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Researcher profile

Xintao Wu

Xintao Wu contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Machine LearningArtificial IntelligenceCryptography and SecurityComputation and Languagecs.CYGenomicsInformation Theorymath.IT

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Published work

8 published item(s)

preprint2026arXiv

Histopathology-centered Computational Evolution of Spatial Omics: Integration, Mapping, and Foundation Models

Spatial omics (SO) technologies enable spatially resolved molecular profiling, while hematoxylin and eosin (H&E) imaging remains the gold standard for morphological assessment in clinical pathology. Recent computational advances increasingly place H&E images at the center of SO analysis, bridging morphology with transcriptomic, proteomic, and other spatial molecular modalities, and pushing resolution toward the single-cell level. In this survey, we systematically review the computational evolution of SO from a histopathology-centered perspective and organize existing methods into three paradigms: integration, which jointly models paired multimodal data; mapping, which infers molecular profiles from H&E images; and foundation models, which learn generalizable representations from large-scale spatial datasets. We analyze how the role of H&E images evolves across these paradigms from spatial context to predictive anchor and ultimately to representation backbone in response to practical constraints such as limited paired data and increasing resolution demands. We further summarize actionable modeling directions enabled by current architectures and delineate persistent gaps driven by data, biology, and technology that are unlikely to be resolved by model design alone. Together, this survey provides a histopathology-centered roadmap for developing and applying computational frameworks in SO.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

How Does Differential Privacy Affect Social Bias in LLMs? A Systematic Evaluation

Large language models (LLMs) trained on web-scale corpora can memorize sensitive training data, posing significant privacy risks. Differential privacy (DP) has emerged as a principled framework that limits the influence of individual data points during training, yet the relationship between differential privacy and social bias in LLMs remains poorly understood. To investigate this, we present a systematic evaluation of social bias in a pretrained LLM trained with DP-SGD, comparing a DP model against non-DP baselines across four complementary paradigms: sentence scoring, text completion, tabular classification, and question answering. We find that DP reduces bias in sentence scoring tasks, where bias is measured through controlled likelihood comparisons, yet this improvement does not generalize across all tasks. Our results reveal a discrepancy between logit-level bias and output-level bias. Moreover, decreasing memorization does not necessarily reduce unfairness, underscoring the importance of multi-paradigm evaluation when assessing fairness in LLMs.

0 citations0 reviewsNo code linkedOpen access
preprint2023arXiv

InfoFair: Information-Theoretic Intersectional Fairness

Algorithmic fairness is becoming increasingly important in data mining and machine learning. Among others, a foundational notation is group fairness. The vast majority of the existing works on group fairness, with a few exceptions, primarily focus on debiasing with respect to a single sensitive attribute, despite the fact that the co-existence of multiple sensitive attributes (e.g., gender, race, marital status, etc.) in the real-world is commonplace. As such, methods that can ensure a fair learning outcome with respect to all sensitive attributes of concern simultaneously need to be developed. In this paper, we study the problem of information-theoretic intersectional fairness (InfoFair), where statistical parity, a representative group fairness measure, is guaranteed among demographic groups formed by multiple sensitive attributes of interest. We formulate it as a mutual information minimization problem and propose a generic end-to-end algorithmic framework to solve it. The key idea is to leverage a variational representation of mutual information, which considers the variational distribution between learning outcomes and sensitive attributes, as well as the density ratio between the variational and the original distributions. Our proposed framework is generalizable to many different settings, including other statistical notions of fairness, and could handle any type of learning task equipped with a gradient-based optimizer. Empirical evaluations in the fair classification task on three real-world datasets demonstrate that our proposed framework can effectively debias the classification results with minimal impact to the classification accuracy.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Adaptive Fairness-Aware Online Meta-Learning for Changing Environments

