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Yinxi Wang

Yinxi Wang contributes to research discovery and scholarly infrastructure.

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Published work

3 published item(s)

preprint2026arXiv

LaST-R1: Reinforcing Robotic Manipulation via Adaptive Physical Latent Reasoning

Robotic foundation models require reasoning over complex visual scenes to execute adaptive actions in dynamic environments. While recent studies on latent-reasoning Vision-Language-Action (VLA) models have demonstrated the capability to capture fine-grained physical dynamics, they remain predominantly confined to static imitation learning, severely limiting their adaptability and generalization. In this paper, we present LaST-R1, a novel reinforcement learning (RL) post-training framework designed to effectively harness "latent reasoning-before-acting" policies. Specifically, we propose Latent-to-Action Policy Optimization (LAPO), a core RL algorithm that jointly optimizes the latent reasoning process and the action generation. By explicitly embedding latent Chain-of-Thought (CoT) reasoning directly within the RL optimization loop, LAPO stimulates profound physical world modeling, which in turn drives robust execution in interactive environments. Furthermore, an adaptive latent CoT mechanism is introduced, allowing the policy to dynamically modulate its reasoning horizon based on diverse environment states. Experiments show that LaST-R1 achieves a near-perfect 99.9% average success rate on the LIBERO benchmark with only one-shot supervised warm-up, significantly improving convergence speed and performance over prior state-of-the-art (SOTA) methods. In real-world deployments, LaST-R1 yields up to a 22.5% average improvement over SOTA supervised fine-tuning approach across four complex tasks, including both single-arm and dual-arm settings. Finally, LaST-R1 demonstrates strong generalization across simulated and real-world environments.

preprint2022arXiv

Using deep learning to detect patients at risk for prostate cancer despite benign biopsies

Background: Transrectal ultrasound guided systematic biopsies of the prostate is a routine procedure to establish a prostate cancer diagnosis. However, the 10-12 prostate core biopsies only sample a relatively small volume of the prostate, and tumour lesions in regions between biopsy cores can be missed, leading to a well-known low sensitivity to detect clinically relevant cancer. As a proof-of-principle, we developed and validated a deep convolutional neural network model to distinguish between morphological patterns in benign prostate biopsy whole slide images from men with and without established cancer. Methods: This study included 14,354 hematoxylin and eosin stained whole slide images from benign prostate biopsies from 1,508 men in two groups: men without an established prostate cancer (PCa) diagnosis and men with at least one core biopsy diagnosed with PCa. 80% of the participants were assigned as training data and used for model optimization (1,211 men), and the remaining 20% (297 men) as a held-out test set used to evaluate model performance. An ensemble of 10 deep convolutional neural network models was optimized for classification of biopsies from men with and without established cancer. Hyperparameter optimization and model selection was performed by cross-validation in the training data . Results: Area under the receiver operating characteristic curve (ROC-AUC) was estimated as 0.727 (bootstrap 95% CI: 0.708-0.745) on biopsy level and 0.738 (bootstrap 95% CI: 0.682 - 0.796) on man level. At a specificity of 0.9 the model had an estimated sensitivity of 0.348. Conclusion: The developed model has the ability to detect men with risk of missed PCa due to under-sampling of the prostate. The proposed model has the potential to reduce the number of false negative cases in routine systematic prostate biopsies and to indicate men who could benefit from MRI-guided re-biopsy.

preprint2020arXiv

Predicting molecular phenotypes from histopathology images: a transcriptome-wide expression-morphology analysis in breast cancer

Molecular phenotyping is central in cancer precision medicine, but remains costly and standard methods only provide a tumour average profile. Microscopic morphological patterns observable in histopathology sections from tumours are determined by the underlying molecular phenotype and associated with clinical factors. The relationship between morphology and molecular phenotype has a potential to be exploited for prediction of the molecular phenotype from the morphology visible in histopathology images. We report the first transcriptome-wide Expression-MOrphology (EMO) analysis in breast cancer, where gene-specific models were optimised and validated for prediction of mRNA expression both as a tumour average and in spatially resolved manner. Individual deep convolutional neural networks (CNNs) were optimised to predict the expression of 17,695 genes from hematoxylin and eosin (HE) stained whole slide images (WSIs). Predictions for 9,334 (52.75%) genes were significantly associated with RNA-sequencing estimates (FDR adjusted p-value < 0.05). 1,011 of the genes were brought forward for validation, with 876 (87%) and 908 (90%) successfully replicated in internal and external test data, respectively. Predicted spatial intra-tumour variabilities in expression were validated in 76 genes, out of which 59 (77.6%) had a significant association (FDR adjusted p-value < 0.05) with spatial transcriptomics estimates. These results suggest that the proposed methodology can be applied to predict both tumour average gene expression and intra-tumour spatial expression directly from morphology, thus providing a scalable approach to characterise intra-tumour heterogeneity.