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Yejin Kim

Yejin Kim contributes to research discovery and scholarly infrastructure.

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Published work

8 published item(s)

preprint2026arXiv

A More Word-like Image Tokenization for MLLMs

Modern multimodal large language models (MLLMs) typically keep the language model fixed and train a visual projector that maps the pixels into a sequence of tokens in its embedding space, so that images can be presented in essentially the same form as text. However, the language model has been optimized to operate on discrete, semantically meaningful tokens, while prevailing visual projectors transform an image into a long stream of continuous and highly correlated embeddings. This causes the visual tokens to behave differently from the word-like units that LLMs are originally trained to understand. We propose a novel Disentangled Visual Tokenization (DiVT) that clusters patch embeddings into coherent semantic units, so each token corresponds to a distinct visual concept instead of a rigid grid cell. DiVT further adapts its token budget to image complexity, providing an explicit accuracy-compute trade-off modifying neither the vision encoder nor the language model. Across diverse multimodal benchmarks, DiVT matches or surpasses baselines with significantly fewer visual tokens, demonstrating robustness under limited token budgets, significantly reducing memory cost and latency while making visual inputs more compatible with LLMs. Our code is available at https://github.com/snuviplab/DiVT.

preprint2023arXiv

Scalable Causal Structure Learning: Scoping Review of Traditional and Deep Learning Algorithms and New Opportunities in Biomedicine

Causal structure learning refers to a process of identifying causal structures from observational data, and it can have multiple applications in biomedicine and health care. This paper provides a practical review and tutorial on scalable causal structure learning models with examples of real-world data to help health care audiences understand and apply them. We reviewed traditional (combinatorial and score-based methods) for causal structure discovery and machine learning-based schemes. We also highlighted recent developments in biomedicine where causal structure learning can be applied to discover structures such as gene networks, brain connectivity networks, and those in cancer epidemiology. We also compared the performance of traditional and machine learning-based algorithms for causal discovery over some benchmark data sets. Machine learning-based approaches, including deep learning, have many advantages over traditional approaches, such as scalability, including a greater number of variables, and potentially being applied in a wide range of biomedical applications, such as genetics, if sufficient data are available. Furthermore, these models are more flexible than traditional models and are poised to positively affect many applications in the future.

preprint2022arXiv

Don't Judge a Language Model by Its Last Layer: Contrastive Learning with Layer-Wise Attention Pooling

Recent pre-trained language models (PLMs) achieved great success on many natural language processing tasks through learning linguistic features and contextualized sentence representation. Since attributes captured in stacked layers of PLMs are not clearly identified, straightforward approaches such as embedding the last layer are commonly preferred to derive sentence representations from PLMs. This paper introduces the attention-based pooling strategy, which enables the model to preserve layer-wise signals captured in each layer and learn digested linguistic features for downstream tasks. The contrastive learning objective can adapt the layer-wise attention pooling to both unsupervised and supervised manners. It results in regularizing the anisotropic space of pre-trained embeddings and being more uniform. We evaluate our model on standard semantic textual similarity (STS) and semantic search tasks. As a result, our method improved the performance of the base contrastive learned BERT_base and variants.

preprint2022arXiv

Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence

Amid the pandemic of 2019 novel coronavirus disease (COVID-19) infected by SARS-CoV-2, a vast amount of drug research for prevention and treatment has been quickly conducted, but these efforts have been unsuccessful thus far. Our objective is to prioritize repurposable drugs using a drug repurposing pipeline that systematically integrates multiple SARS-CoV-2 and drug interactions, deep graph neural networks, and in-vitro/population-based validations. We first collected all the available drugs (n= 3,635) involved in COVID-19 patient treatment through CTDbase. We built a SARS-CoV-2 knowledge graph based on the interactions among virus baits, host genes, pathways, drugs, and phenotypes. A deep graph neural network approach was used to derive the candidate representation based on the biological interactions. We prioritized the candidate drugs using clinical trial history, and then validated them with their genetic profiles, in vitro experimental efficacy, and electronic health records. We highlight the top 22 drugs including Azithromycin, Atorvastatin, Aspirin, Acetaminophen, and Albuterol. We further pinpointed drug combinations that may synergistically target COVID-19. In summary, we demonstrated that the integration of extensive interactions, deep neural networks, and rigorous validation can facilitate the rapid identification of candidate drugs for COVID-19 treatment. This is a post-peer-review, pre-copyedit version of an article published in Scientific Reports The final authenticated version is available online at: https://www.nature.com/articles/s41598-021-02353-5

preprint2022arXiv

Relational graph convolutional networks for predicting blood-brain barrier penetration of drug molecules

