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Washington Mio

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2 published item(s)

preprint2026arXiv

The Observable Wasserstein Distance

We introduce the observable Wasserstein distance, a framework for deriving lower bounds on the Wasserstein distance between probability measures on Polish metric spaces, designed to bypass the computational intractability of exact optimal transport in large-scale, non-Euclidean datasets. Analogous to the sliced Wasserstein distance in $\mathbb{R}^d$, our approach projects measures onto the real line via 1-Lipschitz observables and computes the Wasserstein distances between the resulting pushforward distributions. We define a hierarchy of pseudo-metrics by restricting observables to a nested chain of subspaces. A central theoretical contribution is an injectivity result linking the metric covering dimension of the support of a measure to the specific order in the hierarchy that guarantees unique recovery. This serves as a metric-space analogue to the Cramér-Wold Device for Euclidean distributions. We demonstrate that this hierarchy offers a tunable trade-off between sharpness as a lower bound on the Wasserstein distance and computational efficiency. We also present a discrete computational model for finite grids and numerical experiments validating the efficacy and utility of these approximations.

preprint2016arXiv

The Phylogenetic LASSO and the Microbiome

Scientific investigations that incorporate next generation sequencing involve analyses of high-dimensional data where the need to organize, collate and interpret the outcomes are pressingly important. Currently, data can be collected at the microbiome level leading to the possibility of personalized medicine whereby treatments can be tailored at this scale. In this paper, we lay down a statistical framework for this type of analysis with a view toward synthesis of products tailored to individual patients. Although the paper applies the technique to data for a particular infectious disease, the methodology is sufficiently rich to be expanded to other problems in medicine, especially those in which coincident `-omics' covariates and clinical responses are simultaneously captured.