Researcher profile

Xu Cao

Xu Cao contributes to research discovery and scholarly infrastructure.

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Computer Vision Artificial Intelligence Biomolecules Computation and Language Machine Learning quant-ph

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preprint2026arXiv

Evaluating Cognitive Age Alignment in Interactive AI Agents

While agentic AI and its core multimodal large language models (MLLMs) have demonstrated remarkable promise in language and visual reasoning across domains ranging from daily life to advanced scientific research, a profound gap remains between artificial and human intelligence. Despite the integration of powerful tools and advanced MLLMs, state-of-the-art AI agents frequently fail at foundational, seemingly simple tasks that a child can resolve with ease. Inspired by the Wechsler Intelligence Scale for Children (WISC), we introduce ChildAgentEval, the first psychometrically grounded interactive benchmark for evaluating cognitive age alignment in MLLM-based agents. ChildAgentEval systematically compares the reasoning performance of various MLLM-based interactive agents against age-specific human developmental stages, exposing where current agentic AI systems can and cannot simulate age-specific cognitive behavior.

preprint2026arXiv

Fine-Grained Preference Optimization Improves Spatial Reasoning in VLMs

Current Vision-Language Models (VLMs) struggle with fine-grained spatial reasoning, particularly when multi-step logic and precise spatial alignment are required. In this work, we introduce SpatialReasoner-R1, a vision-language reasoning model designed to address these limitations. To construct high-quality supervision for spatial reasoning, we design a Multi-Model Monte Carlo Tree Search (M3CTS) method that generates diverse, logically consistent Long Chain-of-Thought (LongCOT) reasoning trajectories. In addition, we propose a fine-grained Direct Preference Optimization (fDPO) method that introduces segment-specific preference granularity for descriptive grounding and logical reasoning, guided by a spatial reward mechanism that evaluates candidate responses based on visual consistency, spatial grounding, and logical coherence. Experimental results demonstrate that fDPO achieves relative performance gains of 4.1% and 9.0% over standard DPO on spatial qualitative and quantitative tasks, respectively. SpatialReasoner-R1, trained with fDPO, sets a new SoTA on SpatialRGPT-Bench, outperforming the strongest baseline by 9.4% in average accuracy, while maintaining competitive performance on general vision-language tasks.

preprint2026arXiv

HOLO: Homography-Guided Pose Estimator Network for Fine-Grained Visual Localization on SD Maps

Visual localization on standard-definition (SD) maps has emerged as a promising low-cost and scalable solution for autonomous driving. However, existing regression-based approaches often overlook inherent geometric priors, resulting in suboptimal training efficiency and limited localization accuracy. In this paper, we propose a novel homography-guided pose estimator network for fine-grained visual localization between multi-view images and standard-definition (SD) maps. We construct input pairs that satisfy a homography constraint by projecting ground-view features into the BEV domain and enforcing semantic alignment with map features. Then we leverage homography relationships to guide feature fusion and restrict the pose outputs to a valid feasible region, which significantly improves training efficiency and localization accuracy compared to prior methods relying on attention-based fusion and direct 3-DoF pose regression. To the best of our knowledge, this is the first work to unify BEV semantic reasoning with homography learning for image-to-map localization. Furthermore, by explicitly modeling homography transformations, the proposed framework naturally supports cross-resolution inputs, enhancing model flexibility. Extensive experiments on the nuScenes dataset demonstrate that our approach significantly outperforms existing state-of-the-art visual localization methods. Code and pretrained models will be publicly released to foster future research.

preprint2025arXiv

Quantum-machine-assisted Drug Discovery

Drug discovery is lengthy and expensive, with traditional computer-aided design facing limits. This paper examines integrating quantum computing across the drug development cycle to accelerate and enhance workflows and rigorous decision-making. It highlights quantum approaches for molecular simulation, drug-target interaction prediction, and optimizing clinical trials. Leveraging quantum capabilities could accelerate timelines and costs for bringing therapies to market, improving efficiency and ultimately benefiting public health.

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