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Xiaogen Zhou

Xiaogen Zhou contributes to research discovery and scholarly infrastructure.

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Published work

2 published item(s)

preprint2026arXiv

Seed Hijacking of LLM Sampling and Quantum Random Number Defense

Large language models (LLMs) rely on deterministic pseudorandom number generators (PRNGs) for autoregressive sampling, creating a critical supply-chain attack surface overlooked by existing defenses. We present SeedHijack, a backdoor attack that manipulates PRNG outputs to force attacker-specified token selection without altering model logits. In a 540-trial benchmark on GPT-2 (124M), the attack achieves 99.6% exact token injection across 9 sampling configurations; it reaches 100% success on four aligned models (1.5B-7B, RLHF/SFT/reasoning distillation) and bypasses all alignment methods tested in this work. We further propose a defense based on a hardware quantum random number generator (QRNG), which neutralizes the attack in our evaluated threat model with negligible median overhead (+0.6% latency, +7.7 MB memory). Our work identifies a critical sampling-layer vulnerability and provides a practical, deployable QRNG-based defense.

preprint2020arXiv

Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-1

As the infection of 2019-nCoV coronavirus is quickly developing into a global pneumonia epidemic, careful analysis of its transmission and cellular mechanisms is sorely needed. In this report, we re-analyzed the computational approaches and findings presented in two recent manuscripts by Ji et al. (https://doi.org/10.1002/jmv.25682) and by Pradhan et al. (https://doi.org/10.1101/2020.01.30.927871), which concluded that snakes are the intermediate hosts of 2019-nCoV and that the 2019-nCoV spike protein insertions shared a unique similarity to HIV-1. Results from our re-implementation of the analyses, built on larger-scale datasets using state-of-the-art bioinformatics methods and databases, do not support the conclusions proposed by these manuscripts. Based on our analyses and existing data of coronaviruses, we concluded that the intermediate hosts of 2019-nCoV are more likely to be mammals and birds than snakes, and that the "novel insertions" observed in the spike protein are naturally evolved from bat coronaviruses.