Evaluating the blood-brain barrier (BBB) permeability of drug molecules is a critical step in brain drug development. Traditional methods for the evaluation require complicated in vitro or in vivo testing. Alternatively, in silico predictions based on machine learning have proved to be a cost-efficient way to complement the in vitro and in vivo methods. However, the performance of the established models has been limited by their incapability of dealing with the interactions between drugs and proteins, which play an important role in the mechanism behind the BBB penetrating behaviors. To address this limitation, we employed the relational graph convolutional network (RGCN) to handle the drug-protein interactions as well as the properties of each individual drug. The RGCN model achieved an overall accuracy of 0.872, an AUROC of 0.919 and an AUPRC of 0.838 for the testing dataset with the drug-protein interactions and the Mordred descriptors as the input. Introducing drug-drug similarity to connect structurally similar drugs in the data graph further improved the testing results, giving an overall accuracy of 0.876, an AUROC of 0.926 and an AUPRC of 0.865. In particular, the RGCN model was found to greatly outperform the LightGBM base model when evaluated with the drugs whose BBB penetration was dependent on drug-protein interactions. Our model is expected to provide high-confidence predictions of BBB permeability for drug prioritization in the experimental screening of BBB-penetrating drugs.

preprint2020arXiv

Population stratification enables modeling effects of reopening policies on mortality and hospitalization rates

Objective: We study the influence of local reopening policies on the composition of the infectious population and their impact on future hospitalization and mortality rates. Materials and Methods: We collected datasets of daily reported hospitalization and cumulative morality of COVID 19 in Houston, Texas, from May 1, 2020 until June 29, 2020. These datasets are from multiple sources (USA FACTS, Southeast Texas Regional Advisory Council COVID 19 report, TMC daily news, and New York Times county level mortality reporting). Our model, risk stratified SIR HCD uses separate variables to model the dynamics of local contact (e.g., work from home) and high contact (e.g., work on site) subpopulations while sharing parameters to control their respective $R_0(t)$ over time. Results: We evaluated our models forecasting performance in Harris County, TX (the most populated county in the Greater Houston area) during the Phase I and Phase II reopening. Not only did our model outperform other competing models, it also supports counterfactual analysis to simulate the impact of future policies in a local setting, which is unique among existing approaches. Discussion: Local mortality and hospitalization are significantly impacted by quarantine and reopening policies. No existing model has directly accounted for the effect of these policies on local trends in infections, hospitalizations, and deaths in an explicit and explainable manner. Our work is an attempt to close this important technical gap to support decision making. Conclusion: Despite several limitations, we think it is a timely effort to rethink about how to best model the dynamics of pandemics under the influence of reopening policies.

preprint2019arXiv

Combining Representation Learning with Tensor Factorization for Risk Factor Analysis - an application to Epilepsy and Alzheimer's disease

Existing studies consider Alzheimer's disease (AD) a comorbidity of epilepsy, but also recognize epilepsy to occur more frequently in patients with AD than those without. The goal of this paper is to understand the relationship between epilepsy and AD by studying causal relations among subgroups of epilepsy patients. We develop an approach combining representation learning with tensor factorization to provide an in-depth analysis of the risk factors among epilepsy patients for AD. An epilepsy-AD cohort of ~600,000 patients were extracted from Cerner Health Facts data (50M patients). Our experimental results not only suggested a causal relationship between epilepsy and later onset of AD ( p = 1.92e-51), but also identified five epilepsy subgroups with distinct phenotypic patterns leading to AD. While such findings are preliminary, the proposed method combining representation learning with tensor factorization seems to be an effective approach for risk factor analysis.

preprint2019arXiv

Discriminative Sleep Patterns of Alzheimer's Disease via Tensor Factorization

Sleep change is commonly reported in Alzheimer's disease (AD) patients and their brain wave studies show decrease in dreaming and non-dreaming stages. Although sleep disturbance is generally considered as a consequence of AD, it might also be a risk factor of AD as new biological evidence shows. Leveraging National Sleep Research Resource (NSRR), we built a unique cohort of 83 cases and 331 controls with clinical variables and EEG signals. Supervised tensor factorization method was applied for this temporal dataset to extract discriminative sleep patterns. Among the 30 patterns extracted, we identified 5 significant patterns (4 patterns for AD likely and 1 pattern for normal ones) and their visual patterns provide interesting linkage to sleep with repeated wakefulness, insomnia, epileptic seizure, and etc. This study is preliminary but findings are interesting, which is a first step to provide quantifiable evidences to measure sleep as a risk factor of AD.