our experimental results on a cervical dysplasia classification dataset show that the proposed framework outperforms previous methods under a semi-supervised setting, especially when the labeled samples are scarce.

preprint2020arXiv

SiamParseNet: Joint Body Parsing and Label Propagation in Infant Movement Videos

General movement assessment (GMA) of infant movement videos (IMVs) is an effective method for the early detection of cerebral palsy (CP) in infants. Automated body parsing is a crucial step towards computer-aided GMA, in which infant body parts are segmented and tracked over time for movement analysis. However, acquiring fully annotated data for video-based body parsing is particularly expensive due to the large number of frames in IMVs. In this paper, we propose a semi-supervised body parsing model, termed SiamParseNet (SPN), to jointly learn single frame body parsing and label propagation between frames in a semi-supervised fashion. The Siamese-structured SPN consists of a shared feature encoder, followed by two separate branches: one for intra-frame body parts segmentation, and one for inter-frame label propagation. The two branches are trained jointly, taking pairs of frames from the same videos as their input. An adaptive training process is proposed that alternates training modes between using input pairs of only labeled frames and using inputs of both labeled and unlabeled frames. During testing, we employ a multi-source inference mechanism, where the final result for a test frame is either obtained via the segmentation branch or via propagation from a nearby key frame. We conduct extensive experiments on a partially-labeled IMV dataset where SPN outperforms all prior arts, demonstrating the effectiveness of our proposed method.

preprint2020arXiv

Speeding-up Logic Design and Refining Hardware EDA Flow by Exploring Chinese Character based Graphical Representation

Electrical design automation (EDA) techniques have deeply influenced the computer hardware design, especially in the field of very large scale Integration (VLSI) circuits. Particularly, the popularity of FPGA, ASIC and SOC applications have been dramatically increased due to the well developed EDA tool chains. Over decades, improving EDA tool in terms of functionality, efficiency, accuracy and intelligence is not only the academic research hot spot, but the industry attempting goal as well. In this paper, a novel perspective is taken to review current mainstream EDA working flow and design methods, aiming to shorten the EDA design periods and simplify the logic design overload significantly. Specifically, three major contributions are devoted. First, a Chinese character based representation system (CCRS), which is used for presenting logical abstract syntax tree, is proposed. Second, the register-transfer-level (RTL) level symbolic description technique for CCRS are introduced to replace traditional text-based programming methods. Finally, the refined EDA design flow based on CCRS is discussed. It is convincing that the graphic non-pure-english based EDA flow could lower the design cost and complexity. As a fundamental trial in this new field, it is confirmative that a lot of following works will make the related EDA development prosperous.

preprint2020arXiv

Synthetic Sample Selection via Reinforcement Learning

Synthesizing realistic medical images provides a feasible solution to the shortage of training data in deep learning based medical image recognition systems. However, the quality control of synthetic images for data augmentation purposes is under-investigated, and some of the generated images are not realistic and may contain misleading features that distort data distribution when mixed with real images. Thus, the effectiveness of those synthetic images in medical image recognition systems cannot be guaranteed when they are being added randomly without quality assurance. In this work, we propose a reinforcement learning (RL) based synthetic sample selection method that learns to choose synthetic images containing reliable and informative features. A transformer based controller is trained via proximal policy optimization (PPO) using the validation classification accuracy as the reward. The selected images are mixed with the original training data for improved training of image recognition systems. To validate our method, we take the pathology image recognition as an example and conduct extensive experiments on two histopathology image datasets. In experiments on a cervical dataset and a lymph node dataset, the image classification performance is improved by 8.1% and 2.3%, respectively, when utilizing high-quality synthetic images selected by our RL framework. Our proposed synthetic sample selection method is general and has great potential to boost the performance of various medical image recognition systems given limited annotation.