The fairness-aware online learning framework has arisen as a powerful tool for the continual lifelong learning setting. The goal for the learner is to sequentially learn new tasks where they come one after another over time and the learner ensures the statistic parity of the new coming task across different protected sub-populations (e.g. race and gender). A major drawback of existing methods is that they make heavy use of the i.i.d assumption for data and hence provide static regret analysis for the framework. However, low static regret cannot imply a good performance in changing environments where tasks are sampled from heterogeneous distributions. To address the fairness-aware online learning problem in changing environments, in this paper, we first construct a novel regret metric FairSAR by adding long-term fairness constraints onto a strongly adapted loss regret. Furthermore, to determine a good model parameter at each round, we propose a novel adaptive fairness-aware online meta-learning algorithm, namely FairSAOML, which is able to adapt to changing environments in both bias control and model precision. The problem is formulated in the form of a bi-level convex-concave optimization with respect to the model's primal and dual parameters that are associated with the model's accuracy and fairness, respectively. The theoretic analysis provides sub-linear upper bounds for both loss regret and violation of cumulative fairness constraints. Our experimental evaluation on different real-world datasets with settings of changing environments suggests that the proposed FairSAOML significantly outperforms alternatives based on the best prior online learning approaches.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

The Fairness Field Guide: Perspectives from Social and Formal Sciences

Over the past several years, a slew of different methods to measure the fairness of a machine learning model have been proposed. However, despite the growing number of publications and implementations, there is still a critical lack of literature that explains the interplay of fair machine learning with the social sciences of philosophy, sociology, and law. We hope to remedy this issue by accumulating and expounding upon the thoughts and discussions of fair machine learning produced by both social and formal (specifically machine learning and statistics) sciences in this field guide. Specifically, in addition to giving the mathematical and algorithmic backgrounds of several popular statistical and causal-based fair machine learning methods, we explain the underlying philosophical and legal thoughts that support them. Further, we explore several criticisms of the current approaches to fair machine learning from sociological and philosophical viewpoints. It is our hope that this field guide will help fair machine learning practitioners better understand how their algorithms align with important humanistic values (such as fairness) and how we can, as a field, design methods and metrics to better serve oppressed and marginalized populaces.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Trustworthy Anomaly Detection: A Survey

Anomaly detection has a wide range of real-world applications, such as bank fraud detection and cyber intrusion detection. In the past decade, a variety of anomaly detection models have been developed, which lead to big progress towards accurately detecting various anomalies. Despite the successes, anomaly detection models still face many limitations. The most significant one is whether we can trust the detection results from the models. In recent years, the research community has spent a great effort to design trustworthy machine learning models, such as developing trustworthy classification models. However, the attention to anomaly detection tasks is far from sufficient. Considering that many anomaly detection tasks are life-changing tasks involving human beings, labeling someone as anomalies or fraudsters should be extremely cautious. Hence, ensuring the anomaly detection models conducted in a trustworthy fashion is an essential requirement to deploy the models to conduct automatic decisions in the real world. In this brief survey, we summarize the existing efforts and discuss open problems towards trustworthy anomaly detection from the perspectives of interpretability, fairness, robustness, and privacy-preservation.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

LogBERT: Log Anomaly Detection via BERT

Detecting anomalous events in online computer systems is crucial to protect the systems from malicious attacks or malfunctions. System logs, which record detailed information of computational events, are widely used for system status analysis. In this paper, we propose LogBERT, a self-supervised framework for log anomaly detection based on Bidirectional Encoder Representations from Transformers (BERT). LogBERT learns the patterns of normal log sequences by two novel self-supervised training tasks and is able to detect anomalies where the underlying patterns deviate from normal log sequences. The experimental results on three log datasets show that LogBERT outperforms state-of-the-art approaches for anomaly detection.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Deep Learning for Insider Threat Detection: Review, Challenges and Opportunities

Insider threats, as one type of the most challenging threats in cyberspace, usually cause significant loss to organizations. While the problem of insider threat detection has been studied for a long time in both security and data mining communities, the traditional machine learning based detection approaches, which heavily rely on feature engineering, are hard to accurately capture the behavior difference between insiders and normal users due to various challenges related to the characteristics of underlying data, such as high-dimensionality, complexity, heterogeneity, sparsity, lack of labeled insider threats, and the subtle and adaptive nature of insider threats. Advanced deep learning techniques provide a new paradigm to learn end-to-end models from complex data. In this brief survey, we first introduce one commonly-used dataset for insider threat detection and review the recent literature about deep learning for such research. The existing studies show that compared with traditional machine learning algorithms, deep learning models can improve the performance of insider threat detection. However, applying deep learning to further advance the insider threat detection task still faces several limitations, such as lack of labeled data, adaptive attacks. We then discuss such challenges and suggest future research directions that have the potential to address challenges and further boost the performance of deep learning for insider threat detection.

0 citations0 reviewsNo code linkedOpen access