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Xiaoke Zhang

Xiaoke Zhang contributes to research discovery and scholarly infrastructure.

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Published work

3 published item(s)

preprint2026arXiv

Precision Physical Activity Prescription via Reinforcement Learning for Functional Actions

Physical activity (PA) plays an important role in maintaining and improving health. Daily steps have been a key PA measure that is easily accessible with common wearable devices. However, methods are lacking to recommend a personalized optimal distribution of daily steps over a period of time for the best of certain health biomarkers. In this paper, we fill this void based on the data from the All of Us Research Program which includes months of step counts as well as repeated measurements of key health biomarkers. We develop a new offline reinforcement learning (RL) algorithm to learn personalized and optimal PA distributions associated with cardiometabolic risk, where the action is a function representing the daily step distribution over a period of time. Simulation studies demonstrate the advantage of the proposed approach over existing continuous-action RL methods. The learned optimal policy from the All of Us data generally suggests people take more daily steps and also follow a more consistent pattern of PA over time while offering tailored recommendations for subgroups in blood glucose level, body mass index, blood pressure, age, and sex.

preprint2020arXiv

Average Treatment Effect Estimation in Observational Studies with Functional Covariates

Functional data analysis is an important area in modern statistics and has been successfully applied in many fields. Although many scientific studies aim to find causations, a predominant majority of functional data analysis approaches can only reveal correlations. In this paper, average treatment effect estimation is studied for observational data with functional covariates. This paper generalizes various state-of-art propensity score estimation methods for multivariate data to functional data. The resulting average treatment effect estimators via propensity score weighting are numerically evaluated by a simulation study and applied to a real-world dataset to study the causal effect of duloxitine on the pain relief of chronic knee osteoarthritis patients.

preprint2020arXiv

Functional Data Analysis with Causation in Observational Studies: Covariate Balancing Functional Propensity Score for Functional Treatments

Functional data analysis, which handles data arising from curves, surfaces, volumes, manifolds and beyond in a variety of scientific fields, is a rapidly developing area in modern statistics and data science in the recent decades. The effect of a functional variable on an outcome is an essential theme in functional data analysis, but a majority of related studies are restricted to correlational effects rather than causal effects. This paper makes the first attempt to study the causal effect of a functional variable as a treatment in observational studies. Despite the lack of a probability density function for the functional treatment, the propensity score is properly defined in terms of a multivariate substitute. Two covariate balancing methods are proposed to estimate the propensity score, which minimize the correlation between the treatment and covariates. The appealing performance of the proposed method in both covariate balance and causal effect estimation is demonstrated by a simulation study. The proposed method is applied to study the causal effect of body shape on human visceral adipose tissue.